Growth hormone (GH) responses to arginine and L-dopa alone and after GHRH pretreatment.

abstract：PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

journal_title：Clinical endocrinology

authors： Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Primary glucocorticoid resistance is characterized by decreased sensitivity to cortisol signalling. We have performed genetic analysis of the glucocorticoid receptor (GR) gene in 12 unrelated patients with primary cortisol resistance as defined by a pathological dexamethasone suppression test. METHODS:Exon s...

journal_title：Clinical endocrinology

authors： Ruiz M,Lind U,Gåfvels M,Eggertsen G,Carlstedt-Duke J,Nilsson L,Holtmann M,Stierna P,Wikström AC,Werner S

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of CRH administration on plasma AVP and ANF concentration in patients with Cushing's disease and healthy subjects. SUBJECTS:Fifteen patients with Cushing's disease and 15 sex- and age-matched healthy subjects entered the study. STUDY DESIGN:All subjects were randomly given i.v. 100 mi...

journal_title：Clinical endocrinology

authors： Colao A,Pivonello R,Ferone D,Faggiano A,Facciolli G,Di Somma C,Boudouresque F,Oliver C,Lombardi G

更新日期：1998-07-01 00:00:00

abstract：:The human population which lives and works in polar environments has been increasing steadily over the last 15 years. Very little is known about how these residents adjust to their environment. Cold adaptation in man is a poorly understood phenomenon. Euthermic mammals maintain body temperature during cold exposure vi...

journal_title：Clinical endocrinology

authors： Reed HL,Burman KD,Shakir KM,O'Brian JT

更新日期：1986-07-01 00:00:00

abstract：:We studied variables known to change with thyroid hormone status in 18 patients with subclinical hypothyroidism before and during treatment with thyroxine in a dose sufficient to restore the plasma TSH response to TRH to normal. There was an associated increase in both plasma total T4 and free T4 within the normal ran...

journal_title：Clinical endocrinology

authors： Bell GM,Todd WT,Forfar JC,Martyn C,Wathen CG,Gow S,Riemersma R,Toft AD

更新日期：1985-01-01 00:00:00

abstract：:Using a sensitive enzyme amplified immunoassay for TSH, the evening rise and pulsatile release of TSH were studied in 10 men with chronic renal failure treated by haemodialysis. Compared to euthyroid male controls the evening rise of TSH was attenuated (median 0.066 vs 0.195 mU/l/h, P less than 0.01) and the rate of r...

journal_title：Clinical endocrinology

authors： Wheatley T,Clark PM,Clark JD,Holder R,Raggatt PR,Evans DB

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to investigate the possibility of impaired lipolysis of triglyceride-rich lipoproteins in patients with abdominal visceral fat accumulation by assessing two major lipolytic enzymes in the plasma, lipoprotein lipase (LPL) and hepatic lipase (HL). DESIGN AND PATIENTS:A total of 3...

journal_title：Clinical endocrinology

authors： Kobayashi J,Tashiro J,Murano S,Morisaki N,Saito Y

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

journal_title：Clinical endocrinology

authors： Zhang BC,Liu WJ,Che WL,Xu YW

更新日期：2012-09-01 00:00:00

abstract：:A 16-year-old female patient with an adrenal tumour was studied. Clinically she had progressive hirsutism, showed high urinary 17-oxosteroid excretion with normal plasma cortisol. Plasma C19-steroids, both unconjugated (including testosterone) and sulphate-conjugated, were greatly elevated. On surgical exploration an ...

journal_title：Clinical endocrinology

authors： Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

更新日期：1978-04-01 00:00:00

abstract：:The ultrastructural effects of a Leydig cell tumour of the testis on nontumorous testicular tissue have not yet been reported. Described here are the electron microscopic findings in the nonneoplastic testicular tissue of a patient with a feminizing testicular Leydig cell neoplasm. Serial studies were carried out over...

journal_title：Clinical endocrinology

authors： Sohval AR,Churg J,Suzuki Y,Katz N,Gabrilove JL

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Cabergoline therapy normalizes prolactin levels and reduces the size of macroprolactinomas. However there are no data indicating whether cabergoline can normalize growth hormone secretion in patients who were growth hormone deficient at the time of diagnosis of a macroprolactinoma. SUBJECTS AND METHODS:We st...

journal_title：Clinical endocrinology

authors： George LD,Nicolau N,Scanlon MF,Davies JS

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Low serum testosterone is commonly observed in men with type 2 diabetes (T2DM), but the neuroendocrine pathophysiology remains to be elucidated. OBJECTIVES:The hypothalamic neuropeptide kisspeptin integrates metabolic signals with the reproductive axis in animal models. We hypothesized that administration of...

journal_title：Clinical endocrinology

authors： George JT,Veldhuis JD,Tena-Sempere M,Millar RP,Anderson RA

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

journal_title：Clinical endocrinology

authors： Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Surgery of bone metastases from differentiated thyroid carcinoma seems indicated in individual patients. This study was performed (1) to analyse retrospectively patients with bone metastases from differentiated thyroid carcinoma and (2) to evaluate the impact of surgery of bone metastases on survival. PATIEN...

journal_title：Clinical endocrinology

authors： Zettinig G,Fueger BJ,Passler C,Kaserer K,Pirich C,Dudczak R,Niederle B

更新日期：2002-03-01 00:00:00

abstract：:Exposure to maternal hypothyroxinemia during pregnancy, which is characterized by low free T4 but normal thyroid-stimulating hormone (TSH) levels, can negatively affect the foetus. This review provides an overview of present findings concerning the association between maternal hypothyroxinemia during pregnancy and chi...

journal_title：Clinical endocrinology

authors： Henrichs J,Ghassabian A,Peeters RP,Tiemeier H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:In patients with acromegaly serum IGF-I is increasingly used as a marker of disease activity. As a result, the relationship between serum GH and IGF-I is of profound interest. Healthy females secrete three times more GH than males but have broadly similar serum IGF-I levels, and women with GH deficiency requ...

journal_title：Clinical endocrinology

authors： Parkinson C,Renehan AG,Ryder WD,O'Dwyer ST,Shalet SM,Trainer PJ

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...

journal_title：Clinical endocrinology

authors： Amato MC,Galluzzo A,Finocchiaro S,Criscimanna A,Giordano C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 +/- 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Instit...

journal_title：Clinical endocrinology

authors： Rizzo M,Pernice V,Frasheri A,Di Lorenzo G,Rini GB,Spinas GA,Berneis K

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:We assessed body composition, bone mineral density (BMD), glucose and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN:Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHAN...

journal_title：Clinical endocrinology

authors： Shaikh S,Waxler JL,Lee H,Grinke K,Garry J,Pober BR,Stanley TL

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. DESIGN:The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents wi...

journal_title：Clinical endocrinology

authors： Interdonato M,Pizzino G,Bitto A,Galfo F,Irrera N,Mecchio A,Pallio G,Ramistella V,De Luca F,Santamaria A,Minutoli L,Marini H,Squadrito F,Altavilla D

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To determine whether treatment with transdermal oestrogen replacement therapy (TERT) in postmenopausal women with type 2 diabetes mellitus was able to increase the activity of constitutive nitric oxide synthase (cNOS) in platelets. RESEARCH DESIGN AND METHODS:Eighteen postmenopausal women with type 2 diabete...

journal_title：Clinical endocrinology

authors： Martina V,Bruno GA,Origlia C,Gaia D,Trucco F,Pescarmona G

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

journal_title：Clinical endocrinology

authors： Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Calcium absorption is an important determinant of calcium retention and bone metabolism. However, most methods of measuring calcium absorption, including the well-established dual stable isotope method, are costly and cumbersome to implement. We evaluated whether an oral calcium tolerance test (OCTT), which i...

journal_title：Clinical endocrinology

authors： Ceglia L,Abrams SA,Harris SS,Rasmussen HM,Dallal GE,Dawson-Hughes B

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Data about GnRHa on adult height in girls with central precocious puberty(CPP) have shown variable results, ranging from improvement of growth prognosis to lack of any benefit.This study was designed to delineate the criteria to decide which girls with idiopathic CPP(iCPP) will have a height benefit from GnRH...

journal_title：Clinical endocrinology

authors： Vuralli D,Gonc EN,Ozon ZA,Kandemir N,Alikasifoglu A

更新日期：2021-01-18 00:00:00

abstract：OBJECTIVE:The increasing use in clinical practice of octreotide (a somatostatin analogue which inhibits the secretion of GH and other peptide hormones) led us to study the effects of this treatment on GH, insulin-like growth factors (IGF)-I and II and IGF-binding protein (IGFBP)-3, as well as on circulating IGFBP compl...

journal_title：Clinical endocrinology

authors： Barreca A,Cariola G,Ponzani P,Arvigo M,Foppiani L,Giordano G,Minuto F

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Testosterone replacement is generally considered likely to be required only at testicular radiation doses in excess of 20Gy. Long-term data are not available for patients receiving 9-14.4Gy as part of Total Body Irradiation in childhood. DESIGN:Retrospective cohort study. DATA COLLECTION:notes review, labor...

journal_title：Clinical endocrinology

authors： Taneja S,Rao A,Nussey S,Leiper A

更新日期：2019-11-01 00:00:00

abstract：:Administration of the anti-inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 +/- 8.6 (SEM) nmol/l before therapy was normalized to 70 +/- 6.4 nmol/l after administration of the drug...

journal_title：Clinical endocrinology

authors： Pearson DW,Ratcliffe WA,Thomson JA,Ratcliffe JG

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVE:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. The contribution of lipid abnormalities to this higher risk, in particular atherogenic modifications of low density lipoprotein (LDL) such as a shift towards smaller LDL, has not been properly explored. We aimed to e...

journal_title：Clinical endocrinology

authors： Dejager S,Pichard C,Giral P,Bruckert E,Federspield MC,Beucler I,Turpin G

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

journal_title：Clinical endocrinology

authors： Coussa A,Hasan HA,Barber TM

更新日期：2020-12-01 00:00:00