Responses of plasma adrenocortical steroids to low dose ACTH in normal subjects.

abstract：OBJECTIVE:TSH suppression therapy has been reported to be effective in some cases of papillary carcinoma of the thyroid. However, there has been little information regarding the status of expression of TSH-R mRNA in papillary carcinomas. Therefore, we examined the expression of TSH receptor (TSH-R) mRNA in thyroid tumo...

journal_title：Clinical endocrinology

authors： Tanaka K,Inoue H,Miki H,Komaki K,Monden Y

更新日期：1996-03-01 00:00:00

abstract：:In order to evaluate simultaneously in thyrotoxic subjects the relative contributions of insulin secretion, insulin-sensitivity (SI) and glucose-mediated (SG) glucose disposal to overall glucose tolerance, seven non-obese patients with thyrotoxicosis were studied by the minimal model analysis of the frequently sampled...

journal_title：Clinical endocrinology

authors： Pestell R,Alford F,Ramos R,Sawyer S,Best J,Ward G

更新日期：1990-10-01 00:00:00

abstract：:Bilateral, selective and simultaneous catheterization of the inferior petrosal sinus with measurements of ACTH after stimulation with ovine corticotrophin-releasing factor (CRF) is now frequently used to establish the differential diagnosis in patients with Cushing's disease and to determine the side of the microadeno...

journal_title：Clinical endocrinology

authors： Schulte HM,Allolio B,Günther RW,Benker G,Winkelmann W,Ohnhaus EE,Reinwein D

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:The intensive physical activity is often associated with cardiac changes. OBJECTIVES:(i) To evaluate the IGF-I system and myocardial structure and function by standard Doppler echocardiography and Tissue Doppler in athletes and sedentary controls; and (ii) to determine any relationship between IGF-I system ...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Colao A,Innelli P,Guerra G,Guerra E,Dini FL,Orio F Jr,Soscia A,De Divitiis O,Lombardi G

更新日期：2008-08-01 00:00:00

abstract：:Twenty women with secondary hypogonadism and four normal women in the early follicular phase of the cycle were treated for 7 days with 10, 50 or 100 micrograms synthetic LHRH administered intramuscularly at 4 h intervals. Concentrations of pituitary and ovarian hormones in plasma were measured at intervals during the ...

journal_title：Clinical endocrinology

authors： Vaughan Williams CA,McNeilly AS,Baird DT

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

journal_title：Clinical endocrinology

authors： Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:The molecular events leading to the development of GH-secreting pituitary tumours remain largely unknown. Gsalpha (GNAS1) mutations are found in 27-43% of sporadic GH-secreting adenomas in the Caucasian population, but the frequency of GNAS1 mutations in Japanese and Korean acromegalic patients was reported t...

journal_title：Clinical endocrinology

authors： Yamasaki H,Mizusawa N,Nagahiro S,Yamada S,Sano T,Itakura M,Yoshimoto K

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:We postulated the mechanism for the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and insulin sensitivity might relate to changes in blood flow regulation. We studied the association of this polymorphism with insulin action, and insulin-mediated changes in...

journal_title：Clinical endocrinology

authors： Foo M,Coppack SW,Denver AE,Bulmer K,Yudkin JS

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Non-tumour causes of hyperprolactinaemia, including prolactin-elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000 mU/I, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrat...

journal_title：Clinical endocrinology

authors： Pollock A,McLaren EH

更新日期：1998-10-01 00:00:00

abstract：:The cardiovascular response and the changes of plasma arginine vasopressin (AVP) concentration following graded doses of AVP infused intravenously have been defined in six normal young men. The same measurements were also made during fluid deprivation in a patient with both nephrogenic diabetes insipidus and systemic ...

journal_title：Clinical endocrinology

authors： Khokhar AM,Slater JD,Ma J,Ramage CM

更新日期：1980-09-01 00:00:00

abstract：:Raised activity of the LH axis caused by activating mutations of LH receptor gene presents with precocious puberty in boys, analogous to the presentation of LH secreting pituitary adenomas (Faggiano et al., 1983; Ambrosi et al., 1990). LH "hyperactivity' in females appears to have no effect. Hyperactivity of the FSH a...

journal_title：Clinical endocrinology

authors： Conway GS

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:We assessed the relationship between serum IGFBP-3 levels with IGF-I and quantitative GH secretory status in poorly growing children. DESIGN:We studied the relationship between 24-hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF-I and the IGFBP-3 serum levels. PATIENT...

journal_title：Clinical endocrinology

authors： Phillip M,Chalew SA,Kowarski AA,Stene MA

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to assess the relationship of different doses of a long-acting bromocriptine preparation (Parlodel LAR) to the degree and duration of PRL suppression. We also measured circulating bromocriptine levels and altered tolerability of the drug. DESIGN:A double-blind randomized study...

journal_title：Clinical endocrinology

authors： Pagani MD,Tengattini F,Montini M,Pagani G,Pedroncelli A,Gianola D,Gherardi F,Mazzocchi N,Cortesi L,Lancranjan I

更新日期：1992-04-01 00:00:00

abstract：OBJECTIVE:IGF-I has important actions on cell division, apoptosis, differentiation and metabolism, as well as on cell proliferation in vascular smooth muscle. Deficiency of GH, an important regulator of IGF-I, is associated with reduced well-being. IGF-I levels have been related to cognitive function in older individua...

journal_title：Clinical endocrinology

authors： Unden AL,Elofsson S,Knox S,Lewitt MS,Brismar K

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in acromegaly. Left ventricular mass (LVM) is an important parameter measured to detect LVH, but the relationship with body size should be considered by correcting LVM to body surface area (BSA), height or height2.7. All trials concern...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Pivonello R,Spinelli L,Ciccarelli A,de Divitiis O,Lombardi G,Colao A

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:Adrenocortical tumours in man are characterized mainly on biochemical, anatomical and histological grounds which establish their secretory pattern and, with some uncertainty, their benign or malignant nature. To study further these tumours and eventually to shed some light on their pathogenesis, we determine...

journal_title：Clinical endocrinology

authors： Gicquel C,Leblond-Francillard M,Bertagna X,Louvel A,Chapuis Y,Luton JP,Girard F,Le Bouc Y

更新日期：1994-04-01 00:00:00

abstract：:Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

journal_title：Clinical endocrinology

authors： Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVE:The euglycemic-hyperinsulinemic clamp is the gold standard to evaluate insulin resistance (IR), but there are only a few studies on the prevalence of IR in Chinese Han women with polycystic ovary syndrome (PCOS). This study investigated: (a) the prevalence of IR in Chinese Han women with PCOS by clamp, (b) th...

journal_title：Clinical endocrinology

authors： Li W,Chen Q,Xie Y,Hu J,Yang S,Lin M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

journal_title：Clinical endocrinology

authors： Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

更新日期：2008-08-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or...

journal_title：Clinical endocrinology

authors： Binder G,Schweizer R,Blumenstock G,Braun R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...

journal_title：Clinical endocrinology

authors： Amato MC,Galluzzo A,Finocchiaro S,Criscimanna A,Giordano C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

journal_title：Clinical endocrinology

authors： Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:We assessed the relative risk of both serum TSH and antithyroid antibody concentrations with regard to progression of thyroid failure and studied the lipid profiles of individuals with elevated TSH levels. DESIGN, PATIENTS AND MEASUREMENTS:In a randomly selected group of 427 women aged 40-60 (mean 55) years ...

journal_title：Clinical endocrinology

authors： Geul KW,van Sluisveld IL,Grobbee DE,Docter R,de Bruyn AM,Hooykaas H,van der Merwe JP,van Hemert AM,Krenning EP,Hennemann G

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：:Long-term bromocriptine treatment was discontinued in thirty-seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty-seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but o...

journal_title：Clinical endocrinology

authors： Bergh T,Nillius SJ,Wide L

更新日期：1982-06-01 00:00:00

abstract：OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

journal_title：Clinical endocrinology

authors： Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

更新日期：2010-02-01 00:00:00

abstract：:Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH AND FSH concentrations showed no significant chang...

journal_title：Clinical endocrinology

authors： Buvat J,Thomas K,Racadot A,Blacker C,Buvat-Herbaut M,Ferin F,Linquette M

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:Nonuniformity in suppression of spermatogenesis induced by various hormones or hormone combinations has impeded the development of an effective hormonal male contraceptive. The basis for this heterogeneity in response remained unresolved to date; however, the presence of ethnic differences points to an involv...

journal_title：Clinical endocrinology

authors： Eckardstein SV,Schmidt A,Kamischke A,Simoni M,Gromoll J,Nieschlag E

更新日期：2002-11-01 00:00:00

abstract：:Anorexia nervosa is associated with several abnormalities in GH secretion elicited by different stimuli. To investigate the precise mechanism of this alteration, GHRH was administered to 14 women: a group of eight anorexia nervosa patients in the acute phase of their illness and a control group of six age-matched volu...

journal_title：Clinical endocrinology

authors： Casanueva FF,Borras CG,Burguera B,Lima L,Muruais C,Tresguerres JA,Devesa J

更新日期：1987-11-01 00:00:00