The assay for thyroid stimulating immunoglobulins using cultured human thyroid cells.

abstract：OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

journal_title：Clinical endocrinology

authors： Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

更新日期：1992-12-01 00:00:00

abstract：:In recent years the techniques of molecular and cellular biology have made it possible to begin to dissect the origins and behaviour of the ACTH-secreting tumour cell. It is becoming apparent that these tumours represent undifferentiated neuroendocrine cells, and it may be that their peptide-secreting properties may h...

journal_title：Clinical endocrinology

authors： White A,Clark AJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:We describe four patients with ovarian hyperthecosis and the effects of gonadotrophin releasing hormone on clinical and metabolic variables. DESIGN:Open out-patient study. PATIENTS:Four women presented with post-menopausal hirsuties. They had significant hair growth across the chest, upper back and shoulder...

journal_title：Clinical endocrinology

authors： Barth JH,Jenkins M,Belchetz PE

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:There has been a rapid shift from open to laparoscopic approaches in adrenal surgery, but the safety and efficacy of bilateral laparoscopic adrenalectomy (BLA) in patients with corticotrophin (ACTH)-dependent Cushing's syndrome continues to be defined. OBJECTIVE:Review outcomes in the largest series of pati...

journal_title：Clinical endocrinology

authors： Chow JT,Thompson GB,Grant CS,Farley DR,Richards ML,Young WF Jr

更新日期：2008-04-01 00:00:00

abstract：:Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adi...

journal_title：Clinical endocrinology

authors： Savino F,Fissore MF,Liguori SA,Oggero R

更新日期：2009-12-01 00:00:00

abstract：:Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...

journal_title：Clinical endocrinology

authors： Krassas G,McHardy-Young S,Ramsay I,Florin-Christensen A

更新日期：1977-02-01 00:00:00

abstract：:Sulpiride, a dopamine receptor blocker which raises prolactin, was given to six women with idiopathic amenorrhoea for 10 days and to eleven women with regular cycles for 3 to 6 months. The latter group developed galactorrhoea and amenorrhoea during treatment. Basal LH AND FSH concentrations showed no significant chang...

journal_title：Clinical endocrinology

authors： Buvat J,Thomas K,Racadot A,Blacker C,Buvat-Herbaut M,Ferin F,Linquette M

更新日期：1978-12-01 00:00:00

abstract：:Twenty-three endemic goitrous subjects (goitre grade: III and IV) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms I/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of São Paulo, where daily iodine intake is estimat...

journal_title：Clinical endocrinology

authors： Lima N,Medeiros-Neto G

更新日期：1984-12-01 00:00:00

abstract：:The best long-term results of transsphenoidal surgery appear to be in those patients who have unmeasurable serum cortisol levels in the immediate post-operative period. This appears to be due to isolated ACTH deficiency in the remaining normal pituitary gland. In our experience, however, long-term clinical remission m...

journal_title：Clinical endocrinology

authors： McCance DR,Besser M,Atkinson AB

更新日期：1996-01-01 00:00:00

abstract：:A 24-year-old negress with the triad of acanthosis nigricans, hirsutism associated with polycystic ovaries and insulin resistance is reported. Metabolic studies were done 3 years after a bilateral ovarian wedge resection. Partial remission of the hirsutism and return of menstrual cycles occurred after surgery. Extreme...

journal_title：Clinical endocrinology

authors： Leme CE,Wajchenberg BL,Lerário AC,Goldman J,Borges JL

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVE:Riedel's thyroiditis (RT) is a very rare chronic fibrosing thyroiditis that is often associated with multifocal fibrosclerosis. Although the relationship of RT and IgG4-related disease (IgG4-RD) has been suggested, the expression of IgG and IgG4 in thyroid tissues of patients with RT has seldom been studied. ...

journal_title：Clinical endocrinology

authors： Yu Y,Liu J,Yu N,Zhang Y,Zhang S,Li T,Gao Y,Lu G,Zhang J,Guo X

更新日期：2020-12-10 00:00:00

abstract：OBJECTIVE:Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol, and pubertal status, into genetic and environmental components. DESIGN:A sample of male and female adolescent twins from the greater Austin ...

journal_title：Clinical endocrinology

authors： Grotzinger AD,Mann FD,Patterson MW,Herzhoff K,Tackett JL,Tucker-Drob EM,Paige Harden K

更新日期：2018-02-01 00:00:00

abstract：:The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...

journal_title：Clinical endocrinology

authors： Howlett TA,Drury PL,Perry L,Doniach I,Rees LH,Besser GM

更新日期：1986-06-01 00:00:00

abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

journal_title：Clinical endocrinology

authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

更新日期：1993-02-01 00:00:00

abstract：:We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

journal_title：Clinical endocrinology

authors： Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

更新日期：1983-05-01 00:00:00

abstract：OBJECTIVE:The study was to determine the incidence of GH deficiency (GHD) following cranial radiotherapy (RT) for a childhood brain tumour in a large population based study and analyse the biological effective dose (BED) to the hypothalamus/pituitary (HP) region as a risk factor. DESIGN:BED was assessed by use of the ...

journal_title：Clinical endocrinology

authors： Schmiegelow M,Lassen S,Poulsen HS,Feldt-Rasmussen U,Schmiegelow K,Hertz H,Müller J

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

journal_title：Clinical endocrinology

authors： Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. DESIGN:The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents wi...

journal_title：Clinical endocrinology

authors： Interdonato M,Pizzino G,Bitto A,Galfo F,Irrera N,Mecchio A,Pallio G,Ramistella V,De Luca F,Santamaria A,Minutoli L,Marini H,Squadrito F,Altavilla D

更新日期：2015-09-01 00:00:00

abstract：:The concentration of immunoreactive inhibin in serum was measured in three pregnant women with premature ovarian failure involved in a donor oocyte in-vitro fertilization programme. Inhibin was not detectable in peripheral serum prior to conception but rose within 2-4 weeks of embryo transfer, whereafter levels rose g...

journal_title：Clinical endocrinology

authors： McLachlan RI,Healy DL,Lutjen PJ,Findlay JK,De Kretser M,Burger HG

更新日期：1987-12-01 00:00:00

abstract：:Alopecia is a frequent feature in hereditary resistance to (1,25(OH)2D). We sought insight into this feature by analysing data from affected members of 30 kindreds. We assessed indices of mineral metabolism in one group with normal hair compared with a group with alopecia. Hereditary resistance to 1,25(OH)2D was diagn...

journal_title：Clinical endocrinology

authors： Marx SJ,Bliziotes MM,Nanes M

更新日期：1986-10-01 00:00:00

abstract：:Sixteen consecutive cases of Cushing's disease were treated by radical transphenoidal hypophysectomy. Surgical removal was not possible in two cases. Of the other 14, there was total clinical and biochemical remission of the disease in 13 and partial remission in one. Some form of replacement therapy has been necessar...

journal_title：Clinical endocrinology

authors： Thomas JP,Richards SH

更新日期：1983-11-01 00:00:00

abstract：CONTEXT:Hypoparathyroidism is characterized by hypocalcaemia, hyperphosphataemia, and low or inappropriately normal parathyroid hormone (PTH) levels. Idiopathic or genetic drivers are the predominant causes of hypoparathyroidism in paediatric-age patients. OBJECTIVE:This study investigated the aetiology and clinical c...

journal_title：Clinical endocrinology

authors： Kim JH,Shin YL,Yang S,Cheon CK,Cho JH,Lee BH,Kim GH,Lee JO,Seo EJ,Choi JH,Yoo HW

更新日期：2015-12-01 00:00:00

abstract：:The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

journal_title：Clinical endocrinology

authors： Zahedi A,Booth GL,Smyth HS,Farrell WE,Clayton RN,Asa SL,Ezzat S

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:To determine whether early (4-8h) post-operative ACTH after trans-sphenoidal surgery (TSS) predicts long-term hypothalamic-pituitary-adrenal (HPA) axis function and to investigate early morning day 1 ACTH/cortisol variability using rapid sampling. DESIGN:Prospective observational study. METHODS:Participants...

journal_title：Clinical endocrinology

authors： English KA,Chikani V,Jang C,Dimeski G,Olson S,Inder WJ

更新日期：2020-12-28 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:To assess approaches to patients with a potentially malignant thyroid nodule and patients with differentiated thyroid carcinoma and compare them with the European Consensus and Guidelines by the American Thyroid Association. DESIGN:A survey of the 388 active members of the Belgian Thyroid Club. METHODS:A qu...

journal_title：Clinical endocrinology

authors： Van den Bruel A,Moreno-Reyes R,Bex M,Daumerie C,Glinoer D

更新日期：2008-04-01 00:00:00

abstract：:We designed a systematic study of patients with Cushing's disease to compare the results of acute experiments with cyproheptadine, sodium valproate and bromocriptine with the results of chronic treatment with sodium valproate. In 13 patients the plasma cortisol response to single doses of 2.5 mg bromocriptine, 6 mg cy...

journal_title：Clinical endocrinology

authors： Koppeschaar HP,Croughs RJ,Thijssen JH,Schwarz F

更新日期：1986-12-01 00:00:00

abstract：:Long-term bromocriptine treatment was discontinued in thirty-seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty-seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but o...

journal_title：Clinical endocrinology

authors： Bergh T,Nillius SJ,Wide L

更新日期：1982-06-01 00:00:00

abstract：:In a series of hyperthyroid subjects treated with a high dose 'block-replace' regime, mean thyroidal technetium uptake was shown to fall progressively over an 18 month period. Furthermore, sub-total inhibition of hormone biosynthesis could be demonstrated, without evidence of proportionate inhibition of organification...

journal_title：Clinical endocrinology

authors： Wise PH,Marion M,Pain R

更新日期：1979-06-01 00:00:00

abstract：OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

journal_title：Clinical endocrinology

authors： Ogilvy-Stuart AL,Wallace WH,Shalet SM

更新日期：1994-08-01 00:00:00