Blockage of the positive feedback effect of oestradiol during prolonged administration of clomiphene citrate to normal women.


:The effect of clomiphene citrate on the occurrence and timing of the endogenous LH surge in superovulated cycles is unclear. To study further this event, five normally ovulating women were treated with clomiphene citrate 100 mg per day in two different cycles, that is, for 5 days in one cycle (days 2 to 6, CC-5) and for 15 days in another cycle (days 2 to 16, CC-15). During the CC-5 cycle, the normal pattern of LH levels seen in spontaneous cycles was observed with an endogenous LH surge in all women followed by ovulation and normal luteal function. In contrast, during the CC-15 cycle, a continuous and progressive increase of basal LH levels was seen with no surge, resulting in follicular luteinization but no ovulation. The results suggest that in normal women treated with clomiphene the occurrence of an endogenous LH surge is dependent on a significant decrease in the circulatory concentration of clomiphene at mid-cycle.


Clin Endocrinol (Oxf)


Clinical endocrinology


Messinis IE,Templeton A




Has Abstract


1988-11-01 00:00:00












  • Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues.

    abstract:OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

    更新日期:1997-11-01 00:00:00

  • Optic chiasmal herniation--an under recognized complication of dopamine agonist therapy for macroprolactinoma.

    abstract::The initial presentation of macroprolactinoma with visual field impairment, especially in males, is well recognized. Successful treatment with dopamine agonist therapy is characterized by a reduction in hyperprolactinaemia and often rapid and progressive resolution of the visual impairment. A small proportion of patie...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Jones SE,James RA,Hall K,Kendall-Taylor P

    更新日期:2000-10-01 00:00:00

  • Is testicular endocrine function abnormal in young men with spinal cord injuries?

    abstract::Plasma concentrations of FSH, LH, testosterone and prolactin have been studied in seventeen men, aged 19 to 38 years, with traumatic paraplegia. Plasma testosterone, FSH and LH values were normal in all patients. The median LH concentration in patients was significantly higher (P less than 0.05) than in controls but t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Young RJ,Strachan RK,Seth J,Nicol K,Frier BM,Corrall RJ

    更新日期:1982-09-01 00:00:00

  • A ten-year clinical update of a large RET p.Gly533Cys kindred with medullary thyroid carcinoma emphasizes the need for an individualized assessment of affected relatives.

    abstract:OBJECTIVE:Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making. DESIGN AND PATIENTS:We identified 728 RET533 Brazilian relatives, spread out over 7 generati...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Signorini PS,França MI,Camacho CP,Lindsey SC,Valente FO,Kasamatsu TS,Machado AL,Salim CP,Delcelo R,Hoff AO,Cerutti JM,Dias-da-Silva MR,Maciel RM

    更新日期:2014-02-01 00:00:00

  • Growth hormone secretory pattern and response to treatment in children with short stature followed to adult height.

    abstract:OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

    更新日期:2003-07-01 00:00:00

  • An audit of oestradiol levels and implant frequency in women undergoing subcutaneous implant therapy.

    abstract:OBJECTIVES:The aim of the study was to review our long-term use of subcutaneous oestradiol (E2) implant therapy for the treatment of climacteric symptoms in post-menopausal women. On the grounds that the aim is to restore premenopausal serum E2 levels, our declared clinical policy is not to repeat implants even in the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Buckler HM,Kalsi PK,Cantrill JA,Anderson DC

    更新日期:1995-05-01 00:00:00

  • Rethinking antithyroid drugs in pregnancy.

    abstract::Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Napier C,Pearce SH

    更新日期:2015-04-01 00:00:00

  • Very early prophylactic thyroid surgery for infants with a mutation of the RET proto-oncogene at codon 634: evaluation of the implementation of international guidelines for MEN type 2 in a single centre.

    abstract:OBJECTIVE:Genetic diagnosis available since 1993 established germinal mutations of the RET proto-oncogene at codon 634 as the main cause of inherited medullary thyroid carcinoma (MTC). International guidelines established in 1999 recommend that children with such mutations undergo a total thyroidectomy before age 5, wi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Piolat C,Dyon JF,Sturm N,Pinson S,Bost M,Jouk PS,Plantaz D,Chabre O

    更新日期:2006-07-01 00:00:00

  • Serum and follicular fluid insulin like growth factors I and II during growth hormone co-treatment for in-vitro fertilization and embryo transfer.

    abstract:OBJECTIVE:We wished to assess the changes in serum IGF-I and IGF-II concentrations during gonadotrophin treatment alone or with additional GH treatment and to compare follicular fluid IGF-I and IGF-II concentrations in the two treatment groups. DESIGN:We performed an open study of co-treatment with GH and subsequently...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Owen EJ,Torresani T,West C,Mason BA,Jacobs HS

    更新日期:1991-10-01 00:00:00

  • Prescription of antidepressants is increased in Danish patients with polycystic ovary syndrome and is associated with hyperandrogenism. A population-based cohort study.

    abstract:OBJECTIVE:Quality of life is impaired in polycystic ovary syndrome (PCOS). In this study, we compared the time to first prescription of antidepressants (ADM) in PCOS vs two control groups. DESIGN:Register-based cohort study. PATIENTS:One thousand and one hundred and twenty-four premenopausal women with hirsutism and/...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Altinok ML,Glintborg D,Depont Christensen R,Hallas J,Andersen M

    更新日期:2014-06-01 00:00:00

  • Nontruncated amino-terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation.

    abstract:OBJECTIVE:Some patients with parathyroid carcinoma present with an over-production of nontruncated amino-terminal (NT-N) parathyroid hormone (PTH), a post-transcriptionally modified form of PTH(1-84). This is usually picked up on an elevated whole (W) PTH (third-generation)/total (T) (second-generation) PTH assay ratio...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Caron P,Simonds WF,Maiza JC,Rubin M,Cantor T,Rousseau L,Bilezikian JP,Souberbielle JC,D'Amour P

    更新日期:2011-06-01 00:00:00

  • Physiologic secretion of growth hormone and prolactin in male and female rats.

    abstract::Growth hormone and prolactin are secreted episodically in man and experimental animals. To investigate physiologic mechanisms of GH and PRL secretion, a series of experiments were performed in individual, unanaesthetized male and female rats. GH secretion in the male rat is characterized by intermittent surges that oc...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Terry LC,Saunders A,Audet J,Willoughby JO,Brazeau P,Martin JB

    更新日期:1977-01-01 00:00:00

  • Novel mutations in the calcium-sensing receptor gene associated with biochemical and functional differences in familial hypocalciuric hypercalcaemia.

    abstract:OBJECTIVE:Heterozygous inactivating mutations of the calcium-sensing receptor (CaR) gene cause familial hypocalciuric hypercalcaemia (FHH), a generally benign disorder characterized by mild to moderate PTH-dependent hypercalcaemia. We aimed to identify the causative CaR mutations in three families with FHH and examine ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ward BK,Magno AL,Blitvich BJ,Rea AJ,Stuckey BG,Walsh JP,Ratajczak T

    更新日期:2006-05-01 00:00:00

  • Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients.

    abstract:OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Picolos MK,Lavis VR,Orlander PR

    更新日期:2005-11-01 00:00:00

  • A novel bioassay for human somatogenic activity in serum samples supports the clinical reliability of immunoassays.

    abstract:OBJECTIVE:Because there is discordance between different immunoassay values for serum hGH, and because clinical state may not correlate with immunoreactive hGH, we have developed an assay to accurately measure serum hGH somatogenic bioactivity. The results of this assay were compared with the Elegance two-site ELISA as...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Rowland JE,Marshall NJ,Leung KC,Ho KK,Cotterill AM,Rowlinson SW,Waters MJ

    更新日期:2002-04-01 00:00:00

  • Effects of the GABAergic agent sodium valproate on the arginine vasopressin responses to hypertonic stimulation and upright posture in man.

    abstract::In order to evaluate the possible influence of GABAergic neurotransmission on the arginine vasopressin (AVP) response to osmotic and pressure volumetric stimuli, the GABAergic drug sodium valproate was administered by mouth (200 or 400 mg 16 h, 8 h and just before tests) to eight normal men before osmotic (i.v. infusi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chiodera P,Gnudi A,Volpi R,Marchesi C,Marchesi M,Davoli D,Capretti L,Coiro V

    更新日期:1989-04-01 00:00:00

  • Increased secretion of 32,33 split proinsulin after intravenous glucose in glucose-tolerant first-degree relatives of patients with non-insulin dependent diabetes of European, but not Asian, origin.

    abstract:OBJECTIVE:The aetiology of non-insulin dependent diabetes is unknown, but defective insulin secretion is a feature. The disease also has a strong genetic basis and first-degree relatives of patients have an increased risk of future diabetes. To investigate whether beta-cell dysfunction is an early feature of the diseas...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Gelding SV,Andres C,Niththyananthan R,Gray IP,Mather H,Johnston DG

    更新日期:1995-03-01 00:00:00

  • Primary adrenal and thyroid insufficiencies associated with hypopituitarism: a diagnostic challenge.

    abstract::Polyglandular syndromes have been described for many years but only one case of panhypopituitarism with adrenal and thyroid insufficiencies has been documented. We present a 69-year-old woman with the initial diagnosis of idiopathic primary hypopituitarism. An associated primary adrenal disease was suspected on low pl...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pholsena M,Young J,Couzinet B,Schaison G

    更新日期:1994-05-01 00:00:00

  • α-ketoglutarate is associated with delayed wound healing in diabetes.

    abstract:AIM:A high level of matrix metalloproteinase 9 (MMP-9) is a predictor of poor wound healing in diabetic foot ulcers. In skin keratinocytes, site-specific DNA demethylation plays an important role in MMP-9 expression. Ten-eleven translocation enzyme 2 (TET2) protein, one member of TET family, could rely on α-ketoglutara...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tan Q,Wang W,Yang C,Zhang J,Sun K,Luo HC,Mai LF,Lao Y,Yan L,Ren M

    更新日期:2016-07-01 00:00:00

  • Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis.

    abstract:BACKGROUND:The prognostic value of the telomerase reverse transcriptase (TERT) promoter mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma (PTC), has been generally confirmed. To data, there is no high-level evidence approving the association of TERT promoter mutation and aggressive clinical b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析,评审


    authors: Yin DT,Yu K,Lu RQ,Li X,Xu J,Lei M,Li H,Wang Y,Liu Z

    更新日期:2016-08-01 00:00:00

  • The persistence of maternal vitamin D deficiency and insufficiency during pregnancy and lactation irrespective of season and supplementation.

    abstract:BACKGROUND:Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long-term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of m...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kramer CK,Ye C,Swaminathan B,Hanley AJ,Connelly PW,Sermer M,Zinman B,Retnakaran R

    更新日期:2016-05-01 00:00:00

  • Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan.

    abstract:OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

    更新日期:2015-01-01 00:00:00

  • Changes in heart valve structure and function in patients treated with dopamine agonists for prolactinomas, a 2-year follow-up study.

    abstract:OBJECTIVE:The use of ergot-derived dopamine agonists (DA) to treat patients with prolactinomas has not been associated with an increased risk of significant heart valve dysfunction. Accordingly, the present study evaluated whether the long-term use of DA for hyperprolactinaemia may be associated with increased risk of ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Delgado V,Biermasz NR,van Thiel SW,Ewe SH,Marsan NA,Holman ER,Feelders RA,Smit JW,Bax JJ,Pereira AM

    更新日期:2012-07-01 00:00:00

  • Interleukin-10-592C/A, -819C/T and -1082A/G promoter variants affect the susceptibility to nephropathy in Tunisian type 2 diabetes (T2DM) patients.

    abstract:BACKGROUND:The Interleukin (IL)-10 polymorphic variants -1082G/A, -819C/T and -592C/A were linked with obesity, metabolic syndrome, and type 2 diabetes (T2DM). We investigated the hypothesis that IL-10 promoter polymorphisms may be associated with the progression of diabetic nephropathy (DN). DESIGN:Case-controlled st...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ezzidi I,Mtiraoui N,Kacem M,Mallat SG,Mohamed MB,Chaieb M,Mahjoub T,Almawi WY

    更新日期:2009-03-01 00:00:00

  • Suppression of parathyroid hormone inhibitory activity of plasma in pseudohypoparathyroidism type I by i.v. calcium.

    abstract::The biological response, as measured in the cytochemical bioassay, to the high circulating levels of immunoreactive parathyroid hormone (iPTH) in patients with pseudohypoparathyroidism type I (PSPI) is affected by the presence of an endogenous inhibitor. This is evidenced by the reduced recovery of the biological acti...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Loveridge N,Fischer JA,Devogelaer JP,Nagant de Deuxchaisnes C

    更新日期:1986-05-01 00:00:00

  • Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers.

    abstract::Anorexia nervosa is associated with several abnormalities in GH secretion elicited by different stimuli. To investigate the precise mechanism of this alteration, GHRH was administered to 14 women: a group of eight anorexia nervosa patients in the acute phase of their illness and a control group of six age-matched volu...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Casanueva FF,Borras CG,Burguera B,Lima L,Muruais C,Tresguerres JA,Devesa J

    更新日期:1987-11-01 00:00:00

  • Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomized, placebo-controlled study.

    abstract:OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

    更新日期:1995-12-01 00:00:00

  • Application of a disease-specific, quality-of-life measure (QoL-AGHDA) in growth hormone-deficient adults and a random population sample in Sweden: validation of the measure by rasch analysis.

    abstract:OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

    journal_title:Clinical endocrinology

    pub_type: 评论,杂志文章


    authors: Wirén L,Whalley D,McKenna S,Wilhelmsen L

    更新日期:2000-02-01 00:00:00

  • The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity.

    abstract::Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nowak R,McMillen IC,Redman J,Short RV

    更新日期:1987-10-01 00:00:00

  • Demonstration of thyroid stimulating activity within H chain fragments of TSAb-IgG by protease digestion and reduction.

    abstract:OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

    更新日期:1997-02-01 00:00:00