当前位置： SCI文献检索 > CLINICAL ENDOCRINOLOGY期刊下所有文献 > A case-control study of hyponatraemia as an independent risk factor for inpatient mortality.

A case-control study of hyponatraemia as an independent risk factor for inpatient mortality.

Abstract：

OBJECTIVES:Hyponatraemia is strongly associated with increased inpatient mortality, but it is unknown whether hyponatraemia per se contributes to excess mortality. Our hypothesis was that if hyponatraemic patients had significantly greater mortality compared with controls despite no difference with regard to gender, age, comorbidities and type of primary pathology, this would incriminate hyponatraemia as an independent predictor of mortality. DESIGN:Single-centre, case-control study. PATIENTS:Cases (N = 139) were hospitalized patients with serum Na ≤ 128 mmol/l over 3 months. Controls were 254 age- and gender-matched patients residing in the same hospital ward with serum Na > 128 mmol/l. MEASUREMENTS:Data were collected about age, gender, comorbidities, drug history, serum creatinine, intensive care unit (ICU) admission and length of hospitalization. The main outcome measure was inpatient mortality. RESULTS:Hyponatraemic patients had an inpatient mortality rate of 17·3% and were more than three times more likely to die during their hospital stay compared with controls (OR 3·33, 95% CI 1·68-6·58, P < 0·01) despite no statistically significant difference with respect to age, gender, comorbidities, use of common drugs, serum creatinine, ICU admission rate and length of hospitalization. Comparison of cases with the normonatraemic subgroup of controls demonstrated that cases were almost 12 times more likely to die during admission than normonatraemic controls (OR 11·89, 95% CI 2·75-51·51, P < 0·01). CONCLUSIONS:This study showed that hyponatraemia is an independent predictor of mortality, and hyponatraemia per se is likely to contribute to excess mortality. Further studies are needed to examine whether correction of hyponatraemia can reduce mortality.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Tzoulis P,Bagkeris E,Bouloux PM

doi

10.1111/cen.12429

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

401-7

issue

3

eissn

0300-0664

issn

1365-2265

journal_volume

81

pub_type

杂志文章

相关文献

CLINICAL ENDOCRINOLOGY文献大全
  • Leydig cell failure with testicular radiation doses

    abstract：OBJECTIVE:Testosterone replacement is generally considered likely to be required only at testicular radiation doses in excess of 20Gy. Long-term data are not available for patients receiving 9-14.4Gy as part of Total Body Irradiation in childhood. DESIGN:Retrospective cohort study. DATA COLLECTION:notes review, labor...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.14059

    authors： Taneja S,Rao A,Nussey S,Leiper A

    更新日期：2019-11-01 00:00:00

  • Clearance and identification of thyrotrophin releasing hormone in human urine after intravenous injections.

    abstract：:The urine clearance of TRH after intravenous injection in man has been measured by radioimmunoassay. Between 4.4 percent and 10.7 percent of the dose was excreted within 90 min, the majority within 30 min. The TRH excreted was immunochemically and chromatographically indistinguishable from synthetic TRH and was inacti...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1975.tb01549.x

    authors： Jeffcoate SL,White N

    更新日期：1975-07-01 00:00:00

  • Prophylactic 1alpha-hydroxyvitamin D3 therapy in haemodialysis patients.

    abstract：:Twenty-seven patients starting regular haemodialysis were treated with a 1 microgram daily dose of 1alpha-hydroxyvitamin D3 and concurrent aluminium hydroxide therapy to prevent hyperphosphataemia. There was an increase in plasma calcium, but no significant improvement in plasma alkaline phosphatase activity or parath...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1977.tb03372.x

    authors： Walker GS,Peacock M,Aaron J,Robinson PJ,Davison AM

    更新日期：1977-12-01 00:00:00

  • High thyrotrophin levels at end term increase the risk of breech presentation.

    abstract：OBJECTIVE:To study the relationship between maternal thyrotrophin (TSH) and breech presentation at term. DESIGN:Combined data sets of two prospective studies to obtain adequate epidemiological power. PATIENTS:One thousand and fifty-eight healthy pregnant women (58 breech, 1000 cephalic) and 131 women who presented in...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2010.03846.x

    authors： Kooistra L,Kuppens SM,Hasaart TH,Vader HL,Wijnen HA,Oei SG,Pop VJ

    更新日期：2010-11-01 00:00:00

  • Responses of plasma adrenocortical steroids to low dose ACTH in normal subjects.

    abstract：OBJECTIVE:The standard ACTH test in clinical use employs a pharmacological dose of ACTH which assesses the maximum secretory capacity of the adrenal cortex. We have investigated the responses of plasma adrenocortical steroids including cortisol, aldosterone and dehydroepiandrosterone (DHEA) to physiological doses of AC...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1995.tb02037.x

    authors： Daidoh H,Morita H,Mune T,Murayama M,Hanafusa J,Ni H,Shibata H,Yasuda K

    更新日期：1995-09-01 00:00:00

  • The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy--support for a role of autoimmunity against calsequestrin as the triggering event.

    abstract：BACKGROUND:Graves' Ophthalmopathy (GO) is a complex eye and orbital disorder that is uniquely linked to Graves' Hyperthyroidism (GH) and has traditionally been considered a cross-reactive immune response against the thyroid stimulating hormone receptor (TSHR) in orbital tissue. However, because there is no direct evide...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2009.03753.x

    authors： Wescombe L,Lahooti H,Gopinath B,Wall JR

    更新日期：2010-10-01 00:00:00

  • Menstrual function and serum prolactin levels after long-term bromocriptine treatment of hyperprolactinaemic amenorrhoea.

    abstract：:Long-term bromocriptine treatment was discontinued in thirty-seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty-seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but o...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1982.tb03175.x

    authors： Bergh T,Nillius SJ,Wide L

    更新日期：1982-06-01 00:00:00

  • Suppressed TSH levels secondary to thyroxine replacement therapy are not associated with osteoporosis.

    abstract：OBJECTIVE:Recent studies have suggested that patients receiving thyroxine are at increased risk of osteoporosis. We set out to measure bone mineral densities in two groups of post-menopausal women receiving thyroxine replacement therapy (those with serum TSH levels persistently suppressed or non-suppressed) and to comp...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1993.tb02404.x

    authors： Grant DJ,McMurdo ME,Mole PA,Paterson CR,Davies RR

    更新日期：1993-11-01 00:00:00

  • Prolactin pulsatility in patients with gonadal dysfunction.

    abstract：:Serum prolactin concentrations have been measured at 15 min intervals for 2 h on 240 occasions in 227 patients with symptoms which could have been due to hyperprolactinaemic gonadal dysfunction. Of the 227, 138 had at least one elevated random prolactin level. Overall, 22% showed no significant fluctuation in prolacti...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1981.tb00625.x

    authors： Moult PJ,Dacie JE,Rees LH,Besser GM

    更新日期：1981-04-01 00:00:00

  • Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production.

    abstract：:The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1986.tb01667.x

    authors： Howlett TA,Drury PL,Perry L,Doniach I,Rees LH,Besser GM

    更新日期：1986-06-01 00:00:00

  • Transient thyrotoxicosis in endemic goitre patients following exposure to a normal iodine intake.

    abstract：:Twenty-three endemic goitrous subjects (goitre grade: III and IV) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms I/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of São Paulo, where daily iodine intake is estimat...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1984.tb01405.x

    authors： Lima N,Medeiros-Neto G

    更新日期：1984-12-01 00:00:00

  • Efficacy of a new long-acting injectable form of bromocriptine in hyperprolactinaemic patients.

    abstract：OBJECTIVE:The objective of this study was to assess the relationship of different doses of a long-acting bromocriptine preparation (Parlodel LAR) to the degree and duration of PRL suppression. We also measured circulating bromocriptine levels and altered tolerability of the drug. DESIGN:A double-blind randomized study...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.1992.tb01462.x

    authors： Pagani MD,Tengattini F,Montini M,Pagani G,Pedroncelli A,Gianola D,Gherardi F,Mazzocchi N,Cortesi L,Lancranjan I

    更新日期：1992-04-01 00:00:00

  • Plasma and cyst fluid levels of delta 5 and delta 4 steroid hormones in women with gross cystic breast disease.

    abstract：:delta 5 and delta 4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean +/- SEM) of DHA (11.2 +/- 2.4 ng/ml), DHAS (1.45 +/- 0.6 micrograms/ml) and cortisol 277 +/- 15.7 ng/ml) was found; in follicular ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1987.tb02946.x

    authors： Inaudi P,Bernabei A,Gioffré W,Franchi F,Mazzullo G,De Leo V,D'Antona N

    更新日期：1987-12-01 00:00:00

  • Effects of pyridostigmine on spontaneous and growth hormone-releasing hormone stimulated growth hormone secretion in children on daily glucocorticoid therapy after liver transplantation.

    abstract：OBJECTIVES:We aimed to investigate both nocturnal spontaneous and morning growth hormone (GH)-releasing hormone (GHRH)-induced GH secretion in children on daily glucocorticoid treatment after liver transplantation and to evaluate the effect of pyridostigmine (an acetylcholinesterase inhibitor thought to reduce hypothal...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.1991.tb00933.x

    authors： Giustina A,Girelli A,Alberti D,Bossoni S,Buzi F,Doga M,Schettino M,Wehrenberg WB

    更新日期：1991-12-01 00:00:00

  • Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotrophin and its free beta-subunit.

    abstract：OBJECTIVE:The purpose of the study was to evaluate plasma inhibin as a marker of hydatidiform mole and to compare the results with intact human chorionic gonadotrophin (hCG) and its free beta-subunit. DESIGN:Serial determinations of the plasma concentrations of inhibin, intact human chorionic gonadotrophin and its fre...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1994.tb02524.x

    authors： Badonnel Y,Barbé F,Legagneur H,Poncelet E,Schweitzer M

    更新日期：1994-08-01 00:00:00

  • Effect of an OT antagonist on the control of the midcycle LH surge in women.

    abstract：OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2008.03456.x

    authors： Vanakara P,Dafopoulos K,Papastergiopoulou L,Kallitsaris A,Papageorgiou I,Messinis IE

    更新日期：2009-07-01 00:00:00

  • Pheochromocytomas are diagnosed incidentally and at older age in neurofibromatosis type 1.

    abstract：INTRODUCTION:Guidelines do not currently recommend routine systematic hormonal screening for pheochromocytoma (PHEO) in all/normotensive patients with neurofibromatosis type 1 (NF1), in contrast to other PHEO-predisposing genetic syndromes such as Von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. OBJ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13265

    authors： Moramarco J,El Ghorayeb N,Dumas N,Nolet S,Boulanger L,Burnichon N,Lacroix A,Elhaffaf Z,Gimenez Roqueplo AP,Hamet P,Bourdeau I

    更新日期：2017-03-01 00:00:00

  • Pituitary-ovarian function before, during and after the menopause: a longitudinal study.

    abstract：:The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1982.tb01616.x

    authors： Metcalf MG,Donald RA,Livesey JH

    更新日期：1982-11-01 00:00:00

  • Insulin secretion and insulin-like growth factor-I levels in active and controlled acromegaly.

    abstract：OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1992.tb02902.x

    authors： Hopkins KD,Holdaway IM

    更新日期：1992-01-01 00:00:00

  • Effects of the progestagen-only contraceptive implant Implanon on cardiovascular risk factors.

    abstract：OBJECTIVE:Epidemiological studies on the cardiovascular risk of progestagen-only contraceptives are rare. With the present study we aimed to investigate the effect of the low-dose etonogestrel-releasing contraceptive implant Implanon on cardiovascular risk factors, including markers of inflammation. DESIGN:Longitudina...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2007.03046.x

    authors： Merki-Feld GS,Imthurn B,Seifert B

    更新日期：2008-03-01 00:00:00

  • Discrepancy between ACTH and cortisol responses to insulin induced hypoglycaemia.

    abstract：:The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty-six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlatio...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1978.tb02222.x

    authors： Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

    更新日期：1978-10-01 00:00:00

  • Is postablation whole-body 131 I scintigraphy still necessary in intermediate-risk papillary thyroid cancer patients with pre-ablation stimulated thyroglobulin

    abstract：OBJECTIVE:Postablation whole-body scintigraphy, which is performed 5-7 days after administration of ablation activity of radioactive iodine-131 (131 I) in patients with thyroid cancer, is considered a routine procedure for remnant ablation and a useful tool for disease staging. However, the relationship of pre-ablation...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13158

    authors： Liu B,Chen Y,Jiang L,He Y,Huang R,Kuang A

    更新日期：2017-01-01 00:00:00

  • In-vivo and in-vitro endocrine investigation of pure gonadal dysgenesis.

    abstract：:Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1988.tb03697.x

    authors： Wilson SC,Oakey RE,Scott JS

    更新日期：1988-11-01 00:00:00

  • Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone-binding globulin in men from UK Biobank.

    abstract：OBJECTIVE:Serum testosterone concentrations are affected by factors unrelated to hypothalamo-pituitary-testicular axis pathology. We evaluated the impact of sociodemographic, lifestyle and medical factors, on serum testosterone and sex hormone-binding globulin (SHBG) in men aged 40-69 years. DESIGN:Cross-sectional ana...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.14342

    authors： Yeap BB,Marriott RJ,Antonio L,Bhasin S,Dobs AS,Dwivedi G,Flicker L,Matsumoto AM,Ohlsson C,Orwoll ES,Raj S,Reid CM,Vanderschueren D,Wittert GA,Wu FCW,Murray K

    更新日期：2021-02-01 00:00:00

  • Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.

    abstract：BACKGROUND:We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined. OBJECTIVE:To investigate its clinical significance in humans, we have established a new specific enzyme-linked i...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2010.03835.x

    authors： Tsuchiya T,Shimizu H,Yamada M,Osaki A,Oh-I S,Ariyama Y,Takahashi H,Okada S,Hashimoto K,Satoh T,Kojima M,Mori M

    更新日期：2010-10-01 00:00:00

  • Antigenicity of human chorionic gonadotrophin preparations in men.

    abstract：:The antigenicity of HCG was tested in twenty-three young healthy men receiving two different HCG preparations (A and B). Each subject received 5000 i.u. HCG intramuscularly daily for three consecutive days, followed by another course, 3 weeks later, of 5000 i.u. HCG injections daily for 3 days. Two of the fifteen subj...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1982.tb02762.x

    authors： Nieschlag E,Bernitz S,Töpert M

    更新日期：1982-05-01 00:00:00

  • Which testosterone replacement therapy?

    abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1984.tb03448.x

    authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

    更新日期：1984-08-01 00:00:00

  • The role of opiate peptides in the control of prolactin in the puerperium, and TSH in primary hypothyroidism.

    abstract：:The role of endogenous opiate peptides in puerperal hyperprolactinaemia, and in the control of TSH in hypothyroidism, has been investigated. Although exogenous opioids raise prolactin and TSH levels, 16 mg naloxone administered to women on days 2-4 of the puerperium produced no significant change in serum prolactin an...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.1982.tb00722.x

    authors： Grossman A,West S,Williams J,Evans J,Rees LH,Besser GM

    更新日期：1982-03-01 00:00:00

  • Ultrastructural and steroidogenic characteristics of an androgen-producing adrenocortical tumour.

    abstract：:A 16-year-old female patient with an adrenal tumour was studied. Clinically she had progressive hirsutism, showed high urinary 17-oxosteroid excretion with normal plasma cortisol. Plasma C19-steroids, both unconjugated (including testosterone) and sulphate-conjugated, were greatly elevated. On surgical exploration an ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1978.tb02773.x

    authors： Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

    更新日期：1978-04-01 00:00:00

  • Atrial natriuretic factor reduces vasopressin and angiotensin II but not the ACTH response to acute hypoglycaemic stress in normal men.

    abstract：OBJECTIVE:We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN:Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2265.1993.tb00991.x

    authors： Wittert GA,Espiner EA,Richards AM,Donald RA,Livesey JH,Yandle TG

    更新日期：1993-02-01 00:00:00