Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency.

abstract：BACKGROUND:The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors. AIM:The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellula...

journal_title：Clinical endocrinology

authors： Mattera D,Capuano G,Colao A,Pivonello R,Manguso F,Puzziello A,D'Agostino L

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness and tolerability of quinagolide (CV 205-502) and cabergoline (CAB) treatments in 39 patients with prolactinoma. STUDY DESIGN:All 39 patients were treated first with quinagolide for 12 months and then with cabergoline for 12 months. A wash-out period was performed in all patients afte...

journal_title：Clinical endocrinology

authors： Di Sarno A,Landi ML,Marzullo P,Di Somma C,Pivonello R,Cerbone G,Lombardi G,Colao A

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Hypopituitarism diagnosed in childhood, adolescence and young adulthood has the potential to affect growth and somatic development. Less is known about the impact of such a diagnosis on other aspects of development. DESIGN:An analysis of the KIMS database (Pfizer International Metabolic Database) was perform...

journal_title：Clinical endocrinology

authors： Mitra MT,Jönsson P,Åkerblad AC,Clayton P,Kołtowska-Häggström M,Korbonits M,Toogood A,Gleeson H

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:This study was designed in order to evaluate bone turnover with bone formation and resorption markers in hyperthyroidism and its possible relationship with serum cytokines interleukin 6 (IL-6) and tumour necrosis-alpha (TNF-alpha), levels of thyroid hormones and thyroid autoantibodies. DESIGN AND PATIENTS:Tw...

journal_title：Clinical endocrinology

authors： Akalin A,Colak O,Alatas O,Efe B

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:It has been postulated that a decrease in thyroid size can be achieved by thyroxine treatment in patients with goitrous Hashimoto's thyroiditis but no objective data are available. We have therefore investigated the influence of thyroxine treatment on ultrasonically determined thyroid size. We also measured s...

journal_title：Clinical endocrinology

authors： Hegedüs L,Hansen JM,Feldt-Rasmussen U,Hansen BM,Høier-Madsen M

更新日期：1991-09-01 00:00:00

abstract：CONTEXT:Two main forms of amiodarone-induced thyrotoxicosis (AIT) exist. Type 1 AIT is a form of iodine-induced hyperthyroidism. Its management is complex and includes thionamides, potassium perchlorate and, occasionally, thyroidectomy. Type 2 AIT is a destructive thyroiditis, responds to glucocorticoids, and usually d...

journal_title：Clinical endocrinology

authors： Bogazzi F,Bartalena L,Dell'Unto E,Tomisti L,Rossi G,Pepe P,Tanda ML,Grasso L,Macchia E,Aghini-Lombardi F,Pinchera A,Martino E

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:One of the aims of a subcutaneous (SC) injection is to avoid intradermal or intramuscular injections. Pen systems are an alternative solution to single-use syringes and have become standard for example diabetes therapy. Shorter and smaller needles minimize pain and the risk of intramuscular injections. The th...

journal_title：Clinical endocrinology

authors： Ludescher B,Rommel M,Willmer T,Fritsche A,Schick F,Machann J

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Diagnosing thyroid nodules preoperatively using traditional diagnostic tools - ultrasonography (US) and cytology - still carries a considerable degree of uncertainty, and surgery is recommended for a far from negligible number of patients simply for diagnostic purposes. Thyroid elastosonography (USE) and BRAF...

journal_title：Clinical endocrinology

authors： Nacamulli D,Nico L,Barollo S,Zambonin L,Pennelli G,Girelli ME,Casal Ide E,Pelizzo MR,Vianello F,Negro I,Watutantrige-Fernando S,Mantero F,Rugge M,Mian C

更新日期：2012-10-01 00:00:00

abstract：:Recombinant human TSH (rhTSH) has revolutionized the care of patients with differentiated thyroid cancer. Since its approval for clinical use in 2001 in Europe (1998 in the USA), rhTSH has greatly enhanced the surveillance of these patients by allowing the avoidance of hypothyroidism for TSH stimulation. Previously, a...

journal_title：Clinical endocrinology

authors： Woodmansee WW,Haugen BR

更新日期：2004-08-01 00:00:00

abstract：:Amniotic fluid concentrations of 3,3',5'-tri-iodothyronine (rT3), 3,3'-Di-iodothyronine (3,3'-T2), 3,5,3'-tri-iodothyronine (T3) and T4 were studied in 384 women during normal and complicated pregnancy. An inverse correlation was observed between decreasing rT3 and increasing 3,3'-T2 concentrations in amniotic fluid w...

journal_title：Clinical endocrinology

authors： Meinhold H,Dudenhausen JW,Wenzel KW,Saling E

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Classical congenital adrenal hyperplasia (CAH) is characterized by a defect in cortisol and aldosterone secretion, adrenal hyperandrogenism, impaired adrenal medullary function and insulin insensitivity. The latter along with the increased tendency towards obesity raises questions whether other cardiovascula...

journal_title：Clinical endocrinology

authors： Roche EF,Charmandari E,Dattani MT,Hindmarsh PC

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

journal_title：Clinical endocrinology

authors： Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

更新日期：2016-04-01 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evid...

journal_title：Clinical endocrinology

authors： Livingstone C,Borai A

更新日期：2014-06-01 00:00:00

abstract：:The cardiovascular response and the changes of plasma arginine vasopressin (AVP) concentration following graded doses of AVP infused intravenously have been defined in six normal young men. The same measurements were also made during fluid deprivation in a patient with both nephrogenic diabetes insipidus and systemic ...

journal_title：Clinical endocrinology

authors： Khokhar AM,Slater JD,Ma J,Ramage CM

更新日期：1980-09-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is associated with a varied clinical presentation. The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes. DESIGN:An obser...

journal_title：Clinical endocrinology

authors： Owen PJ,Chatterjee VK,John R,Halsall D,Lazarus JH

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume. OBJECTIVE:To evaluate the potential usefulness of MR methodology, to estimate adrenal size ...

journal_title：Clinical endocrinology

authors： Mouritsen A,Johansen ML,Wohlfahrt-Veje C,Hagen CP,Tinggaard J,Mieritz MG,Tefre de Renzy-Martin K,Soeborg T,Fallentin E,Juul A,Main KM

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

journal_title：Clinical endocrinology

authors： Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Parathyroid carcinoma remains difficult to diagnose. Recently, it has been shown that mutations in the HRPT2 gene (encoding parafibromin) are associated with the development of parathyroid carcinoma. Although MEN1 is not typically thought to be involved in carcinoma formation, parathyroid carcinoma may be an ...

journal_title：Clinical endocrinology

authors： Haven CJ,van Puijenbroek M,Tan MH,Teh BT,Fleuren GJ,van Wezel T,Morreau H

更新日期：2007-09-01 00:00:00

abstract：:Plasma aldosterone (PA), plasma renin activity (PRA), extracellular fluid volume (EFV) and hepatic blood flow were measured in forty-four patients with sustained essential hypertension and compared with forty-two normotensive controls of same age and sex. All patient had inulin clearances within the normal range and b...

journal_title：Clinical endocrinology

authors： Safar ME,Simon AC,Dard SA,Parlier HR,Pauleau NE,Vincent ML,Sassard JE

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether, in the absence of gonads, GH could bring forward the age of neuroendocrine activation resulting in onset of puberty. DESIGN:In girls with Turner's syndrome, we evaluated the effects of GH therapy on developmental changes in FSH serum concentrations used as an indicator of ...

journal_title：Clinical endocrinology

authors： Bourguignon JP,Gérard A,Deby-Dupont G,Franchimont P

更新日期：1993-07-01 00:00:00

abstract：:Rathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC...

journal_title：Clinical endocrinology

authors： Trifanescu R,Ansorge O,Wass JA,Grossman AB,Karavitaki N

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：:Urinary immunoreactive PGA and PGE, plasma and urinary aldosterone, and plasma renin activity (PRA) were determined in eleven control subjects and four patients with diabetic hyporeninaemic hypoaldosteronism (HH) before and during 4 days of sodium chloride restriction and frusemide administration. Aldosterone and PRA ...

journal_title：Clinical endocrinology

authors： Farese RV,Rodriguez-Colomé M,O'Malley BC

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). ...

journal_title：Clinical endocrinology

authors： Cahoon EK,Rozhko A,Hatch M,Polyanskaya O,Ostroumova E,Tang M,Nadirov E,Yauseyenka V,Savasteeva I,McConnell RJ,Pfeiffer RM,Brenner AV

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Androgen insensitivity syndromes (AIS) in subjects with 46, XY karyotype and normal or even elevated androgen blood levels are characterized by various aberrations in male differentiation and virilization. AIS is often accompanied by a broad spectrum of abnormal binding characteristics of the androgen recepto...

journal_title：Clinical endocrinology

authors： Weidemann W,Linck B,Haupt H,Mentrup B,Romalo G,Stockklauser K,Brinkmann AO,Schweikert HU,Spindler KD

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Whether or not the distribution of biologically active fragments in TSAb-IgG molecules parallels antigen-binding activity in other anti-thyroidal antibodies was examined. DESIGN:Both the thyroid stimulating (TS) activity (cAMP production in thyroid cells) and TSH binding inhibition (TBI) activity (determined...

journal_title：Clinical endocrinology

authors： Kouki T,Inui T,Hachiya T,Okabe H,Ochi Y,Kajita Y

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:There are advantages and disadvantages with all of the presently available types of testosterone replacement for hypogonadal men. We performed this investigation to establish detailed data about the pharmacokinetics, pharmacodynamics, feasibility and side-effects of subcutaneously implanted testosterone (T) p...

journal_title：Clinical endocrinology

authors： Jockenhövel F,Vogel E,Kreutzer M,Reinhardt W,Lederbogen S,Reinwein D

更新日期：1996-07-01 00:00:00

abstract：INTRODUCTION:The present clinical investigation uses a high-precision GH immunofluorometric assay to examine the postulate that principally the amplitude mode of GH secretory control is disrupted in adults with GH deficiency. PATIENTS AND METHODS:To this end, we investigated GH secretory dynamics in a cohort of 19 adu...

journal_title：Clinical endocrinology

authors： Roelfsema F,Biermasz NR,Veldhuis JD

更新日期：2002-01-01 00:00:00

abstract：:Immunoreactive calcitonin was found in extracts of seven out of eight consecutive breast carcinomas and four selected lung carcinomas, but not in extracts of benign breast lesions or normal tissues. This suggests that the high plasma calcitonin levels observed in patients with a wide variety of cancers reflect ectopic...

journal_title：Clinical endocrinology

authors： Hillyard CJ,Coombes RC,Greenberg PB,Galante LS,MacIntyre I

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:We determined the ovarian response to human chorionic gonadotrophin (hCG) in terms of relaxin and progesterone secretion during the peri-implantation period of normal and failing pregnancies. We wished to test the hypotheses that relaxin production in failing pregnancies is different from that in normal pregn...

journal_title：Clinical endocrinology

authors： Stewart DR,Overstreet JW,Celniker AC,Hess DL,Cragun JR,Boyers SP,Lasley BL

更新日期：1993-04-01 00:00:00