The relationship between hCG and relaxin secretion in normal pregnancies vs peri-implantation spontaneous abortions.

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：:The antigenicity of HCG was tested in twenty-three young healthy men receiving two different HCG preparations (A and B). Each subject received 5000 i.u. HCG intramuscularly daily for three consecutive days, followed by another course, 3 weeks later, of 5000 i.u. HCG injections daily for 3 days. Two of the fifteen subj...

journal_title：Clinical endocrinology

authors： Nieschlag E,Bernitz S,Töpert M

更新日期：1982-05-01 00:00:00

abstract：:Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. Recombinant human (rh) insulin-like growth factor-1 (rhIGF-1) therapy is approved for severe primary IGF-I deficiency - a state of severe GH resistance. Evidence is increasing for an unacceptably high rate of p...

journal_title：Clinical endocrinology

authors： Bang P,Ahmed SF,Argente J,Backeljauw P,Bettendorf M,Bona G,Coutant R,Rosenfeld RG,Walenkamp MJ,Savage MO

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:The intravenous low-dose ACTH test has been proposed as a sensitive tool to assess adrenal function through circulating steroids. The aims of this study were to: (a) find the minimal intramuscular ACTH dose that induced serum and salivary cortisol and aldosterone responses equivalent to those obtained after a...

journal_title：Clinical endocrinology

authors： Contreras LN,Arregger AL,Persi GG,Gonzalez NS,Cardoso EM

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine (1) the diurnal variation in SHBG and (2) the inter-relationships of insulin, IGF-I, SHBG and IGFBP-1 over 24 hours in 10 women with anovulatory PCOS and compare them with weight-matched ovulatory controls. PATIENTS AND METHODS:The two groups comprised 10 anovulatory wom...

journal_title：Clinical endocrinology

authors： Hamilton-Fairley D,White D,Griffiths M,Anyaoku V,Koistinen R,Seppälä M,Franks S

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:There are advantages and disadvantages with all of the presently available types of testosterone replacement for hypogonadal men. We performed this investigation to establish detailed data about the pharmacokinetics, pharmacodynamics, feasibility and side-effects of subcutaneously implanted testosterone (T) p...

journal_title：Clinical endocrinology

authors： Jockenhövel F,Vogel E,Kreutzer M,Reinhardt W,Lederbogen S,Reinwein D

更新日期：1996-07-01 00:00:00

abstract：:In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

journal_title：Clinical endocrinology

authors： Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

更新日期：1987-01-01 00:00:00

abstract：:Cushing's syndrome in pregnancy is rare but associated with a high fetal loss rate, premature labour and excessive maternal morbidity. There has been controversy regarding the safety and efficacy of surgical treatment during pregnancy. We describe two further cases, both due to adrenal adenomas, in whom the diagnosis ...

journal_title：Clinical endocrinology

authors： Bevan JS,Gough MH,Gillmer MD,Burke CW

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. DESIGN:In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated th...

journal_title：Clinical endocrinology

authors： Burman P,Hetta J,Wide L,Månsson JE,Ekman R,Karlsson FA

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:In polycystic ovary syndrome (PCOS) inappropriate gonadotrophin secretion is characterized by increased pulse frequency and amplitude, elevated 24-h mean serum concentrations, and greater responses to GnRH. While the mechanism(s) responsible for this increased release of LH are not well underst...

journal_title：Clinical endocrinology

authors： Patel K,Coffler MS,Dahan MH,Malcom PJ,Deutsch R,Chang RJ

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Appropriate replacement doses of glucocorticoid are important to determine in primary and secondary adrenal deficiency in children, both to avoid the risks of hypoglycaemia and adrenal crisis associated with undertreatment, and to avoid growth suppression and reduced final height potential associated with ste...

journal_title：Clinical endocrinology

authors： DeVile CJ,Stanhope R

更新日期：1997-07-01 00:00:00

abstract：:Fasting plasma proinsulin, insulin and glucose concentrations were measured in ten women with mild gestational diabetes and ten controls matched for race, age (32 +/- 6 vs 31 +/- 6 years), body mass index (28 +/- 8 vs 27 +/- 6) and gestational week (24 +/- 4 vs 25 +/- 4 weeks). There was no significant difference in f...

journal_title：Clinical endocrinology

authors： Dornhorst A,Davies M,Anyaoku V,Hampton SM,Elkeles RS,Beard RW,Johnston DG

更新日期：1991-03-01 00:00:00

abstract：:Hypercalcaemia, a common complication of malignancy, may result from either the lytic effect of multiple osseous metastases or the effect of tumour-derived humoral factors. Excessive secretion of parathyroid hormone-related peptide (PTHrP), a major cause of humoral hypercalcaemia of malignancy, has been incriminated a...

journal_title：Clinical endocrinology

authors： Mantzoros CS,Suva LJ,Moses AC,Spark R

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Although abnormalities of the humoral immune system, such as increased immunoglobulin production, are known in sarcoidosis, the relationship between sarcoidosis and autoimmune disorders in uncertain. We studied the incidence of thyroid autoantibodies and the prevalence of Hashimoto's thyroiditis in patients w...

journal_title：Clinical endocrinology

authors： Nakamura H,Genma R,Mikami T,Kitahara A,Natsume H,Andoh S,Nagasawa S,Nishiyama K,Chida K,Sato A,Yoshimi T

更新日期：1997-04-01 00:00:00

abstract：:Thyroid status was estimated serially by measuring triiodothyronine (T3), thyroxine (T4) and thyrotrophin (hTSH) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. Significantly low T3 and only slightly increased T4 were observed in all the patients. hTSH was norma...

journal_title：Clinical endocrinology

authors： Maharajan G,Etta KM,Singh A,Ahuja IS,Ahuja GK

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN:Members of all major endocrine and andrological societies were invited to pa...

journal_title：Clinical endocrinology

authors： Grossmann M,Anawalt BD,Wu FC

更新日期：2015-02-01 00:00:00

abstract：:A 39-year-old woman presented with secondary amenorrhoea in the absence of galactorrhoea, hirsutism or virilization. Investigation revealed a strikingly elevated serum testosterone, dihydrotesterone, free testosterone and LH level. At laparotomy a large granulosa cell tumour was encountered and totally removed. Analys...

journal_title：Clinical endocrinology

authors： Taylor HC,Velasco ME,Flores SG,Berg G,Brown TR

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:To determine whether early (4-8h) post-operative ACTH after trans-sphenoidal surgery (TSS) predicts long-term hypothalamic-pituitary-adrenal (HPA) axis function and to investigate early morning day 1 ACTH/cortisol variability using rapid sampling. DESIGN:Prospective observational study. METHODS:Participants...

journal_title：Clinical endocrinology

authors： English KA,Chikani V,Jang C,Dimeski G,Olson S,Inder WJ

更新日期：2020-12-28 00:00:00

abstract：OBJECTIVE:Human GH treatment of short children who had intrauterine growth retardation (IUGR) results in a highly variable growth response. The object of this study was to test the hypothesis that differences in responsiveness to exogenously administered GH might reflect differences in endogenous GH secretion or sensit...

journal_title：Clinical endocrinology

authors： Frank GR,Cheung PT,Horn JA,Alfaro MP,Smith EP,Chernausek SD

更新日期：1996-06-01 00:00:00

abstract：:The biological response, as measured in the cytochemical bioassay, to the high circulating levels of immunoreactive parathyroid hormone (iPTH) in patients with pseudohypoparathyroidism type I (PSPI) is affected by the presence of an endogenous inhibitor. This is evidenced by the reduced recovery of the biological acti...

journal_title：Clinical endocrinology

authors： Loveridge N,Fischer JA,Devogelaer JP,Nagant de Deuxchaisnes C

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or...

journal_title：Clinical endocrinology

authors： Binder G,Schweizer R,Blumenstock G,Braun R

更新日期：2015-01-01 00:00:00

abstract：:In recent years the techniques of molecular and cellular biology have made it possible to begin to dissect the origins and behaviour of the ACTH-secreting tumour cell. It is becoming apparent that these tumours represent undifferentiated neuroendocrine cells, and it may be that their peptide-secreting properties may h...

journal_title：Clinical endocrinology

authors： White A,Clark AJ

更新日期：1993-08-01 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in lack of cortisol and often aldosterone and overproduction of androgens. Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice. D...

journal_title：Clinical endocrinology

authors： Nygren U,Södersten M,Falhammar H,Thorén M,Hagenfeldt K,Nordenskjöld A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

journal_title：Clinical endocrinology

authors： Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

更新日期：1992-12-01 00:00:00

abstract：:100 mg i.m. sulpiride (a dopamine-receptor-blocking drug) led to a significant rise in plasma TSH in normal womem, in female patients with galactorrhoea, and, to a much more marked degree, in male and female patients with primary hypothyroidism. In the hypothyroid patients, there was a significant positive correlation...

journal_title：Clinical endocrinology

authors： Massara F,Camanni F,Belforte L,Vergano V,Molinatti GM

更新日期：1978-11-01 00:00:00

abstract：:Delayed puberty is defined arbitrarily on the basis of statistical consideration, when no signs of puberty have occurred at 2.0 SD (13.4 years in girls and 13.8 in boys) above the mean chronological age for the onset of puberty. The vast majority of these patients have no endocrine abnormality and their pubertal devel...

journal_title：Clinical endocrinology

authors： Albanese A,Stanhope R

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:The impact of exogenous GH on thyroid function remains controversial although most data add support to a stimulation of peripheral T4 to T3 conversion. For further elucidation we evaluated iodothyronine and circadian TSH levels in GH-deficient patients as part of a GH dose-response study. PATIENTS:Eight GH-d...

journal_title：Clinical endocrinology

authors： Jørgensen JO,Møller J,Laursen T,Orskov H,Christiansen JS,Weeke J

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:The molecular events leading to the development of GH-secreting pituitary tumours remain largely unknown. Gsalpha (GNAS1) mutations are found in 27-43% of sporadic GH-secreting adenomas in the Caucasian population, but the frequency of GNAS1 mutations in Japanese and Korean acromegalic patients was reported t...

journal_title：Clinical endocrinology

authors： Yamasaki H,Mizusawa N,Nagahiro S,Yamada S,Sano T,Itakura M,Yoshimoto K

更新日期：2003-04-01 00:00:00

abstract：:A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/l, physiological concentrations of insulin (50 mu/l) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung respond...

journal_title：Clinical endocrinology

authors： Stubbs WA,Morgan I,Lloyd B,Alberti KG

更新日期：1977-09-01 00:00:00