Is testicular endocrine function abnormal in young men with spinal cord injuries?


:Plasma concentrations of FSH, LH, testosterone and prolactin have been studied in seventeen men, aged 19 to 38 years, with traumatic paraplegia. Plasma testosterone, FSH and LH values were normal in all patients. The median LH concentration in patients was significantly higher (P less than 0.05) than in controls but there was no difference for FSH or testosterone. Plasma prolactin was high in five patients and the median prolactin concentration in patients was significantly greater (P less than 0.001) than in controls. It is concluded that there is no evidence of primary testicular failure in young paraplegics but it is possible that testicular hypofunction in some paraplegics may be related to increased prolactin production.


Clin Endocrinol (Oxf)


Clinical endocrinology


Young RJ,Strachan RK,Seth J,Nicol K,Frier BM,Corrall RJ




Has Abstract


1982-09-01 00:00:00












  • Hyperprolactinaemia in congenital hypothyroidism.

    abstract::Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McCormick KL

    更新日期:1986-03-01 00:00:00

  • Cardiovascular risk factors in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:The prevalence of cardiovascular risk factors in congenital adrenal hyperplasia (CAH) varies widely. In the light of recent changes in treatment regimens, we have reassessed the prevalence of these risk factors in our current cohort of patients with CAH due to P450c21 deficiency. METHODS:A retrospective cros...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Subbarayan A,Dattani MT,Peters CJ,Hindmarsh PC

    更新日期:2014-04-01 00:00:00

  • Osmoregulation of thirst and vasopressin secretion in Kallmann's syndrome.

    abstract::It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Thompson CJ,White MC,Baylis PH

    更新日期:1989-05-01 00:00:00

  • Normal prolactin response following thyrotrophin releasing hormone in patients with autonomously functioning euthyroid multinodular goitre.

    abstract::Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Elte JW,Wiarda KS,Frölich M,Haak A

    更新日期:1978-11-01 00:00:00

  • Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens.

    abstract:BACKGROUND:Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume. OBJECTIVE:To evaluate the potential usefulness of MR methodology, to estimate adrenal size ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mouritsen A,Johansen ML,Wohlfahrt-Veje C,Hagen CP,Tinggaard J,Mieritz MG,Tefre de Renzy-Martin K,Soeborg T,Fallentin E,Juul A,Main KM

    更新日期:2014-08-01 00:00:00

  • Variability in hydrocortisone plasma and saliva pharmacokinetics following intravenous and oral administration to patients with adrenal insufficiency.

    abstract:OBJECTIVE:The best method for determining hydrocortisone replacement therapy is not well defined. This study aimed to assess interindividual variability in cortisol pharmacokinetics and to investigate whether measurement of salivary cortisol provides a useful alternative to plasma concentration measurements. DESIGN:In...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Thomson AH,Devers MC,Wallace AM,Grant D,Campbell K,Freel M,Connell JM

    更新日期:2007-06-01 00:00:00

  • The hypothalamic-pituitary-adrenal axis in infantile malnutrition.

    abstract::We studied the circadian rhythm and the response of the hypothalamic-pituitary-adrenal (HPA) axis to ovine corticotrophin releasing hormone (oCRH) stimulation and dexamethasone suppression in 32 children with grade II-III marasmus. Children were studied prior to and after nutritional rehabilitation. Mean baseline plas...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Malozowski S,Muzzo S,Burrows R,Leiva L,Loriaux L,Chrousos G,Winterer J,Cassorla F

    更新日期:1990-04-01 00:00:00

  • Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.

    abstract:OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

    更新日期:2013-02-01 00:00:00

  • Hyperthyroidism associated with metastatic thyroid carcinoma.

    abstract::We report a patient with unilateral thyroid carcinoma, who developed hyperfunction of the thyroid gland during the metastatic progression of the thyroid carcinoma. Concurrently with this event, TSI increased and it is suggested that the differentiated aggressive metastatic thyroid neoplasm had initiated the autoimmune...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Steffensen FH,Aunsholt NA

    更新日期:1994-11-01 00:00:00

  • Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention.

    abstract:OBJECTIVE:Ghrelin has been implicated in energy homeostasis, body weight regulation and glucose metabolism. Level of unacylated ghrelin (UAG), but not acylated ghrelin (AG), has been suggested to increase during long-term exercise. However, the association of the level of UAG with exercise-induced changes of insulin se...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cederberg H,Koivisto VM,Jokelainen J,Surcel HM,Keinänen-Kiukaanniemi S,Rajala U

    更新日期:2012-01-01 00:00:00

  • Mode of action of carbimazole in Graves' disease.

    abstract::In a series of hyperthyroid subjects treated with a high dose 'block-replace' regime, mean thyroidal technetium uptake was shown to fall progressively over an 18 month period. Furthermore, sub-total inhibition of hormone biosynthesis could be demonstrated, without evidence of proportionate inhibition of organification...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wise PH,Marion M,Pain R

    更新日期:1979-06-01 00:00:00

  • Comparison of the relationship of age and beta cell function in three ethnic groups.

    abstract:DESIGN:Prevalence of type 2 diabetes and glucose intolerance increase with age. It has been demonstrated that beta cell function declines at about 1% per year in glucose tolerant Caucasians. However, this relationship is not known to exist in other ethnic groups. SUBJECTS AND MEASUREMENTS:We investigated the relations...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chiu KC,Martinez DS,Chu A

    更新日期:2005-03-01 00:00:00

  • Pulsed tissue Doppler identifies subclinical myocardial biventricular dysfunction in active acromegaly.

    abstract:OBJECTIVE:The aim of this study was to assess the role of pulsed tissue Doppler (TD) to identify left (LV) and right ventricular (RV) myocardial regional involvement in acromegaly. PATIENTS AND MEASUREMENTS:Thirty active acromegaly patients, free of diabetes mellitus, thyroid dysfunction, valvular and coronary heart d...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Galderisi M,Vitale G,Bianco A,Pivonello R,Lombardi G,Divitiis Od,Colao A

    更新日期:2006-04-01 00:00:00

  • Increased thyrotrophin levels and loss of the nocturnal thyrotrophin surge in Sheehan's syndrome.

    abstract:OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Abucham J,Castro V,Maccagnan P,Vieira JG

    更新日期:1997-11-01 00:00:00

  • Serum iodothyronine concentrations during introduction of thyroxine replacement therapy in hypothyroidism.

    abstract::Serum concentrations of total and free T4 (TT4 and FT4), total and free T3 (TT3 and FT3), rT3, T4 binding globulin (TBG), T3 uptake (T3U) and TSH were measured in 12 patients with severe hypothyroidism before and during the introduction of replacement therapy with oral T4. The dose of T4 was increased by increments of...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pearce CJ,Himsworth RL

    更新日期:1986-09-01 00:00:00

  • The sequential administration of growth hormone-releasing hormone followed 120 minutes later by hexarelin, as an effective test to assess the pituitary GH reserve in man.

    abstract:OBJECTIVE:GH deficiency, either in children or in adults, is a clinically relevant problem. The diagnosis is based on dynamic tests of GH secretion, which are clear cut on a group basis but highly problematic for individual diagnosis. The controversy surrounding the diagnosis of GH deficiency reflects the absence of a ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Micic D,Popovic V,Kendereski A,Peino R,Dieguez C,Casanueva FF

    更新日期:1996-11-01 00:00:00

  • The influence of thiazide intake on calcium and parathyroid hormone levels in patients with primary hyperparathyroidism.

    abstract:OBJECTIVE:The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patient...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Riss P,Kammer M,Selberherr A,Bichler C,Kaderli R,Scheuba C,Niederle B

    更新日期:2016-08-01 00:00:00

  • CAG repeat length in the androgen receptor gene and gonadotrophin suppression influence the effectiveness of hormonal male contraception.

    abstract:OBJECTIVE:Nonuniformity in suppression of spermatogenesis induced by various hormones or hormone combinations has impeded the development of an effective hormonal male contraceptive. The basis for this heterogeneity in response remained unresolved to date; however, the presence of ethnic differences points to an involv...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Eckardstein SV,Schmidt A,Kamischke A,Simoni M,Gromoll J,Nieschlag E

    更新日期:2002-11-01 00:00:00

  • Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin-like growth factor-I.

    abstract:OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

    更新日期:1991-07-01 00:00:00

  • Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan.

    abstract:OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

    更新日期:2015-01-01 00:00:00

  • An audit of oestradiol levels and implant frequency in women undergoing subcutaneous implant therapy.

    abstract:OBJECTIVES:The aim of the study was to review our long-term use of subcutaneous oestradiol (E2) implant therapy for the treatment of climacteric symptoms in post-menopausal women. On the grounds that the aim is to restore premenopausal serum E2 levels, our declared clinical policy is not to repeat implants even in the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Buckler HM,Kalsi PK,Cantrill JA,Anderson DC

    更新日期:1995-05-01 00:00:00

  • Efficacy of a new long-acting injectable form of bromocriptine in hyperprolactinaemic patients.

    abstract:OBJECTIVE:The objective of this study was to assess the relationship of different doses of a long-acting bromocriptine preparation (Parlodel LAR) to the degree and duration of PRL suppression. We also measured circulating bromocriptine levels and altered tolerability of the drug. DESIGN:A double-blind randomized study...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pagani MD,Tengattini F,Montini M,Pagani G,Pedroncelli A,Gianola D,Gherardi F,Mazzocchi N,Cortesi L,Lancranjan I

    更新日期:1992-04-01 00:00:00

  • Ovarian hyperthecosis, diabetes and hirsuties in post-menopausal women.

    abstract:OBJECTIVE:We describe four patients with ovarian hyperthecosis and the effects of gonadotrophin releasing hormone on clinical and metabolic variables. DESIGN:Open out-patient study. PATIENTS:Four women presented with post-menopausal hirsuties. They had significant hair growth across the chest, upper back and shoulder...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Barth JH,Jenkins M,Belchetz PE

    更新日期:1997-02-01 00:00:00

  • A new germline VHL gene mutation in three patients with apparently sporadic pheochromocytoma.

    abstract:CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

    更新日期:2013-03-01 00:00:00

  • A receptor assay for the measurement of TSH receptor antibodies in unextracted serum.

    abstract::A receptor assay for TSH receptor antibodies is described in which unextracted serum, detergent solubilised TSH receptors and 125I-labelled TSH are used. The assay was rapid and reproducible with coefficients of inter-assay variation of 12.3%, 2.1 and 2.6% at mean inhibition of TSH binding values of 11, 53, and 79 res...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Southgate K,Creagh F,Teece M,Kingswood C,Rees Smith B

    更新日期:1984-05-01 00:00:00

  • Gonadal-pituitary hormone levels in gynaecomastia.

    abstract::Plasma levels of LH, FSH, oestradiol 17 beta and testosterone were measured in twenty-two men with gynaecomastia. The group was divided by age into those under and those over 50-years-old and the mean hormone levels of the two groups were compared with two groups of age-matched normal men. In the young men with gynaec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McFadyen IJ,Bolton AE,Cameron EH,Hunter WM,Raab G,Forrest AP

    更新日期:1980-07-01 00:00:00

  • Extracervical fibrosclerosis causing obstruction of a ventriculo-peritoneal shunt in a patient with hydrocephalus and invasive fibrous thyroiditis (Riedel's struma).

    abstract::The association of invasive fibrous thyroiditis (IFT) with foci of extracervical fibrosclerosis is well recognized. Affected sites include the retroperitoneum, the mediastinum, the biliary tract, and the orbit. The development of subcutaneous fibrosclerosis, however, is extremely rare. We report a patient with known i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Natt N,Heufelder AE,Hay ID,Grant CS,Goellner JR

    更新日期:1997-07-01 00:00:00

  • Effects of evening vs morning thyroxine ingestion on serum thyroid hormone profiles in hypothyroid patients.

    abstract:OBJECTIVE:Standard drug information resources recommend that l-thyroxine be taken half an hour before breakfast on an empty stomach, to prevent interference of its intestinal uptake by food or medication. We observed cases in which TSH levels improved markedly after changing the administration time of l-thyroxine to th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bolk N,Visser TJ,Kalsbeek A,van Domburg RT,Berghout A

    更新日期:2007-01-01 00:00:00

  • The pharmacokinetics, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects.

    abstract::The pharmacokinetics, safety and endocrine effects of an authentic human growth hormone (bio-hGH), produced by the expression of genomic hGH in a mammalian cell line, were studied in six healthy young men who were administered 0.2 U/kg/day subcutaneously for five consecutive days. Changes in sodium balance and in thyr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ho KY,Weissberger AJ,Stuart MC,Day RO,Lazarus L

    更新日期:1989-04-01 00:00:00

  • Effect of body mass index on the growth hormone response to clonidine stimulation testing in children with short stature.

    abstract:OBJECTIVES:An inverse relationship has been shown between body mass index (BMI) and the peak growth hormone (GH) response to stimulation in adults and in children with short stature. This relation is observed even within a normal range of BMI. The aim of this study was to investigate the effect of BMI on the GH respons...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Loche S,Guzzetti C,Pilia S,Ibba A,Civolani P,Porcu M,Minerba L,Casini MR

    更新日期:2011-06-01 00:00:00