The Clinical Impact of [68 Ga]-DOTATATE PET/CT for the Diagnosis and Management of Ectopic Adrenocorticotropic Hormone - Secreting Tumours.

abstract：OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

journal_title：Clinical endocrinology

authors： Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

更新日期：2018-01-01 00:00:00

abstract：:We studied the acute effect of standard therapeutic doses of oral frusemide on indices of thyroid function in 34 hospital in-patients with congestive cardiac failure. A transient decrease in total T4, elevation in the T3 resin uptake and consequent increase in the free T4 index (FT4I) were seen 2-5 h after ingestion o...

journal_title：Clinical endocrinology

authors： Newnham HH,Hamblin PS,Long F,Lim CF,Topliss DJ,Stockigt JR

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

journal_title：Clinical endocrinology

authors： Picolos MK,Lavis VR,Orlander PR

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Low serum testosterone is commonly observed in men with type 2 diabetes (T2DM), but the neuroendocrine pathophysiology remains to be elucidated. OBJECTIVES:The hypothalamic neuropeptide kisspeptin integrates metabolic signals with the reproductive axis in animal models. We hypothesized that administration of...

journal_title：Clinical endocrinology

authors： George JT,Veldhuis JD,Tena-Sempere M,Millar RP,Anderson RA

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:IGF-1 stimulates growth, development and function of lymphocytes. The aim of this study was to examine whether functional variants of the IGF-1 gene are associated with absolute lymphocyte subset counts in neonates. STUDY DESIGN AND MEASUREMENTS:This study was embedded in the Generation R Study, a prospectiv...

journal_title：Clinical endocrinology

authors： Duijts L,Bakker-Jonges LE,Mook-Kanamori DO,Labout JA,Hofman A,van Duijn CM,van Dongen JJ,Hooijkaas H,Moll HA,Jaddoe VW

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults. PATIENTS:Forty patients with hyperprolactinaemia (20 with disease onset during adolescence and 20 during adulthood) and 40 healthy control subjects. DES...

journal_title：Clinical endocrinology

authors： Colao A,Di Somma C,Loche S,Di Sarno A,Klain M,Pivonello R,Pietrosante M,Salvatore M,Lombardi G

更新日期：2000-03-01 00:00:00

abstract：:The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h period has shown the existence of a circadian rhythm in normal males which is absent in patients with primary hyperparathyroidism. The physiological significance of this observation is reflected in the presence of parallel changes in nephroge...

journal_title：Clinical endocrinology

authors： Logue FC,Fraser WD,Gallacher SJ,Cameron DA,O'Reilly DS,Beastall GH,Patel U,Boyle IT

更新日期：1990-04-01 00:00:00

abstract：INTRODUCTION:  Surgical remission rates for acromegaly vary and are dependent on the tumour morphology, biochemical definition of disease remission and surgical expertise. A previous report from the Manchester region in 1998 reported an overall surgical remission rate of 27% using accepted criteria for biochemical remi...

journal_title：Clinical endocrinology

authors： Wang YY,Higham C,Kearney T,Davis JR,Trainer P,Gnanalingham KK

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

journal_title：Clinical endocrinology

authors： Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002. DESIGN:Descriptive epidemiological study. METHODS:Thyroid cancer registratio...

journal_title：Clinical endocrinology

authors： Reynolds RM,Weir J,Stockton DL,Brewster DH,Sandeep TC,Strachan MW

更新日期：2005-02-01 00:00:00

abstract：:Two female patients with functioning adrenocortical carcinomas had plasma ACTH detectable by RIA at presentation. In both patients there was evidence for biological activity of ACTH. There was no evidence for an ectopic source of ACTH, nor for a pituitary tumour. Urinary steroid analysis showed patterns of multiple ho...

journal_title：Clinical endocrinology

authors： Law A,Hague WM,Daly JG,Honour JW,Taylor N,Jeffcoate SL,Himsworth RL,Joplin GF

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVES:Hyponatraemia is strongly associated with increased inpatient mortality, but it is unknown whether hyponatraemia per se contributes to excess mortality. Our hypothesis was that if hyponatraemic patients had significantly greater mortality compared with controls despite no difference with regard to gender, ag...

journal_title：Clinical endocrinology

authors： Tzoulis P,Bagkeris E,Bouloux PM

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:We wished to assess the changes in serum IGF-I and IGF-II concentrations during gonadotrophin treatment alone or with additional GH treatment and to compare follicular fluid IGF-I and IGF-II concentrations in the two treatment groups. DESIGN:We performed an open study of co-treatment with GH and subsequently...

journal_title：Clinical endocrinology

authors： Owen EJ,Torresani T,West C,Mason BA,Jacobs HS

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:The standard ACTH test in clinical use employs a pharmacological dose of ACTH which assesses the maximum secretory capacity of the adrenal cortex. We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of AC...

journal_title：Clinical endocrinology

authors： Daidoh H,Morita H,Mune T,Murayama M,Hanafusa J,Ni H,Shibata H,Yasuda K

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:PTH(1-84) secretion in normal male subjects follows a circadian rhythm. The control of this rhythm is multifactorial with both neuroendocrine and chemical influences. The aim of this study was to assess the effect of a 96-hour fast on the circadian rhythm of PTH(1-84), serum calcium, phosphate and nephrogenou...

journal_title：Clinical endocrinology

authors： Fraser WD,Logue FC,Christie JP,Cameron DA,O'Reilly DS,Beastall GH

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

journal_title：Clinical endocrinology

authors： Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies on the cardiovascular risk of progestagen-only contraceptives are rare. With the present study we aimed to investigate the effect of the low-dose etonogestrel-releasing contraceptive implant Implanon on cardiovascular risk factors, including markers of inflammation. DESIGN:Longitudina...

journal_title：Clinical endocrinology

authors： Merki-Feld GS,Imthurn B,Seifert B

更新日期：2008-03-01 00:00:00

abstract：:To explore the mechanism for the hypogonadism associated with prolactin hypersecretion in men we examined luteinizing hormone (LH) secretory profiles in four hyperprolactinaemic men before and during treatment with bromocriptine. Pretreatment serum prolactin levels were increased 4-100 fold and serum testosterone leve...

journal_title：Clinical endocrinology

authors： Winters SJ,Troen P

更新日期：1984-09-01 00:00:00

abstract：:Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. Recombinant human (rh) insulin-like growth factor-1 (rhIGF-1) therapy is approved for severe primary IGF-I deficiency - a state of severe GH resistance. Evidence is increasing for an unacceptably high rate of p...

journal_title：Clinical endocrinology

authors： Bang P,Ahmed SF,Argente J,Backeljauw P,Bettendorf M,Bona G,Coutant R,Rosenfeld RG,Walenkamp MJ,Savage MO

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：:1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was ach...

journal_title：Clinical endocrinology

authors： Saratchandran P,Carson ER,Reeve J

更新日期：1976-09-01 00:00:00

abstract：:Radioiodine has been in use for over 60 years as a treatment for hyperthyroidism. Major changes in clinical practice have occurred with the realization that accurate dosimetry is incapable of avoiding the risks of hypothyroidism, while more accurate assessment of the risks of other adverse effects of radioiodine such ...

journal_title：Clinical endocrinology

authors： Weetman AP

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:We examined the obesity phenotype most strongly associated with increased plasma concentrations of sTNFR2, and compared which of the two markers, TNF-alpha or sTNFR2, better predicts indices of plasma glucose-insulin homeostasis. DESIGN, PATIENTS AND MEASUREMENTS:Plasma sTNFR2 levels were measured in a sampl...

journal_title：Clinical endocrinology

authors： Cartier A,Côté M,Bergeron J,Alméras N,Tremblay A,Lemieux I,Després JP

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

journal_title：Clinical endocrinology

authors： Fuller PJ,Alexiadis M,Jobling T,McNeilage J

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains u...

journal_title：Clinical endocrinology

authors： Tang Y,Qiao P,Qu X,Bao Y,Li Y,Liao Y,Ying H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:A new protocol for postoperative calcium management was developed with the aim of achieving an increase in the proportion of patients being safely discharged on the first postoperative day. We present our experience with the first 50 patients treated under this new protocol. PATIENTS AND DESIGN:A cohort stud...

journal_title：Clinical endocrinology

authors： Grodski S,Lundgren CI,Sidhu S,Sywak M,Delbridge L

更新日期：2009-02-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:Antithyroidal drugs (ATD) are used in the management of Graves' disease either as primary therapy for several months while awaiting remission of the disease or as pretreatment for several weeks prior to definitive radioactive iodine therapy (RAI). We have reported previously that pretreatment with propylthiou...

journal_title：Clinical endocrinology

authors： Hancock LD,Tuttle RM,LeMar H,Bauman J,Patience T

更新日期：1997-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Individuals with impaired fasting glucose (IFG) are at increased risk of developing diabetes over the subsequent decade. However, there is uncertainty as to the mechanisms contributing to the development of diabetes. We sought to quantitate insulin secretion and action across the prediabetic range of fa...

journal_title：Clinical endocrinology

authors： Sathananthan A,Dalla Man C,Zinsmeister AR,Camilleri M,Rodeheffer RJ,Toffolo G,Cobelli C,Rizza RA,Vella A

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Studies assessing quality of life in GH-deficient adults have shown varying results. This may be due to a number of factors including varying causes of GH deficiency, the use of radiotherapy in treatment and patient selection. We aimed to assess whether anterior pituitary hormone deficiency or external pituit...

journal_title：Clinical endocrinology

authors： Page RC,Hammersley MS,Burke CW,Wass JA

更新日期：1997-04-01 00:00:00