Effect of body mass index on the growth hormone response to clonidine stimulation testing in children with short stature.

abstract：:Familial neurohypophysial diabetes insipidus (FNDI) is a rare autosomal dominant syndrome stemming from the absence of arginine vasopressin (AVP). More than thirty-five different germline mutations in the arginine vasopressin-neurophysin II gene have been reported. These mutations are either in the signal peptide or s...

journal_title：Clinical endocrinology

authors： Boson WL,Sarubi JC,d'Alva CB,Friedman E,Faria D,De Marco L,Wajchenberg B

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:To report and explore potential reasons for undetectable or low-normal serum intact PTH levels in patients with surgically verified primary hyperparathyroidism with parathyroid adenomas, review the relevant literature, and offer suggestions for management of such patients occasionally encountered in clinical...

journal_title：Clinical endocrinology

authors： Bhadada SK,Cardenas M,Bhansali A,Mittal BR,Behera A,Chanukya GV,Nahar U,Rao DS

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

journal_title：Clinical endocrinology

authors： Delgrange E,Duprez T,Maiter D

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Whether nonalcoholic fatty liver disease (NAFLD) can predict atherosclerosis in obese patients remains unclear. The aim of our study was to investigate the usefulness of NAFLD and other cardiometabolic parameters in predicting subclinical atherosclerosis in obese patients. DESIGN, PATIENTS AND MEASUREMENTS:W...

journal_title：Clinical endocrinology

authors： Puig J,Blasco G,Daunis-I-Estadella J,Loshuertos E,Codina J,Cuba V,Ortiz R,Xifra G,Ricart W,Pedraza S,Federici M,Fernández-Real JM

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that patients with hyperprolactinaemia due to biologically inactive macroprolactin will not show the characteristically increased dopaminergic inhibition of TSH release seen in patients with microprolactinomas secreting biologically active monomeric PRL. DESIGN:Comparison of the TSH an...

journal_title：Clinical endocrinology

authors： Pinto LP,Hanna FW,Evans LM,Davies JS,John R,Scanlon MF

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:With increasing use of computed tomography and magnetic resonance imaging, pituitary adenomas are being discovered incidentally with increasing frequency. However, limited data are available concerning the clinical importance and natural history of such 'incicentalomas'. We have undertaken a prospective study...

journal_title：Clinical endocrinology

authors： Feldkamp J,Santen R,Harms E,Aulich A,Mödder U,Scherbaum WA

更新日期：1999-07-01 00:00:00

abstract：:The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

journal_title：Clinical endocrinology

authors： Lamberts SW,Verleun T,Hofland L,Del Pozo E

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN:Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2...

journal_title：Clinical endocrinology

authors： Wittert GA,Espiner EA,Richards AM,Donald RA,Livesey JH,Yandle TG

更新日期：1993-02-01 00:00:00

abstract：:Pituitary-dependent Cushing's syndrome is rare in childhood. Two patients are reported who had unsuccessful transsphenoidal microadenomectomy and therefore underwent pituitary radiotherapy. In both patients there was progressive normalization of hypothalamo-pituitary-adrenal function and at 8 and 10 years after radiot...

journal_title：Clinical endocrinology

authors： Johnston LB,Grossmann AB,Plowman PN,Besser GM,Savage MO

更新日期：1998-05-01 00:00:00

abstract：:Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...

journal_title：Clinical endocrinology

authors： Elte JW,Wiarda KS,Frölich M,Haak A

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:A relationship between the serotoninergic and the opiatergic system in the pathogenesis of head pain is supported by several data. This study was carried out to investigate the neuroendocrine effects of sumatriptan, a specific serotonin agonist used in the treatment of migraine, on hypothalamic-pituitary-adre...

journal_title：Clinical endocrinology

authors： Facchinetti F,Nappi RE,Sances G,Fioroni L,Nappi G,Genazzani AR

更新日期：1994-02-01 00:00:00

abstract：:Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagno...

journal_title：Clinical endocrinology

authors： Nixon AM,Provatopoulou X,Kalogera E,Zografos GN,Gounaris A

更新日期：2017-08-01 00:00:00

abstract：:The concentration of immunoreactive inhibin in serum was measured in three pregnant women with premature ovarian failure involved in a donor oocyte in-vitro fertilization programme. Inhibin was not detectable in peripheral serum prior to conception but rose within 2-4 weeks of embryo transfer, whereafter levels rose g...

journal_title：Clinical endocrinology

authors： McLachlan RI,Healy DL,Lutjen PJ,Findlay JK,De Kretser M,Burger HG

更新日期：1987-12-01 00:00:00

abstract：:We have recently reported an impaired growth hormone (GH) response to a single i.v. bolus dose of growth hormone releasing factor (1 microgram/kg body weight) in obese women. We have now investigated whether the i.v. administration of low dose GHRF(1-29)NH2 (0.33 microgram/kg/h) by 15 min pulsed injections for 3 h fol...

journal_title：Clinical endocrinology

authors： Kopelman PG,Noonan K

更新日期：1986-02-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to elucidate the parathyroid responsiveness by measurements of blood ionized calcium and serum intact parathyroid hormone (PTH) concentrations, before and during trisodium citrate induced hypocalcaemia. PATIENTS AND CONTROLS:Sixteen patients with primary hyperparathyroi...

journal_title：Clinical endocrinology

authors： Schwarz P,Sørensen HA,Momsen G,McNair P,Transbøl I

更新日期：1992-10-01 00:00:00

abstract：:3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

journal_title：Clinical endocrinology

authors： Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

更新日期：2012-09-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...

journal_title：Clinical endocrinology

authors： van Dam PS,Dieguez C,Cordido F,de Vries WR,Veldhuyzen BF,van Thiel E,Casanueva FF,Koppeschaar HP

更新日期：2003-02-01 00:00:00

abstract：:Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

journal_title：Clinical endocrinology

authors： Grant SJ,Luttrell BM,Hales IB

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:In the present study we have performed a grey-scale quantitative analysis of thyroid echogenicity in the patients affected by Hashimoto's thyroiditis (HT), obtaining a numerical estimate of the degree of hypoechogenicity associated with the appearance of thyroid dysfunction. MATERIALS AND METHODS:The study g...

journal_title：Clinical endocrinology

authors： Mazziotti G,Sorvillo F,Iorio S,Carbone A,Romeo A,Piscopo M,Capuano S,Capuano E,Amato G,Carella C

更新日期：2003-08-01 00:00:00

abstract：:OBJECTIVE The aim of the study was to investigate whether pyridostigmine, a cholinesterase inhibitor which is thought to act at the hypothalamus to inhibit somatostatin secretion, would augment spontaneous or GHRH-stimulated serum GH levels in patients with GH-insufficiency. DESIGN Oral pyridostigmine 60 mg or placebo...

journal_title：Clinical endocrinology

authors： Kirk JM,Ross RJ,Trainer PJ,Froud AL,Davies SC,Savage MO,Besser GM

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging U...

journal_title：Clinical endocrinology

authors： Choi JS,Lee HS,Kim EK,Moon HJ,Kwak JY

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains u...

journal_title：Clinical endocrinology

authors： Tang Y,Qiao P,Qu X,Bao Y,Li Y,Liao Y,Ying H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

journal_title：Clinical endocrinology

authors： Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:We have demonstrated previously that obesity in men was significantly associated with low plasma testosterone levels and higher concentrations of the androgen metabolite androstane-3 alpha, 17 beta-diol glucuronide, suggesting that androgen metabolism and elimination is increased in this condition. The objec...

journal_title：Clinical endocrinology

authors： Tchernof A,Lévesque E,Beaulieu M,Couture P,Després JP,Hum DW,Bélanger A

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

journal_title：Clinical endocrinology

authors： Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

更新日期：2006-11-01 00:00:00