Physiologic secretion of growth hormone and prolactin in male and female rats.

abstract：:Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two ...

journal_title：Clinical endocrinology

authors： Thompson DG,Mason AS,Goodwin FJ

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVES:Graves' disease (GD) complicates 0.1% to 0.2% of pregnancies, but congenital thyrotoxicosis is rare occurring in one in 70 of these pregnancies independent of maternal disease status. Antenatal prediction of affected infants is imprecise; however, maternal history, coupled with a high maternal serum TSH rece...

journal_title：Clinical endocrinology

authors： Smith C,Thomsett M,Choong C,Rodda C,McIntyre HD,Cotterill AM

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

journal_title：Clinical endocrinology

authors： Zhang BC,Liu WJ,Che WL,Xu YW

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：:This study deals with serum prolactin concentrations during various conditions in the early puerperium in an attempt to investigate some characteristics of the mechanisms responsible for the regulation of the lactotropes. In nursing, in non-nursing, non-medicated and in non-nursing, bromocriptine-treated women prolact...

journal_title：Clinical endocrinology

authors： Vemer HM,Rolland R

更新日期：1981-08-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Nonfunctioning pituitary adenomas (NFPAs) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPAs due to tumour- or treatment-related factors and may increase mortality risk. Here, we analysed the associations of hypopituitarism, hormone replacement and mortality in a...

journal_title：Clinical endocrinology

authors： O'Reilly MW,Reulen RC,Gupta S,Thompson CA,Dineen R,Goulden EL,Bugg G,Pearce H,Toogood AA,Gittoes NJ,Mitchell R,Thompson CJ,Ayuk J

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this a...

journal_title：Clinical endocrinology

authors： Choi SH,An JH,Lim S,Koo BK,Park SE,Chang HJ,Choi SI,Park YJ,Park KS,Jang HC,Shin CS

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Complications of childhood cirrhosis include abnormal growth and malnutrition, associated with abnormalities in circulating IGFs and IGFBPs. Controlled studies suggest that intensive enteral feeding enhances nutritional status. The aim was to ascertain whether nasogastric feeding improves nutritional status i...

journal_title：Clinical endocrinology

authors： Holt RI,Miell JP,Jones JS,Mieli-Vergani G,Baker AJ

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:The impact of exogenous GH on thyroid function remains controversial although most data add support to a stimulation of peripheral T4 to T3 conversion. For further elucidation we evaluated iodothyronine and circadian TSH levels in GH-deficient patients as part of a GH dose-response study. PATIENTS:Eight GH-d...

journal_title：Clinical endocrinology

authors： Jørgensen JO,Møller J,Laursen T,Orskov H,Christiansen JS,Weeke J

更新日期：1994-11-01 00:00:00

abstract：:Several weeks after thyroidectomy (T), female rats stopped growing, and their pituitary GH content had decreased to less than 2--3% of the values found for age-matched controls (C). The liver membranes of such animals were explored with human GH (hGH). It was found that in the severely hypothyroid T rat, the number, b...

journal_title：Clinical endocrinology

authors： Duran-Garcia S,Gomez-Nieto J,Fouchereau-Peron M,Padron VF,Obregon MJ,Morreale de Escobar G,Escobar del Rey F

更新日期：1979-09-01 00:00:00

abstract：:Amniotic fluid concentrations of 3,3',5'-tri-iodothyronine (rT3), 3,3'-Di-iodothyronine (3,3'-T2), 3,5,3'-tri-iodothyronine (T3) and T4 were studied in 384 women during normal and complicated pregnancy. An inverse correlation was observed between decreasing rT3 and increasing 3,3'-T2 concentrations in amniotic fluid w...

journal_title：Clinical endocrinology

authors： Meinhold H,Dudenhausen JW,Wenzel KW,Saling E

更新日期：1979-04-01 00:00:00

abstract：:A 47-year-old woman was evaluated for congenital dwarfism, primary amenorrhoea due to hypogonadotrophic hypogonadism, severe hyperlipidaemia with pancreatitis, and overt diabetes mellitus associated with severe insulin resistance requiring 2.5-3 units of insulin per kilogram body weight. Chromosomal analysis with tryp...

journal_title：Clinical endocrinology

authors： Mantzoros CS,Moses AC

更新日期：1995-08-01 00:00:00

abstract：CONTEXT:Besides medullary thyroid carcinoma and other endocrinopathies, people with Multiple Endocrine Neoplasia Type 2 (MEN2) are at risk of gastrointestinal (GI) symptoms. OBJECTIVE:To investigate the impact of GI symptoms on the daily lives of patients with MEN2. DESIGN:An online survey was conducted among patient...

journal_title：Clinical endocrinology

authors： Goncharova M,Grey J,Druce M

更新日期：2020-11-10 00:00:00

abstract：OBJECTIVE:The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central fat depots. This distribution is associated with an increased risk of type 2 diabetes and cardiovascular disease that are linked to low-grade inflammation. We determined whether p...

journal_title：Clinical endocrinology

authors： Alvehus M,Simonyte K,Andersson T,Söderström I,Burén J,Rask E,Mattsson C,Olsson T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In ...

journal_title：Clinical endocrinology

authors： de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr T

更新日期：2010-06-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:We compared IGF-1 and IGFBP3 concentrations in a group of adults treated for brain tumours in childhood with those of matched controls, and investigated the relationship between the GH secretory pattern and IGF-1/IGFBP3 concentrations in the entire group. DESIGN:We performed 24 h serum GH profiles using 20 m...

journal_title：Clinical endocrinology

authors： Achermann JC,Hindmarsh PC,Brook CG

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

journal_title：Clinical endocrinology

authors： Wirén L,Whalley D,McKenna S,Wilhelmsen L

更新日期：2000-02-01 00:00:00

abstract：:We report an 11-year-old boy with undermasculinized genitalia and an abnormally expanded CAG repeat length at exon 1 of the androgen receptor (AR) gene. He had microphallus and scrotal hypospadias with chordee, and underwent urethroplasty at 4 years of age. At 11 years of age, a gonadotropin releasing hormone (GnRH) t...

journal_title：Clinical endocrinology

authors： Ogata T,Muroya K,Ishii T,Suzuki Y,Nakada T,Sasagawa I

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:Macroprolactinomas are pituitary tumours that can be managed with dopamine agonists (DA), surgery and radiotherapy. We aimed to assess the outcomes of these treatment modalities. DESIGN:Retrospective case-note study of patients managed in a single tertiary referral centre. PATIENTS:One hundred patients (68...

journal_title：Clinical endocrinology

authors： Green AI,Sherlock M,Stewart PM,Gittoes NJ,Toogood AA

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol, and pubertal status, into genetic and environmental components. DESIGN:A sample of male and female adolescent twins from the greater Austin ...

journal_title：Clinical endocrinology

authors： Grotzinger AD,Mann FD,Patterson MW,Herzhoff K,Tackett JL,Tucker-Drob EM,Paige Harden K

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To assess the relationship between circulating leptin levels, bone mineral content and density in the elderly. DESIGN:A cross-sectional study. PATIENTS:A cohort of 92 men and 171 women, with ages ranging from 68 to 75 years, selected as a healthy and normal functioning group, in the city centre of Verona. ...

journal_title：Clinical endocrinology

authors： Zoico E,Zamboni M,Adami S,Vettor R,Mazzali G,Tosoni P,Bissoli L,Bosello O

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN:The study consists of a cross-sectional arm compari...

journal_title：Clinical endocrinology

authors： Kyriakakis N,Lynch J,Gilbey SG,Webb SM,Murray RD

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00

abstract：:Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alk...

journal_title：Clinical endocrinology

authors： MacFarlane IA,Davies D,Longson D,Shalet SM,Beardwell CG

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Papillary thyroid cancer (PTC) is a common endocrine cancer and commonly presents with lymph node (LN) metastases. The role of surgical removal of the central cervical LN compartment is poorly defined. There are no prospective randomized controlled trials addressing the relevance to the extent of the initial...

journal_title：Clinical endocrinology

authors： Mulla M,Schulte KM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The Asp727Glu polymorphism in the TSH receptor (TSHR) gene is associated with serum TSH levels. However, the proportion of genetic variation accounted for by this polymorphism is unknown. In this study, we (1) examined the association of the Asp727Glu polymorphism with thyroid size, serum levels of TSH, thyr...

journal_title：Clinical endocrinology

authors： Hansen PS,van der Deure WM,Peeters RP,Iachine I,Fenger M,Sørensen TI,Kyvik KO,Visser TJ,Hegedüs L

更新日期：2007-06-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:Recently, a somatic point mutation of the BRAF gene (V599E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (about 25-70%) in different series from USA, Japan, Portugal and Ukraine. DESIGN:In the present study, the genetic analysis of BRAF i...

journal_title：Clinical endocrinology

authors： Fugazzola L,Mannavola D,Cirello V,Vannucchi G,Muzza M,Vicentini L,Beck-Peccoz P

更新日期：2004-08-01 00:00:00