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Mode of action of carbimazole in Graves' disease.

Abstract：

:In a series of hyperthyroid subjects treated with a high dose 'block-replace' regime, mean thyroidal technetium uptake was shown to fall progressively over an 18 month period. Furthermore, sub-total inhibition of hormone biosynthesis could be demonstrated, without evidence of proportionate inhibition of organification, the regression of radio-iodine on technetium thyroid uptake showing similar slopes in euthyroid, treated and untreated hyperthyroid subjects. Together with the reported differential in remission rates between propranolol and anti-thyroid drugs, it is concluded that carbimazole does not act solely by inhibiting intrathyroid hormono-genesis, but more definitively by affecting thyroid hyperstimulation at a pre-biosynthetic level. The inability to demonstrate normal suppressibility of trapping in any subject in the present series despite extended therapy with a 'block-replace' regime, further suggests that current concepts of 'suppressibility' are invalid, the progressive fall in technetium uptake being unlikely to represent spontaneous restoration of a normal pituitary-thyroid axis, but rather a direct influence or prolonged therapy with anti-thyroid drugs on the natural history of the disease.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Wise PH,Marion M,Pain R

doi

10.1111/j.1365-2265.1979.tb02124.x

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

655-64

issue

6

eissn

0300-0664

issn

1365-2265

journal_volume

10

pub_type

杂志文章

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