Atrial natriuretic factor reduces vasopressin and angiotensin II but not the ACTH response to acute hypoglycaemic stress in normal men.


OBJECTIVE:We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN:Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2.5 pmol/kg/min for 120 minutes) commencing 30 minutes before bolus administration of insulin (0.15 U/kg body weight). RESULTS:ANF infusion raised venous plasma ANF levels four to five-fold (mean level 32 +/- 0.3 pmol/l at time of insulin injection) without affecting resting blood pressure or heart rate. After insulin, the fall in plasma glucose and rise in plasma adrenaline and noradrenaline were similar in both studies. In contrast, the responses in plasma arginine vasopressin (P < 0.02) and in plasma angiotensin II (P < 0.05) were inhibited by ANF. Plasma corticotrophin releasing factor, ACTH and cortisol responses to hypoglycaemic stress did not differ significantly in the presence and absence of ANF. CONCLUSION:We conclude that four to five-fold acute increase in plasma ANF, while attenuating vasopressin and angiotensin II responses to hypoglycaemia, does not inhibit the hypothalamic, pituitary and adrenal responses or inhibit sympathetic nervous activation in normal men.


Clin Endocrinol (Oxf)


Clinical endocrinology


Wittert GA,Espiner EA,Richards AM,Donald RA,Livesey JH,Yandle TG




Has Abstract


1993-02-01 00:00:00












  • Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism.

    abstract:OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

    更新日期:2012-01-01 00:00:00

  • Effects of low-dose oral hydrocortisone replacement versus short-term reproduction of physiological serum cortisol concentrations on insulin action in adult-onset hypopituitarism.

    abstract:OBJECTIVE:Hypercortisolism is associated with impaired glucose tolerance and insulin resistance. For many years hydrocortisone 30 mg was the standard total daily replacement dose in adult hypopituitarism. The use of this conventional dose has now been shown to result in mild biochemical hypercortisolism and might contr...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: McConnell EM,Bell PM,Ennis C,Hadden DR,McCance DR,Sheridan B,Atkinson AB

    更新日期:2002-02-01 00:00:00

  • Diagnosis of growth hormone deficiency after pituitary surgery: the combined acipimox/GH-releasing hormone test.

    abstract:OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: van Dam PS,Dieguez C,Cordido F,de Vries WR,Veldhuyzen BF,van Thiel E,Casanueva FF,Koppeschaar HP

    更新日期:2003-02-01 00:00:00

  • A longitudinal study on bone mineral density until adulthood in girls with Turner's syndrome participating in a growth hormone injection frequency-response trial.

    abstract:OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

    更新日期:2000-05-01 00:00:00

  • Quinagolide efficacy and tolerability in hyperprolactinaemic patients who are resistant to or intolerant of bromocriptine.

    abstract:OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Vilar L,Burke CW

    更新日期:1994-12-01 00:00:00

  • Sex hormone binding globulin in postmenopausal women: a predictor of osteoporosis superior to endogenous oestrogens.

    abstract::To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA

    更新日期:1989-10-01 00:00:00

  • Adrenocortical insufficiency after pituitary surgery: an audit of the reliability of the conventional short synacthen test.

    abstract:BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

    更新日期:2005-11-01 00:00:00

  • Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal.

    abstract:OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

    更新日期:2018-09-01 00:00:00

  • Effect of a single bolus of etomidate upon eight major corticosteroid hormones and plasma ACTH.

    abstract::In a prospective controlled trial we investigated the effect of an induction dose of etomidate (0.26 mg/kg i.v.) on plasma ACTH, progesterone, 17 alpha OH-progesterone, 11-deoxycortisol, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, and aldosterone in seven males undergoing general anaesthesia. Seven ot...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Allolio B,Dörr H,Stuttmann R,Knorr D,Engelhardt D,Winkelmann W

    更新日期:1985-03-01 00:00:00

  • Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.

    abstract:OBJECTIVE:The protein-tyrosine-phosphate nonreceptor 22 gene (PTPN22) has recently been identified as a susceptibility locus for a number of autoimmune diseases including Graves' disease (GD). PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Zeitlin AA,Heward JM,Brand OJ,Newby PR,Franklyn JA,Gough SC,Simmonds MJ

    更新日期:2006-09-01 00:00:00

  • Glucose and lipid metabolism, bone density, and body composition in individuals with Williams syndrome.

    abstract:OBJECTIVE:We assessed body composition, bone mineral density (BMD), glucose and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN:Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHAN...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Shaikh S,Waxler JL,Lee H,Grinke K,Garry J,Pober BR,Stanley TL

    更新日期:2018-11-01 00:00:00

  • Impaired endothelial- and nonendothelial-mediated vasodilation in patients with acute or chronic hypothyroidism.

    abstract:OBJECTIVE:Vascular dysfunction and accelerated atherosclerosis are prominent features of hypothyroidism. The relative roles of thyroid hormone (TH) deficiency and the associated vascular risk conditions are still unclear. We studied the impact of acute and chronic hypothyroidism on vascular reactivity. PATIENTS:We stu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Napoli R,Guardasole V,Zarra E,D'Anna C,De Sena A,Lupoli GA,Oliviero U,Matarazzo M,Lupoli G,Saccà L

    更新日期:2010-01-01 00:00:00

  • Associations between metabolomic-identified changes of biomarkers and arterial stiffness in subjects progressing to impaired fasting glucose.

    abstract:OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Jung S,Kim M,Lee YJ,Lee SH,Lee JH

    更新日期:2015-08-01 00:00:00

  • Percutaneous coronary intervention increases leptin and decreases adiponectin levels.

    abstract:OBJECTIVE:The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabol...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Azar RR,Sarkis A,Salameh E,Gannagé-Yared MH,Amm-Azar M,Badaoui G,Germanos M,Kassab R

    更新日期:2006-12-01 00:00:00

  • The pharmacokinetics, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects.

    abstract::The pharmacokinetics, safety and endocrine effects of an authentic human growth hormone (bio-hGH), produced by the expression of genomic hGH in a mammalian cell line, were studied in six healthy young men who were administered 0.2 U/kg/day subcutaneously for five consecutive days. Changes in sodium balance and in thyr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ho KY,Weissberger AJ,Stuart MC,Day RO,Lazarus L

    更新日期:1989-04-01 00:00:00

  • Thyroid suppression test with L-thyroxine and [99mTc] pertechnetate.

    abstract:OBJECTIVE:The thyroid suppression test is still used in some centres as an adjunt in the diagnosis of autonomous functioning thyroid nodules. With the purpose of minimizing the disadvantages of the original T3 suppression test, we have evaluated the efficacy of a method using L-thyroxine as TSH suppression agent and [9...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ramos CD,Zantut-Wittmann DE,Tambascia MA,Assumpção L,Etchebehere EC,Camargo EE

    更新日期:2000-04-01 00:00:00

  • The basal plasma glucose: a simple relevant index of maturity-onset diabetes.

    abstract::The 'basal' plasma glucose, defined as the stable overnight concentration, has been assessed as an index of diabetes control by comparison with plasma glucose measurements during 24-h profiles in diet-treated maturity-onset diabetic patients and normal subjects. The basal plasma glucose correlated with the total (r=0....

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Holman RR,Turner RC

    更新日期:1981-03-01 00:00:00

  • Prevalence of hypopituitarism and growth hormone deficiency in adults long-term after severe traumatic brain injury.

    abstract:OBJECTIVE:Traumatic brain injury (TBI) has been associated with hypopituitarism and GH deficiency. However, TBI-mediated hypopituitarism may be more frequent than previously thought. The present work, performed in patients with severe TBI at least 1 year before, had three aims: (i) to evaluate the prevalence of hypopit...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Leal-Cerro A,Flores JM,Rincon M,Murillo F,Pujol M,Garcia-Pesquera F,Dieguez C,Casanueva FF

    更新日期:2005-05-01 00:00:00

  • Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production.

    abstract::The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Howlett TA,Drury PL,Perry L,Doniach I,Rees LH,Besser GM

    更新日期:1986-06-01 00:00:00

  • Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomized, placebo-controlled study.

    abstract:OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

    更新日期:1995-12-01 00:00:00

  • The neuroendocrine effects of sumatriptan, a specific ligand for 5-HT1-like receptors.

    abstract:OBJECTIVE:A relationship between the serotoninergic and the opiatergic system in the pathogenesis of head pain is supported by several data. This study was carried out to investigate the neuroendocrine effects of sumatriptan, a specific serotonin agonist used in the treatment of migraine, on hypothalamic-pituitary-adre...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Facchinetti F,Nappi RE,Sances G,Fioroni L,Nappi G,Genazzani AR

    更新日期:1994-02-01 00:00:00

  • Responses to the 35% CO challenge in postpartum women.

    abstract::Lactation has been associated with suppression of some components of the neuroendocrine stress response. In humans, suppression of the hypothalamo-pituitary-adrenal (HPA) axis has been demonstrated in response to both a psychological and an exercise challenge, but appears to be limited to a short period of time follow...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kaye J,Soothill P,Hunt M,Lightman S

    更新日期:2004-11-01 00:00:00

  • Thyrotoxicosis induced by alpha-interferon therapy in chronic viral hepatitis.

    abstract:BACKGROUND AND OBJECTIVE:It has been well documented that treatment of chronic hepatitis B and C infection with interferon alpha (IFN-alpha) can lead to the induction of thyroid autoantibodies and hypothyroidism. Thyrotoxicosis, however, is less frequently observed and less well characterized. PATIENTS AND METHODS:We ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wong V,Fu AX,George J,Cheung NW

    更新日期:2002-06-01 00:00:00

  • Prophylactic 1alpha-hydroxyvitamin D3 therapy in haemodialysis patients.

    abstract::Twenty-seven patients starting regular haemodialysis were treated with a 1 microgram daily dose of 1alpha-hydroxyvitamin D3 and concurrent aluminium hydroxide therapy to prevent hyperphosphataemia. There was an increase in plasma calcium, but no significant improvement in plasma alkaline phosphatase activity or parath...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Walker GS,Peacock M,Aaron J,Robinson PJ,Davison AM

    更新日期:1977-12-01 00:00:00

  • The effect of the menopause on prolactin levels in patients with hyperprolactinaemia.

    abstract:OBJECTIVE:Microprolactinomas have been reported to resolve spontaneously after pregnancy and there have been suggestions that oestrogen therapy increases the size of microprolactinomas. Little is known, however, about the effect of the menopause in patients previously known to be hyperprolactinaemic. The aim of this st...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Karunakaran S,Page RC,Wass JA

    更新日期:2001-03-01 00:00:00

  • Insulin ameliorating endotoxaemia-induced muscle wasting is associated with the alteration of hypothalamic neuropeptides and inflammation in rats.

    abstract:OBJECTIVES:Septic patients always develop muscle wasting, which delays the rehabilitation and contributes to the increased complications and mortality. Previous studies have implied the crucial role of central inflammation and neuropeptides in the energy balance and muscle metabolism. Insulin has been confirmed to atte...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Duan K,Yu W,Lin Z,Tan S,Bai X,Gao T,Xi F,Li N

    更新日期:2015-05-01 00:00:00

  • Changes in serum IGF-I and IGFBP-3 concentrations during the IGF-I generation test performed prospectively in children with short stature.

    abstract:OBJECTIVE:Genotype and phenotype heterogeneity in patients with GH insensitivity syndrome suggests that partial defects exist in the GH receptor. Children with partial GH resistance would be expected to have short stature, elevated GH levels and relatively low levels of IGF-I and IGFBP-3. Provocation tests of the GH-IG...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cotterill AM,Camacho-Hübner C,Duquesnoy P,Savage MO

    更新日期:1998-06-01 00:00:00

  • Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study.

    abstract:OBJECTIVE:Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters. DESIGN, PATIENTS AND MEASUREMENTS:We established the specificity and effectiveness of the new ELI...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Retnakaran R,Youn BS,Liu Y,Hanley AJ,Lee NS,Park JW,Song ES,Vu V,Kim W,Tungtrongchitr R,Havel PJ,Swarbrick MM,Shaw C,Sweeney G

    更新日期:2008-12-01 00:00:00

  • Co-expression of ghrelin and its receptor in pancreatic endocrine tumours.

    abstract:OBJECTIVE:Expression of ghrelin has been reported in pancreatic endocrine tumours, but data on ghrelin receptor protein expression are lacking. The aim of this study was to examine the ghrelin receptor, as well as ghrelin, in a selected series of these tumours, including multiple endocrine neoplasia 1 (MEN1) associated...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ekeblad S,Lejonklou MH,Grimfjärd P,Johansson T,Eriksson B,Grimelius L,Stridsberg M,Stålberg P,Skogseid B

    更新日期:2007-01-01 00:00:00

  • Factors affecting inadequate sampling of ultrasound-guided fine-needle aspiration biopsy of thyroid nodules.

    abstract:PURPOSE:The aim of this study was to evaluate the overall ultrasonographic features and clinical factors that contribute to inadequate sampling in ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules. MATERIALS AND METHODS:From April 2008 to December 2008, 4077 US-FNABs in 3767 consecutive pati...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Choi SH,Han KH,Yoon JH,Moon HJ,Son EJ,Youk JH,Kim EK,Kwak JY

    更新日期:2011-06-01 00:00:00