Growth hormone receptor expression and function in pituitary adenomas.

abstract：:The cardiovascular response and the changes of plasma arginine vasopressin (AVP) concentration following graded doses of AVP infused intravenously have been defined in six normal young men. The same measurements were also made during fluid deprivation in a patient with both nephrogenic diabetes insipidus and systemic ...

journal_title：Clinical endocrinology

authors： Khokhar AM,Slater JD,Ma J,Ramage CM

更新日期：1980-09-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours that arise from the adrenal medulla or extra-adrenal sympathetic or parasympathetic paraganglia. Recent advances in genetics have greatly enhanced understanding of the pathogenesis and molecular physiology of PPGL. Concomitantly, advances in molecular imag...

journal_title：Clinical endocrinology

authors： Ryder SJ,Love AJ,Duncan EL,Pattison DA

更新日期：2020-12-09 00:00:00

abstract：:The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increase during p...

journal_title：Clinical endocrinology

authors： Odlind V,Carlström K,Michaëlsson G,Vahlqvist A,Victor A,Mellbin T

更新日期：1982-03-01 00:00:00

abstract：OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

journal_title：Clinical endocrinology

authors： Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein-to-peripheral vein ratio (LAV/PV) were proposed to predict the lateralization index without the right AVS. OBJECTIVE:To assess external validity of MRM and LAV...

journal_title：Clinical endocrinology

authors： Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To investigate two patients with the hyperparathyroidism-jaw tumour (HPT-JT) syndrome and three patients with familial isolated hyperparathyroidism (FIHP), together with 31 parathyroid tumours (2 HPT-JT, 2 FIHP and 27 sporadic) for HRPT2 mutations. The HPT-JT syndrome and FIHP are autosomal dominant disorders...

journal_title：Clinical endocrinology

authors： Bradley KJ,Cavaco BM,Bowl MR,Harding B,Cranston T,Fratter C,Besser GM,Conceição Pereira M,Davie MW,Dudley N,Leite V,Sadler GP,Seller A,Thakker RV

更新日期：2006-03-01 00:00:00

abstract：:We describe a 40-year-old male with acromegaly, multiple and recurrent cutaneous myxomas, spotty cutaneous pigmentation, a mammary myxoma, a large-cell calcifying Sertoli cell tumour of the testis, and an unusual calcifying pigmented neuroectodermal tumour. He presented a combination of clinical and histological featu...

journal_title：Clinical endocrinology

authors： Leedman PJ,Cohen AK,Matz LR

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:Leptin serves as a hormonal signal linking food intake and energy expenditure to fat mass. As significant effects of testosterone administration on body composition and adipose tissue have been described recently, we examined a possible association between serum levels of leptin and testosterone which has not...

journal_title：Clinical endocrinology

authors： Behre HM,Simoni M,Nieschlag E

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

journal_title：Clinical endocrinology

authors： Holmer H,Link K,Erfurth EM

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The metabolites of steroidal hormones, including sulphate, glucuronide, and fatty acid (FA) ester derivatives, have received little attention, although these steroid derivatives are essential components in the global assessment of steroid metabolism. The study of FA-derivatives could, in obesity, contribute s...

journal_title：Clinical endocrinology

authors： Fernández-Real JM,Sanchis D,Ricart W,Casamitjana R,Balada F,Remesar X,Alemany M

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:One of the aims of a subcutaneous (SC) injection is to avoid intradermal or intramuscular injections. Pen systems are an alternative solution to single-use syringes and have become standard for example diabetes therapy. Shorter and smaller needles minimize pain and the risk of intramuscular injections. The th...

journal_title：Clinical endocrinology

authors： Ludescher B,Rommel M,Willmer T,Fritsche A,Schick F,Machann J

更新日期：2011-12-01 00:00:00

abstract：:Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order. The peak serum GH concentrations elicited by clonidine or GHRH were variable but one factor influencing the GH response to GHRH was the GH secretory status in the hour prior to the administration of the GHRH. Pe...

journal_title：Clinical endocrinology

authors： Suri D,Hindmarsh PC,Brain CE,Pringle PJ,Brook CG

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

journal_title：Clinical endocrinology

authors： Wirén L,Whalley D,McKenna S,Wilhelmsen L

更新日期：2000-02-01 00:00:00

abstract：:Clinical observations and serial determinations of serum thyroglobulin (Tg) were made in five patients with acute haemorrhage into the thyroid gland. Fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum T4 and T3 were normal. Although all patients showed an ...

journal_title：Clinical endocrinology

authors： Kawamura S,Kishino B,Tajima K,Mashita K,Tarui S

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

journal_title：Clinical endocrinology

authors： Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

更新日期：2013-02-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:To study the effects of short (6 months) and longer-term (up to 24 months) growth hormone (GH) replacement therapy using a dose titration regimen, on lipid and glucose metabolism in GH-deficient, hypopituitary adults. DESIGN:On-going open study of GH treatment up to 24 months. Measurements were performed at ...

journal_title：Clinical endocrinology

authors： Florakis D,Hung V,Kaltsas G,Coyte D,Jenkins PJ,Chew SL,Grossman AB,Besser GM,Monson JP

更新日期：2000-10-01 00:00:00

abstract：:Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months. In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibi...

journal_title：Clinical endocrinology

authors： Kauli R,Pertzelan A,Ben-Zeev Z,Lewin RP,Kaufman H,Schally AM,Schally AV,Laron Z

更新日期：1984-04-01 00:00:00

abstract：CONTEXT:Primary hyperparathyroidism is a common condition and results in hypercalcaemia, especially in older women. Thus, it is critical to obtain a robust estimate for the upper limit of the reference interval for albumin-adjusted serum calcium in the general population. The current reference interval in use in the UK...

journal_title：Clinical endocrinology

authors： Schini M,Hannan FM,Walsh JS,Eastell R

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves' disease. DESIGN AND MEASUREMENTS:Cultured thyroid cells were ...

journal_title：Clinical endocrinology

authors： Hiromatsu Y,Sato M,Yamada K,Nonaka K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There are currently no sensitive and specific assays for activin B that could be utilized to study human biological fluids. The aim of this project was to develop and validate a 'total' activin B ELISA for use with human biological fluids and establish concentrations of activin B in the circula...

journal_title：Clinical endocrinology

authors： Ludlow H,Phillips DJ,Myers M,McLachlan RI,de Kretser DM,Allan CA,Anderson RA,Groome NP,Hyvönen M,Duncan WC,Muttukrishna S

更新日期：2009-12-01 00:00:00

abstract：:Transdermal oestradiol, 100 micrograms/d, was used to treat 11 women suffering from postmenopausal symptoms. After 3 weeks therapy there was a significant rise in the plasma oestradiol into the premenopausal range and a significant fall in plasma FSH level and symptom score. Bone resorption, assessed by urinary excret...

journal_title：Clinical endocrinology

authors： Selby PL,Peacock M

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:To compare ultrasonography and 99mTc thyroid scintigraphy for the aetiologic diagnosis of permanent congenital hypothyroidism (CH). STUDY DESIGN:Eighty-eight consecutive patients with CH were recruited at an endocrinology outpatient clinic and submitted to high-frequency ultrasonography and to 99mTc scintigr...

journal_title：Clinical endocrinology

authors： Kreisner E,Camargo-Neto E,Maia CR,Gross JL

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Sex steroid hormones influence bone mineral density (BMD) in women, but are less well-studied in men. We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years. DESIGN:BMD and sex steroid hormones were mea...

journal_title：Clinical endocrinology

authors： Paller CJ,Shiels MS,Rohrmann S,Basaria S,Rifai N,Nelson W,Platz EA,Dobs A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The autoimmune thyroid diseases, Graves disease and autoimmune hypothyroidism, result from a complex interaction between genetic, environmental and endogenous factors. The genetic loci conferring susceptibility remain unclear. A recent report has demonstrated an association between a microsatellite polymorphi...

journal_title：Clinical endocrinology

authors： Kotsa K,Watson PF,Weetman AP

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Although autoantibody production is a key feature of autoimmunity, it is not known whether variation in autoantibody production and clearance pathways is involved in disease susceptibility. The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucl...

journal_title：Clinical endocrinology

authors： Yesmin K,Hargreaves C,Newby PR,Brand OJ,Heward JM,Franklyn JA,Gough SC,Simmonds MJ

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVE:Both severe growth hormone (GH) deficiency in hypopituitary adults and physiological ageing are associated with an increase in fat mass, dyslipidaemia, and an increased incidence of cardiovascular disease. Ageing is also associated with a physiological decrease in spontaneous as well as stimulated GH secretio...

journal_title：Clinical endocrinology

authors： Vahl N,Klausen I,Christiansen JS,Jørgensen JO

更新日期：1999-09-01 00:00:00

abstract：:Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

journal_title：Clinical endocrinology

authors： De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

journal_title：Clinical endocrinology

authors： Abucham J,Castro V,Maccagnan P,Vieira JG

更新日期：1997-11-01 00:00:00