Central hypothyroidism improves with age in very young children with Prader-Willi syndrome.

abstract：OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

journal_title：Clinical endocrinology

authors： Hammami MM,Haq A,AlSedairy S

更新日期：1994-03-01 00:00:00

abstract：:Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...

journal_title：Clinical endocrinology

authors： Elte JW,Wiarda KS,Frölich M,Haak A

更新日期：1978-11-01 00:00:00

abstract：:Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated with L-thyroxine and placebo in a double-blind cross-over design during 2 x 6 months. Three women did not complete the study, one because she moved to another part of the country, and t...

journal_title：Clinical endocrinology

authors： Nyström E,Caidahl K,Fager G,Wikkelsö C,Lundberg PA,Lindstedt G

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:We assessed body composition, bone mineral density (BMD), glucose and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN:Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHAN...

journal_title：Clinical endocrinology

authors： Shaikh S,Waxler JL,Lee H,Grinke K,Garry J,Pober BR,Stanley TL

更新日期：2018-11-01 00:00:00

abstract：:Seven women with primary amenorrhoea and hyperprolactinaemia were treated with bromocriptine. All the women had started to develop secondary sex characteristics at normal age but pubertal development stopped and menarche did not occur. Radiological signs of a pituitary tumour were found in all the women. Before the pi...

journal_title：Clinical endocrinology

authors： Bergh T,Nillius SJ,Wide L

更新日期：1979-02-01 00:00:00

abstract：:Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

journal_title：Clinical endocrinology

authors： Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:GH may be beneficial in treating patients with end-stage renal disease (ESRD). However, the efficacy and safety of GH could be compromised by the potential for accumulation in the circulation. OBJECTIVE:The objective was to investigate the pharmacokinetics and safety of GH treatment in ESRD patients. DESIG...

journal_title：Clinical endocrinology

authors： Langbakke IH,Nielsen JN,Skettrup MP,Harper A,Klitgaard T,Weil A,Engelhardt E,Lange M

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as t...

journal_title：Clinical endocrinology

authors： Grimnes G,Emaus N,Cashman KD,Jorde R

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

journal_title：Clinical endocrinology

authors： Abucham J,Castro V,Maccagnan P,Vieira JG

更新日期：1997-11-01 00:00:00

abstract：:The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

journal_title：Clinical endocrinology

authors： Zahedi A,Booth GL,Smyth HS,Farrell WE,Clayton RN,Asa SL,Ezzat S

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：:The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second...

journal_title：Clinical endocrinology

authors： Wang C,Chan V,Yeung RT

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:Over 1% of the UK population is receiving thyroid hormone replacement with l-thyroxine (T4). However, many patients complain of persistent lethargy and related symptoms on T4 even with normal TSH levels. To date there has been no large study to determine whether this is related to thyroxine replacement or coi...

journal_title：Clinical endocrinology

authors： Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:To determine whether treatment with transdermal oestrogen replacement therapy (TERT) in postmenopausal women with type 2 diabetes mellitus was able to increase the activity of constitutive nitric oxide synthase (cNOS) in platelets. RESEARCH DESIGN AND METHODS:Eighteen postmenopausal women with type 2 diabete...

journal_title：Clinical endocrinology

authors： Martina V,Bruno GA,Origlia C,Gaia D,Trucco F,Pescarmona G

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

journal_title：Clinical endocrinology

authors： Jung S,Kim M,Lee YJ,Lee SH,Lee JH

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

journal_title：Clinical endocrinology

authors： Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

journal_title：Clinical endocrinology

authors： Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

更新日期：2007-03-01 00:00:00

abstract：CONTEXT:It is unclear if people who develop stress hyperglycaemia have underlying abnormal glucose metabolism, an exaggerated hormonal response to stress, or both. Similarly, it is unknown whether stress hyperglycaemia predicts future glucose intolerance. OBJECTIVE:To determine the relationship between illness severit...

journal_title：Clinical endocrinology

authors： Carmen Wong KY,Wong V,Ho JT,Torpy DJ,McLean M,Cheung NW

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Hyperandrogenism is one of the characteristic features of the polycystic ovary syndrome (PCOS). Androgens are important for bone mass. Studies on bone mineral density (BMD) and fractures in postmenopausal women with PCOS are lacking. The aim of this study was to investigate whether postmenopausal women with P...

journal_title：Clinical endocrinology

authors： Schmidt J,Dahlgren E,Brännström M,Landin-Wilhelmsen K

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To explore differences in irisin concentrations between lean adolescents with PCOS and age- and body mass index (BMI)-matched controls and examine the associations of irisin with core features of the syndrome. DESIGN:Cross-sectional study. PATIENTS:Lean females with PCOS, aged 13-21 years. MEASUREMENTS:Phy...

journal_title：Clinical endocrinology

authors： Bacopoulou F,Athanasopoulos N,Efthymiou V,Mantzou A,Aravantinos L,Vlahopoulos S,Deligeoroglou E

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Fibroblast growth factor (FGF21) is a potent regulator of glucose and lipid metabolism. In rodents, the hepatic expression of FGF21 is controlled by fasting and a circadian regulation, but the physiological role and regulation of FGF21 in humans is not well established. Therefore, the objective of this study ...

journal_title：Clinical endocrinology

authors： Andersen B,Beck-Nielsen H,Højlund K

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). DESIGN:Prospective, intervention with both ...

journal_title：Clinical endocrinology

authors： Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Strategies to limit the final height of tall children have centred on the use of high doses of sex steroids to advance skeletal maturation. This limits therapy to the peripubertal years whereas the greatest gain in height is in the prepubertal years. Prepubertal growth is largely GH dependent and previous wor...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Pringle PJ,Stanhope R,Brook CG

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

journal_title：Clinical endocrinology

authors： Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

journal_title：Clinical endocrinology

authors： Kirk J,Clayton P

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

journal_title：Clinical endocrinology

authors： Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

更新日期：1991-07-01 00:00:00

abstract：:Alopecia is a frequent feature in hereditary resistance to (1,25(OH)2D). We sought insight into this feature by analysing data from affected members of 30 kindreds. We assessed indices of mineral metabolism in one group with normal hair compared with a group with alopecia. Hereditary resistance to 1,25(OH)2D was diagn...

journal_title：Clinical endocrinology

authors： Marx SJ,Bliziotes MM,Nanes M

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune thyroiditis is one of the most common autoimmune disorders. Autoantibodies against the thyroid gland, with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common autoantibodies, can often be demonstrated in serum in population surveys. In the present st...

journal_title：Clinical endocrinology

authors： Pedersen IB,Knudsen N,Jørgensen T,Perrild H,Ovesen L,Laurberg P

更新日期：2003-01-01 00:00:00

abstract：RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

journal_title：Clinical endocrinology

authors： Coussa A,Hasan HA,Barber TM

更新日期：2020-12-01 00:00:00

abstract：:Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold diffe...

journal_title：Clinical endocrinology

authors： Andersen AN,Hertz J,Kjer JJ,Eskildsen PC,Larsen PS,Svenstrup B,Nielsen J,Arends J

更新日期：1980-08-01 00:00:00