The role of opiate peptides in the control of prolactin in the puerperium, and TSH in primary hypothyroidism.

abstract：BACKGROUND:Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion. OBJECTIVE:To investigate the clinical characteristics and accurate management of aromatase-deficient children. PATIENTS AND METHOD...

journal_title：Clinical endocrinology

authors： Fan L,Zhang B,Li L,Gong C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

journal_title：Clinical endocrinology

authors： Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West ...

journal_title：Clinical endocrinology

authors： Knight BA,Shields BM,He X,Pearce EN,Braverman LE,Sturley R,Vaidya B

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

journal_title：Clinical endocrinology

authors： Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

更新日期：1997-02-01 00:00:00

abstract：:Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanis...

journal_title：Clinical endocrinology

authors： Monticone S,Losano I,Tetti M,Buffolo F,Veglio F,Mulatero P

更新日期：2018-10-01 00:00:00

abstract：:A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

journal_title：Clinical endocrinology

authors： Nabarro JD

更新日期：1987-04-01 00:00:00

abstract：:Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multifactorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances and, in some patients, supraphysiologic glucocorticoid replacement...

journal_title：Clinical endocrinology

authors： Lee P,Greenfield JR

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...

journal_title：Clinical endocrinology

authors： Vanakara P,Dafopoulos K,Papastergiopoulou L,Kallitsaris A,Papageorgiou I,Messinis IE

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...

journal_title：Clinical endocrinology

authors： Amato MC,Galluzzo A,Finocchiaro S,Criscimanna A,Giordano C

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:We determined the effect of subclinical hyperthyroidism (defined as low circulating TSH with normal serum free T4) and subclinical hypothyroidism (raised serum TSH with normal free T4) on fasting levels of blood lipids. DESIGN:Prospective study of lipid concentrations in patients identified as having abnorma...

journal_title：Clinical endocrinology

authors： Parle JV,Franklyn JA,Cross KW,Jones SR,Sheppard MC

更新日期：1992-11-01 00:00:00

abstract：CONTEXT:The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts. OBJECTIVE:To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel. DESIGN:A population-based coh...

journal_title：Clinical endocrinology

authors： Libruder C,Blumenfeld O,Dichtiar R,Laron Z,Zadik Z,Shohat T,Afek A

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE AND METHODS:To better understand acylghrelin plasma stability, human synthetic acylghrelin was spiked into plasma and tracked by liquid chromatography tandem mass spectrometry. To investigate the best method for quantifying clinical plasma acylghrelin levels, pre- and postprandial human blood was collected fr...

journal_title：Clinical endocrinology

authors： Blatnik M,Soderstrom CI

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:Hyponatraemia is strongly associated with increased inpatient mortality, but it is unknown whether hyponatraemia per se contributes to excess mortality. Our hypothesis was that if hyponatraemic patients had significantly greater mortality compared with controls despite no difference with regard to gender, ag...

journal_title：Clinical endocrinology

authors： Tzoulis P,Bagkeris E,Bouloux PM

更新日期：2014-09-01 00:00:00

abstract：:In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high curre...

journal_title：Clinical endocrinology

authors： Phillips DI,Barker DJ,Rees Smith B,Didcote S,Morgan D

更新日期：1985-09-01 00:00:00

abstract：:A young man is reported with an autoimmune polyglandular syndrome (APS) characterized by Addison's disease, primary hypothyroidism, primary hypogonadism, vitiligo, associated with primary empty sella and partial impairment of pituitary hormone secretion. Two years later the patient showed a null cell type acute lympho...

journal_title：Clinical endocrinology

authors： De Rosa G,Della Casa S,Corsello SM,Cecchini L,Callà C

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:To compare the value of the thyroid imaging reporting and data system proposed by Kwak (KWAK TI-RADS) and the 2015 American Thyroid Association (ATA) guidelines for diagnosis of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). To confirm the role of cell block (CB)-assisted fine-needle...

journal_title：Clinical endocrinology

authors： Li J,Li H,Yang Y,Zhang X,Qian L

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Postsurgical regrowth or recurrence of nonfunctioning pituitary adenomas (NFAs) is not uncommon and often requires further surgery or radiotherapy (DXT). Routine postoperative DXT increases the incidence of hypopituitarism, which is associated with increased morbidity and mortality. Identification of genetic...

journal_title：Clinical endocrinology

authors： Buch HN,Raskauskiene D,Bahar A,Bicknell EJ,Farrell WE,Clayton RN

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:Expression of ghrelin has been reported in pancreatic endocrine tumours, but data on ghrelin receptor protein expression are lacking. The aim of this study was to examine the ghrelin receptor, as well as ghrelin, in a selected series of these tumours, including multiple endocrine neoplasia 1 (MEN1) associated...

journal_title：Clinical endocrinology

authors： Ekeblad S,Lejonklou MH,Grimfjärd P,Johansson T,Eriksson B,Grimelius L,Stridsberg M,Stålberg P,Skogseid B

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The success of a low-iodine diet (LID) is best determined by measurement of 24-h urine iodine (U-I) excretion. The aim of this study was to determine reliable estimates for 24-h U-I based on spot-urine samples and to provide cut-offs to determine the effectiveness of LID preparation. DESIGN:We prospectively ...

journal_title：Clinical endocrinology

authors： Kim HK,Lee SY,Lee JI,Jang HW,Kim SK,Chung HS,Tan AH,Hur KY,Kim JH,Chung JH,Kim SW

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

journal_title：Clinical endocrinology

authors： Zhang BC,Liu WJ,Che WL,Xu YW

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:SRY-negative 46,XX testicular and ovotesticular disorders/differences of sex development (T/OTDSD) represent a very rare and unique DSD condition where testicular tissue develops in the absence of a Y chromosome. To date, very few studies have described the phenotype, clinical and surgical management and long...

journal_title：Clinical endocrinology

authors： Lambert S,Peycelon M,Samara-Boustani D,Hyon C,Dumeige L,Peuchmaur M,Fiot E,Léger J,Simon D,Paye-Jaouen A,Bouligand J,Siffroi JP,Carel JC,McElreavey K,El Ghoneimi A,Brachet C,Bouvattier C,Martinerie L

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:Hyperandrogenism is one of the characteristic features of the polycystic ovary syndrome (PCOS). Androgens are important for bone mass. Studies on bone mineral density (BMD) and fractures in postmenopausal women with PCOS are lacking. The aim of this study was to investigate whether postmenopausal women with P...

journal_title：Clinical endocrinology

authors： Schmidt J,Dahlgren E,Brännström M,Landin-Wilhelmsen K

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. OBJECTIVE:To assess if PCOS increases CV risk independently in young obese women by examining carotid intima-media wal...

journal_title：Clinical endocrinology

authors： Kahal H,Aburima A,Ungvari T,Rigby AS,Dawson AJ,Coady AM,Vince RV,Ajjan RA,Kilpatrick ES,Naseem KM,Atkin SL

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Glucokinase (GCK) phosphorylates and thereby "traps" glucose in cells, thus serving as a gatekeeper for cellular glucose metabolism, particularly in hepatocytes and pancreatic beta cells. In humans, activating GCK mutations cause familial hyperinsulinaemic hypoglycaemia (GCK-HH), leading to keen interest in the...

journal_title：Clinical endocrinology

authors： Challis BG,Harris J,Sleigh A,Isaac I,Orme SM,Seevaratnam N,Dhatariya K,Simpson HL,Semple RK

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein-to-peripheral vein ratio (LAV/PV) were proposed to predict the lateralization index without the right AVS. OBJECTIVE:To assess external validity of MRM and LAV...

journal_title：Clinical endocrinology

authors： Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

更新日期：2020-12-01 00:00:00

abstract：:The effect of pretreatment with biosynthetic methionyl human GH (hGH) on the GH response to GHRH has been studied in normal subjects. Eight volunteers were given either 4 IU hGH or placebo s.c. 12-hourly for 72 h before a GHRH test, or a single s.c. dose of 4 IU hGH 12 h before a GHRH test. Somatomedin-C (Sm-C) levels...

journal_title：Clinical endocrinology

authors： Ross RJ,Borges F,Grossman A,Smith R,Ngahfoong L,Rees LH,Savage MO,Besser GM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined. OBJECTIVE:To investigate its clinical significance in humans, we have established a new specific enzyme-linked i...

journal_title：Clinical endocrinology

authors： Tsuchiya T,Shimizu H,Yamada M,Osaki A,Oh-I S,Ariyama Y,Takahashi H,Okada S,Hashimoto K,Satoh T,Kojima M,Mori M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Fibroblast growth factor (FGF21) is a potent regulator of glucose and lipid metabolism. In rodents, the hepatic expression of FGF21 is controlled by fasting and a circadian regulation, but the physiological role and regulation of FGF21 in humans is not well established. Therefore, the objective of this study ...

journal_title：Clinical endocrinology

authors： Andersen B,Beck-Nielsen H,Højlund K

更新日期：2011-10-01 00:00:00

abstract：RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

journal_title：Clinical endocrinology

authors： Coussa A,Hasan HA,Barber TM

更新日期：2020-12-01 00:00:00