Relationships between emerging cardiovascular risk factors, z-BMI, waist circumference and body adiposity index (BAI) on adolescents.


OBJECTIVE:The body adiposity index (BAI) has been recently proposed as an alternative index to body mass index (BMI) and waist circumference (WC) to evaluate adiposity in adults, with special focus on its ability to discriminate gender specificities on adiposity. Endothelial dysfunction, circulating endothelial cells (CECs), endothelin-1 and adipocytokines are all related to atherosclerosis and nowadays considered as markers of emerging cardiovascular (CV) risk. This study aimed to determine in normal weight and obese adolescents which measures of body composition (BAI and z-BMI) or distribution (WC) correlate better with emerging CV risk markers. PATIENTS:Forty adolescents were selected according to BMI: normal weight (n = 20; 7 girls/13 boys, 14·7 ± 1·4 years, 53·4 ± 6·0 kg, z-BMI 0·6 ± 0·1) and obese ones (n = 20; 13 girls/7 boys, 14·1± 1·0 years, 86·7 ± 11·5 kg, z-BMI 2·7 ± 0·4). MEASUREMENTS:Body fat and fat mass were measured by dual-energy X-ray absorptiometry (DXA). Non-nutritive skin microvascular reactivity was evaluated by laser Doppler flowmetry with iontophoretic release of vasoactive drugs. Activated CECs were assessed by flow cytometric analysis. RESULTS:In adolescents, the measurement of % fat by DXA showed high correlation with BAI (ρ = 0·75, P < 0·0001), z-BMI (r = 0·84, P < 0·0001) and WC (r = 0·83, P < 0·0001). Endothelin-1 and activated CECs did not correlate with any anthropometric measures while adipocytokines expressed variable associations among them. Endothelium-dependent vasodilation showed higher correlation with BAI (r = -0·51, P < 0·0001) compared to z-BMI (r = -0·40, P < 0·001) or WC (r = -0·45, P < 0·001), specially on females. CONCLUSIONS:BAI was associated with emerging CV risk markers in adolescents but further research is needed to evaluate its potential in clinical and epidemiological sets.


Clin Endocrinol (Oxf)


Clinical endocrinology


Dias IB,Panazzolo DG,Marques MF,Paredes BD,Souza MG,Manhanini DP,Morandi V,Farinatti PT,Bouskela E,Kraemer-Aguiar LG




Has Abstract


2013-11-01 00:00:00












  • Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE cohort study.

    abstract:OBJECTIVES:To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. DESIGN:Prospective cohort. PATIENTS AND MEASUREMENTS:Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screeni...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bahri Khomami M,Moran LJ,Kenny L,Grieger JA,Myers J,Poston L,McCowan L,Walker J,Dekker G,Norman R,Roberts CT

    更新日期:2019-06-01 00:00:00

  • Women with high early pregnancy urinary iodine levels have an increased risk of hyperthyroid newborns: the population-based Generation R Study.

    abstract:OBJECTIVE:Iodine deficiency during pregnancy results in thyroid dysfunction and has been associated with adverse obstetric and foetal effects, leading to worldwide salt iodization programmes. As nowadays 69% of the world's population lives in iodine-sufficient regions, we investigated the effects of variation in iodine...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Medici M,Ghassabian A,Visser W,de Muinck Keizer-Schrama SM,Jaddoe VW,Visser WE,Hooijkaas H,Hofman A,Steegers EA,Bongers-Schokking JJ,Ross HA,Tiemeier H,Visser TJ,de Rijke YB,Peeters RP

    更新日期:2014-04-01 00:00:00

  • The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients.

    abstract:CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Celi FS,Zemskova M,Linderman JD,Babar NI,Skarulis MC,Csako G,Wesley R,Costello R,Penzak SR,Pucino F

    更新日期:2010-05-01 00:00:00

  • Thyroid cells in Graves' disease and Hashimoto's thyroiditis stimulate allogeneic T cells when pretreated with phorbol ester.

    abstract:OBJECTIVE:To assess the capacity of thyroid follicular cells to function as antigen presenting cells, we have examined their ability to stimulate allogeneic T cells. DESIGN:Thyroid follicular cells were pretreated with interferon-gamma or phorbol myristate acetate, washed thoroughly, and their capacity to induce allog...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tandon N,Weetman AP

    更新日期:1992-09-01 00:00:00

  • Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment.

    abstract:OBJECTIVE:In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH-deficient children tre...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Radetti G,Pasquino B,Gottardi E,Contadin IB,Rigon F,Aimaretti G

    更新日期:2004-10-01 00:00:00

  • Acromegaly.

    abstract::A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Nabarro JD

    更新日期:1987-04-01 00:00:00

  • The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non-obese and obese children.

    abstract:OBJECTIVE:There is a lack of normal reference data on urinary GH (u-GH) excretion in children. We have investigated the impact of age, gender, pubertal development and body mass on reference values for u-GH excretion in normally growing non-obese and obese children. STUDY DESIGN:u-GH levels were evaluated in 1153 heal...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bona G,Petri A,Rapa A,Conti A,Sartorio A

    更新日期:1999-06-01 00:00:00

  • Glucose tolerance and plasma immunoreactive insulin levels in acromegalics before and after selective transsphenoidal surgery.

    abstract::The glucose and immunoreactive insulin (IRI) responses to a 100 g oral glucose tolerance test (oGTT) administered to 23 acromegalic patients before and after transsphenoidal adenomectomy and to a sex and age-matched control group were studied. The preoperative growth hormone levels, ranging from 11 to 360 mU/l, had no...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Roelfsema F,Frölich M

    更新日期:1985-04-01 00:00:00

  • MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis.

    abstract:PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

    更新日期:2010-06-01 00:00:00

  • Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.

    abstract:OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

    更新日期:1996-09-01 00:00:00

  • Thyroid function and antibody studies in pernicious anaemia.

    abstract::Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Krassas G,McHardy-Young S,Ramsay I,Florin-Christensen A

    更新日期:1977-02-01 00:00:00

  • A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients.

    abstract::The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lamberts SW,Verleun T,Hofland L,Del Pozo E

    更新日期:1987-07-01 00:00:00

  • Outcomes of the Bethesda system for reporting thyroid cytopathology: Real-life experience.

    abstract:OBJECTIVE:The 2017 revised Bethesda System for Reporting Thyroid Cytopathology (BSRTC) included new malignancy rates for each category as well as new management recommendations. Here, we evaluate the malignancy rate and test performance for BSRTC categories in a middle-sized institution outside the United States (US). ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Avior G,Dagan O,Shochat I,Frenkel Y,Tessler I,Meir A,Jaffe A,Cohen O

    更新日期:2020-09-27 00:00:00

  • Peripheral bone density in women with untreated multinodular goitre.

    abstract:OBJECTIVES:We wished to determine whether women with multinodular goitre and spontaneous subclinical hyperthyroidism have decreased bone density. DESIGN AND SUBJECTS:Bone density was measured at the distal and proximal forearm. Data were expressed as Z-scores relative to the mean values out of 125 control subjects mat...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mudde AH,Reijnders FJ,Kruseman AC

    更新日期:1992-07-01 00:00:00

  • Predicting the growth response to growth hormone in patients with intrauterine growth retardation.

    abstract:OBJECTIVE:Human GH treatment of short children who had intrauterine growth retardation (IUGR) results in a highly variable growth response. The object of this study was to test the hypothesis that differences in responsiveness to exogenously administered GH might reflect differences in endogenous GH secretion or sensit...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Frank GR,Cheung PT,Horn JA,Alfaro MP,Smith EP,Chernausek SD

    更新日期:1996-06-01 00:00:00

  • Clinical and genetic changes in a case of a Cushing's carcinoma.

    abstract::A 30-year-old presented in 1984 with a clinically nonfunctional tumour which subsequently developed into a metastatic corticotrophinoma from which he died despite surgery in 1984, 1986 and 1991 and external radiotherapy in 1986. Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bates AS,Buckley N,Boggild MD,Bicknell EJ,Perrett CW,Broome JC,Clayton RN

    更新日期:1995-06-01 00:00:00

  • Clinical indicators of biochemical remission in acromegaly: does incomplete disease control always mean therapeutic failure?

    abstract:OBJECTIVE:Correction of GH and IGF-I levels are associated with improvements in insulin secretion, cardiac performance and body composition in patients with acromegaly, but whether these parallel post-treatment levels of GH-IGF-I axis activity is undefined. We investigate whether various biochemical outcomes after tran...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Damjanovic SS,Neskovic AN,Petakov MS,Popovic V,Macut D,Vukojevic P,Joksimovic MM

    更新日期:2005-04-01 00:00:00

  • Acute endocrine profile of sulpiride in the human.

    abstract::Normal men and normally menstruating women received i.m. injections of 0.1 to 4.0 mg/kg sulpiride. This psychotropic drug induced a very rapid (already significant after 5 minutes) and sustained (still significant after 7 hours) elevation of prolactin (PRL) concentrations in all subjects with no consistent modificatio...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: L'Hermite M,Denayer P,Golstein J,Virasoro E,Vanhaelst L,Copinschi G,Robyn C

    更新日期:1978-09-01 00:00:00

  • Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population.

    abstract:CONTEXT:In contrast to the cardiac hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), variations in plasma concentrations of C-type natriuretic peptide (CNP) in healthy adults are ill-defined, limiting their clinical application. OBJECTIVE:Our objective was to define the effect of age, ph...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Prickett TC,Olney RC,Cameron VA,Ellis MJ,Richards AM,Espiner EA

    更新日期:2013-05-01 00:00:00

  • Association of FcGRIIa with Graves' disease: a potential role for dysregulated autoantibody clearance in disease onset/progression.

    abstract:OBJECTIVE:Although autoantibody production is a key feature of autoimmunity, it is not known whether variation in autoantibody production and clearance pathways is involved in disease susceptibility. The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucl...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yesmin K,Hargreaves C,Newby PR,Brand OJ,Heward JM,Franklyn JA,Gough SC,Simmonds MJ

    更新日期:2010-07-01 00:00:00

  • Effects of increasing levothyroxine on pregnancy outcomes in women with uncontrolled hypothyroidism.

    abstract:OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

    更新日期:2017-01-01 00:00:00

  • Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2·6 years.

    abstract:OBJECTIVE:Obesity is characterized by hyperleptinaemia, which is associated with diabetes, hypertension and coronary heart disease. The aim of this study was to determine if body fat and muscle measures predict the natural increase in leptin over 2·6 years in older adults. METHODS:A total of 190 subjects (50% females)...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Antony B,Jones G,Stannus O,Blizzard L,Ding C

    更新日期:2013-11-01 00:00:00

  • Radiation and neuroregulatory control of growth hormone secretion.

    abstract:OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ogilvy-Stuart AL,Wallace WH,Shalet SM

    更新日期:1994-08-01 00:00:00

  • Effect of calcitonin on gastrointestinal regulatory peptides in man.

    abstract::A major physiological role of calcitonin in humans appears to be regulation of skeletal turnover. It has been suggested that another function of calcitonin is to prevent post-prandial rises in calcium, particularly in animals, but the importance of such a function in man remains to be determined. Although it is known ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Stevenson JC,Adrian TE,Christofides ND,Bloom SR

    更新日期:1985-05-01 00:00:00

  • Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia.

    abstract:OBJECTIVE:To elucidate the interaction between insulin and dehydroepi-androsterone (DHEA) concentrations, we evaluated serum DHEA and DHEA-sulphate (DHEA-S) levels in diabetic patients with hyperinsulinaemia. PATIENTS AND DESIGN:Twenty-four subjects with non-insulin dependent diabetes mellitus, 12 hyperinsulinaemic su...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yamaguchi Y,Tanaka S,Yamakawa T,Kimura M,Ukawa K,Yamada Y,Ishihara M,Sekihara H

    更新日期:1998-09-01 00:00:00

  • Influence of thyroxine treatment on thyroid size and anti-thyroid peroxidase antibodies in Hashimoto's thyroiditis.

    abstract:OBJECTIVE:It has been postulated that a decrease in thyroid size can be achieved by thyroxine treatment in patients with goitrous Hashimoto's thyroiditis but no objective data are available. We have therefore investigated the influence of thyroxine treatment on ultrasonically determined thyroid size. We also measured s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hegedüs L,Hansen JM,Feldt-Rasmussen U,Hansen BM,Høier-Madsen M

    更新日期:1991-09-01 00:00:00

  • Effect of Sandostatin LAR on sleep apnoea in acromegaly: correlation with computerized tomographic cephalometry and hormonal activity.

    abstract:OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ip MS,Tan KC,Peh WC,Lam KS

    更新日期:2001-10-01 00:00:00

  • Simultaneous study of somatotrophic and corticotrophic pituitary secretions during ornithine infusion test.

    abstract::An ornithine infusion test was performed in fifty-four children with constitutional short stature. The ornithine infusion induced an elevated level of GH at 45 min (mean value = 873 pmol/l) and a similar rise of cortisol levels (mean value = 544 nmol/l). An important peak of ACTH appeared 15 min before the increase of...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Evain-Brion D,Donnadieu M,Roger M,Job JC

    更新日期:1982-08-01 00:00:00

  • Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan.

    abstract:OBJECTIVE:We aimed to elucidate the accuracy and limitations of [(18)F]-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism. Although [(18)F]DOPA PET is reported to be useful for precisely localizing the focal form of congenital hyperin...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Masue M,Nishibori H,Fukuyama S,Yoshizawa A,Okamoto S,Doi R,Uemoto S,Tokumi T,Kasai T,Yorifuji T

    更新日期:2011-09-01 00:00:00

  • Factors associated with serum thyroglobulin levels in a population living in Belarus.

    abstract:OBJECTIVE:Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cahoon EK,Rozhko A,Hatch M,Polyanskaya O,Ostroumova E,Tang M,Nadirov E,Yauseyenka V,Savasteeva I,McConnell RJ,Pfeiffer RM,Brenner AV

    更新日期:2013-07-01 00:00:00