Genetic developments in autoimmune thyroid disease: an evolutionary process.

abstract：OBJECTIVE:The use of ergot-derived dopamine agonists (DA) to treat patients with prolactinomas has not been associated with an increased risk of significant heart valve dysfunction. Accordingly, the present study evaluated whether the long-term use of DA for hyperprolactinaemia may be associated with increased risk of ...

journal_title：Clinical endocrinology

authors： Delgado V,Biermasz NR,van Thiel SW,Ewe SH,Marsan NA,Holman ER,Feelders RA,Smit JW,Bax JJ,Pereira AM

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:We examined the individual pharmacological effects of the addition of rosiglitazone and metformin to glimepiride on inflammatory markers and adipokines in patients with type 2 diabetes mellitus. We analysed the relationships between these variables, the measurements of insulin sensitivity and beta-cell functi...

journal_title：Clinical endocrinology

authors： Kim HJ,Kang ES,Kim DJ,Kim SH,Ahn CW,Cha BS,Nam M,Chung CH,Lee KW,Nam CM,Lee HC

更新日期：2007-02-01 00:00:00

abstract：:Measurements of circulating thyroglobulin (hTg) and 131I whole body scan were performed in 101 patients with differentiated thyroid carcinoma who had been subjected to surgical thyroidectomy and 131I ablation of remaining thyroid tissue. All 45 patients with positive scans (i.e. functioning metastases) had elevated hT...

journal_title：Clinical endocrinology

authors： Pacini F,Pinchera A,Giani C,Grasso L,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...

journal_title：Clinical endocrinology

authors： Li WF,Wang G,Zhao ZB,Liu CA

更新日期：2015-10-01 00:00:00

abstract：:100 mg i.m. sulpiride (a dopamine-receptor-blocking drug) led to a significant rise in plasma TSH in normal womem, in female patients with galactorrhoea, and, to a much more marked degree, in male and female patients with primary hypothyroidism. In the hypothyroid patients, there was a significant positive correlation...

journal_title：Clinical endocrinology

authors： Massara F,Camanni F,Belforte L,Vergano V,Molinatti GM

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of reduced tissue responsiveness to thyroid hormone usually due to mutations located in the ligand-binding domain and adjacent hinge region of the thyroid hormone receptor beta (TRbeta). In the present report we describe the clinical and l...

journal_title：Clinical endocrinology

authors： Magalhães PK,Rodrigues Dare GL,Rodrigues Dos Santos S,Nogueira CR,de Castro M,Zanini Maciel LM

更新日期：2007-11-01 00:00:00

abstract：:The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has...

journal_title：Clinical endocrinology

authors： Cesareo R,Palermo A,Pasqualini V,Cianni R,Gaspa G,Manfrini S,Pacella CM

更新日期：2017-12-01 00:00:00

abstract：:The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of st...

journal_title：Clinical endocrinology

authors： Ellemann K,Thorsteinsson B,Fugleberg S,Feldt-Rasmussen B,Andersen OO,Grønbaek P,Binder C

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:We describe four patients with ovarian hyperthecosis and the effects of gonadotrophin releasing hormone on clinical and metabolic variables. DESIGN:Open out-patient study. PATIENTS:Four women presented with post-menopausal hirsuties. They had significant hair growth across the chest, upper back and shoulder...

journal_title：Clinical endocrinology

authors： Barth JH,Jenkins M,Belchetz PE

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that Graves' disease (GD) is linked to and associated with alleles of the cytotoxic T lymphocyte antigen-4 (CTLA4) locus. However, the true pathogenic polymorphism(s) at this locus remains uncertain. Moreover, the association studies of the promoter CTLA4(-318)C/T polymorphism in whi...

journal_title：Clinical endocrinology

authors： Vaidya B,Oakes EJ,Imrie H,Dickinson AJ,Perros P,Kendall-Taylor P,Pearce SH

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVES:We have demonstrated previously that obesity in men was significantly associated with low plasma testosterone levels and higher concentrations of the androgen metabolite androstane-3 alpha, 17 beta-diol glucuronide, suggesting that androgen metabolism and elimination is increased in this condition. The objec...

journal_title：Clinical endocrinology

authors： Tchernof A,Lévesque E,Beaulieu M,Couture P,Després JP,Hum DW,Bélanger A

更新日期：1999-05-01 00:00:00

abstract：:Clinical observations and serial determinations of serum thyroglobulin (Tg) were made in five patients with acute haemorrhage into the thyroid gland. Fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum T4 and T3 were normal. Although all patients showed an ...

journal_title：Clinical endocrinology

authors： Kawamura S,Kishino B,Tajima K,Mashita K,Tarui S

更新日期：1984-02-01 00:00:00

abstract：:Six healthy subjects were infused with angiotensin II and plasma concentrations of angiotensin, ACTH and cortisol were measured before, during and after the infusion. In all cases the plasma ACTH concentration fell as plasma angiotensin increased and rose again, sometimes to higher than basal levels, when the angioten...

journal_title：Clinical endocrinology

authors： Semple PF,Buckingham JC,Mason PA,Fraser R

更新日期：1979-02-01 00:00:00

abstract：OBJECTIVE:We examined the charge heterogeneity and carbohydrate complexity of hCG in healthy pregnant Asian subjects and Asian women with gestational thyrotoxicosis to assess whether particular glycoforms of hCG are associated with the thyrotoxicosis of pregnancy. DESIGN:Blood was taken at 8-16 weeks of gestation from...

journal_title：Clinical endocrinology

authors： Talbot JA,Lambert A,Anobile CJ,McLoughlin JD,Price A,Weetman AP,Robertson WR

更新日期：2001-07-01 00:00:00

abstract：:Objective African-Americans have been shown to have low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. Design A survey, representative of the population of Rio de Janeiro, a large metropolitan city in ...

journal_title：Clinical endocrinology

authors： Sichieri R,Baima J,Marante T,de Vasconcellos MT,Moura AS,Vaisman M

更新日期：2007-06-01 00:00:00

abstract：CONTEXT:Transient thelarche (TT), that is, the appearance, regression and subsequent reappearance of breast buds, is a frequent phenomenon, but little is known about pubertal transition in these girls. OBJECTIVE:To describe pubertal progression, growth, genotypes, reproductive hormones and growth factors in girls with...

journal_title：Clinical endocrinology

authors： Soto J,Pereira A,Busch AS,Almstrup K,Corvalan C,Iñiguez G,Juul A,Mericq V

更新日期：2020-09-01 00:00:00

abstract：:Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...

journal_title：Clinical endocrinology

authors： Krassas G,McHardy-Young S,Ramsay I,Florin-Christensen A

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

journal_title：Clinical endocrinology

authors： Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:Iodine deficiency during pregnancy results in thyroid dysfunction and has been associated with adverse obstetric and foetal effects, leading to worldwide salt iodization programmes. As nowadays 69% of the world's population lives in iodine-sufficient regions, we investigated the effects of variation in iodine...

journal_title：Clinical endocrinology

authors： Medici M,Ghassabian A,Visser W,de Muinck Keizer-Schrama SM,Jaddoe VW,Visser WE,Hooijkaas H,Hofman A,Steegers EA,Bongers-Schokking JJ,Ross HA,Tiemeier H,Visser TJ,de Rijke YB,Peeters RP

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To study the effects of long-term combined continuous oral hormone replacement therapy (HRT) on vascular function in healthy postmenopausal women. BACKGROUND:The cardiovascular effects of HRT are controversial. Improvement in vascular function is a proposed mechanism of oestrogen action but there are no long...

journal_title：Clinical endocrinology

authors： Teede HJ,Liang YL,Kotsopoulos D,Zoungas S,Cravent R,McGrath BP

更新日期：2001-11-01 00:00:00

abstract：:A single fasting level of serum prolactin was measured in each of sixty control subjects and eighty-three psychiatric patients of both sexes who had been on neuroleptic therapy for 2-4 weeks (acute treatment) or at least 5 years (chronic treatment) and who were aged either 17-45 or 48-85 years. All groups of patients ...

journal_title：Clinical endocrinology

authors： Rivera JL,Lal S,Ettigi P,Hontela S,Muller HF,Friesen HG

更新日期：1976-05-01 00:00:00

abstract：:Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for...

journal_title：Clinical endocrinology

authors： Okosieme OE,Khan I,Taylor PN

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:This study was conducted to determine the effects of folate supplementation on inflammatory factors and biomarkers of oxidative stress among women with polycystic ovary syndrome (PCOS). DESIGN, PATIENTS AND MEASUREMENTS:This randomized, double-blind, placebo-controlled clinical trial was conducted among 69 w...

journal_title：Clinical endocrinology

authors： Bahmani F,Karamali M,Shakeri H,Asemi Z

更新日期：2014-10-01 00:00:00

abstract：:There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

journal_title：Clinical endocrinology

authors： Ginsberg J,Rafter DJ,von Westarp C,Murray PG

更新日期：1987-04-01 00:00:00

abstract：:Cushing's syndrome in pregnancy is rare but associated with a high fetal loss rate, premature labour and excessive maternal morbidity. There has been controversy regarding the safety and efficacy of surgical treatment during pregnancy. We describe two further cases, both due to adrenal adenomas, in whom the diagnosis ...

journal_title：Clinical endocrinology

authors： Bevan JS,Gough MH,Gillmer MD,Burke CW

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:The autoimmune thyroid diseases, Graves disease and autoimmune hypothyroidism, result from a complex interaction between genetic, environmental and endogenous factors. The genetic loci conferring susceptibility remain unclear. A recent report has demonstrated an association between a microsatellite polymorphi...

journal_title：Clinical endocrinology

authors： Kotsa K,Watson PF,Weetman AP

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:The 2017 revised Bethesda System for Reporting Thyroid Cytopathology (BSRTC) included new malignancy rates for each category as well as new management recommendations. Here, we evaluate the malignancy rate and test performance for BSRTC categories in a middle-sized institution outside the United States (US). ...

journal_title：Clinical endocrinology

authors： Avior G,Dagan O,Shochat I,Frenkel Y,Tessler I,Meir A,Jaffe A,Cohen O

更新日期：2020-09-27 00:00:00

abstract：OBJECTIVE:Standard drug information resources recommend that l-thyroxine be taken half an hour before breakfast on an empty stomach, to prevent interference of its intestinal uptake by food or medication. We observed cases in which TSH levels improved markedly after changing the administration time of l-thyroxine to th...

journal_title：Clinical endocrinology

authors： Bolk N,Visser TJ,Kalsbeek A,van Domburg RT,Berghout A

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:There has been much debate concerning the relative contribution of insulin resistance to the development of polycystic ovaries (PCO). We therefore aimed to assess ovarian morphology and insulin/androgen status in females with the hepatic glycogen storage diseases types Ia (GSD-Ia) and III (GSD-III), disorders...

journal_title：Clinical endocrinology

authors： Lee PJ,Patel A,Hindmarsh PC,Mowat AP,Leonard JV

更新日期：1995-06-01 00:00:00