The effect of oral glucose on the leucocyte sodium pump in normal and obese subjects.

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

journal_title：Clinical endocrinology

authors： Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism and calcium supplementation have been linked to cardiovascular outcomes. The study objective was to examine plasma calcium as a predictor of cardiovascular disease in the general population, as results from previous cohort studies are conflicting. DESIGN, PARTICIPANTS AND MEASUREM...

journal_title：Clinical endocrinology

authors： Walsh JP,Divitini ML,Knuiman MW

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:The metabolites of steroidal hormones, including sulphate, glucuronide, and fatty acid (FA) ester derivatives, have received little attention, although these steroid derivatives are essential components in the global assessment of steroid metabolism. The study of FA-derivatives could, in obesity, contribute s...

journal_title：Clinical endocrinology

authors： Fernández-Real JM,Sanchis D,Ricart W,Casamitjana R,Balada F,Remesar X,Alemany M

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Non-tumour causes of hyperprolactinaemia, including prolactin-elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000 mU/I, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrat...

journal_title：Clinical endocrinology

authors： Pollock A,McLaren EH

更新日期：1998-10-01 00:00:00

abstract：:A 39-year-old woman presented with secondary amenorrhoea in the absence of galactorrhoea, hirsutism or virilization. Investigation revealed a strikingly elevated serum testosterone, dihydrotesterone, free testosterone and LH level. At laparotomy a large granulosa cell tumour was encountered and totally removed. Analys...

journal_title：Clinical endocrinology

authors： Taylor HC,Velasco ME,Flores SG,Berg G,Brown TR

更新日期：1982-12-01 00:00:00

abstract：:Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

journal_title：Clinical endocrinology

authors： De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Papillary thyroid cancer (PTC) is a common endocrine cancer and commonly presents with lymph node (LN) metastases. The role of surgical removal of the central cervical LN compartment is poorly defined. There are no prospective randomized controlled trials addressing the relevance to the extent of the initial...

journal_title：Clinical endocrinology

authors： Mulla M,Schulte KM

更新日期：2012-01-01 00:00:00

abstract：:In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.), arginine (30 g i.v. over 30 min) and L-dopa (500 mg orally) administered alone and 120 minutes following pretreatment with GHRH 1-44 (200 micrograms i.v.) in no...

journal_title：Clinical endocrinology

authors： Page MD,Dieguez C,Valcavi R,Edwards C,Hall R,Scanlon MF

更新日期：1988-05-01 00:00:00

abstract：INTRODUCTION:Diagnostic I-123 scans have been shown to underestimate the disease burden in differentiated thyroid cancer (DTC) when compared to I-131 post-treatment scans, especially in children and patients who have had prior radioiodine (RAI) therapy and/or distant metastasis. I-124 PET/CT has been shown to be highly...

journal_title：Clinical endocrinology

authors： Santhanam P,Taieb D,Solnes L,Marashdeh W,Ladenson PW

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Oestradiol sensitizes the pituitary to GnRH, while gonadotrophin surge attenuating factor (GnSAF) may oppose this action. Using the LH response to GnRH during treatment with FSH as an in vivo bioassay for GnSAF, we tested the hypothesis that the augmented LH response to GnRH in the late follicular phase is re...

journal_title：Clinical endocrinology

authors： Dimitraki M,Messini CI,Dafopoulos K,Gioka T,Koutlaki N,Garas A,Georgoulias P,Messinis IE

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. However, there have been no previous reports on the ...

journal_title：Clinical endocrinology

authors： Liang H,Murase Y,Katuta Y,Asano A,Kobayashi J,Mabuchi H

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the impact of a long-acting somatostatin analogue, octreotide, on glucose tolerance and on insulin sensitivity in acromegaly. DESIGN:We performed a non-randomized controlled trial. PATIENTS:Seven patients with active acromegaly were assessed before and during octreotide therapy given...

journal_title：Clinical endocrinology

authors： Ho KK,Jenkins AB,Furler SM,Borkman M,Chisholm DJ

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:Previous studies have suggested that hypothyroidism affects both systolic and diastolic cardiac function. We have applied equilibrium radionuclide angiography to the study of heart function at rest in hypothyroidism. DESIGN:A prospective study, evaluating cardiac function at rest in primary hypothyroidism. ...

journal_title：Clinical endocrinology

authors： Tielens ET,Pillay M,Storm C,Berghout A

更新日期：1999-04-01 00:00:00

abstract：:The HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves' disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 110 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased...

journal_title：Clinical endocrinology

authors： Hawkins BR,Ma JT,Lam KS,Wang CC,Yeung RT

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVE:It has previously been shown that patients with postpartum pituitary necrosis (Sheehan's syndrome, SS) have paradoxically increased TSH levels and loss of the nocturnal TSH surge. This study sought to determine the circadian and pulsatile characteristics of TSH secretion underlying those abnormalities. DESIG...

journal_title：Clinical endocrinology

authors： MacCagnan P,Oliveira JH,Castro V,Abucham J

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Previous studies report impaired health-related quality of life (HRQoL) in patients with functional pituitary adenomas (FPA). We assessed HRQoL in FPA patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal ...

journal_title：Clinical endocrinology

authors： Ritvonen E,Karppinen A,Sintonen H,Vehkavaara S,Kivipelto L,Roine RP,Niemelä M,Schalin-Jäntti C

更新日期：2015-03-01 00:00:00

abstract：:Myotonic dystrophy (MyD) is a common genetic neuromuscular disorder in which chromosome 19 gives rise to an abnormal expansion of CTG-trinucleotide repeats. MyD is a highly variable multisystem disorder with muscular and nonmuscular abnormalities. Increasingly, endocrine abnormalities, such as gonadal, pancreatic, and...

journal_title：Clinical endocrinology

authors： Misra D,DeSilva S,Fellerman H,Dufour DR,Streeten DH,Nylen ES

更新日期：2002-02-01 00:00:00

abstract：:In a prospective controlled trial we investigated the effect of an induction dose of etomidate (0.26 mg/kg i.v.) on plasma ACTH, progesterone, 17 alpha OH-progesterone, 11-deoxycortisol, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, and aldosterone in seven males undergoing general anaesthesia. Seven ot...

journal_title：Clinical endocrinology

authors： Allolio B,Dörr H,Stuttmann R,Knorr D,Engelhardt D,Winkelmann W

更新日期：1985-03-01 00:00:00

abstract：OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

journal_title：Clinical endocrinology

authors： Fuller PJ,Alexiadis M,Jobling T,McNeilage J

更新日期：2005-07-01 00:00:00

abstract：:An immunochemiluminometric assay has been developed for the measurement of free T4 concentrations in serum. The assay uses chemiluminescent acridinium ester labelled monoclonal antibodies which react with free T4 in the sample. A T4-rabbit immunoglobulin G conjugate competes for antibody binding sites, immune-complexe...

journal_title：Clinical endocrinology

authors： Sturgess ML,Weeks I,Evans PJ,Mpoko CN,Laing I,Woodhead JS

更新日期：1987-09-01 00:00:00

abstract：:Trilostane is a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase activity in vitro and an orally active inhibitor of steroidogenesis in vivo. A cytochemical section bioassay for this drug (4 alpha, 5-epoxy-17 beta-hydroxy-3-oxo-5 alpha-androstane-2 alpha-carbonitrile) in human plasma has been developed. Th...

journal_title：Clinical endocrinology

authors： Earnshaw RJ,Mitchell R,Robertson WR

更新日期：1984-07-01 00:00:00

abstract：OBJECTIVE:Vascular dysfunction and accelerated atherosclerosis are prominent features of hypothyroidism. The relative roles of thyroid hormone (TH) deficiency and the associated vascular risk conditions are still unclear. We studied the impact of acute and chronic hypothyroidism on vascular reactivity. PATIENTS:We stu...

journal_title：Clinical endocrinology

authors： Napoli R,Guardasole V,Zarra E,D'Anna C,De Sena A,Lupoli GA,Oliviero U,Matarazzo M,Lupoli G,Saccà L

更新日期：2010-01-01 00:00:00

abstract：:The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

journal_title：Clinical endocrinology

authors： Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

更新日期：1988-09-01 00:00:00

abstract：:An LHRH test was performed on twenty-eight regularly menstruating females during follicular phase of their cycles. Twenty-four were then given an intramuscular injection of progesterone in oil and retested with LHRH 20 or 44 h later, the remaining four received no pretreatment and acted as controls. The twelve subject...

journal_title：Clinical endocrinology

authors： Shaw RW,Butt WR,London DR

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:Although the polymorphisms of the cytotoxic T lymphocyte antigen 4 (CTLA4) gene have been shown to be associated with Type 1 diabetes in Caucasians, some conflicting results have been reported among subjects of different ethnic backgrounds. We examined a CTLA4 polymorphism and its relationship to human leucoc...

journal_title：Clinical endocrinology

authors： Kikuoka N,Sugihara S,Yanagawa T,Ikezaki A,Kim HS,Matsuoka H,Kobayashi Y,Wataki K,Konda S,Sato H,Miyamoto S,Sasaki N,Sakamaki T,Niimi H,Murata M

更新日期：2001-11-01 00:00:00

abstract：:In-vitro data of pituitary adenoma cells from 28 acromegalic patients were evaluated. In addition to GH, PRL was produced by 16 adenomas (57%) and alpha-subunit by 15 adenomas (54%) while there was a significantly higher incidence of tumours producing PRL and alpha-subunit simultaneously. From 26 pituitary adenomas en...

journal_title：Clinical endocrinology

authors： Hofland LJ,van Koetsveld PM,Verleun TM,Lamberts SW

更新日期：1989-06-01 00:00:00

abstract：OBJECTIVE:Recovery of thyroid function in patients following hypothyroidism induced by 131I therapy for Graves' disease has been described, but only a few detailed clinical and biochemical studies of this phenomenon (transient hypothyroidism) have been published. The prevalence, mechanism, and final outcome of transien...

journal_title：Clinical endocrinology

authors： Aizawa Y,Yoshida K,Kaise N,Fukazawa H,Kiso Y,Sayama N,Hori H,Abe K

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:We evaluated menopausal symptoms, menstrual cycle bleeding characteristics and reproductive hormones for their associations with thyroid stimulating hormone (TSH) concentrations in women at the mid-life from five ethnic groups. METHODS:This report is from the baseline evaluation of the Study of Women's Healt...

journal_title：Clinical endocrinology

authors： Sowers M,Luborsky J,Perdue C,Araujo KL,Goldman MB,Harlow SD,SWAN.

更新日期：2003-03-01 00:00:00

abstract：:The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine. 48 h after the onset of treatment with thyroxine, the capacity of rat plasma to inactivate [3H]TRH was significantly increased. The percentage of dea...

journal_title：Clinical endocrinology

authors： Dupont A,Labrie F,Levasseur L,Dussault JH,Schally AV

更新日期：1976-07-01 00:00:00