Serum total adiponectin level and risk of cardiovascular disease in Han Chinese populations: a meta-analysis of 17 case-control studies.


OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electronic databases were searched for relevant articles up to July 2011. A total of nine (n = 933), eight (n = 939) articles were included in each meta-analysis regarding the association of serum adiponectin level with coronary heart disease (CHD) and ischaemic stroke, respectively. Publication bias was examined by the Egger's linear regression test. Sensitivity analysis was performed by omitting one study at a time, and the pooled standardized mean difference (SMD) was estimated using fixed-effects model and random-effects model, respectively. RESULTS:Serum total adiponectin concentrations were lower in patients with CHD and ischaemic stroke, with pooled SMD of -1·41 (95% CI -1·69, -1·12, P < 0·00001) and -1·69 (95% CI -2·04, -1·33, P < 0·00001), respectively. By performing a meta-regression analysis, homeostasis model assessment of insulin resistance, study size, adiponectin measurement assays, gender and mean body mass index of cases failed to account for heterogeneity for comparisons between lower adiponectin level and ischaemic stroke. However, study size had significant effect on the association of lower adiponectin level with CHD and accounted for 96·72% of the between-study variance. No publication bias was detected. No single study was found to affect the overall result of each analysis by sensitivity testing. CONCLUSIONS:The accumulated evidence suggested that low serum adiponectin level increased the risk of a first cardiovascular event in the Han Chinese population. Further study is recommended with larger sample size to explore the role of hypoadiponectinemia in the causation of CVD.


Clin Endocrinol (Oxf)


Clinical endocrinology


Zhang BC,Liu WJ,Che WL,Xu YW




Has Abstract


2012-09-01 00:00:00












  • Influence of different genotypes on 17-hydroxyprogesterone levels in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:The diagnosis of the nonclassical form of 21-hydroxylase (NC-21OH) deficiency, established before molecular studies, is based on basal 17OH-progesterone (17OH-P) values > 15 nmol/l or ACTH-stimulated 17OH-P values > 30 nmol/l. This disease is caused by mutations in the structural gene that can be grouped into...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bachega TA,Billerbeck AE,Marcondes JA,Madureira G,Arnhold IJ,Mendonca BB

    更新日期:2000-05-01 00:00:00

  • Comparison of serum thyrotrophin concentrations determined by a third generation assay in patients with various types of overt and subclinical thyrotoxicosis.

    abstract:OBJECTIVE:Recent increases in the sensitivity of methods used to measure TSH, especially third generation assays, have enabled separation of partial from complete pituitary suppression in patients with thyrotoxicosis. We have investigated the use of a sensitive chemiluminescent enzymeimmunoassay in the differential dia...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kasagi K,Kousaka T,Misaki T,Iwata M,Alam MS,Konishi J

    更新日期:1999-02-01 00:00:00

  • Identification and management of poor response to growth-promoting therapy in children with short stature.

    abstract::Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. Recombinant human (rh) insulin-like growth factor-1 (rhIGF-1) therapy is approved for severe primary IGF-I deficiency - a state of severe GH resistance. Evidence is increasing for an unacceptably high rate of p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Bang P,Ahmed SF,Argente J,Backeljauw P,Bettendorf M,Bona G,Coutant R,Rosenfeld RG,Walenkamp MJ,Savage MO

    更新日期:2012-08-01 00:00:00

  • The influence of body mass index on the diagnostic performance of pre-operative staging ultrasound in papillary thyroid carcinoma.

    abstract:OBJECTIVE:The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging U...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Choi JS,Lee HS,Kim EK,Moon HJ,Kwak JY

    更新日期:2015-10-01 00:00:00

  • Changes in TNM stage, reoperation and 131-I ablation rate during the use of newer methods for the preoperative diagnosis of differentiated thyroid carcinoma.

    abstract:OBJECTIVE:To define and discuss the changes of important risk factors and TNM staging over the last 40 years in patients operated on for differentiated thyroid carcinoma (DTC), resulting from the introduction of newer sensitive diagnostic procedures in the preoperative evaluation of thyroid nodules. PATIENTS:We review...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Karga H,Mavroudis K,Giagourta I,Triantaphyllopoulou M,Ktena V,Kassi G,Veloutsou H,Papapetrou P

    更新日期:2012-02-01 00:00:00

  • The persistence of maternal vitamin D deficiency and insufficiency during pregnancy and lactation irrespective of season and supplementation.

    abstract:BACKGROUND:Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long-term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of m...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kramer CK,Ye C,Swaminathan B,Hanley AJ,Connelly PW,Sermer M,Zinman B,Retnakaran R

    更新日期:2016-05-01 00:00:00

  • Changes in gonadotrophin response to gonadotrophin releasing hormone in normal women following bilateral ovariectomy.

    abstract:OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

    更新日期:1997-12-01 00:00:00

  • Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization.

    abstract:OBJECTIVE:To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults. PATIENTS:Forty patients with hyperprolactinaemia (20 with disease onset during adolescence and 20 during adulthood) and 40 healthy control subjects. DES...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Colao A,Di Somma C,Loche S,Di Sarno A,Klain M,Pivonello R,Pietrosante M,Salvatore M,Lombardi G

    更新日期:2000-03-01 00:00:00

  • Results of long-term continuous subcutaneous octreotide administration in 14 patients with medullary thyroid carcinoma.

    abstract:OBJECTIVE:Treatment by octreotide has been suggested in medullary thyroid carcinoma patients with post-surgery metastases. The purpose of this study was to evaluate if the tumoral regression could be improved by a high dose and by prolonged octreotide treatment. DESIGN:Fourteen thyroidectomized patients were studied. ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Modigliani E,Cohen R,Joannidis S,Siame-Mourot C,Guliana JM,Charpentier G,Cassuto D,Bentata Pessayre M,Tabarin A,Roger P

    更新日期:1992-02-01 00:00:00

  • The levels and subcellular distribution of hormones and marker enzymes in pituitaries from control subjects and patients with prolactinomas, acromegaly or functionless pituitary tumours.

    abstract::Pituitary homogenates were prepared from patients undergoing pituitary ablation for breast or prostatic carcinoma (controls) and from patients with either PRL- and GH-secreting pituitary adenomas or from patients with 'functionless' pituitary tumours. The principal subcellular organelles, plasma membrane, lysosomes, m...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: De Marco L,Mashiter K,Peters TJ

    更新日期:1984-11-01 00:00:00

  • Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers.

    abstract:BACKGROUND:The intensive physical activity is often associated with cardiac changes. OBJECTIVES:(i) To evaluate the IGF-I system and myocardial structure and function by standard Doppler echocardiography and Tissue Doppler in athletes and sedentary controls; and (ii) to determine any relationship between IGF-I system ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vitale G,Galderisi M,Colao A,Innelli P,Guerra G,Guerra E,Dini FL,Orio F Jr,Soscia A,De Divitiis O,Lombardi G

    更新日期:2008-08-01 00:00:00

  • Prolactin levels in hypothyroid and euthyroid infants during the first week of life.

    abstract::A radioimmunoassay (RIA) procedure was devised for the estimation of PRL in eluates of dried whole blood from filter paper. Levels of PRL were measured in newborn blood obtained during the first week of life from 530 infants of normal birthweight (greater than 2500 g) with normal T4 values, 114 infants of normal birth...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mitchell ML,Hermos RJ,Bennett JE,McKenna JJ,Mitchell EL

    更新日期:1986-01-01 00:00:00

  • Adrenocortical insufficiency after pituitary surgery: an audit of the reliability of the conventional short synacthen test.

    abstract:BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

    更新日期:2005-11-01 00:00:00

  • In-vivo and in-vitro endocrine investigation of pure gonadal dysgenesis.

    abstract::Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wilson SC,Oakey RE,Scott JS

    更新日期:1988-11-01 00:00:00

  • Effects of thyroid hormones on liver binding sites for human growth hormone, as studied in the rat.

    abstract::Several weeks after thyroidectomy (T), female rats stopped growing, and their pituitary GH content had decreased to less than 2--3% of the values found for age-matched controls (C). The liver membranes of such animals were explored with human GH (hGH). It was found that in the severely hypothyroid T rat, the number, b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Duran-Garcia S,Gomez-Nieto J,Fouchereau-Peron M,Padron VF,Obregon MJ,Morreale de Escobar G,Escobar del Rey F

    更新日期:1979-09-01 00:00:00

  • Rapid improvement in visual field defects following bromocriptine treatment of patients with non-functioning pituitary adenomas.

    abstract::The role of bromocriptine in the treatment of non-functioning pituitary tumours is not yet defined. Patients with these tumours who present with visual field defects usually undergo immediate surgery. Three consecutive patients are reported: each had rapid improvement in their visual field defects following bromocript...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: D'Emden MC,Harrison LC

    更新日期:1986-12-01 00:00:00

  • Prevalence and functional analysis of the S107P polymorphism (rs6647476) of the monocarboxylate transporter 8 (SLC16A2) gene in the male population of north-west Spain (Galicia).

    abstract:OBJECTIVE:Mutations in SLC16A2, the gene encoding the thyroid hormone (TH)-specific transporter monocarboxylate transporter 8 (MCT8), result in a thyroid phenotype and severe mental retardation caused by neuronal TH deficiency. These mutational effects raise the question of whether polymorphic variation in SLC16A2 may ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lago-Lestón R,Iglesias MJ,San-José E,Areal C,Eiras A,Araújo-Vilar D,Lado-Abeal J,Domínguez-Gerpe L

    更新日期:2009-04-01 00:00:00

  • The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy--support for a role of autoimmunity against calsequestrin as the triggering event.

    abstract:BACKGROUND:Graves' Ophthalmopathy (GO) is a complex eye and orbital disorder that is uniquely linked to Graves' Hyperthyroidism (GH) and has traditionally been considered a cross-reactive immune response against the thyroid stimulating hormone receptor (TSHR) in orbital tissue. However, because there is no direct evide...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wescombe L,Lahooti H,Gopinath B,Wall JR

    更新日期:2010-10-01 00:00:00

  • Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention.

    abstract:OBJECTIVE:Ghrelin has been implicated in energy homeostasis, body weight regulation and glucose metabolism. Level of unacylated ghrelin (UAG), but not acylated ghrelin (AG), has been suggested to increase during long-term exercise. However, the association of the level of UAG with exercise-induced changes of insulin se...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cederberg H,Koivisto VM,Jokelainen J,Surcel HM,Keinänen-Kiukaanniemi S,Rajala U

    更新日期:2012-01-01 00:00:00

  • Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis.

    abstract:BACKGROUND:The prognostic value of the telomerase reverse transcriptase (TERT) promoter mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma (PTC), has been generally confirmed. To data, there is no high-level evidence approving the association of TERT promoter mutation and aggressive clinical b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析,评审


    authors: Yin DT,Yu K,Lu RQ,Li X,Xu J,Lei M,Li H,Wang Y,Liu Z

    更新日期:2016-08-01 00:00:00

  • Headache and pituitary disease: a systematic review.

    abstract::Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. Tumour size, cavernous sinus invasion, traction or displacement of intracranial pain-sensitive structures such as blood vessels, cranial nerves and dura mater, and hormonal hypersecr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Kreitschmann-Andermahr I,Siegel S,Weber Carneiro R,Maubach JM,Harbeck B,Brabant G

    更新日期:2013-12-01 00:00:00

  • Increased incidence of neoplasia in patients with pituitary adenomas. The Pituitary Study Group.

    abstract:OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

    更新日期:1998-10-01 00:00:00

  • Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method.

    abstract:OBJECTIVES:We have demonstrated previously that obesity in men was significantly associated with low plasma testosterone levels and higher concentrations of the androgen metabolite androstane-3 alpha, 17 beta-diol glucuronide, suggesting that androgen metabolism and elimination is increased in this condition. The objec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tchernof A,Lévesque E,Beaulieu M,Couture P,Després JP,Hum DW,Bélanger A

    更新日期:1999-05-01 00:00:00

  • The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours.

    abstract:BACKGROUND AND OBJECTIVE:Clinical acromegaly is characterized by dysregulation of somatotroph GH secretion in the presence of high circulating serum IGF-I levels. Physiologically, IGF-I exerts a negative feedback on GH secretion at both the hypothalamic and the pituitary levels. We have previously shown that the 943 an...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Greenman Y,Prager D,Melmed S

    更新日期:1995-02-01 00:00:00

  • Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery.

    abstract:OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

    更新日期:1992-12-01 00:00:00

  • The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain.

    abstract:BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

    更新日期:2008-08-01 00:00:00

  • Cranial radiotherapy of childhood brain tumours: growth hormone deficiency and its relation to the biological effective dose of irradiation in a large population based study.

    abstract:OBJECTIVE:The study was to determine the incidence of GH deficiency (GHD) following cranial radiotherapy (RT) for a childhood brain tumour in a large population based study and analyse the biological effective dose (BED) to the hypothalamus/pituitary (HP) region as a risk factor. DESIGN:BED was assessed by use of the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schmiegelow M,Lassen S,Poulsen HS,Feldt-Rasmussen U,Schmiegelow K,Hertz H,Müller J

    更新日期:2000-08-01 00:00:00

  • Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas - results of a prospective study.

    abstract:OBJECTIVE:With increasing use of computed tomography and magnetic resonance imaging, pituitary adenomas are being discovered incidentally with increasing frequency. However, limited data are available concerning the clinical importance and natural history of such 'incicentalomas'. We have undertaken a prospective study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Feldkamp J,Santen R,Harms E,Aulich A,Mödder U,Scherbaum WA

    更新日期:1999-07-01 00:00:00

  • Diagnosis of growth hormone deficiency after pituitary surgery: the combined acipimox/GH-releasing hormone test.

    abstract:OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: van Dam PS,Dieguez C,Cordido F,de Vries WR,Veldhuyzen BF,van Thiel E,Casanueva FF,Koppeschaar HP

    更新日期:2003-02-01 00:00:00

  • Cystic fibrosis and normal fibroblasts have identical glucocorticoid receptor profiles and induced protein responses.

    abstract::The possibility of differences in glucocorticoid sensitivity between normal and cystic fibrosis fibroblasts was studied in cultured cells derived from forearm skin biopsies. Both normal and cystic fibrosis cells bound tritiated dexamethasone with high affinity (Kd 37 degrees C approximately equal to 10 nmol/1) to a li...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Khalid BA,Gyorki S,Warne GL,Funder JW

    更新日期:1983-04-01 00:00:00