Effects of a feminizing testicular Leydig cell tumour on nontumorous testicular tissue: an ultrastructual study.

abstract：OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

journal_title：Clinical endocrinology

authors： Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

更新日期：1997-02-01 00:00:00

abstract：:Specific, homologous human neurophysin I and II radioimmunoassays were established and used to measure the individual, immunoreactive neurophysin concentrations in human plasma. Circulating levels of human neurophysin I in normal individuals were less than 1 ng/ml and neurophysin II levels were 1-2 ng/ml. During dehyd...

journal_title：Clinical endocrinology

authors： Dax EM,Clappison BH,Pullan PT,Pepperell R,Johnston CI

更新日期：1979-03-01 00:00:00

abstract：:In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.), arginine (30 g i.v. over 30 min) and L-dopa (500 mg orally) administered alone and 120 minutes following pretreatment with GHRH 1-44 (200 micrograms i.v.) in no...

journal_title：Clinical endocrinology

authors： Page MD,Dieguez C,Valcavi R,Edwards C,Hall R,Scanlon MF

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To analyse the effectiveness of age on HbA1c as a criterion for the diagnosis of diabetes in Chinese different age subjects. METHODS:This retrospective study enrolled a total of 1147 outpatients with untreated newly diagnosed diabetes (aged 18-80 years, 42·55% women) from the Fujian Province, China, and 427 ...

journal_title：Clinical endocrinology

authors： Yang L,Shen X,Yan S,Xu F,Wu P

更新日期：2015-02-01 00:00:00

abstract：:Current guidelines do not recommend the routine use of somatostatin analogue pretreatment prior to surgery in patients with growth hormone-secreting pituitary tumours. In theory, presurgical use of somatostatin analogues should improve metabolic control and reduce soft tissue swelling, leading to improved anaesthetic ...

journal_title：Clinical endocrinology

authors： Jacob JJ,Bevan JS

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:We investigated the clinical usefulness of thyroid blood-flow measurement in predicting relapse of Graves' disease (GD) in comparison with known risk factors for GD relapse. MEASUREMENT:Thyroid blood flow was measured in pulsed Doppler mode at the inferior thyroid artery (ITA), and the peak systolic velocity...

journal_title：Clinical endocrinology

authors： Ueda M,Inaba M,Kumeda Y,Nagasaki T,Hiura Y,Tahara H,Onoda N,Ishikawa T,Nishizawa Y

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00

abstract：:Transsphenoidal surgery is the treatment of choice for nonfunctioning pituitary macroadenomas but is seldom curative. Tumour progression rates are high in patients with postoperative remnants. Therefore, long-term monitoring is necessary to detect tumour growth, which may be asymptomatic or manifest with visual field ...

journal_title：Clinical endocrinology

authors： Greenman Y,Stern N

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Staging systems applied to medullary thyroid cancer (MTC) rely on initial clinical and pathological features and do not consider the response to treatment. To determine whether MTC staging can be improved by incorporating the first postoperative calcitonin measurement. PATIENTS AND MEASUREMENTS:Eighty-five p...

journal_title：Clinical endocrinology

authors： Yang JH,Lindsey SC,Camacho CP,Valente FO,Germano-Neto F,Machado AL,Mamone MC,Brodskyn F,Biscolla RP,Tuttle RM,Dias-da-Silva MR,Maciel RM

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Recently, a somatic point mutation of the BRAF gene (V599E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (about 25-70%) in different series from USA, Japan, Portugal and Ukraine. DESIGN:In the present study, the genetic analysis of BRAF i...

journal_title：Clinical endocrinology

authors： Fugazzola L,Mannavola D,Cirello V,Vannucchi G,Muzza M,Vicentini L,Beck-Peccoz P

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

journal_title：Clinical endocrinology

authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making. DESIGN AND PATIENTS:We identified 728 RET533 Brazilian relatives, spread out over 7 generati...

journal_title：Clinical endocrinology

authors： Signorini PS,França MI,Camacho CP,Lindsey SC,Valente FO,Kasamatsu TS,Machado AL,Salim CP,Delcelo R,Hoff AO,Cerutti JM,Dias-da-Silva MR,Maciel RM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy; however, circulating antithyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting circulating Tg in the context ...

journal_title：Clinical endocrinology

authors： McGrath RT,Preda VA,Clifton-Bligh P,Robinson B,Sywak M,Delbridge L,Ward P,Clifton-Bligh RJ,Learoyd DL

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:As only sparse data are available, we aimed to investigate whether needs for activated vitamin D and calcium supplements change in women with hypoparathyroidism during pregnancy and lactation and risk of pregnancy-related complications. DESIGN:Retrospective review of medical records. PATIENTS:Twelve Danish ...

journal_title：Clinical endocrinology

authors： Hartogsohn EAR,Khan AA,Kjaersulf LU,Sikjaer T,Hussain S,Rejnmark L

更新日期：2020-09-01 00:00:00

abstract：:Although vasomotor instability or hot flushes are a well-known occurrence in women with natural or artificially-induced menopause, they have not previously been described in children. We report three children in different stages of puberty who developed vasomotor instability following surgery involving the hypothalami...

journal_title：Clinical endocrinology

authors： Witt MF,Blethen SL

更新日期：1983-06-01 00:00:00

abstract：CONTEXT:Childbearing is considered to be a significant risk factor for developing overweight and obesity. Physical activity might influence weight change via hormonal changes. OBJECTIVE:To test the hypothesis that higher levels of moderate-to-vigorous intensity physical activity (MVPA) are positively associated with m...

journal_title：Clinical endocrinology

authors： van der Wijden CL,Delemarre-van de Waal HA,van Mechelen W,van Poppel MN

更新日期：2015-01-01 00:00:00

abstract：:Plasma concentrations of FSH, LH, testosterone and prolactin have been studied in seventeen men, aged 19 to 38 years, with traumatic paraplegia. Plasma testosterone, FSH and LH values were normal in all patients. The median LH concentration in patients was significantly higher (P less than 0.05) than in controls but t...

journal_title：Clinical endocrinology

authors： Young RJ,Strachan RK,Seth J,Nicol K,Frier BM,Corrall RJ

更新日期：1982-09-01 00:00:00

abstract：OBJECTIVE:Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN:Cross-sectional,...

journal_title：Clinical endocrinology

authors： López-Bermejo A,Casano-Sancho P,Fernández-Real JM,Kihara S,Funahashi T,Rodríguez-Hierro F,Ricart W,Ibañez L

更新日期：2004-09-01 00:00:00

abstract：:Thyroid status was estimated serially by measuring triiodothyronine (T3), thyroxine (T4) and thyrotrophin (hTSH) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. Significantly low T3 and only slightly increased T4 were observed in all the patients. hTSH was norma...

journal_title：Clinical endocrinology

authors： Maharajan G,Etta KM,Singh A,Ahuja IS,Ahuja GK

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:Ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although the latter has not been firmly demonstrated in humans. So far, little data have been reported in relation to its potential association with metabolic syndrome (MS). The objective was to study obestatin concentrations in...

journal_title：Clinical endocrinology

authors： Mora M,Granada ML,Roca M,Palomera E,Puig R,Serra-Prat M,Puig-Domingo M

更新日期：2013-06-01 00:00:00

abstract：:In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH respons...

journal_title：Clinical endocrinology

authors： Brown GM,Verhaegan H,Van Wimersma Greidanus TB,Brugmans J

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVE:Cabergoline therapy normalizes prolactin levels and reduces the size of macroprolactinomas. However there are no data indicating whether cabergoline can normalize growth hormone secretion in patients who were growth hormone deficient at the time of diagnosis of a macroprolactinoma. SUBJECTS AND METHODS:We st...

journal_title：Clinical endocrinology

authors： George LD,Nicolau N,Scanlon MF,Davies JS

更新日期：2000-11-01 00:00:00

abstract：:Growth hormone and prolactin are secreted episodically in man and experimental animals. To investigate physiologic mechanisms of GH and PRL secretion, a series of experiments were performed in individual, unanaesthetized male and female rats. GH secretion in the male rat is characterized by intermittent surges that oc...

journal_title：Clinical endocrinology

authors： Terry LC,Saunders A,Audet J,Willoughby JO,Brazeau P,Martin JB

更新日期：1977-01-01 00:00:00

abstract：:Measurements of circulating thyroglobulin (hTg) and 131I whole body scan were performed in 101 patients with differentiated thyroid carcinoma who had been subjected to surgical thyroidectomy and 131I ablation of remaining thyroid tissue. All 45 patients with positive scans (i.e. functioning metastases) had elevated hT...

journal_title：Clinical endocrinology

authors： Pacini F,Pinchera A,Giani C,Grasso L,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:The protein-tyrosine-phosphate nonreceptor 22 gene (PTPN22) has recently been identified as a susceptibility locus for a number of autoimmune diseases including Graves' disease (GD). PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-...

journal_title：Clinical endocrinology

authors： Zeitlin AA,Heward JM,Brand OJ,Newby PR,Franklyn JA,Gough SC,Simmonds MJ

更新日期：2006-09-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

journal_title：Clinical endocrinology

authors： Fuller PJ,Alexiadis M,Jobling T,McNeilage J

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:Graves' disease (GD) complicates 0.1% to 0.2% of pregnancies, but congenital thyrotoxicosis is rare occurring in one in 70 of these pregnancies independent of maternal disease status. Antenatal prediction of affected infants is imprecise; however, maternal history, coupled with a high maternal serum TSH rece...

journal_title：Clinical endocrinology

authors： Smith C,Thomsett M,Choong C,Rodda C,McIntyre HD,Cotterill AM

更新日期：2001-03-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours that arise from the adrenal medulla or extra-adrenal sympathetic or parasympathetic paraganglia. Recent advances in genetics have greatly enhanced understanding of the pathogenesis and molecular physiology of PPGL. Concomitantly, advances in molecular imag...

journal_title：Clinical endocrinology

authors： Ryder SJ,Love AJ,Duncan EL,Pattison DA

更新日期：2020-12-09 00:00:00