Central hypothyroidism improves with age in very young children with Prader-Willi syndrome.


OBJECTIVE:Abnormalities in the hypothalamic-pituitary-thyroid (HPT) axis have been implicated in Prader-Willi syndrome (PWS); however, limited information is currently available on age-dependent alterations in the HPT axis. We herein investigated age-dependent differences in thyroid hormone levels in PWS children. DESIGN/PATIENTS/MEASUREMENTS:Free T4 (FT4), free T3 (FT3) and thyroid-stimulating hormone (TSH) concentrations were retrospectively compared between genetically confirmed PWS children (N = 43, median age: 11.2 months) and controls (N = 85, median age: 14.5 months) matched for age, sex, body weight-SD score (SDS), height-SDS, body mass index-SDS and serum albumin level, a marker of the nutritional status. Subjects were subdivided into two groups based on their age: an infant group aged between 1 and 11 months (PWS: N = 22, controls: N = 30) and a toddler group aged between 12 and 47 months (PWS: N = 21, controls: N = 55). None of the subjects had ever been treated with growth hormone or levothyroxine. RESULTS:After adjustments for confounding variables, in the infant group, FT4 levels (pmol/L) were significantly lower in PWS (11.24 in PWS vs 14.32 in controls, P = .0002), whereas no significant differences were observed in FT3 or TSH levels. In the toddler group, no significant differences were noted in FT4 (12.23 in PWS vs 15.31 in controls, P = .10), FT3 or TSH levels. The FT3/FT4 ratio was significantly increased in PWS in both groups. FT4 levels were positively correlated with age in PWS. CONCLUSIONS:Infants with PWS had lower FT4 levels, but FT3 levels were normal, indicating that the levothyroxine replacement therapy may not need to be routinely performed.


Clin Endocrinol (Oxf)


Clinical endocrinology


Konishi A,Ida S,Shoji Y,Etani Y,Kawai M




Has Abstract


2020-08-31 00:00:00






  • The level of endothelin-like immunoreactivity in seminal fluid correlates positively with semen volume and negatively with plasma gonadotrophin levels.

    abstract:OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hammami MM,Haq A,AlSedairy S

    更新日期:1994-03-01 00:00:00

  • Normal prolactin response following thyrotrophin releasing hormone in patients with autonomously functioning euthyroid multinodular goitre.

    abstract::Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Elte JW,Wiarda KS,Frölich M,Haak A

    更新日期:1978-11-01 00:00:00

  • A double-blind cross-over 12-month study of L-thyroxine treatment of women with 'subclinical' hypothyroidism.

    abstract::Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated with L-thyroxine and placebo in a double-blind cross-over design during 2 x 6 months. Three women did not complete the study, one because she moved to another part of the country, and t...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


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    更新日期:1988-07-01 00:00:00

  • Glucose and lipid metabolism, bone density, and body composition in individuals with Williams syndrome.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Shaikh S,Waxler JL,Lee H,Grinke K,Garry J,Pober BR,Stanley TL

    更新日期:2018-11-01 00:00:00

  • Bromocriptine treatment of seven women with primary amenorrhoea and prolactin-secreting pituitary tumours.

    abstract::Seven women with primary amenorrhoea and hyperprolactinaemia were treated with bromocriptine. All the women had started to develop secondary sex characteristics at normal age but pubertal development stopped and menarche did not occur. Radiological signs of a pituitary tumour were found in all the women. Before the pi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bergh T,Nillius SJ,Wide L

    更新日期:1979-02-01 00:00:00

  • Endemic infantile hypothyroidism in a severe endemic goitre area of central Africa.

    abstract::Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

    更新日期:1984-03-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of growth hormone in patients on chronic haemodialysis compared with matched healthy subjects: an open, nonrandomized, parallel-group trial.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Langbakke IH,Nielsen JN,Skettrup MP,Harper A,Klitgaard T,Weil A,Engelhardt E,Lange M

    更新日期:2007-11-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Grimnes G,Emaus N,Cashman KD,Jorde R

    更新日期:2017-07-01 00:00:00

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    abstract:OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Abucham J,Castro V,Maccagnan P,Vieira JG

    更新日期:1997-11-01 00:00:00

  • Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma.

    abstract::The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

    更新日期:2001-06-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wang C,Chan V,Yeung RT

    更新日期:1978-09-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

    更新日期:2002-11-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Martina V,Bruno GA,Origlia C,Gaia D,Trucco F,Pescarmona G

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Jung S,Kim M,Lee YJ,Lee SH,Lee JH

    更新日期:2015-08-01 00:00:00

  • Scalp hair loss after transsphenoidal adenomectomy in patients with acromegaly.

    abstract:OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

    更新日期:2013-09-01 00:00:00

  • Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function.

    abstract:OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

    更新日期:2007-03-01 00:00:00

  • High cortisol levels in hyperglycaemic myocardial infarct patients signify stress hyperglycaemia and predict subsequent normalization of glucose tolerance.

    abstract:CONTEXT:It is unclear if people who develop stress hyperglycaemia have underlying abnormal glucose metabolism, an exaggerated hormonal response to stress, or both. Similarly, it is unknown whether stress hyperglycaemia predicts future glucose intolerance. OBJECTIVE:To determine the relationship between illness severit...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Carmen Wong KY,Wong V,Ho JT,Torpy DJ,McLean M,Cheung NW

    更新日期:2010-02-01 00:00:00

  • Body composition, bone mineral density and fractures in late postmenopausal women with polycystic ovary syndrome - a long-term follow-up study.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schmidt J,Dahlgren E,Brännström M,Landin-Wilhelmsen K

    更新日期:2012-08-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bacopoulou F,Athanasopoulos N,Efthymiou V,Mantzou A,Aravantinos L,Vlahopoulos S,Deligeoroglou E

    更新日期:2018-04-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

    更新日期:2006-08-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Hindmarsh PC,Pringle PJ,Stanhope R,Brook CG

    更新日期:1995-05-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

    更新日期:1998-12-01 00:00:00

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    abstract:OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kirk J,Clayton P

    更新日期:2006-07-01 00:00:00

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    abstract:OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

    更新日期:1991-07-01 00:00:00

  • Analysis of the relation between alopecia and resistance to 1,25-dihydroxyvitamin D.

    abstract::Alopecia is a frequent feature in hereditary resistance to (1,25(OH)2D). We sought insight into this feature by analysing data from affected members of 30 kindreds. We assessed indices of mineral metabolism in one group with normal hair compared with a group with alopecia. Hereditary resistance to 1,25(OH)2D was diagn...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Marx SJ,Bliziotes MM,Nanes M

    更新日期:1986-10-01 00:00:00

  • Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pedersen IB,Knudsen N,Jørgensen T,Perrild H,Ovesen L,Laurberg P

    更新日期:2003-01-01 00:00:00

  • Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

    abstract:RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Coussa A,Hasan HA,Barber TM

    更新日期:2020-12-01 00:00:00

  • Ovarian and placental hormones during prolactin suppression and stimulation in early human pregnancy.

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    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


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    更新日期:1980-08-01 00:00:00