当前位置： SCI文献检索 > CLINICAL ENDOCRINOLOGY期刊下所有文献 > Bone mineral density and fractures in congenital adrenal hyperplasia: Findings from the dsd-LIFE study.

Bone mineral density and fractures in congenital adrenal hyperplasia: Findings from the dsd-LIFE study.

Abstract：

BACKGROUND:In patients with congenital adrenal hyperplasia (CAH) type and doses of glucocorticoids used as well as sex hormone secretion during puberty have important actions on bone mineral density (BMD) in adulthood. AIM:To evaluate BMD in adult CAH patients depending on current glucocorticoid therapy and on androgen levels in adulthood and at age 16 years. METHODS:We included 244 CAH patients from the dsd-LIFE cohort (women n = 147, men n = 97; salt-wasting n = 148, simple-virilizing n = 71, nonclassical n = 25) in which BMD and bloods were available. Clinical and hormonal data at age 16years were retrieved from patients' files. RESULTS:Simple-virilizing women showed lower BMD compared to salt-wasting women at trochanter (0.65 ± 0.12 vs 0.75 ± 0.15 g/cm2 ; P < .050), whole femur T-score (-0.87 ± 1.08 vs -0.16 ± 1.24; P < .05) and lumbar T-score (-0.81 ± 1.34 vs 0.09 ± 1.3; P < .050). Fracture prevalence did not differ significantly between the CAH groups. Prednisolone vs. hydrocortisone only therapy caused worse trochanter Z-score (-1.38 ± 1.46 vs -0.47 ± 1.16; P < .050). In women lumbar spine, BMD correlated negatively with hydrocortisone-equivalent dose per body surface (r2  = 0.695, P < .001). Furthermore, BMI at age 16years correlated positively with lumbar spine T-score (r2  = 0.439, P = .003) and BMD (r2  = 0.420, P = .002) in women. The androstenedione/testosterone ratio at age 16years correlated positively with lumbar spine Z-score in women (r2  = 0.284, P = .024) and trochanter Z-score in men (r2  = 0.600, P = .025). CONCLUSION:Higher glucocorticoid doses seemed to cause lower BMD especially in women. Prednisolone appeared to have more detrimental effects on BMD than hydrocortisone. Higher glucocorticoid doses (lower androstenedione/testosterone ratio) during adolescence may cause lower BMD in adulthood.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Riehl G,Reisch N,Roehle R,Claahsen van der Grinten H,Falhammar H,Quinkler M

doi

10.1111/cen.14149

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

284-294

issue

4

eissn

0300-0664

issn

1365-2265

journal_volume

92

pub_type

杂志文章

相关文献

CLINICAL ENDOCRINOLOGY文献大全
  • MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis.

    abstract：PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2009.03725.x

    authors： Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

    更新日期：2010-06-01 00:00:00

  • Stilboestrol pretreatment of children with short stature does not affect the growth hormone response to growth hormone-releasing hormone.

    abstract：:Oestrogens are known to enhance both basal and stimulated GH secretion. To examine whether this effect is mediated through the hypothalamus or the pituitary we performed insulin tolerance and GH-releasing hormone (GHRH) tests with and without oestrogen priming in a group of 14 short children. Pretreatment with stilboe...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1987.tb01140.x

    authors： Ross RJ,Grossman A,Davies PS,Savage MO,Besser GM

    更新日期：1987-08-01 00:00:00

  • The importance of thyroid microsomal antibodies in the development of elevated serum TSH in middle-aged women: associations with serum lipids.

    abstract：OBJECTIVE:We assessed the relative risk of both serum TSH and antithyroid antibody concentrations with regard to progression of thyroid failure and studied the lipid profiles of individuals with elevated TSH levels. DESIGN, PATIENTS AND MEASUREMENTS:In a randomly selected group of 427 women aged 40-60 (mean 55) years ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1993.tb02366.x

    authors： Geul KW,van Sluisveld IL,Grobbee DE,Docter R,de Bruyn AM,Hooykaas H,van der Merwe JP,van Hemert AM,Krenning EP,Hennemann G

    更新日期：1993-09-01 00:00:00

  • T-cell sensitization to autologous thyroid cells and normal non-specific suppressor T-cell function in Graves' disease.

    abstract：:We have employed a syngeneic system utilizing thyroid cell monolayers initiated following thyroid surgery co-cultured with autologous T cells to demonstrate T cell autosensitization in patients with Graves' disease. Antigen-induced blastogenesis was monitored using 24 h [3H]thymidine uptake. Control experiments with 5...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1985.tb01077.x

    authors： Davies TF,Bermas B,Platzer M,Roman SH

    更新日期：1985-02-01 00:00:00

  • The level of endothelin-like immunoreactivity in seminal fluid correlates positively with semen volume and negatively with plasma gonadotrophin levels.

    abstract：OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1994.tb03932.x

    authors： Hammami MM,Haq A,AlSedairy S

    更新日期：1994-03-01 00:00:00

  • Clinical and biochemical effects of incremental doses of the long-acting somatostatin analogue SMS 201-995 in ten acromegalic patients.

    abstract：:Ten patients (seven women, three men) with active acromegaly, five previously treated and five newly diagnosed, were included in an open-label prospective trial of 3 daily subcutaneous injections of the long-acting somatostatin analogue SMS 201-995 (Sandostatin) at increasing doses in order to obtain maximum growth ho...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1990.tb00916.x

    authors： Shi YF,Harris AG,Zhu XF,Deng JY

    更新日期：1990-06-01 00:00:00

  • Phospholipase C activity in human endometrium: its significance in endometrial pathology.

    abstract：:Phospholipase C activity was measured in human endometrium using an assay based on the release of total labelled water soluble products (inositol, inositol phosphates) from L-3-phosphatidyl-[2-3H] inositol. The enzyme was shown to be calcium dependent and to have an optimum pH of 5.5. There was no difference between p...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1987.tb01157.x

    authors： Bonney RC,Franks S

    更新日期：1987-09-01 00:00:00

  • The role of endogenous opioids in the chlorpropamide alcohol flush.

    abstract：:The response of plasma immunoreactive met-enkephalin (IR-met-enkephalin) to ethanol (8 g by mouth) after chlorpropamide (250 mg daily for 14 d) was studied in three groups of non-insulin dependent diabetics (a) six diabetics who showed chlorpropamide alcohol flush (CPAF) and in whom the reaction could be blocked by in...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1984.tb01386.x

    authors： Johnston C,Wiles PG,Medbak S,Bowcock S,Cooke ED,Pyke DA,Rees LH

    更新日期：1984-11-01 00:00:00

  • The sulpiride test in panhypopituitarism.

    abstract：:The results obtained with a new test of prolactin (PRL) release in six panhypopituitary patients as compared to fourteen normal subjects (eight females and six males) are presented. The test consists of the i.m. administration of 100 mg of sulpiride and the measurement of plasma PRL by a double antibody radioimmunoass...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1978.tb01494.x

    authors： Batrinos ML,Pavlou SN,Pitoulis SA,Sfikaki AP,Alexandrides TK,Piaditis GP

    更新日期：1978-03-01 00:00:00

  • Hyperprolactinaemia in congenital hypothyroidism.

    abstract：:Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1986.tb03269.x

    authors： McCormick KL

    更新日期：1986-03-01 00:00:00

  • Elevated insulin-like growth factor-1 in Cushing's disease.

    abstract：OBJECTIVE:To determine if patients with untreated Cushing's disease have higher serum insulin-like growth factor-1 (IGF-1) compared to matched controls, and if IGF-1 decreases following remission of Cushing's disease. DESIGN:Retrospective case-control study matching Cushing's disease cases to control patients for aden...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13974

    authors： English K,Chikani V,Dimeski G,Inder WJ

    更新日期：2019-07-01 00:00:00

  • Thyroid suppression test with L-thyroxine and [99mTc] pertechnetate.

    abstract：OBJECTIVE:The thyroid suppression test is still used in some centres as an adjunt in the diagnosis of autonomous functioning thyroid nodules. With the purpose of minimizing the disadvantages of the original T3 suppression test, we have evaluated the efficacy of a method using L-thyroxine as TSH suppression agent and [9...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.2000.00898.x

    authors： Ramos CD,Zantut-Wittmann DE,Tambascia MA,Assumpção L,Etchebehere EC,Camargo EE

    更新日期：2000-04-01 00:00:00

  • Recent concerns surrounding HRT.

    abstract：:Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2265.2003.01815.x

    authors： Armitage M,Nooney J,Evans S

    更新日期：2003-08-01 00:00:00

  • BclI polymorphism of the glucocorticoid receptor gene is associated with increased bone resorption in patients on glucocorticoid replacement therapy.

    abstract：CONTEXT:Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive weight-adapted standard glucocorticoid replacement therapy. Clinically, some patients appear more sensitive to therapeutic administration of glucocorticoids than others. Glucocorticoid sensitivity is...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.12096

    authors： Koetz KR,van Rossum EF,Ventz M,Diederich S,Quinkler M

    更新日期：2013-06-01 00:00:00

  • Effect of thyroxine on the inactivation of thyrotrophin-releasing hormone by rat and human plasma.

    abstract：:The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine. 48 h after the onset of treatment with thyroxine, the capacity of rat plasma to inactivate [3H]TRH was significantly increased. The percentage of dea...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1976.tb01961.x

    authors： Dupont A,Labrie F,Levasseur L,Dussault JH,Schally AV

    更新日期：1976-07-01 00:00:00

  • Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case-control study.

    abstract：OBJECTIVE:Foetal exposure to high testosterone concentrations seems to be involved in the development of mammalian brain and related to pervasive developmental disorders (PDDs). The aim of the current study was to test the hypothesis that children born from hyperandrogenic women with polycystic ovary syndrome (PCOS) ar...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2012.04443.x

    authors： Palomba S,Marotta R,Di Cello A,Russo T,Falbo A,Orio F,Tolino A,Zullo F,Esposito R,La Sala GB

    更新日期：2012-12-01 00:00:00

  • Identification and characterization of the human hepatic androgen receptor.

    abstract：:Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) prese...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1985.tb01108.x

    authors： Bannister P,Sheridan P,Losowsky MS

    更新日期：1985-11-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of subcutaneous testosterone implants in hypogonadal men.

    abstract：OBJECTIVE:There are advantages and disadvantages with all of the presently available types of testosterone replacement for hypogonadal men. We performed this investigation to establish detailed data about the pharmacokinetics, pharmacodynamics, feasibility and side-effects of subcutaneously implanted testosterone (T) p...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1996.tb02061.x

    authors： Jockenhövel F,Vogel E,Kreutzer M,Reinhardt W,Lederbogen S,Reinwein D

    更新日期：1996-07-01 00:00:00

  • Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomized, placebo-controlled study.

    abstract：OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.1995.tb00536.x

    authors： Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

    更新日期：1995-12-01 00:00:00

  • Alterations in the hypothalamic-pituitary-thyroid axis after prolonged residence in Antarctica.

    abstract：:The human population which lives and works in polar environments has been increasing steadily over the last 15 years. Very little is known about how these residents adjust to their environment. Cold adaptation in man is a poorly understood phenomenon. Euthermic mammals maintain body temperature during cold exposure vi...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1986.tb03595.x

    authors： Reed HL,Burman KD,Shakir KM,O'Brian JT

    更新日期：1986-07-01 00:00:00

  • Pituitary-ovarian function before, during and after the menopause: a longitudinal study.

    abstract：:The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1982.tb01616.x

    authors： Metcalf MG,Donald RA,Livesey JH

    更新日期：1982-11-01 00:00:00

  • Abnormal circadian rhythm and increased non-pulsatile secretion of thyrotrophin in Sheehan's syndrome.

    abstract：OBJECTIVE:It has previously been shown that patients with postpartum pituitary necrosis (Sheehan's syndrome, SS) have paradoxically increased TSH levels and loss of the nocturnal TSH surge. This study sought to determine the circadian and pulsatile characteristics of TSH secretion underlying those abnormalities. DESIG...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1999.00808.x

    authors： MacCagnan P,Oliveira JH,Castro V,Abucham J

    更新日期：1999-10-01 00:00:00

  • The basal plasma glucose: a simple relevant index of maturity-onset diabetes.

    abstract：:The 'basal' plasma glucose, defined as the stable overnight concentration, has been assessed as an index of diabetes control by comparison with plasma glucose measurements during 24-h profiles in diet-treated maturity-onset diabetic patients and normal subjects. The basal plasma glucose correlated with the total (r=0....

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1981.tb00196.x

    authors： Holman RR,Turner RC

    更新日期：1981-03-01 00:00:00

  • A review of the tumour spectrum of germline succinate dehydrogenase gene mutations: Beyond phaeochromocytoma and paraganglioma.

    abstract：:The citric acid cycle, also known as the Krebs cycle, plays an integral role in cellular metabolism and aerobic respiration. Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes. The succinate dehydr...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/cen.14289

    authors： MacFarlane J,Seong KC,Bisambar C,Madhu B,Allinson K,Marker A,Warren A,Park SM,Giger O,Challis BG,Maher ER,Casey RT

    更新日期：2020-11-01 00:00:00

  • The effect of thyroxine on small intestinal motility in the elderly.

    abstract：OBJECTIVE:To study the effects of thyroxine on orocaecal transit time in a group of elderly hypothyroid patients on long-term thyroxine replacement therapy. DESIGN:Measurement of the effect of withdrawal and subsequent replacement of thyroxine replacement therapy on orocaecal transit time. PATIENTS:Fifteen elderly, p...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1991.tb03563.x

    authors： Rahman Q,Haboubi NY,Hudson PR,Lee GS,Shah IU

    更新日期：1991-11-01 00:00:00

  • PCR analysis and sequencing of the SRY sex determining gene in four patients with bilateral congenital anorchia.

    abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1993.tb00993.x

    authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

    更新日期：1993-02-01 00:00:00

  • Long term results of radical hypophysectomy for Cushing's disease.

    abstract：:Sixteen consecutive cases of Cushing's disease were treated by radical transphenoidal hypophysectomy. Surgical removal was not possible in two cases. Of the other 14, there was total clinical and biochemical remission of the disease in 13 and partial remission in one. Some form of replacement therapy has been necessar...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1983.tb00041.x

    authors： Thomas JP,Richards SH

    更新日期：1983-11-01 00:00:00

  • Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).

    abstract：OBJECTIVE:To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/cen.12864

    authors： Bosch E,Nyboe Andersen A,Barri P,García-Velasco JA,de Sutter P,Fernández-Sánchez M,Visnova H,Klein BM,Mannaerts B,Arce JC

    更新日期：2015-12-01 00:00:00

  • The octreotide suppression test and [111In-DTPA-D-Phe1]-octreotide scintigraphy in neuroendocrine tumours correlate with responsiveness to somatostatin analogue treatment.

    abstract：OBJECTIVE:The somatostatin analogue octreotide (Sandostatin, Novartis, Basie) significantly improves the syndromes suffered by most patients with neuroendocrine tumours (NETs). The use of [111In-DTPA-D-Phe1]-octreotide scintigraphy ([111In]-pentetreotide) to predict the response to octreotide treatment has been describ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1998.00373.x

    authors： Shi W,Buchanan KD,Johnston CF,Larkin C,Ong YL,Ferguson R,Laird J

    更新日期：1998-03-01 00:00:00

  • Impaired circulating glucagon-like peptide-1 response to oral glucose in women with previous gestational diabetes.

    abstract：BACKGROUND AND OBJECTIVE:Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon-like peptide-1 (GLP-1) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP-1 secretion might be ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2004.02172.x

    authors： Forbes S,Moonan M,Robinson S,Anyaoku V,Patterson M,Murphy KG,Ghatei MA,Bloom SR,Johnston DG

    更新日期：2005-01-01 00:00:00