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Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers.

Abstract：

BACKGROUND:The intensive physical activity is often associated with cardiac changes. OBJECTIVES:(i) To evaluate the IGF-I system and myocardial structure and function by standard Doppler echocardiography and Tissue Doppler in athletes and sedentary controls; and (ii) to determine any relationship between IGF-I system and echocardiographic parameters. METHODS:Nineteen male top-level rowers and 19 age-matched healthy sedentary male controls underwent blood determination of fasting serum IGF-I, IGFBP-3 and acid-labile subunit levels and standard Doppler echocardiography combined with pulsed Tissue Doppler of posterior septal wall, left ventricular (LV) lateral mitral annulus and right ventricular (RV) tricuspid annulus. Myocardial presystolic (PS(m)), systolic (S(m)), the ratio of early diastolic (E(m)) to atrial (A(m)) velocities as well as myocardial time intervals were calculated. RESULTS:Rowers had higher serum IGF-I levels (P = 0.04), higher biventricular cavity dimensions and wall thicknesses compared to controls. They also had better LV and RV myocardial function than controls. In the rowers, IGF-I was associated with LV ejection fraction (r = 0.50, P = 0.03), RV PS(m) velocity (r = 0.55, P = 0.01) and with RV myocardial precontraction time (r = -0.57, P = 0.01). These associations remained significant after adjusting for age and heart rate. CONCLUSIONS:Top-level athletes showed higher IGF-I levels and a better myocardial performance than controls, particularly for the RV systolic activity. The independent correlations between IGF-I and systolic parameters of the left (ejection fraction) and right (PS(m) velocity and precontraction time) ventricles may possibly indicate a role of IGF-I system in the modulation of myocardial inotropism in athletes. Further studies are needed to confirm this hypothesis.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Vitale G,Galderisi M,Colao A,Innelli P,Guerra G,Guerra E,Dini FL,Orio F Jr,Soscia A,De Divitiis O,Lombardi G

doi

10.1111/j.1365-2265.2008.03177.x

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

231-6

issue

eissn

0300-0664

issn

1365-2265

pii

CEN3177

journal_volume

pub_type

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Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers.