The effect of thyroxine on small intestinal motility in the elderly.

abstract：:The identification of genes placing individuals at an increased risk for the development of autoimmune thyroid disease (AITD) has been a slow process. However, over the last 20 years or so real progress has been made with the mapping of novel loci, via a number of different approaches. First, through the use of tradit...

journal_title：Clinical endocrinology

authors： Zeitlin AA,Simmonds MJ,Gough SC

更新日期：2008-05-01 00:00:00

abstract：:Hypercalcaemia, a common complication of malignancy, may result from either the lytic effect of multiple osseous metastases or the effect of tumour-derived humoral factors. Excessive secretion of parathyroid hormone-related peptide (PTHrP), a major cause of humoral hypercalcaemia of malignancy, has been incriminated a...

journal_title：Clinical endocrinology

authors： Mantzoros CS,Suva LJ,Moses AC,Spark R

更新日期：1997-03-01 00:00:00

abstract：CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

journal_title：Clinical endocrinology

authors： Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

journal_title：Clinical endocrinology

authors： Moreira AC,Castro M,Machado HR

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended ...

journal_title：Clinical endocrinology

authors： Kim HW,Park H,Cho KH,Han K,Ko BJ

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The association of adrenal hyperactivity with ovarian dysfunction may involve direct inhibition of ovarian steroidogenesis by glucocorticoids. Therefore, the objectives of this study were to investigate the direct effects of cortisol on luteinizing hormone (LH) action in human granulosa-lutein cells and the m...

journal_title：Clinical endocrinology

authors： Michael AE,Pester LA,Curtis P,Shaw RW,Edwards CR,Cooke BA

更新日期：1993-06-01 00:00:00

abstract：:Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adi...

journal_title：Clinical endocrinology

authors： Savino F,Fissore MF,Liguori SA,Oggero R

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Obestatin is a novel hormone that is encoded by the Ghrelin gene and produced in the gut. Ghrelin is profoundly orexogenic and adipogenic, increasing food intake and body weight. This new ghrelin-associated peptide behaves as a physiological opponent of ghrelin in rodent animals, but its pathophysiological r...

journal_title：Clinical endocrinology

authors： Qi X,Li L,Yang G,Liu J,Li K,Tang Y,Liou H,Boden G

更新日期：2007-04-01 00:00:00

abstract：CONTEXT:Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIG...

journal_title：Clinical endocrinology

authors： Garrahy A,Galloway I,Hannon AM,Dineen R,Javadpour M,Tormey WP,Gan KJ,Twomey PJ,Mc Kenna MJ,Kilbane M,Crowley RK,Sherlock M,Thompson CJ

更新日期：2020-11-11 00:00:00

abstract：OBJECTIVES:To report and explore potential reasons for undetectable or low-normal serum intact PTH levels in patients with surgically verified primary hyperparathyroidism with parathyroid adenomas, review the relevant literature, and offer suggestions for management of such patients occasionally encountered in clinical...

journal_title：Clinical endocrinology

authors： Bhadada SK,Cardenas M,Bhansali A,Mittal BR,Behera A,Chanukya GV,Nahar U,Rao DS

更新日期：2008-09-01 00:00:00

abstract：:In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.), arginine (30 g i.v. over 30 min) and L-dopa (500 mg orally) administered alone and 120 minutes following pretreatment with GHRH 1-44 (200 micrograms i.v.) in no...

journal_title：Clinical endocrinology

authors： Page MD,Dieguez C,Valcavi R,Edwards C,Hall R,Scanlon MF

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

journal_title：Clinical endocrinology

authors： Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Acromegalic patients have increased prevalence of colonic polyps. Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) 2 haploinsufficiency in animal models of acromegaly. OBJECTIVE AND PATIENTS:To evaluate whether variations in SOCS2 expression in the colonic mucosa of...

journal_title：Clinical endocrinology

authors： Bogazzi F,Ultimieri F,Raggi F,Russo D,Costa A,Marciano E,Bartalena L,Martino E

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

journal_title：Clinical endocrinology

authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:There has been a rapid shift from open to laparoscopic approaches in adrenal surgery, but the safety and efficacy of bilateral laparoscopic adrenalectomy (BLA) in patients with corticotrophin (ACTH)-dependent Cushing's syndrome continues to be defined. OBJECTIVE:Review outcomes in the largest series of pati...

journal_title：Clinical endocrinology

authors： Chow JT,Thompson GB,Grant CS,Farley DR,Richards ML,Young WF Jr

更新日期：2008-04-01 00:00:00

abstract：:Trilostane is a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase activity in vitro and an orally active inhibitor of steroidogenesis in vivo. A cytochemical section bioassay for this drug (4 alpha, 5-epoxy-17 beta-hydroxy-3-oxo-5 alpha-androstane-2 alpha-carbonitrile) in human plasma has been developed. Th...

journal_title：Clinical endocrinology

authors： Earnshaw RJ,Mitchell R,Robertson WR

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:There is a lack of normal reference data on urinary GH (u-GH) excretion in children. We have investigated the impact of age, gender, pubertal development and body mass on reference values for u-GH excretion in normally growing non-obese and obese children. STUDY DESIGN:u-GH levels were evaluated in 1153 heal...

journal_title：Clinical endocrinology

authors： Bona G,Petri A,Rapa A,Conti A,Sartorio A

更新日期：1999-06-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagno...

journal_title：Clinical endocrinology

authors： Nixon AM,Provatopoulou X,Kalogera E,Zografos GN,Gounaris A

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:Poorly differentiated thyroid cancer (PDTC) is a rare, but aggressive thyroid cancer (TC) and a main cause of death from non-anaplastic follicular cell-derived TC. Assessing the risk of PDTC-related death and the risk of recurrence is important for clinicians. The recent American Thyroid Association (ATA) 201...

journal_title：Clinical endocrinology

authors： Walczyk A,Kopczyński J,Gąsior-Perczak D,Pałyga I,Kowalik A,Chrapek M,Hejnold M,Góźdź S,Kowalska A

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX. DE...

journal_title：Clinical endocrinology

authors： Lu KC,Ma WY,Yu JC,Wu CC,Chu P

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:A population-based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population. METHODS:In this study, patients identified with chronic hypoparathyroidism using data linkage from regional datasets were compared with five age- and gender...

journal_title：Clinical endocrinology

authors： Vadiveloo T,Donnan PT,Leese CJ,Abraham KJ,Leese GP

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Although the polymorphisms of the cytotoxic T lymphocyte antigen 4 (CTLA4) gene have been shown to be associated with Type 1 diabetes in Caucasians, some conflicting results have been reported among subjects of different ethnic backgrounds. We examined a CTLA4 polymorphism and its relationship to human leucoc...

journal_title：Clinical endocrinology

authors： Kikuoka N,Sugihara S,Yanagawa T,Ikezaki A,Kim HS,Matsuoka H,Kobayashi Y,Wataki K,Konda S,Sato H,Miyamoto S,Sasaki N,Sakamaki T,Niimi H,Murata M

更新日期：2001-11-01 00:00:00

abstract：:Serum immunoreactive melatonin was measured in thirty-three male subjects with delayed puberty, thirty of whom had simple (idiopathic) delayed puberty (SDP) and three of whom were GH deficient. The results were compared with a control population of twenty-six subjects. Significantly elevated values of serum melatonin ...

journal_title：Clinical endocrinology

authors： Cohen HN,Hay ID,Annesley TM,Beastall GH,Wallace AM,Spooner R,Thomson JA,Eastwold P,Klee GG

更新日期：1982-11-01 00:00:00

abstract：:Transsphenoidal surgery is the treatment of choice for nonfunctioning pituitary macroadenomas but is seldom curative. Tumour progression rates are high in patients with postoperative remnants. Therefore, long-term monitoring is necessary to detect tumour growth, which may be asymptomatic or manifest with visual field ...

journal_title：Clinical endocrinology

authors： Greenman Y,Stern N

更新日期：2009-06-01 00:00:00

abstract：:A single-dose study was performed to examine the pharmacokinetics of subcutaneous octreotide in acromegalic patients and to investigate the relationship between growth hormone and the elimination half-life of the drug. Fourteen acromegalic patients (six men and eight women; age range 35-59 years) who had previously re...

journal_title：Clinical endocrinology

authors： Nicholls J,Wynick D,Domin J,Sandler LM,Bloom SR

更新日期：1990-05-01 00:00:00

abstract：:Infertility with azoospermia requires a diligent search for reversible factors and treatment to restore natural fertility, even though most cases are due to untreatable primary spermatogenic failure and are destined to require consideration of assisted reproductive treatment (ART) options. Complete clinical and diagno...

journal_title：Clinical endocrinology

authors： McLachlan RI

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Calcium absorption is an important determinant of calcium retention and bone metabolism. However, most methods of measuring calcium absorption, including the well-established dual stable isotope method, are costly and cumbersome to implement. We evaluated whether an oral calcium tolerance test (OCTT), which i...

journal_title：Clinical endocrinology

authors： Ceglia L,Abrams SA,Harris SS,Rasmussen HM,Dallal GE,Dawson-Hughes B

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore, we investigated the adi...

journal_title：Clinical endocrinology

authors： Wagenmakers M,Roerink S,Gil L,Plantinga T,Smit J,Netea-Maier R,Hermus A

更新日期：2015-02-01 00:00:00

abstract：:Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...

journal_title：Clinical endocrinology

authors： McCormick KL

更新日期：1986-03-01 00:00:00