Is oleic acid the thyroxine binding inhibitor in the serum of ill patients?

abstract：OBJECTIVES:Localization of ectopic ACTH-secreting tumours causing Cushing syndrome (ECS) is essential for clinical management, yet often difficult. [68 Ga]-DOTATATE PET/CT ([68 Ga]-DOTA-(Tyr3 )-octreotate)] is an FDA-approved high-resolution diagnostic tool for imaging neuroendocrine tumours. Data on the clinical utili...

journal_title：Clinical endocrinology

authors： Wannachalee T,Turcu AF,Bancos I,Habra MA,Avram AM,Chuang HH,Waguespack SG,Auchus RJ

更新日期：2019-08-01 00:00:00

abstract：:A 39-year-old woman presented with secondary amenorrhoea in the absence of galactorrhoea, hirsutism or virilization. Investigation revealed a strikingly elevated serum testosterone, dihydrotesterone, free testosterone and LH level. At laparotomy a large granulosa cell tumour was encountered and totally removed. Analys...

journal_title：Clinical endocrinology

authors： Taylor HC,Velasco ME,Flores SG,Berg G,Brown TR

更新日期：1982-12-01 00:00:00

abstract：:The improvement in iodine status among the UK population from the 1930s onwards has been described as an 'accidental public health triumph' despite the lack of any iodine fortification program. However, iodine deficiency in the UK has re-emerged in vulnerable groups and is likely due to a combination of changing farmi...

journal_title：Clinical endocrinology

authors： Woodside JV,Mullan KR

更新日期：2020-11-29 00:00:00

abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

journal_title：Clinical endocrinology

authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. DESIGN:In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated th...

journal_title：Clinical endocrinology

authors： Burman P,Hetta J,Wide L,Månsson JE,Ekman R,Karlsson FA

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...

journal_title：Clinical endocrinology

authors： van Dam PS,Dieguez C,Cordido F,de Vries WR,Veldhuyzen BF,van Thiel E,Casanueva FF,Koppeschaar HP

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Skewed X chromosome inactivation (XCI) was associated with female predominance in adult autoimmune thyroid disease (ATD). In normal females, skewed XCI is increased with age. Whether early-onset skewed XCI is associated with childhood ATD remains unknown. This study aimed to determine XCI skewing in paediatri...

journal_title：Clinical endocrinology

authors： Santiwatana S,Mahachoklertwattana P,Limwongse C,Khlairit P,Pongratanakul S,Roothumnong E,Prangphan K,Choubtum L,Songdej D,Poomthavorn P

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

journal_title：Clinical endocrinology

authors： Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Clinical acromegaly is characterized by dysregulation of somatotroph GH secretion in the presence of high circulating serum IGF-I levels. Physiologically, IGF-I exerts a negative feedback on GH secretion at both the hypothalamic and the pituitary levels. We have previously shown that the 943 an...

journal_title：Clinical endocrinology

authors： Greenman Y,Prager D,Melmed S

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Circulating testosterone declines during male ageing, and low testosterone may predispose to ill health. We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men. DESIGN:Cross-sectional analysis of a population...

journal_title：Clinical endocrinology

authors： Yeap BB,Almeida OP,Hyde Z,Norman PE,Chubb SA,Jamrozik K,Hankey GJ,Flicker L

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Insulin and glucocorticoids are known to increase total leptin levels. However, the effects of insulin and glucocorticoids on the components of the leptin system - free leptin (FL), bound leptin (BL) and soluble leptin receptor (SR) - have not been elucidated. The aim of this study was to determine if there i...

journal_title：Clinical endocrinology

authors： Lewandowski K,Randeva HS,O'Callaghan CJ,Horn R,Medley GF,Hillhouse EW,Brabant G,O'Hare P

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：:The best long-term results of transsphenoidal surgery appear to be in those patients who have unmeasurable serum cortisol levels in the immediate post-operative period. This appears to be due to isolated ACTH deficiency in the remaining normal pituitary gland. In our experience, however, long-term clinical remission m...

journal_title：Clinical endocrinology

authors： McCance DR,Besser M,Atkinson AB

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:One of the aims of a subcutaneous (SC) injection is to avoid intradermal or intramuscular injections. Pen systems are an alternative solution to single-use syringes and have become standard for example diabetes therapy. Shorter and smaller needles minimize pain and the risk of intramuscular injections. The th...

journal_title：Clinical endocrinology

authors： Ludescher B,Rommel M,Willmer T,Fritsche A,Schick F,Machann J

更新日期：2011-12-01 00:00:00

abstract：:Changes in the excretion of urinary cyclic AMP, calcium and phosphate, and serum calcium, ionized calcium, and magnesium were studied after parathyroidectomy for primary hyperparathyroidism. Urinary cyclic AMP decreased rapidly and 8 of 11 patients had a significant reduction 1 h postoperatively, but changes in serum ...

journal_title：Clinical endocrinology

authors： Kohri K,Kataoka K,Yachiku S,Kurita T,Sonoda T

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:Although the polymorphisms of the cytotoxic T lymphocyte antigen 4 (CTLA4) gene have been shown to be associated with Type 1 diabetes in Caucasians, some conflicting results have been reported among subjects of different ethnic backgrounds. We examined a CTLA4 polymorphism and its relationship to human leucoc...

journal_title：Clinical endocrinology

authors： Kikuoka N,Sugihara S,Yanagawa T,Ikezaki A,Kim HS,Matsuoka H,Kobayashi Y,Wataki K,Konda S,Sato H,Miyamoto S,Sasaki N,Sakamaki T,Niimi H,Murata M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:The diagnostic impact of chromogranin A (CgA) measurement has been studied in various neuroendocrine tumours (NET) such as pheochromocytomas, gastrinomas and neuroblastomas. Clinically nonfunctioning pituitary adenomas (NFPA) are generally diagnosed on tumoural symptoms or hypopituitarism and, except for gona...

journal_title：Clinical endocrinology

authors： Gussi IL,Young J,Baudin E,Bidart JM,Chanson P

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Glucagon-like peptide-1 is an insulin secretion-stimulating gut hormone that is produced in response to food intake. Orlistat (Xenical, F. Hoffman-La Roche, Basel, Switzerland), which decreases fat absorption and increases intestinal fat content, may therefore affect the secretion of glucagon-like peptide-1. ...

journal_title：Clinical endocrinology

authors： Sahin M,Tanaci N,Yucel M,Tutuncu NB,Guvener N

更新日期：2007-09-01 00:00:00

abstract：:We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

journal_title：Clinical endocrinology

authors： Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In ...

journal_title：Clinical endocrinology

authors： de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr T

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Traditional methods of bone densitometry may not provide a comprehensive assessment of bone health. We aimed to assess bone micro-architecture and bone marrow adiposity (BMA) by MRI in adults with osteogenesis imperfecta (OI) and endocrinopathy including GH deficiency and/or hypogonadism. MEASUREMENTS:High-r...

journal_title：Clinical endocrinology

authors： McComb C,Harpur A,Yacoubian C,Leddy C,Anderson G,Shepherd S,Perry C,Shaikh MG,Foster J,Ahmed SF

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:It has previously been shown that patients with postpartum pituitary necrosis (Sheehan's syndrome, SS) have paradoxically increased TSH levels and loss of the nocturnal TSH surge. This study sought to determine the circadian and pulsatile characteristics of TSH secretion underlying those abnormalities. DESIG...

journal_title：Clinical endocrinology

authors： MacCagnan P,Oliveira JH,Castro V,Abucham J

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:To optimize the indications for treating girls with idiopathic central precocious puberty with GnRH analogues, since outcomes may vary. DESIGN:Comparison of adult heights with the data at initial evaluation and the target heights. PATIENTS:Group 1 patients (n = 43) were treated with GnRH analogue from 7.9 ...

journal_title：Clinical endocrinology

authors： Adan L,Chemaitilly W,Trivin C,Brauner R

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

journal_title：Clinical endocrinology

authors： Hopkins KD,Holdaway IM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEA...

journal_title：Clinical endocrinology

authors： Mäntyselkä A,Jääskeläinen J,Eloranta AM,Väistö J,Voutilainen R,Ong K,Brage S,Lakka TA,Lindi V

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

journal_title：Clinical endocrinology

authors： Holmer H,Link K,Erfurth EM

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of prenatal dexamethasone treatment in offspring at risk for congenital adrenal hyperplasia. METHODS:MEDLINE, EMBASE, the Cochrane Library, the clinicaltrials.gov website databases were systematically searched from inception through March 2019. WMD and SMD with 95%CIs were c...

journal_title：Clinical endocrinology

authors： Xu L,Lin W,Cai L,Huang H,Liang J,Li L,Zong L,Wang N,Wen J,Chen G

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:The prevalence of cardiovascular risk factors in congenital adrenal hyperplasia (CAH) varies widely. In the light of recent changes in treatment regimens, we have reassessed the prevalence of these risk factors in our current cohort of patients with CAH due to P450c21 deficiency. METHODS:A retrospective cros...

journal_title：Clinical endocrinology

authors： Subbarayan A,Dattani MT,Peters CJ,Hindmarsh PC

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Diagnosing thyroid nodules preoperatively using traditional diagnostic tools - ultrasonography (US) and cytology - still carries a considerable degree of uncertainty, and surgery is recommended for a far from negligible number of patients simply for diagnostic purposes. Thyroid elastosonography (USE) and BRAF...

journal_title：Clinical endocrinology

authors： Nacamulli D,Nico L,Barollo S,Zambonin L,Pennelli G,Girelli ME,Casal Ide E,Pelizzo MR,Vianello F,Negro I,Watutantrige-Fernando S,Mantero F,Rugge M,Mian C

更新日期：2012-10-01 00:00:00

abstract：:Hyperthyroidism is a well recognized complication of gestational trophoblastic tumours (GTT) and may be due to high circulating concentrations of human chorionic gonadotrophin (hCG) or its variants. We have studied 24 clinically euthyroid women with GTT. Eight were biochemically hyperthyroid with low or undetectable s...

journal_title：Clinical endocrinology

authors： Kennedy RL,Sheridan E,Darne J,Griffiths H,Davies R,Price A,Cohn M

更新日期：1990-08-01 00:00:00