Relationship between leptin levels and bone mineral density in the elderly.


OBJECTIVE:To assess the relationship between circulating leptin levels, bone mineral content and density in the elderly. DESIGN:A cross-sectional study. PATIENTS:A cohort of 92 men and 171 women, with ages ranging from 68 to 75 years, selected as a healthy and normal functioning group, in the city centre of Verona. MEASUREMENTS:Plasma leptin levels were determined in each participant. Body composition was evaluated with dual energy X-ray absorptiometry (DXA). Bone mineral content (BMC) and bone mineral density (BMD) were measured at whole-body, hip and femoral neck level in all subjects. RESULTS:In both men and women a significant relationship between fat mass and whole-body BMC or BMD was found. The strength of this association was consistently reduced after adjustment for plasma leptin. A significant association between circulating leptin levels, whole-body, total hip and femoral neck BMC and BMD was found in both sexes. This association retained the statistical significance after adjustment for fat mass percentage, especially in women. In stepwise multiple linear regression analyses, leptin was shown to be a significant predictor of whole-body, total hip and femoral neck BMC and BMD, independently of age and the percentage of body fat in both sexes. The circulating levels of leptin accounted for a variance in whole-body BMC of 8.9% in men and 18.2% in women, and in whole-body BMD of 10.6% in women. CONCLUSION:Our data show a significant relationship between leptin, bone mineral mass and density in healthy elderly men and women.


Clin Endocrinol (Oxf)


Clinical endocrinology


Zoico E,Zamboni M,Adami S,Vettor R,Mazzali G,Tosoni P,Bissoli L,Bosello O





Has Abstract


2003-07-01 00:00:00














  • The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity.

    abstract::Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nowak R,McMillen IC,Redman J,Short RV

    更新日期:1987-10-01 00:00:00

  • Genetic effects of adiponectin on blood lipids and blood pressure.

    abstract:OBJECTIVE:Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析


    authors: Zhao T,Zhao J

    更新日期:2011-02-01 00:00:00

  • The effects of arginine, insulin and metoclopramide on growth hormone, prolactin and cortisol release in children.

    abstract::The growth hormone (GH) and prolactin (PRL) responses to metoclopramide (MCP) were compared to those with arginine and insulin-induced hypoglycaemia in eight children. While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ijaiya K,Roth B,Schwenk A

    更新日期:1980-06-01 00:00:00

  • Evaluation of bone mineral density of the peripheral skeleton in pre- and postmenopausal women with newly diagnosed endogenous Cushing's syndrome.

    abstract:OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

    更新日期:2004-02-01 00:00:00

  • Is testicular endocrine function abnormal in young men with spinal cord injuries?

    abstract::Plasma concentrations of FSH, LH, testosterone and prolactin have been studied in seventeen men, aged 19 to 38 years, with traumatic paraplegia. Plasma testosterone, FSH and LH values were normal in all patients. The median LH concentration in patients was significantly higher (P less than 0.05) than in controls but t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Young RJ,Strachan RK,Seth J,Nicol K,Frier BM,Corrall RJ

    更新日期:1982-09-01 00:00:00

  • Metabolic outcome of GH treatment in prepubertal short children with and without classical GH deficiency.

    abstract:CONTEXT:Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover, children with ISS appear to need higher GH doses than children with GH deficiency (GHD) to achieve the same amount of growth and may therefore be at increased risk of adverse events du...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Decker R,Albertsson-Wikland K,Kriström B,Nierop AF,Gustafsson J,Bosaeus I,Fors H,Hochberg Z,Dahlgren J

    更新日期:2010-09-01 00:00:00

  • Thyroxine, triiodothyronine and thyrotrophin levels in meningococcal meningitis, typhoid fever and other febrile conditions.

    abstract::Thyroid status was estimated serially by measuring triiodothyronine (T3), thyroxine (T4) and thyrotrophin (hTSH) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. Significantly low T3 and only slightly increased T4 were observed in all the patients. hTSH was norma...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Maharajan G,Etta KM,Singh A,Ahuja IS,Ahuja GK

    更新日期:1978-11-01 00:00:00

  • A new germline VHL gene mutation in three patients with apparently sporadic pheochromocytoma.

    abstract:CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

    更新日期:2013-03-01 00:00:00

  • A clinical profile of memory impairment in humans due to endogenous glucocorticoid excess.

    abstract:OBJECTIVE:Glucocorticoid excess is commonly related to neuropsychiatric and neurological disorders, with memory impairment typically found among these disorders. The objective of this study is to offer a clinical profile of memory deficits resulting from exposure to chronic stress-level elevations of endogenous glucoco...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: León-Carrión J,Atutxa AM,Mangas MA,Soto-Moreno A,Pumar A,Leon-Justel A,Martín-Rodriguez JF,Venegas E,Domínguez-Morales MR,Leal-Cerro A

    更新日期:2009-02-01 00:00:00

  • Familial male pseudohermaphroditism due to deficiency of 5 alpha-reductase.

    abstract::Two brothers of Greek Cypriot origin, karyotype 46 XY, aged 17 and 19 years were brought up as females because of predominantly female external genitalia with clitoromegaly and urogenital sinus. At puberty there was genital masculinization with testicular enlargment and descent and development of male musculature and ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Savage MO,Preece MA,Jeffcoate SL,Ransley PG,Rumsby G,Mansfield MD,Williams DI

    更新日期:1980-04-01 00:00:00

  • Influence of thyroxine treatment on thyroid size and anti-thyroid peroxidase antibodies in Hashimoto's thyroiditis.

    abstract:OBJECTIVE:It has been postulated that a decrease in thyroid size can be achieved by thyroxine treatment in patients with goitrous Hashimoto's thyroiditis but no objective data are available. We have therefore investigated the influence of thyroxine treatment on ultrasonically determined thyroid size. We also measured s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hegedüs L,Hansen JM,Feldt-Rasmussen U,Hansen BM,Høier-Madsen M

    更新日期:1991-09-01 00:00:00

  • FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance.

    abstract:OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

    更新日期:2000-06-01 00:00:00

  • Influence of parasellar extension of macroprolactinomas defined by magnetic resonance imaging on their responsiveness to dopamine agonist therapy.

    abstract:OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Delgrange E,Duprez T,Maiter D

    更新日期:2006-04-01 00:00:00

  • Effect of Sandostatin LAR on sleep apnoea in acromegaly: correlation with computerized tomographic cephalometry and hormonal activity.

    abstract:OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ip MS,Tan KC,Peh WC,Lam KS

    更新日期:2001-10-01 00:00:00

  • Ovarian morphology and insulin sensitivity in women with bulimia nervosa.

    abstract:OBJECTIVE:Hyperinsulinaemia has a role in the development of hyperandrogenism and polycystic ovary syndrome in women of normal weight. Polycystic ovaries are common in women with bulimia nervosa and this study aimed to determine whether women with bulimia nervosa are insulin resistant and to examine the relation betwee...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Raphael FJ,Rodin DA,Peattie A,Bano G,Kent A,Nussey SS,Lacey JH

    更新日期:1995-10-01 00:00:00

  • Percutaneous ethanol injection treatment of autonomous thyroid adenoma: hormonal and clinical evaluation.

    abstract:OBJECTIVE:We have evaluated the efficacy of percutaneous ethanol injection as an alternative to surgery and iodine-131 treatment in solitary autonomous thyroid adenoma. DESIGN:Percutaneous ethanol injection (0.5-2.8 ml ethanol/ml nodular tissue) was performed under sonographic guidance in 3-5 (1-2 weekly) sessions; a ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Monzani F,Goletti O,Caraccio N,Del Guerra P,Ferdeghini M,Pucci E,Baschieri L

    更新日期:1992-05-01 00:00:00

  • Recombinant human luteinizing hormone, lutropin alfa, for the induction of follicular development and pregnancy in profoundly gonadotrophin-deficient women.

    abstract:OBJECTIVE:To provide evidence of efficacy and safety for use of lutropin alfa in inducing follicular development and pregnancy in hypogonadotrophic hypogonadal women with profound gonadotrophin deficiency. DESIGN:An open-label, noncomparative extension of a randomized, double-blind, placebo-controlled study PATIENTS:...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kaufmann R,Dunn R,Vaughn T,Hughes G,O'Brien F,Hemsey G,Thomson B,O'Dea LS

    更新日期:2007-10-01 00:00:00

  • Increased thyrotrophin levels and loss of the nocturnal thyrotrophin surge in Sheehan's syndrome.

    abstract:OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Abucham J,Castro V,Maccagnan P,Vieira JG

    更新日期:1997-11-01 00:00:00

  • Smaller LDL particle size in women with polycystic ovary syndrome compared to controls.

    abstract:OBJECTIVE:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. The contribution of lipid abnormalities to this higher risk, in particular atherogenic modifications of low density lipoprotein (LDL) such as a shift towards smaller LDL, has not been properly explored. We aimed to e...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Dejager S,Pichard C,Giral P,Bruckert E,Federspield MC,Beucler I,Turpin G

    更新日期:2001-04-01 00:00:00

  • Specialist services and transitional care in paediatric endocrinology in the UK and Ireland.

    abstract:OBJECTIVE:To assess current provision of specialist and transitional paediatric endocrine services in the UK and Ireland. DESIGN:A questionnaire was sent to paediatric endocrinologists requesting details of patients receiving GH and also details of specialist and transitional services. RESULTS:Of 72 questionnaires re...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kirk J,Clayton P

    更新日期:2006-07-01 00:00:00

  • Impaired body balance, fine motor function and hearing in women with Turner syndrome.

    abstract:OBJECTIVE:Fractures are related to falling. Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures and has been considered as a syndrome of early ageing. The aim was to study whether fine motor function (FM) and body balance (BB) were impaired and related to genotype, fractures, metabolic vari...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: El-Mansoury M,Barrenäs ML,Bryman I,Hanson C,Landin-Wilhelmsen K

    更新日期:2009-08-01 00:00:00

  • Use of GnRH agonist and human chorionic gonadotrophin tests for differentiating constitutional delayed puberty from gonadotrophin deficiency in boys.

    abstract:OBJECTIVES:The differentiation of constitutional delayed puberty (CDP) from gonadotrophin deficiency (GD) in boys at referral poses a difficult challenge. The effectiveness of the GnRH agonist (GnRH-a) test in distinguishing between the two conditions was evaluated and compared with findings of the GnRH and hCG stimula...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kauschansky A,Dickerman Z,Phillip M,Weintrob N,Strich D

    更新日期:2002-05-01 00:00:00

  • Augmentation index in resistance to thyroid hormone (RTH).

    abstract:OBJECTIVE:Resistance to thyroid hormone (RTH) is associated with a varied clinical presentation. The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes. DESIGN:An obser...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Owen PJ,Chatterjee VK,John R,Halsall D,Lazarus JH

    更新日期:2009-04-01 00:00:00

  • Autonomous cortisol secretion in adrenal incidentalomas and increased visceral fat accumulation during follow-up.

    abstract:OBJECTIVE:Autonomous cortisol secretion of adrenal incidentalomas (AIs) is associated with poor cardiovascular outcome. Because centripetal obesity is a cardiovascular risk factor, we aimed to investigate whether autonomous cortisol secretion is associated with increased visceral fat accumulation. DESIGN:Retrospective...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yener S,Baris M,Peker A,Demir O,Ozgen B,Secil M

    更新日期:2017-11-01 00:00:00

  • Effect of surgical stress on pituitary-testicular function.

    abstract::The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wang C,Chan V,Yeung RT

    更新日期:1978-09-01 00:00:00

  • Sex hormone binding globulin in postmenopausal women: a predictor of osteoporosis superior to endogenous oestrogens.

    abstract::To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA

    更新日期:1989-10-01 00:00:00

  • IL-14 and IL-16 are expressed in the thyroid of patients with either Graves' disease or Hashimoto's thyroiditis.

    abstract:OBJECTIVES:Cytokines have an important role in orchestrating the pathophysiology in autoimmune thyroid disease. The aim of the current study was to analyse the expression of interleukin (IL)-14 and IL-16 in the thyroid tissue of patients with Graves' disease (GD), Hashimoto's thyroiditis (HT) or multinodular goitre (MN...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kemp EH,Ajjan RA,Metcalfe RA,Watson PF,Weetman AP

    更新日期:2015-11-01 00:00:00

  • Intractable hypercalcaemia due to parathyroid hormone-related peptide secretion by a carcinoid tumour.

    abstract::Hypercalcaemia, a common complication of malignancy, may result from either the lytic effect of multiple osseous metastases or the effect of tumour-derived humoral factors. Excessive secretion of parathyroid hormone-related peptide (PTHrP), a major cause of humoral hypercalcaemia of malignancy, has been incriminated a...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mantzoros CS,Suva LJ,Moses AC,Spark R

    更新日期:1997-03-01 00:00:00

  • Subcutaneous adipose tissue thickness in adults - correlation with BMI and recommendations for pen needle lengths for subcutaneous self-injection.

    abstract:OBJECTIVE:One of the aims of a subcutaneous (SC) injection is to avoid intradermal or intramuscular injections. Pen systems are an alternative solution to single-use syringes and have become standard for example diabetes therapy. Shorter and smaller needles minimize pain and the risk of intramuscular injections. The th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ludescher B,Rommel M,Willmer T,Fritsche A,Schick F,Machann J

    更新日期:2011-12-01 00:00:00

  • Risk for severe hypoglycaemia with unawareness in GH-deficient patients during the insulin tolerance test.

    abstract:OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Holmer H,Link K,Erfurth EM

    更新日期:2006-02-01 00:00:00