Fertility induction in hypogonadotropic hypogonadal men.

abstract：OBJECTIVE:We compared IGF-1 and IGFBP3 concentrations in a group of adults treated for brain tumours in childhood with those of matched controls, and investigated the relationship between the GH secretory pattern and IGF-1/IGFBP3 concentrations in the entire group. DESIGN:We performed 24 h serum GH profiles using 20 m...

journal_title：Clinical endocrinology

authors： Achermann JC,Hindmarsh PC,Brook CG

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

journal_title：Clinical endocrinology

authors： Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

更新日期：2017-01-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：:The catechol oestrogen 2-hydroxyoestrone has been reported to lower serum prolactin concentrations acutely in normal women and it has been proposed that it may be effective in suppressing prolactin secretion in hyperprolactinaemic patients. Five women with hyperprolactinaemia and anovulation were studied. Following a ...

journal_title：Clinical endocrinology

authors： Franks S,Lightman SL,MaClusky NJ,Naftolin F,Lynch SS,Butt WR,Jacobs HS

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Charmandari E

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

journal_title：Clinical endocrinology

authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:Macroprolactinomas are pituitary tumours that can be managed with dopamine agonists (DA), surgery and radiotherapy. We aimed to assess the outcomes of these treatment modalities. DESIGN:Retrospective case-note study of patients managed in a single tertiary referral centre. PATIENTS:One hundred patients (68...

journal_title：Clinical endocrinology

authors： Green AI,Sherlock M,Stewart PM,Gittoes NJ,Toogood AA

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Disordered water balance causes substantial morbidity in a subset of schizophrenics and is the consequence of unexplained defects in the regulation of fluid intake and antidiuretic function. We aimed to determine whether oropharyngeal regulation of water balance is altered in these patients. DESIGN:A 2-hour ...

journal_title：Clinical endocrinology

authors： Goldman MB,Robertson GL,Hedeker D

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Conflicting data have been reported previously on the effects of oestrogen replacement therapy on glucose tolerance, and the effects on glycosylated haemoglobin GHbA(1c) have been studied only among diabetics. The objective of this study was to evaluate the effects on glucose and insulin metabolism among nond...

journal_title：Clinical endocrinology

authors： Karjalainen A,Paassilta M,Heikkinen J,Bäckström AC,Savolainen M,Kesäniemi YA

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Turner syndrome (TS) is characterized by growth retardation, hypogonadism and a high risk of cardiovascular complications and atherosclerosis; case reports suggest that thrombo-embolic complications may be present. DESIGN:Cross-sectional study. PATIENTS:Sixty women with TS. MEASUREMENTS:We characterized th...

journal_title：Clinical endocrinology

authors： Gravholt CH,Mortensen KH,Andersen NH,Ibsen L,Ingerslev J,Hjerrild BE

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN:Open-label randomized controlled trial. SETTING:Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS:Seventy-eight wom...

journal_title：Clinical endocrinology

authors： Rodda CP,Benson JE,Vincent AJ,Whitehead CL,Polykov A,Vollenhoven B

更新日期：2015-09-01 00:00:00

abstract：:Administration of the anti-inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 +/- 8.6 (SEM) nmol/l before therapy was normalized to 70 +/- 6.4 nmol/l after administration of the drug...

journal_title：Clinical endocrinology

authors： Pearson DW,Ratcliffe WA,Thomson JA,Ratcliffe JG

更新日期：1982-04-01 00:00:00

abstract：:The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

journal_title：Clinical endocrinology

authors： Lamberts SW,Verleun T,Hofland L,Del Pozo E

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVES:Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN meta...

journal_title：Clinical endocrinology

authors： Jeon MJ,Chung MS,Kwon H,Kim M,Park S,Baek JH,Song DE,Sung TY,Hong SJ,Kim TY,Kim WB,Shong YK,Lee JH,Kim WG

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Nonclassical congenital adrenal hyperplasia (NC-CAH) is caused by mutations of the CYP21A2 gene. The clinical manifestations and hormonal derangements of NC-CAH are quite variable. OBJECTIVES:(i) To define the phenotype and its relation to genotype according to gender and age and (ii) to evaluate the validi...

journal_title：Clinical endocrinology

authors： Livadas S,Dracopoulou M,Dastamani A,Sertedaki A,Maniati-Christidi M,Magiakou AM,Kanaka-Gantenbein C,Chrousos GP,Dacou-Voutetakis C

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

journal_title：Clinical endocrinology

authors： Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults. METHODS:This study was based on cros...

journal_title：Clinical endocrinology

authors： Tang L,Zhang F,Tong N

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:The diagnostic impact of chromogranin A (CgA) measurement has been studied in various neuroendocrine tumours (NET) such as pheochromocytomas, gastrinomas and neuroblastomas. Clinically nonfunctioning pituitary adenomas (NFPA) are generally diagnosed on tumoural symptoms or hypopituitarism and, except for gona...

journal_title：Clinical endocrinology

authors： Gussi IL,Young J,Baudin E,Bidart JM,Chanson P

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To determine whether early (4-8h) post-operative ACTH after trans-sphenoidal surgery (TSS) predicts long-term hypothalamic-pituitary-adrenal (HPA) axis function and to investigate early morning day 1 ACTH/cortisol variability using rapid sampling. DESIGN:Prospective observational study. METHODS:Participants...

journal_title：Clinical endocrinology

authors： English KA,Chikani V,Jang C,Dimeski G,Olson S,Inder WJ

更新日期：2020-12-28 00:00:00

abstract：:Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two ...

journal_title：Clinical endocrinology

authors： Thompson DG,Mason AS,Goodwin FJ

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

journal_title：Clinical endocrinology

authors： Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

journal_title：Clinical endocrinology

authors： Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:SRY-negative 46,XX testicular and ovotesticular disorders/differences of sex development (T/OTDSD) represent a very rare and unique DSD condition where testicular tissue develops in the absence of a Y chromosome. To date, very few studies have described the phenotype, clinical and surgical management and long...

journal_title：Clinical endocrinology

authors： Lambert S,Peycelon M,Samara-Boustani D,Hyon C,Dumeige L,Peuchmaur M,Fiot E,Léger J,Simon D,Paye-Jaouen A,Bouligand J,Siffroi JP,Carel JC,McElreavey K,El Ghoneimi A,Brachet C,Bouvattier C,Martinerie L

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:Thyrotoxic hypokalaemic periodic paralysis (THPP) is an uncommon condition with intermittent episodes of muscle weakness and occasionally severe paralysis. THPP is a common complication of hyperthyroidism in Asian populations, and has also been reported in other ethnic groups including Caucasians. This study ...

journal_title：Clinical endocrinology

authors： Cesur M,Bayram F,Temel MA,Ozkaya M,Kocer A,Ertorer ME,Koc F,Kaya A,Gullu S

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

journal_title：Clinical endocrinology

authors： Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Serum testosterone concentrations are affected by factors unrelated to hypothalamo-pituitary-testicular axis pathology. We evaluated the impact of sociodemographic, lifestyle and medical factors, on serum testosterone and sex hormone-binding globulin (SHBG) in men aged 40-69 years. DESIGN:Cross-sectional ana...

journal_title：Clinical endocrinology

authors： Yeap BB,Marriott RJ,Antonio L,Bhasin S,Dobs AS,Dwivedi G,Flicker L,Matsumoto AM,Ohlsson C,Orwoll ES,Raj S,Reid CM,Vanderschueren D,Wittert GA,Wu FCW,Murray K

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:ACTH-producing non-pituitary tumours are often associated with altered precursor processing, particularly in the most aggressive ones. Since placental tissue is characterized by its ability to express the proopiomelanocortin (POMC) gene and rapid cellular proliferation, we examined whether intact POMC could b...

journal_title：Clinical endocrinology

authors： Raffin-Sanson ML,Massias JF,Ankotche A,Coste J,de Keyzer Y,Oliver C,Dumont C,Cabrol D,Ferré F,Bertagna X

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：:Serum immunoreactive melatonin was measured in thirty-three male subjects with delayed puberty, thirty of whom had simple (idiopathic) delayed puberty (SDP) and three of whom were GH deficient. The results were compared with a control population of twenty-six subjects. Significantly elevated values of serum melatonin ...

journal_title：Clinical endocrinology

authors： Cohen HN,Hay ID,Annesley TM,Beastall GH,Wallace AM,Spooner R,Thomson JA,Eastwold P,Klee GG

更新日期：1982-11-01 00:00:00