Relationship between leptin levels and bone mineral density in the elderly.

abstract：OBJECTIVE:Final adult height is determined by both childhood and pubertal growth. The later is a function of growth velocity and bone maturation, and both are regulated by growth hormone. In a study of the safety and efficacy of GH therapy, we analysed the impact of age on bone maturation and predicted adult height. P...

journal_title：Clinical endocrinology

authors： Hochberg Z,Leiberman E,Landau H,Koren R,Zadik Z

更新日期：1994-09-01 00:00:00

abstract：:The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty-six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlatio...

journal_title：Clinical endocrinology

authors： Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

更新日期：1978-10-01 00:00:00

abstract：:Men with hypogonadotropic hypogonadism (HH) are typically azoospermic, and yet HH is one of the few treatable forms of male infertility. Sperm induction protocols using gonadotrophins aim to replicate the natural endocrine control of spermatogenesis. Previously virilised men with adult-onset HH and normal testicular v...

journal_title：Clinical endocrinology

authors： Prior M,Stewart J,McEleny K,Dwyer AA,Quinton R

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor-23 (FGF-23) in untreated Graves' disease. PATIENTS AND MEASUREMENTS:The study comprised 39 patients, with or without Graves' disease. The Graves' disease group was made up...

journal_title：Clinical endocrinology

authors： Park SE,Cho MA,Kim SH,Rhee Y,Kang ES,Ahn CW,Cha BS,Lee EJ,Kim KR,Lee HC,Lim SK

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Both severe growth hormone (GH) deficiency in hypopituitary adults and physiological ageing are associated with an increase in fat mass, dyslipidaemia, and an increased incidence of cardiovascular disease. Ageing is also associated with a physiological decrease in spontaneous as well as stimulated GH secretio...

journal_title：Clinical endocrinology

authors： Vahl N,Klausen I,Christiansen JS,Jørgensen JO

更新日期：1999-09-01 00:00:00

abstract：:The antigenicity of HCG was tested in twenty-three young healthy men receiving two different HCG preparations (A and B). Each subject received 5000 i.u. HCG intramuscularly daily for three consecutive days, followed by another course, 3 weeks later, of 5000 i.u. HCG injections daily for 3 days. Two of the fifteen subj...

journal_title：Clinical endocrinology

authors： Nieschlag E,Bernitz S,Töpert M

更新日期：1982-05-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

journal_title：Clinical endocrinology

authors： Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Nonsurgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (PHP) are rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively. Only few studies on Quality of Life (QoL) among patients with Ns-HypoPT and PHP are available. We aimed to investigate the QoL among patients with Ns-Hyp...

journal_title：Clinical endocrinology

authors： Underbjerg L,Sikjaer T,Rejnmark L

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to develop an assay for the measurement of thyroid blocking antibodies (TBAb), based on the ability of patient serum to inhibit TSH stimulated 3H-cAMP production following incubation of FRTL-5 or JPO9 cells with 3H-adenine. The assay was then used to evaluate a child born with neonat...

journal_title：Clinical endocrinology

authors： Michelangeli VP,Poon CW,Arnus EE,Frauman AG,Connelly J,Colman PG

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism...

journal_title：Clinical endocrinology

authors： Di Nisio A,Rocca MS,Fadini GP,De Toni L,Marcuzzo G,Marescotti MC,Sanna M,Plebani M,Vettor R,Avogaro A,Foresta C

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. DESIGN:Prospective cohort. PATIENTS AND MEASUREMENTS:Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screeni...

journal_title：Clinical endocrinology

authors： Bahri Khomami M,Moran LJ,Kenny L,Grieger JA,Myers J,Poston L,McCowan L,Walker J,Dekker G,Norman R,Roberts CT

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Some evidence suggests that dysbiosis of the gut microbiota could be associated with PCOS clinical parameters, but little is known for the association between vaginal microbiome and PCOS. OBJECTIVE:To determine ...

journal_title：Clinical endocrinology

authors： Hong X,Qin P,Huang K,Ding X,Ma J,Xuan Y,Zhu X,Peng D,Wang B

更新日期：2020-07-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

journal_title：Clinical endocrinology

authors： Ip MS,Tan KC,Peh WC,Lam KS

更新日期：2001-10-01 00:00:00

abstract：:Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

journal_title：Clinical endocrinology

authors： Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1-α-(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium/vitamin D malabsorption. OBJECTIVE:We assessed t...

journal_title：Clinical endocrinology

authors： Saha S,Saini S,Makharia GK,Datta Gupta S,Goswami R

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients. Osteoblasts and chondrocytes express growth hormone (GH) receptor. Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment enc...

journal_title：Clinical endocrinology

authors： Mormando M,Chiloiro S,Bianchi A,Giampietro A,Angelini F,Tartaglione L,Nasto L,Milardi D,Formenti AM,Giustina A,De Marinis L

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：:A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

journal_title：Clinical endocrinology

authors： Nabarro JD

更新日期：1987-04-01 00:00:00

abstract：:We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH...

journal_title：Clinical endocrinology

authors： Pringle PJ,Stanhope R,Hindmarsh P,Brook CG

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:IGF-1 stimulates growth, development and function of lymphocytes. The aim of this study was to examine whether functional variants of the IGF-1 gene are associated with absolute lymphocyte subset counts in neonates. STUDY DESIGN AND MEASUREMENTS:This study was embedded in the Generation R Study, a prospectiv...

journal_title：Clinical endocrinology

authors： Duijts L,Bakker-Jonges LE,Mook-Kanamori DO,Labout JA,Hofman A,van Duijn CM,van Dongen JJ,Hooijkaas H,Moll HA,Jaddoe VW

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Disturbances in the GH/IGF-I axis are reported in 25-60% of short children born small for gestational age (SGA). We hypothesized that these abnormalities might be related to abnormalities in the pituitary region. Therefore, the results of magnetic resonance imaging (MRI) of short SGA children were compared t...

journal_title：Clinical endocrinology

authors： Arends NJ,V d Lip W,Robben SG,Hokken-Koelega AC

更新日期：2002-12-01 00:00:00

abstract：INTRODUCTION:Diagnostic I-123 scans have been shown to underestimate the disease burden in differentiated thyroid cancer (DTC) when compared to I-131 post-treatment scans, especially in children and patients who have had prior radioiodine (RAI) therapy and/or distant metastasis. I-124 PET/CT has been shown to be highly...

journal_title：Clinical endocrinology

authors： Santhanam P,Taieb D,Solnes L,Marashdeh W,Ladenson PW

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Loss of E-cadherin is an important marker of epithelial tumour progression. The aims of this study were to explore whether E-cadherin expression and localization correlate to corticotroph tumour progression, relate the expression of the E-cadherin gene (CDH1) to immunohistochemical E-cadherin staining patter...

journal_title：Clinical endocrinology

authors： Evang JA,Berg JP,Casar-Borota O,Lekva T,Kringen MK,Ramm-Pettersen J,Bollerslev J

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

journal_title：Clinical endocrinology

authors： Ogilvy-Stuart AL,Wallace WH,Shalet SM

更新日期：1994-08-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：CONTEXT:Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE:To investigate the changes in bone mineral densi...

journal_title：Clinical endocrinology

authors： Hong N,Kim JE,Lee SJ,Kim SH,Rhee Y

更新日期：2018-05-01 00:00:00