A placebo-controlled trial of long-term oral combined continuous hormone replacement therapy in postmenopausal women: effects on arterial compliance and endothelial function.

abstract：:Two female patients with functioning adrenocortical carcinomas had plasma ACTH detectable by RIA at presentation. In both patients there was evidence for biological activity of ACTH. There was no evidence for an ectopic source of ACTH, nor for a pituitary tumour. Urinary steroid analysis showed patterns of multiple ho...

journal_title：Clinical endocrinology

authors： Law A,Hague WM,Daly JG,Honour JW,Taylor N,Jeffcoate SL,Himsworth RL,Joplin GF

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:PTH(1-84) secretion in normal male subjects follows a circadian rhythm. The control of this rhythm is multifactorial with both neuroendocrine and chemical influences. The aim of this study was to assess the effect of a 96-hour fast on the circadian rhythm of PTH(1-84), serum calcium, phosphate and nephrogenou...

journal_title：Clinical endocrinology

authors： Fraser WD,Logue FC,Christie JP,Cameron DA,O'Reilly DS,Beastall GH

更新日期：1994-04-01 00:00:00

abstract：:1,24,25-trihydroxyvitamin D3 has been detected in human serum using a sensitive radioimmunoassay. Tritiated 1,24,25-trihydroxyvitamin D3 was synthesized biologically and used as tracer to monitor the recovery of endogenous metabolite during isolation from serum. Circulating 1,24,25(OH)3D3 in normal subjects ranged fro...

journal_title：Clinical endocrinology

authors： Clemens TL,Fraher LJ,Sandler LM,O'Riordan JL

更新日期：1982-04-01 00:00:00

abstract：:Normal men and normally menstruating women received i.m. injections of 0.1 to 4.0 mg/kg sulpiride. This psychotropic drug induced a very rapid (already significant after 5 minutes) and sustained (still significant after 7 hours) elevation of prolactin (PRL) concentrations in all subjects with no consistent modificatio...

journal_title：Clinical endocrinology

authors： L'Hermite M,Denayer P,Golstein J,Virasoro E,Vanhaelst L,Copinschi G,Robyn C

更新日期：1978-09-01 00:00:00

abstract：:In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high curre...

journal_title：Clinical endocrinology

authors： Phillips DI,Barker DJ,Rees Smith B,Didcote S,Morgan D

更新日期：1985-09-01 00:00:00

abstract：:We have previously reported that L-thyroxine treated patients may often have elevated serum T4 concentrations and yet show no clinical signs of hyperthyroidism. We found that such patients had normal serum T3 concentrations. The present study explored the relationship between serum T3 and T4 and dosage of L-thyroxine....

journal_title：Clinical endocrinology

authors： Rendell M,Salmon D

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

journal_title：Clinical endocrinology

authors： Jung S,Kim M,Lee YJ,Lee SH,Lee JH

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in ...

journal_title：Clinical endocrinology

authors： Zhao T,Zhao J

更新日期：2011-02-01 00:00:00

abstract：:Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alk...

journal_title：Clinical endocrinology

authors： MacFarlane IA,Davies D,Longson D,Shalet SM,Beardwell CG

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：:Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two ...

journal_title：Clinical endocrinology

authors： Thompson DG,Mason AS,Goodwin FJ

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

journal_title：Clinical endocrinology

authors： Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Over 1% of the UK population is receiving thyroid hormone replacement with l-thyroxine (T4). However, many patients complain of persistent lethargy and related symptoms on T4 even with normal TSH levels. To date there has been no large study to determine whether this is related to thyroxine replacement or coi...

journal_title：Clinical endocrinology

authors： Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

更新日期：2002-11-01 00:00:00

abstract：:Twenty women with secondary hypogonadism and four normal women in the early follicular phase of the cycle were treated for 7 days with 10, 50 or 100 micrograms synthetic LHRH administered intramuscularly at 4 h intervals. Concentrations of pituitary and ovarian hormones in plasma were measured at intervals during the ...

journal_title：Clinical endocrinology

authors： Vaughan Williams CA,McNeilly AS,Baird DT

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:The 2017 revised Bethesda System for Reporting Thyroid Cytopathology (BSRTC) included new malignancy rates for each category as well as new management recommendations. Here, we evaluate the malignancy rate and test performance for BSRTC categories in a middle-sized institution outside the United States (US). ...

journal_title：Clinical endocrinology

authors： Avior G,Dagan O,Shochat I,Frenkel Y,Tessler I,Meir A,Jaffe A,Cohen O

更新日期：2020-09-27 00:00:00

abstract：:This study deals with serum prolactin concentrations during various conditions in the early puerperium in an attempt to investigate some characteristics of the mechanisms responsible for the regulation of the lactotropes. In nursing, in non-nursing, non-medicated and in non-nursing, bromocriptine-treated women prolact...

journal_title：Clinical endocrinology

authors： Vemer HM,Rolland R

更新日期：1981-08-01 00:00:00

abstract：OBJECTIVE:Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol, and pubertal status, into genetic and environmental components. DESIGN:A sample of male and female adolescent twins from the greater Austin ...

journal_title：Clinical endocrinology

authors： Grotzinger AD,Mann FD,Patterson MW,Herzhoff K,Tackett JL,Tucker-Drob EM,Paige Harden K

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Patients undergoing abdominal surgery often suffer from morbidity associated with increased protein catabolism. Therapeutic recombinant human insulin-like growth factor (rhIGF)-I has been proposed as a means of reversing this process. As IGFBPs modulate the bioavailability of the IGFs, we have studied the ch...

journal_title：Clinical endocrinology

authors： Cotterill AM,Mendel P,Holly JM,Timmins AG,Camacho-Hübner C,Hughes SC,Ross RM,Blum WF,Langford RM

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

journal_title：Clinical endocrinology

authors： Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Young women with Turner syndrome (TS) are known to be at risk for loss to medical follow-up. Recent literature indicates that there are disparities regarding transition readiness between different chronic conditions. So far, studies in young women with TS investigating their transition readiness compared to y...

journal_title：Clinical endocrinology

authors： Culen C,Herle M,Ertl DA,Fröhlich-Reiterer E,Blümel P,Wagner G,Häusler G

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Antithyroidal drugs (ATD) are used in the management of Graves' disease either as primary therapy for several months while awaiting remission of the disease or as pretreatment for several weeks prior to definitive radioactive iodine therapy (RAI). We have reported previously that pretreatment with propylthiou...

journal_title：Clinical endocrinology

authors： Hancock LD,Tuttle RM,LeMar H,Bauman J,Patience T

更新日期：1997-10-01 00:00:00

abstract：:A single fasting level of serum prolactin was measured in each of sixty control subjects and eighty-three psychiatric patients of both sexes who had been on neuroleptic therapy for 2-4 weeks (acute treatment) or at least 5 years (chronic treatment) and who were aged either 17-45 or 48-85 years. All groups of patients ...

journal_title：Clinical endocrinology

authors： Rivera JL,Lal S,Ettigi P,Hontela S,Muller HF,Friesen HG

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Growth hormone treatment in children with idiopathic short stature (ISS) leads to growth acceleration in the first years, but the effect on final height is still poorly documented. We therefore studied the long-term effect of GH therapy in children with idiopathic short stature. DESIGN:We have...

journal_title：Clinical endocrinology

authors： Wit JM,Boersma B,de Muinck Keizer-Schrama SM,Nienhuis HE,Oostdijk W,Otten BJ,Delemarre-Van de Waal HA,Reeser M,Waelkens JJ,Rikken B

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:The disruption between the brain and the spinal cord leads to a decentralized sympathetic nervous system in people with chronic, cervical spinal cord lesions. These tetraplegic subjects are prone to disorders of energy metabolism and osteoporosis, and they experience alterations in their body composition with...

journal_title：Clinical endocrinology

authors： Hjeltnes N,De Groot P,Birkeland KI,Falch JA,Iversen PO

更新日期：2005-02-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. It is produced exclusively in the gonads and is involved in the regulation of follicular growth and development. In the ovary AMH is produced by the granulosa cells of early developing follicles and se...

journal_title：Clinical endocrinology

authors： La Marca A,Volpe A

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in path...

journal_title：Clinical endocrinology

authors： Oflaz H,Sen F,Elitok A,Cimen AO,Onur I,Kasikcioglu E,Korkmaz S,Demirturk M,Kutluturk F,Pamukcu B,Ozbey N

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

journal_title：Clinical endocrinology

authors： Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：:Long-term bromocriptine treatment was discontinued in thirty-seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty-seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but o...

journal_title：Clinical endocrinology

authors： Bergh T,Nillius SJ,Wide L

更新日期：1982-06-01 00:00:00