Different states of clinical control are associated with changes in IGF-I and IGFBPs in children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

abstract：OBJECTIVE:A high prevalence of diabetes mellitus has been shown in patients with primary hyperparathyroidism (PHPT). However, it is unclear whether this is related to the metabolic abnormalities in PHPT or to the presence of other risk factors for glucose intolerance in these patients. The aim of our study was to deter...

journal_title：Clinical endocrinology

authors： Kumar S,Olukoga AO,Gordon C,Mawer EB,France M,Hosker JP,Davies M,Boulton AJ

更新日期：1994-01-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours that arise from the adrenal medulla or extra-adrenal sympathetic or parasympathetic paraganglia. Recent advances in genetics have greatly enhanced understanding of the pathogenesis and molecular physiology of PPGL. Concomitantly, advances in molecular imag...

journal_title：Clinical endocrinology

authors： Ryder SJ,Love AJ,Duncan EL,Pattison DA

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:To define and discuss the changes of important risk factors and TNM staging over the last 40 years in patients operated on for differentiated thyroid carcinoma (DTC), resulting from the introduction of newer sensitive diagnostic procedures in the preoperative evaluation of thyroid nodules. PATIENTS:We review...

journal_title：Clinical endocrinology

authors： Karga H,Mavroudis K,Giagourta I,Triantaphyllopoulou M,Ktena V,Kassi G,Veloutsou H,Papapetrou P

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Mutations in CYP21A2 lead to deficiency of 21-hydroxylase and can have either severe or moderate effects on phenotype, which can be prevented by early treatment. We studied long-term effects of this deficiency on phenotype in patients who had not been treated for prolonged periods and correlated these phenot...

journal_title：Clinical endocrinology

authors： Goossens K,Juniarto AZ,Timmerman MA,Faradz SM,Wolffenbuttel KP,Drop SL,de Jong FH

更新日期：2009-11-01 00:00:00

abstract：:We describe a 40-year-old male with acromegaly, multiple and recurrent cutaneous myxomas, spotty cutaneous pigmentation, a mammary myxoma, a large-cell calcifying Sertoli cell tumour of the testis, and an unusual calcifying pigmented neuroectodermal tumour. He presented a combination of clinical and histological featu...

journal_title：Clinical endocrinology

authors： Leedman PJ,Cohen AK,Matz LR

更新日期：1986-11-01 00:00:00

abstract：:Anorexia nervosa is associated with several abnormalities in GH secretion elicited by different stimuli. To investigate the precise mechanism of this alteration, GHRH was administered to 14 women: a group of eight anorexia nervosa patients in the acute phase of their illness and a control group of six age-matched volu...

journal_title：Clinical endocrinology

authors： Casanueva FF,Borras CG,Burguera B,Lima L,Muruais C,Tresguerres JA,Devesa J

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (...

journal_title：Clinical endocrinology

authors： Qasim AN,Budharaju V,Mehta NN,St Clair C,Farouk S,Braunstein S,Schutta M,Iqbal N,Rader DJ,Reilly MP

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:We wished to assess the changes in serum IGF-I and IGF-II concentrations during gonadotrophin treatment alone or with additional GH treatment and to compare follicular fluid IGF-I and IGF-II concentrations in the two treatment groups. DESIGN:We performed an open study of co-treatment with GH and subsequently...

journal_title：Clinical endocrinology

authors： Owen EJ,Torresani T,West C,Mason BA,Jacobs HS

更新日期：1991-10-01 00:00:00

abstract：:The glucose and immunoreactive insulin (IRI) responses to a 100 g oral glucose tolerance test (oGTT) administered to 23 acromegalic patients before and after transsphenoidal adenomectomy and to a sex and age-matched control group were studied. The preoperative growth hormone levels, ranging from 11 to 360 mU/l, had no...

journal_title：Clinical endocrinology

authors： Roelfsema F,Frölich M

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:Provocative stimulation tests for GH assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to evaluate the capability of pegvisomant, as an enhancer of GH secretion, in unmasking false-positive results in short children undergoing GH test...

journal_title：Clinical endocrinology

authors： Radetti G,Wu Z,Elsedfy HH,El Kholy M,Bozzola M,Strasburger CJ

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Obesity is a major risk factor for coronary heart disease, and surgical treatment of obese patients as part of a multidisciplinary approach seems to provide faster results than diet therapy. The aim of this study was to evaluate the effect of dermolipectomy on insulin action and inflammatory markers in 20 obe...

journal_title：Clinical endocrinology

authors： Rizzo MR,Paolisso G,Grella R,Barbieri M,Grella E,Ragno E,Grella R,Nicoletti G,D'Andrea F

更新日期：2005-09-01 00:00:00

abstract：:In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high curre...

journal_title：Clinical endocrinology

authors： Phillips DI,Barker DJ,Rees Smith B,Didcote S,Morgan D

更新日期：1985-09-01 00:00:00

abstract：:A wide variety of adverse effects of methimazole (MMI) have been reported. Here we report a new MMI-induced disorder, acute pancreatitis and parotitis. Three weeks after a woman started MMI treatment for Graves' disease, she developed a high fever, painful parotid swelling and dull pain in the upper abdomen with eleva...

journal_title：Clinical endocrinology

authors： Taguchi M,Yokota M,Koyano H,Endo Y,Ozawa Y

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEA...

journal_title：Clinical endocrinology

authors： Mäntyselkä A,Jääskeläinen J,Eloranta AM,Väistö J,Voutilainen R,Ong K,Brage S,Lakka TA,Lindi V

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

journal_title：Clinical endocrinology

authors： Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Hyperandrogenism is one of the characteristic features of the polycystic ovary syndrome (PCOS). Androgens are important for bone mass. Studies on bone mineral density (BMD) and fractures in postmenopausal women with PCOS are lacking. The aim of this study was to investigate whether postmenopausal women with P...

journal_title：Clinical endocrinology

authors： Schmidt J,Dahlgren E,Brännström M,Landin-Wilhelmsen K

更新日期：2012-08-01 00:00:00

abstract：:Twenty-three endemic goitrous subjects (goitre grade: III and IV) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms I/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of São Paulo, where daily iodine intake is estimat...

journal_title：Clinical endocrinology

authors： Lima N,Medeiros-Neto G

更新日期：1984-12-01 00:00:00

abstract：:A new radioreceptor assay for insulin-like growth factor-II (IGF-II), using receptors on ovine placental membranes, is described. Half-maximal displacement of specifically bound radioiodinated human IGF-II tracer was seen at 1.0 ng/tube of unlabelled IGF-II. The cross-reactivity of IGF-I was 1%, and insulin was entire...

journal_title：Clinical endocrinology

authors： Baxter RC,de Mellow JS

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

journal_title：Clinical endocrinology

authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:It has been well documented that treatment of chronic hepatitis B and C infection with interferon alpha (IFN-alpha) can lead to the induction of thyroid autoantibodies and hypothyroidism. Thyrotoxicosis, however, is less frequently observed and less well characterized. PATIENTS AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Wong V,Fu AX,George J,Cheung NW

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to elucidate the parathyroid responsiveness by measurements of blood ionized calcium and serum intact parathyroid hormone (PTH) concentrations, before and during trisodium citrate induced hypocalcaemia. PATIENTS AND CONTROLS:Sixteen patients with primary hyperparathyroi...

journal_title：Clinical endocrinology

authors： Schwarz P,Sørensen HA,Momsen G,McNair P,Transbøl I

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN:The study consists of a cross-sectional arm compari...

journal_title：Clinical endocrinology

authors： Kyriakakis N,Lynch J,Gilbey SG,Webb SM,Murray RD

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is a rare hereditary disorder. We present four patients from a single family with FIHP, and genetic analysis of their parathyroid adenomas and parathyroid carcinoma. DESIGN:DNA was extracted from tumours resected at surgery. Tumours were examined for loss ...

journal_title：Clinical endocrinology

authors： Yoshimoto K,Endo H,Tsuyuguchi M,Tanaka C,Kimura T,Iwahana H,Kato G,Sano T,Itakura M

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Pubertal gynaecomastia is a very common condition. Although the underlying aetiology is poorly understood, it is generally accepted that excess of oestrogens and deficit of androgens are involved in the pathogenesis. Furthermore, adiposity as well as the GH/IGF-I axis may play a role. In this study, we elucid...

journal_title：Clinical endocrinology

authors： Mieritz MG,Sorensen K,Aksglaede L,Mouritsen A,Hagen CP,Hilsted L,Andersson AM,Juul A

更新日期：2014-05-01 00:00:00

abstract：:We report the case of a male infant who at 10 days of life presented with salt-wasting. Congenital adrenal hyperplasia was excluded on the basis of normal 17 alpha-hydroxy-progesterone plasma levels evaluated before the onset of steroid replacement therapy. The incidental finding of hypertriglyceridaemia led us to sus...

journal_title：Clinical endocrinology

authors： Balducci R,Municchi G,Toscano V,Mangiantini A,Sabatini R,Caiola S,Tedeschi B,Orlandi L,Boscherini B

更新日期：1995-04-01 00:00:00

abstract：:An oestrogen provocation test was performed in five healthy women during chronic intranasal treatment with 400 or 600 micrograms of the superactive LHRH agonist D-Ser(TBU)6-EA10-LHRH daily. Oestradiol benzoate 2.5 mg was administered intramuscularly after at least 3 months of LHRH agonist treatment. The serum levels o...

journal_title：Clinical endocrinology

authors： Bergquist C,Nillius SJ,Wide L

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVE:Studies assessing quality of life in GH-deficient adults have shown varying results. This may be due to a number of factors including varying causes of GH deficiency, the use of radiotherapy in treatment and patient selection. We aimed to assess whether anterior pituitary hormone deficiency or external pituit...

journal_title：Clinical endocrinology

authors： Page RC,Hammersley MS,Burke CW,Wass JA

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVES:There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this a...

journal_title：Clinical endocrinology

authors： Choi SH,An JH,Lim S,Koo BK,Park SE,Chang HJ,Choi SI,Park YJ,Park KS,Jang HC,Shin CS

更新日期：2009-11-01 00:00:00

abstract：:In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

journal_title：Clinical endocrinology

authors： Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

更新日期：1987-01-01 00:00:00