Blockage of the positive feedback effect of oestradiol during prolonged administration of clomiphene citrate to normal women.

abstract：OBJECTIVE:The aim of this study was to group patients with MODY (maturity-onset diabetes of the young) according to the genetic alterations underlying the disease and to investigate their clinical characteristics. PATIENTS AND METHODS:Molecular analysis of GCK (MODY2), HNF-1alpha (MODY3), HNF-4alpha (MODY1) and HNF-1b...

journal_title：Clinical endocrinology

authors： Estalella I,Rica I,Perez de Nanclares G,Bilbao JR,Vazquez JA,San Pedro JI,Busturia MA,Castaño L,Spanish MODY Group.

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To compare the outcome of different treatment options used in several cases of non-islet cell tumour hypoglycaemia (NICTH). PATIENTS:Eight cases of NICTH were referred for diagnosis and monitoring following either surgical or medical treatment. METHODS:Serum samples collected throughout the time-course of e...

journal_title：Clinical endocrinology

authors： Teale JD,Wark G

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

journal_title：Clinical endocrinology

authors： Höybye C,Hilding A,Jacobsson H,Thorén M

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：CONTEXT:Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIG...

journal_title：Clinical endocrinology

authors： Garrahy A,Galloway I,Hannon AM,Dineen R,Javadpour M,Tormey WP,Gan KJ,Twomey PJ,Mc Kenna MJ,Kilbane M,Crowley RK,Sherlock M,Thompson CJ

更新日期：2020-11-11 00:00:00

abstract：:The urine clearance of TRH after intravenous injection in man has been measured by radioimmunoassay. Between 4.4 percent and 10.7 percent of the dose was excreted within 90 min, the majority within 30 min. The TRH excreted was immunochemically and chromatographically indistinguishable from synthetic TRH and was inacti...

journal_title：Clinical endocrinology

authors： Jeffcoate SL,White N

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

journal_title：Clinical endocrinology

authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of CRH administration on plasma AVP and ANF concentration in patients with Cushing's disease and healthy subjects. SUBJECTS:Fifteen patients with Cushing's disease and 15 sex- and age-matched healthy subjects entered the study. STUDY DESIGN:All subjects were randomly given i.v. 100 mi...

journal_title：Clinical endocrinology

authors： Colao A,Pivonello R,Ferone D,Faggiano A,Facciolli G,Di Somma C,Boudouresque F,Oliver C,Lombardi G

更新日期：1998-07-01 00:00:00

abstract：:We have studied the inositol phospholipid turnover response to thyrotrophin-releasing hormone (TRH) gonadotrophin-releasing hormone (GnRH) and arginine vasopressin (AVP) in five corticotroph and six somatotroph pituitary adenomas. GnRH (100 nM) increased inositol phospholipid turnover in five of five somatotroph adeno...

journal_title：Clinical endocrinology

authors： Levy A,Lightman SL,Hoyland J,Mason WT

更新日期：1990-07-01 00:00:00

abstract：:Only five cases of growth hormone secreting pituitary carcinoma have been documented. We present a 49-year-old West Indian male with grossly elevated plasma growth hormone (760-10,400 mU/l), and a large aggressive pituitary tumour that continued to grow despite repeated pituitary surgery, radiotherapy and medical ther...

journal_title：Clinical endocrinology

authors： Stewart PM,Carey MP,Graham CT,Wright AD,London DR

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:Parathyroid carcinoma remains difficult to diagnose. Recently, it has been shown that mutations in the HRPT2 gene (encoding parafibromin) are associated with the development of parathyroid carcinoma. Although MEN1 is not typically thought to be involved in carcinoma formation, parathyroid carcinoma may be an ...

journal_title：Clinical endocrinology

authors： Haven CJ,van Puijenbroek M,Tan MH,Teh BT,Fleuren GJ,van Wezel T,Morreau H

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Pubertal gynaecomastia is a very common condition. Although the underlying aetiology is poorly understood, it is generally accepted that excess of oestrogens and deficit of androgens are involved in the pathogenesis. Furthermore, adiposity as well as the GH/IGF-I axis may play a role. In this study, we elucid...

journal_title：Clinical endocrinology

authors： Mieritz MG,Sorensen K,Aksglaede L,Mouritsen A,Hagen CP,Hilsted L,Andersson AM,Juul A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Durham JA,Kljakovic M,Cooke RR

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteoca...

journal_title：Clinical endocrinology

authors： Rochefort GY,Rocher E,Aveline PC,Garnero P,Bab I,Chappard C,Jaffré C,Benhamou CL

更新日期：2011-08-01 00:00:00

abstract：AIM:A high level of matrix metalloproteinase 9 (MMP-9) is a predictor of poor wound healing in diabetic foot ulcers. In skin keratinocytes, site-specific DNA demethylation plays an important role in MMP-9 expression. Ten-eleven translocation enzyme 2 (TET2) protein, one member of TET family, could rely on α-ketoglutara...

journal_title：Clinical endocrinology

authors： Tan Q,Wang W,Yang C,Zhang J,Sun K,Luo HC,Mai LF,Lao Y,Yan L,Ren M

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Treatment by octreotide has been suggested in medullary thyroid carcinoma patients with post-surgery metastases. The purpose of this study was to evaluate if the tumoral regression could be improved by a high dose and by prolonged octreotide treatment. DESIGN:Fourteen thyroidectomized patients were studied. ...

journal_title：Clinical endocrinology

authors： Modigliani E,Cohen R,Joannidis S,Siame-Mourot C,Guliana JM,Charpentier G,Cassuto D,Bentata Pessayre M,Tabarin A,Roger P

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

journal_title：Clinical endocrinology

authors： Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well-being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of...

journal_title：Clinical endocrinology

authors： Siegmund W,Spieker K,Weike AI,Giessmann T,Modess C,Dabers T,Kirsch G,Sänger E,Engel G,Hamm AO,Nauck M,Meng W

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the levels of thrombospondin-1 (TSP-1), transforming growth factor-β1 (TGF-β1) and nuclear factor kappaβ (NF-κβ) in polycystic ovarian syndrome (PCOS) patients with and without insulin resistance and after treatment with cyproterone acetate/ethinyloestradiol with o...

journal_title：Clinical endocrinology

authors： Liu M,Gao J,Zhang Y,Li P,Wang H,Ren X,Li C

更新日期：2015-12-01 00:00:00

abstract：:3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

journal_title：Clinical endocrinology

authors： Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (...

journal_title：Clinical endocrinology

authors： Qasim AN,Budharaju V,Mehta NN,St Clair C,Farouk S,Braunstein S,Schutta M,Iqbal N,Rader DJ,Reilly MP

更新日期：2011-01-01 00:00:00

abstract：:Cushing's syndrome in pregnancy is rare but associated with a high fetal loss rate, premature labour and excessive maternal morbidity. There has been controversy regarding the safety and efficacy of surgical treatment during pregnancy. We describe two further cases, both due to adrenal adenomas, in whom the diagnosis ...

journal_title：Clinical endocrinology

authors： Bevan JS,Gough MH,Gillmer MD,Burke CW

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Hypopituitarism, in particular GH deficiency, is prevalent in patients with clinically nonfunctioning pituitary adenomas (NFPAs) both before and after surgery. The factors regulating the growth of pituitary adenomas in general and residual tumour tissue in particular are not fully characterized, an...

journal_title：Clinical endocrinology

authors： Clausen LR,Kristiansen MT,Rasmussen LM,Billestrup N,Blaabjerg O,Ledet T,Jørgensen JO

更新日期：2004-05-01 00:00:00

abstract：:Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two ...

journal_title：Clinical endocrinology

authors： Thompson DG,Mason AS,Goodwin FJ

更新日期：1979-05-01 00:00:00

abstract：:Serum immunoreactive melatonin was measured in thirty-three male subjects with delayed puberty, thirty of whom had simple (idiopathic) delayed puberty (SDP) and three of whom were GH deficient. The results were compared with a control population of twenty-six subjects. Significantly elevated values of serum melatonin ...

journal_title：Clinical endocrinology

authors： Cohen HN,Hay ID,Annesley TM,Beastall GH,Wallace AM,Spooner R,Thomson JA,Eastwold P,Klee GG

更新日期：1982-11-01 00:00:00

abstract：CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoi...

journal_title：Clinical endocrinology

authors： Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A

更新日期：2016-02-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagno...

journal_title：Clinical endocrinology

authors： Nixon AM,Provatopoulou X,Kalogera E,Zografos GN,Gounaris A

更新日期：2017-08-01 00:00:00

abstract：:This study was to examine indirectly the effect of endogenous progesterone, a known competitor for 5 alpha-reductase, on androgen metabolism in target organs in hirsute women. Serum levels of progesterone, testosterone (T), androstenedione (A), dihydrotestosterone (DHT) and 5 alpha-androstane 3 alpha 17 beta-diol (3 a...

journal_title：Clinical endocrinology

authors： Dewis P,Newman M,Anderson DC

更新日期：1984-10-01 00:00:00

abstract：:Two cases of Cushing's syndrome are reported in which apparently autonomous adrenal adenomata were associated with the presence of pituitary tumours. In one case the patient was apparently cured by unilateral adrenalectomy, although she was noted to have radiological evidence of an intrasellar tumour; serum cortisol w...

journal_title：Clinical endocrinology

authors： Sturrock ND,Morgan L,Jeffcoate WJ

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Heterozygous inactivating mutations of the calcium-sensing receptor (CaR) gene cause familial hypocalciuric hypercalcaemia (FHH), a generally benign disorder characterized by mild to moderate PTH-dependent hypercalcaemia. We aimed to identify the causative CaR mutations in three families with FHH and examine ...

journal_title：Clinical endocrinology

authors： Ward BK,Magno AL,Blitvich BJ,Rea AJ,Stuckey BG,Walsh JP,Ratajczak T

更新日期：2006-05-01 00:00:00