Quantification and regulation of adipsin in human cerebrospinal fluid (CSF).


CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoing neurological evaluation and spinal puncture. DESIGN:A total of 270 consecutive patients with specified neurological diagnosis were included in this study without prior selection. MAIN OUTCOME MEASURES:Adipsin serum and CSF concentrations were measured by ELISA. A variety of serum and CSF routine parameters were measured by standard procedures. Anthropometric data, medication and patient history were available. RESULTS:Adipsin concentrations ranged between 467 and 5148 ng/ml in serum and between 4·2 and 133·5 ng/ml in CSF. Serum adipsin concentrations were correlated positively with respective CSF concentrations and were approximately 40-fold higher when compared to CSF. The mean CSF/serum ratio for adipsin was 27 ± 22 × 10-3 . Serum and CSF adipsin levels were independent of gender and significantly higher in overweight/obese individuals. Serum and CSF adipsin levels correlated significantly with age and were higher in patients suffering from diabetes mellitus or hypertension. CSF adipsin concentrations showed a significant correlation with markers of inflammation in CSF, but not with CSF total cell count or the presence of oligoclonal bands. Patients suffering from infectious diseases had higher CSF levels of adipsin than multiple sclerosis patients. CONCLUSIONS:Adipsin is present in human CSF under pathophysiological conditions. The positive correlation between serum and CSF concentrations, the positive correlation between the CSF/serum ratios for adipsin and total protein and the lack of association with CSF cell count argue against an autochthonous production in the central nervous system. In contrast, the present data argue for a significant BBB permeability to adipsin.


Clin Endocrinol (Oxf)


Clinical endocrinology


Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A




Has Abstract


2016-02-01 00:00:00












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    abstract:BACKGROUND AND OBJECTIVE:In polycystic ovary syndrome (PCOS) inappropriate gonadotrophin secretion is characterized by increased pulse frequency and amplitude, elevated 24-h mean serum concentrations, and greater responses to GnRH. While the mechanism(s) responsible for this increased release of LH are not well underst...

    journal_title:Clinical endocrinology

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    authors: Patel K,Coffler MS,Dahan MH,Malcom PJ,Deutsch R,Chang RJ

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  • Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study.

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    authors: Retnakaran R,Youn BS,Liu Y,Hanley AJ,Lee NS,Park JW,Song ES,Vu V,Kim W,Tungtrongchitr R,Havel PJ,Swarbrick MM,Shaw C,Sweeney G

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  • Effect of thyroxine on the inactivation of thyrotrophin-releasing hormone by rat and human plasma.

    abstract::The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine. 48 h after the onset of treatment with thyroxine, the capacity of rat plasma to inactivate [3H]TRH was significantly increased. The percentage of dea...

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    authors: Dupont A,Labrie F,Levasseur L,Dussault JH,Schally AV

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    authors: Di Cosmo C,Fanelli G,Tonacchera M,Ferrarini E,Dimida A,Agretti P,De Marco G,Vitti P,Pinchera A,Bevilacqua G,Naccarato AG,Viacava P

    更新日期:2006-10-01 00:00:00

  • Plasma soluble tumour necrosis factor-alpha receptor 2 is elevated in obesity: specific contribution of visceral adiposity.

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    authors: Cartier A,Côté M,Bergeron J,Alméras N,Tremblay A,Lemieux I,Després JP

    更新日期:2010-03-01 00:00:00

  • Chromogranin A as serum marker of pituitary adenomas.

    abstract:OBJECTIVE:The diagnostic impact of chromogranin A (CgA) measurement has been studied in various neuroendocrine tumours (NET) such as pheochromocytomas, gastrinomas and neuroblastomas. Clinically nonfunctioning pituitary adenomas (NFPA) are generally diagnosed on tumoural symptoms or hypopituitarism and, except for gona...

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    pub_type: 杂志文章


    authors: Gussi IL,Young J,Baudin E,Bidart JM,Chanson P

    更新日期:2003-11-01 00:00:00

  • The evidence for the regulatory role of endogenous GIP as a glucose dependent insulinotropic hormone in patients with duodenal ulcer.

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    authors: Takemura J,Seino Y,Yamamura T,Yoshiya K,Ishikawa Y,Itoh N,Imura H

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    authors: Van den Bruel A,Moreno-Reyes R,Bex M,Daumerie C,Glinoer D

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    更新日期:2014-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Rong R,Tao YX,Cheung BM,Xu A,Cheung GC,Lam KS

    更新日期:2006-08-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Sahin M,Tanaci N,Yucel M,Tutuncu NB,Guvener N

    更新日期:2007-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Dax EM,Clappison BH,Pullan PT,Pepperell R,Johnston CI

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    authors: Bowes SB,Benn JJ,Scobie IN,Umpleby AM,Lowy C,Sönksen PH

    更新日期:1993-11-01 00:00:00

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    authors: Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

    更新日期:1997-12-01 00:00:00

  • Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.

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    authors: Johnston DG,Haigh J,Prescott RW,Heaton A,Kendall-Taylor P,Baylis P,Alberti KG,Rowe R,Friesen H,Cook D

    更新日期:1985-05-01 00:00:00

  • High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency.

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    authors: Nermoen I,Rørvik J,Holmedal SH,Hykkerud DL,Fougner KJ,Svartberg J,Husebye ES,Løvås K

    更新日期:2011-12-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Terry LC,Saunders A,Audet J,Willoughby JO,Brazeau P,Martin JB

    更新日期:1977-01-01 00:00:00

  • Discrepancy between ACTH and cortisol responses to insulin induced hypoglycaemia.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

    更新日期:1978-10-01 00:00:00

  • Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.

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    authors: Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

    更新日期:1991-12-01 00:00:00

  • Treatment of post-menopausal osteoporosis with a combination of growth hormone and pamidronate: a placebo controlled trial.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Erdtsieck RJ,Pols HA,Valk NK,van Ouwerkerk BM,Lamberts SW,Mulder P,Birkenhäger JC

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    authors: Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

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  • Smaller LDL particle size in women with polycystic ovary syndrome compared to controls.

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    journal_title:Clinical endocrinology

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    authors: Dejager S,Pichard C,Giral P,Bruckert E,Federspield MC,Beucler I,Turpin G

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    更新日期:2006-12-01 00:00:00

  • Serum irisin concentrations in lean adolescents with polycystic ovary syndrome.

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    pub_type: 杂志文章


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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ezzidi I,Mtiraoui N,Kacem M,Mallat SG,Mohamed MB,Chaieb M,Mahjoub T,Almawi WY

    更新日期:2009-03-01 00:00:00

  • Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Coussa A,Hasan HA,Barber TM

    更新日期:2020-12-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Contreras LN,Arregger AL,Persi GG,Gonzalez NS,Cardoso EM

    更新日期:2004-12-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Estalella I,Rica I,Perez de Nanclares G,Bilbao JR,Vazquez JA,San Pedro JI,Busturia MA,Castaño L,Spanish MODY Group.

    更新日期:2007-10-01 00:00:00

  • Insulin secretion and insulin-like growth factor-I levels in active and controlled acromegaly.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hopkins KD,Holdaway IM

    更新日期:1992-01-01 00:00:00