Associations between metabolomic-identified changes of biomarkers and arterial stiffness in subjects progressing to impaired fasting glucose.

abstract：OBJECTIVE:Recent studies have suggested that patients receiving thyroxine are at increased risk of osteoporosis. We set out to measure bone mineral densities in two groups of post-menopausal women receiving thyroxine replacement therapy (those with serum TSH levels persistently suppressed or non-suppressed) and to comp...

journal_title：Clinical endocrinology

authors： Grant DJ,McMurdo ME,Mole PA,Paterson CR,Davies RR

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

journal_title：Clinical endocrinology

authors： Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:One of the aims of a subcutaneous (SC) injection is to avoid intradermal or intramuscular injections. Pen systems are an alternative solution to single-use syringes and have become standard for example diabetes therapy. Shorter and smaller needles minimize pain and the risk of intramuscular injections. The th...

journal_title：Clinical endocrinology

authors： Ludescher B,Rommel M,Willmer T,Fritsche A,Schick F,Machann J

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:There are advantages and disadvantages with all of the presently available types of testosterone replacement for hypogonadal men. We performed this investigation to establish detailed data about the pharmacokinetics, pharmacodynamics, feasibility and side-effects of subcutaneously implanted testosterone (T) p...

journal_title：Clinical endocrinology

authors： Jockenhövel F,Vogel E,Kreutzer M,Reinhardt W,Lederbogen S,Reinwein D

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

journal_title：Clinical endocrinology

authors： Hopkins KD,Holdaway IM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To assess possible side-effects of long-term continuous growth hormone (GH) treatment on carbohydrate (CH) metabolism in children with short stature born small for gestational age. DESIGN:In a prospective, randomised double-blind, dose-response multicentre trial, the effect of GH treatment on CH metabolism w...

journal_title：Clinical endocrinology

authors： Sas T,Mulder P,Aanstoot HJ,Houdijk M,Jansen M,Reeser M,Hokken-Koelega A

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Androgens have paradoxically different effects on hair follicles depending on body site, stimulating beard growth while inducing regression in some areas of the scalp. The mesenchyme derived dermal papilla at the base of the hair follicle regulates many aspects of the growth of follicular epithelium, and is p...

journal_title：Clinical endocrinology

authors： Thornton MJ,Laing I,Hamada K,Messenger AG,Randall VA

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Excess endogenous thyroxine causes bone loss, but the effects of exogenous thyroxine are disputed. We report on bone mass and metabolism in women taking L-thyroxine therapy. DESIGN:Cross-sectional and longitudinal studies. PATIENTS:Cross-sectional study: 40 healthy premenopausal women with au...

journal_title：Clinical endocrinology

authors： Garton M,Reid I,Loveridge N,Robins S,Murchison L,Beckett G,Reid D

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:The purpose of the study was to evaluate plasma inhibin as a marker of hydatidiform mole and to compare the results with intact human chorionic gonadotrophin (hCG) and its free beta-subunit. DESIGN:Serial determinations of the plasma concentrations of inhibin, intact human chorionic gonadotrophin and its fre...

journal_title：Clinical endocrinology

authors： Badonnel Y,Barbé F,Legagneur H,Poncelet E,Schweitzer M

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:The development and progression of sporadic adrenocortical tumours are poorly understood. In autopsy studies adrenocortical tumours are found in between 2 and 9% of the general population. In congenital adrenal hyperplasia (CAH), decreased production of cortisol leads to increased secretion of ACTH from the p...

journal_title：Clinical endocrinology

authors： Kjellman M,Holst M,Bäckdahl M,Larsson C,Farnebo LO,Wedell A

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). DESIGN:Prospective, intervention with both ...

journal_title：Clinical endocrinology

authors： Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA). METHODS:We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test ad...

journal_title：Clinical endocrinology

authors： Pirola I,Di Lodovico E,Casella C,Pezzaioli L,Facondo P,Ferlin A,Lombardi D,Cappelli C

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

journal_title：Clinical endocrinology

authors： Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Acylation-stimulating protein (ASP) is an adipose tissue-derived hormone, which stimulates glucose and free fatty acid (FFA) uptake into adipocytes. Changes in ASP metabolism are associated with alterations in lipid metabolism. As postnatal catch-up growth has been associated with dyslipidaemia in...

journal_title：Clinical endocrinology

authors： Leunissen RW,Gao Y,Cianflone K,Stijnen T,Hokken-Koelega AC

更新日期：2010-06-01 00:00:00

abstract：:Oestrogens are known to enhance both basal and stimulated GH secretion. To examine whether this effect is mediated through the hypothalamus or the pituitary we performed insulin tolerance and GH-releasing hormone (GHRH) tests with and without oestrogen priming in a group of 14 short children. Pretreatment with stilboe...

journal_title：Clinical endocrinology

authors： Ross RJ,Grossman A,Davies PS,Savage MO,Besser GM

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In polycystic ovary syndrome (PCOS) inappropriate gonadotrophin secretion is characterized by increased pulse frequency and amplitude, elevated 24-h mean serum concentrations, and greater responses to GnRH. While the mechanism(s) responsible for this increased release of LH are not well underst...

journal_title：Clinical endocrinology

authors： Patel K,Coffler MS,Dahan MH,Malcom PJ,Deutsch R,Chang RJ

更新日期：2004-01-01 00:00:00

abstract：CONTEXT:Nonalcoholic fatty liver disease represents the hepatic manifestation of the metabolic syndrome. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury. The pathophysiology that leads to NASH is not well understood. OBJECTIVE:We hypothesize that an altered cortisol metabolism in the liver ...

journal_title：Clinical endocrinology

authors： Konopelska S,Kienitz T,Hughes B,Pirlich M,Bauditz J,Lochs H,Strasburger CJ,Stewart PM,Quinkler M

更新日期：2009-04-01 00:00:00

abstract：:In order to investigate the mechanism of GIP secretion and the role of endogenous GIP in the enteroinsular axis in duodenal ulcer patients, we have compared plasma GIP, insulin, and blood glucose responses to oral glucose ingestion in 10 duodenal ulcer patients, 5 patients with total gastrectomy, and 20 normal subject...

journal_title：Clinical endocrinology

authors： Takemura J,Seino Y,Yamamura T,Yoshiya K,Ishikawa Y,Itoh N,Imura H

更新日期：1983-09-01 00:00:00

abstract：:Patients with thyrotoxic Graves' disease were treated daily for 10 d with 1 g sodium ipodate, an iodine rich X-ray contrast agent which impairs outer ring (5'-) deiodination of T4 to T3, or with 12 drops of a saturated solution of potassium iodide (SSKI). T4, T3 and reverse T3 (rT3) concentrations were measured before...

journal_title：Clinical endocrinology

authors： Roti E,Robuschi G,Manfredi A,D'Amato L,Gardini E,Salvi M,Montermini M,Barlli AL,Gnudi A,Braverman LE

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVES:Localization of ectopic ACTH-secreting tumours causing Cushing syndrome (ECS) is essential for clinical management, yet often difficult. [68 Ga]-DOTATATE PET/CT ([68 Ga]-DOTA-(Tyr3 )-octreotate)] is an FDA-approved high-resolution diagnostic tool for imaging neuroendocrine tumours. Data on the clinical utili...

journal_title：Clinical endocrinology

authors： Wannachalee T,Turcu AF,Bancos I,Habra MA,Avram AM,Chuang HH,Waguespack SG,Auchus RJ

更新日期：2019-08-01 00:00:00

abstract：:The role of bromocriptine in the treatment of non-functioning pituitary tumours is not yet defined. Patients with these tumours who present with visual field defects usually undergo immediate surgery. Three consecutive patients are reported: each had rapid improvement in their visual field defects following bromocript...

journal_title：Clinical endocrinology

authors： D'Emden MC,Harrison LC

更新日期：1986-12-01 00:00:00

abstract：:Using a sensitive enzyme amplified immunoassay for TSH, the evening rise and pulsatile release of TSH were studied in 10 men with chronic renal failure treated by haemodialysis. Compared to euthyroid male controls the evening rise of TSH was attenuated (median 0.066 vs 0.195 mU/l/h, P less than 0.01) and the rate of r...

journal_title：Clinical endocrinology

authors： Wheatley T,Clark PM,Clark JD,Holder R,Raggatt PR,Evans DB

更新日期：1989-07-01 00:00:00

abstract：:Recent evidence suggests that oxytocin (OXT) and arginine vasopressin (AVP) are involved in the response to stress. We have examined the changes in peripheral plasma OXT during abdominal surgery in eight patients (six males, two female; ages 60-82 years) undergoing hemicolectomy and compared the results with those for...

journal_title：Clinical endocrinology

authors： Nussey SS,Page SR,Ang VT,Jenkins JS

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN:The study consists of a cross-sectional arm compari...

journal_title：Clinical endocrinology

authors： Kyriakakis N,Lynch J,Gilbey SG,Webb SM,Murray RD

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late-maturing adolescents grow slower than postulated by age-related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity refe...

journal_title：Clinical endocrinology

authors： Binder G,Lehrian TJ,Hoffmann E,Blumenstock G,Rahmaoui A,Trzaskoma B,Reinehr T

更新日期：2021-02-01 00:00:00

abstract：:Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for...

journal_title：Clinical endocrinology

authors： Okosieme OE,Khan I,Taylor PN

更新日期：2018-09-01 00:00:00

abstract：:Twenty women with secondary hypogonadism and four normal women in the early follicular phase of the cycle were treated for 7 days with 10, 50 or 100 micrograms synthetic LHRH administered intramuscularly at 4 h intervals. Concentrations of pituitary and ovarian hormones in plasma were measured at intervals during the ...

journal_title：Clinical endocrinology

authors： Vaughan Williams CA,McNeilly AS,Baird DT

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Insulin and glucocorticoids are known to increase total leptin levels. However, the effects of insulin and glucocorticoids on the components of the leptin system - free leptin (FL), bound leptin (BL) and soluble leptin receptor (SR) - have not been elucidated. The aim of this study was to determine if there i...

journal_title：Clinical endocrinology

authors： Lewandowski K,Randeva HS,O'Callaghan CJ,Horn R,Medley GF,Hillhouse EW,Brabant G,O'Hare P

更新日期：2001-04-01 00:00:00