Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques.

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS:This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 w...

journal_title：Clinical endocrinology

authors： Bahmani F,Karamali M,Shakeri H,Asemi Z

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:It has previously been shown that higher serum TSH is associated with increased thyroid cancer incidence and advanced-stage disease. In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for thyroid cancer, it is important to know whether higher TS...

journal_title：Clinical endocrinology

authors： Haymart MR,Glinberg SL,Liu J,Sippel RS,Jaume JC,Chen H

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:We wished to determine whether women with multinodular goitre and spontaneous subclinical hyperthyroidism have decreased bone density. DESIGN AND SUBJECTS:Bone density was measured at the distal and proximal forearm. Data were expressed as Z-scores relative to the mean values out of 125 control subjects mat...

journal_title：Clinical endocrinology

authors： Mudde AH,Reijnders FJ,Kruseman AC

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether, in the absence of gonads, GH could bring forward the age of neuroendocrine activation resulting in onset of puberty. DESIGN:In girls with Turner's syndrome, we evaluated the effects of GH therapy on developmental changes in FSH serum concentrations used as an indicator of ...

journal_title：Clinical endocrinology

authors： Bourguignon JP,Gérard A,Deby-Dupont G,Franchimont P

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:Constitutional delay in growth and adolescence (CDGA) is common in boys, some of whom request treatment to accelerate growth and attainment of secondary sexual characteristics. The aims of this study were to confirm that a 3-month course of intramuscular testosterone oenanthate does not impair final height i...

journal_title：Clinical endocrinology

authors： Kelly BP,Paterson WF,Donaldson MD

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Complications of childhood cirrhosis include abnormal growth and malnutrition, associated with abnormalities in circulating IGFs and IGFBPs. Controlled studies suggest that intensive enteral feeding enhances nutritional status. The aim was to ascertain whether nasogastric feeding improves nutritional status i...

journal_title：Clinical endocrinology

authors： Holt RI,Miell JP,Jones JS,Mieli-Vergani G,Baker AJ

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

journal_title：Clinical endocrinology

authors： Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

更新日期：2012-01-01 00:00:00

abstract：:Changes in the excretion of urinary cyclic AMP, calcium and phosphate, and serum calcium, ionized calcium, and magnesium were studied after parathyroidectomy for primary hyperparathyroidism. Urinary cyclic AMP decreased rapidly and 8 of 11 patients had a significant reduction 1 h postoperatively, but changes in serum ...

journal_title：Clinical endocrinology

authors： Kohri K,Kataoka K,Yachiku S,Kurita T,Sonoda T

更新日期：1983-04-01 00:00:00

abstract：:Although vasomotor instability or hot flushes are a well-known occurrence in women with natural or artificially-induced menopause, they have not previously been described in children. We report three children in different stages of puberty who developed vasomotor instability following surgery involving the hypothalami...

journal_title：Clinical endocrinology

authors： Witt MF,Blethen SL

更新日期：1983-06-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:Loss of E-cadherin is an important marker of epithelial tumour progression. The aims of this study were to explore whether E-cadherin expression and localization correlate to corticotroph tumour progression, relate the expression of the E-cadherin gene (CDH1) to immunohistochemical E-cadherin staining patter...

journal_title：Clinical endocrinology

authors： Evang JA,Berg JP,Casar-Borota O,Lekva T,Kringen MK,Ramm-Pettersen J,Bollerslev J

更新日期：2011-12-01 00:00:00

abstract：:Cushing's syndrome in pregnancy is rare but associated with a high fetal loss rate, premature labour and excessive maternal morbidity. There has been controversy regarding the safety and efficacy of surgical treatment during pregnancy. We describe two further cases, both due to adrenal adenomas, in whom the diagnosis ...

journal_title：Clinical endocrinology

authors： Bevan JS,Gough MH,Gillmer MD,Burke CW

更新日期：1987-08-01 00:00:00

abstract：:Recombinant human TSH (rhTSH) has revolutionized the care of patients with differentiated thyroid cancer. Since its approval for clinical use in 2001 in Europe (1998 in the USA), rhTSH has greatly enhanced the surveillance of these patients by allowing the avoidance of hypothyroidism for TSH stimulation. Previously, a...

journal_title：Clinical endocrinology

authors： Woodmansee WW,Haugen BR

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEA...

journal_title：Clinical endocrinology

authors： Mäntyselkä A,Jääskeläinen J,Eloranta AM,Väistö J,Voutilainen R,Ong K,Brage S,Lakka TA,Lindi V

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE:To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian). DESIGN AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Madeira JL,Nishi MY,Nakaguma M,Benedetti AF,Biscotto IP,Fernandes T,Pequeno T,Figueiredo T,Franca MM,Correa FA,Otto AP,Abrão M,Miras MB,Santos S,Jorge AA,Costalonga EF,Mendonca BB,Arnhold IJ,Carvalho LR

更新日期：2017-12-01 00:00:00

abstract：:A single-dose study was performed to examine the pharmacokinetics of subcutaneous octreotide in acromegalic patients and to investigate the relationship between growth hormone and the elimination half-life of the drug. Fourteen acromegalic patients (six men and eight women; age range 35-59 years) who had previously re...

journal_title：Clinical endocrinology

authors： Nicholls J,Wynick D,Domin J,Sandler LM,Bloom SR

更新日期：1990-05-01 00:00:00

abstract：:We have recently reported an impaired growth hormone (GH) response to a single i.v. bolus dose of growth hormone releasing factor (1 microgram/kg body weight) in obese women. We have now investigated whether the i.v. administration of low dose GHRF(1-29)NH2 (0.33 microgram/kg/h) by 15 min pulsed injections for 3 h fol...

journal_title：Clinical endocrinology

authors： Kopelman PG,Noonan K

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

journal_title：Clinical endocrinology

authors： Chubb SA,Davis WA,Inman Z,Davis TM

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Growth deficiency is commonly seen in polytransfused beta-thalassaemia patients, especially in adolescence. It is not completely dependent on the lack of their pubertal growth spurt. GH impairment at different levels (hypothalamic or pituitary) and/or a reduced IGF-1 synthesis have been suggested the main cau...

journal_title：Clinical endocrinology

authors： Cavallo L,Gurrado R,Gallo F,Zacchino C,De Mattia D,Tatò L

更新日期：1997-06-01 00:00:00

abstract：:As long ago as 1970, it was proposed that Ca2+ can act as a 'second messenger' like cAMP (Rasmussen & Nagata, 1979). The recognition that calmodulin is a major Ca2+ binding protein in non-muscle cells has prompted the suggestion that calmodulin may serve an analogous role for Ca2+ to that served by protein kinase for ...

journal_title：Clinical endocrinology

authors： Brown BL,Walker SW,Tomlinson S

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:Fibroblast growth factor (FGF21) is a potent regulator of glucose and lipid metabolism. In rodents, the hepatic expression of FGF21 is controlled by fasting and a circadian regulation, but the physiological role and regulation of FGF21 in humans is not well established. Therefore, the objective of this study ...

journal_title：Clinical endocrinology

authors： Andersen B,Beck-Nielsen H,Højlund K

更新日期：2011-10-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

journal_title：Clinical endocrinology

authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

更新日期：1997-06-01 00:00:00

abstract：CONTEXT:Primary hyperparathyroidism is a common condition and results in hypercalcaemia, especially in older women. Thus, it is critical to obtain a robust estimate for the upper limit of the reference interval for albumin-adjusted serum calcium in the general population. The current reference interval in use in the UK...

journal_title：Clinical endocrinology

authors： Schini M,Hannan FM,Walsh JS,Eastell R

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

journal_title：Clinical endocrinology

authors： Jung S,Kim M,Lee YJ,Lee SH,Lee JH

更新日期：2015-08-01 00:00:00

abstract：:In order to evaluate simultaneously in thyrotoxic subjects the relative contributions of insulin secretion, insulin-sensitivity (SI) and glucose-mediated (SG) glucose disposal to overall glucose tolerance, seven non-obese patients with thyrotoxicosis were studied by the minimal model analysis of the frequently sampled...

journal_title：Clinical endocrinology

authors： Pestell R,Alford F,Ramos R,Sawyer S,Best J,Ward G

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:Patients undergoing abdominal surgery often suffer from morbidity associated with increased protein catabolism. Therapeutic recombinant human insulin-like growth factor (rhIGF)-I has been proposed as a means of reversing this process. As IGFBPs modulate the bioavailability of the IGFs, we have studied the ch...

journal_title：Clinical endocrinology

authors： Cotterill AM,Mendel P,Holly JM,Timmins AG,Camacho-Hübner C,Hughes SC,Ross RM,Blum WF,Langford RM

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). AIM:To investigate whether the endometrium of women with PCOS possesses gene expression changes similar to those found in EC. DESIGN AND METHODS:Patients with EC, PCOS and control women unaffect...

journal_title：Clinical endocrinology

authors： Atiomo W,Shafiee MN,Chapman C,Metzler VM,Abouzeid J,Latif A,Chadwick A,Kitson S,Sivalingam VN,Stratford IJ,Rutland CS,Persson JL,Ødum N,Fuentes-Utrilla P,Jeyapalan JN,Heery DM,Crosbie EJ,Mongan NP

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Macroprolactinomas are pituitary tumours that can be managed with dopamine agonists (DA), surgery and radiotherapy. We aimed to assess the outcomes of these treatment modalities. DESIGN:Retrospective case-note study of patients managed in a single tertiary referral centre. PATIENTS:One hundred patients (68...

journal_title：Clinical endocrinology

authors： Green AI,Sherlock M,Stewart PM,Gittoes NJ,Toogood AA

更新日期：2014-07-01 00:00:00