Clinical utility of telomerase for the diagnosis of malignant well-differentiated endocrine tumours.

abstract：OBJECTIVE:Antithyroidal drugs (ATD) are used in the management of Graves' disease either as primary therapy for several months while awaiting remission of the disease or as pretreatment for several weeks prior to definitive radioactive iodine therapy (RAI). We have reported previously that pretreatment with propylthiou...

journal_title：Clinical endocrinology

authors： Hancock LD,Tuttle RM,LeMar H,Bauman J,Patience T

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The aim was to determine the target range into which mean daily serum cortisol should be lowered in patients on medical therapy for Cushing's syndrome, using isotopically estimated cortisol production rates as 'gold standard'. DESIGN:Patients with Cushing's syndrome on medical treatment were given 12 ng of t...

journal_title：Clinical endocrinology

authors： Trainer PJ,Eastment C,Grossman AB,Wheeler MJ,Perry L,Besser GM

更新日期：1993-10-01 00:00:00

abstract：CONTEXT:In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE:To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) ...

journal_title：Clinical endocrinology

authors： Gautier A,Bonnet F,Dubois S,Massart C,Grosheny C,Bachelot A,Aubé C,Balkau B,Ducluzeau PH

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The disruption between the brain and the spinal cord leads to a decentralized sympathetic nervous system in people with chronic, cervical spinal cord lesions. These tetraplegic subjects are prone to disorders of energy metabolism and osteoporosis, and they experience alterations in their body composition with...

journal_title：Clinical endocrinology

authors： Hjeltnes N,De Groot P,Birkeland KI,Falch JA,Iversen PO

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

journal_title：Clinical endocrinology

authors： Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

更新日期：2015-01-01 00:00:00

abstract：:A gonadotrophin response testosterone producing adrenal cortical adenoma in a 61-year-old woman is described. Oophorectomy was performed before adrenalectomy as at first an ovarian origin of excess and androgen production was suspected. The hypophyseal gonadal feedback system was studied after oophorectomy using LHRH ...

journal_title：Clinical endocrinology

authors： de Lange WE,Pratt JJ,Doorenbos H

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to develop an assay for the measurement of thyroid blocking antibodies (TBAb), based on the ability of patient serum to inhibit TSH stimulated 3H-cAMP production following incubation of FRTL-5 or JPO9 cells with 3H-adenine. The assay was then used to evaluate a child born with neonat...

journal_title：Clinical endocrinology

authors： Michelangeli VP,Poon CW,Arnus EE,Frauman AG,Connelly J,Colman PG

更新日期：1995-01-01 00:00:00

abstract：:Ten patients (seven women, three men) with active acromegaly, five previously treated and five newly diagnosed, were included in an open-label prospective trial of 3 daily subcutaneous injections of the long-acting somatostatin analogue SMS 201-995 (Sandostatin) at increasing doses in order to obtain maximum growth ho...

journal_title：Clinical endocrinology

authors： Shi YF,Harris AG,Zhu XF,Deng JY

更新日期：1990-06-01 00:00:00

abstract：:Nine acromegalic patients were treated by the somatostatin analogue SMS 201-995 octreotide (Sandostatin (octreotide), Sandoz, Basle, Switzerland] 250 micrograms/day in 4 divided s.c. injections (50 + 50 + 50 + 100 micrograms) for 1 month, 250 micrograms/24 has continuous s.c. infusions for another month and thereafter...

journal_title：Clinical endocrinology

authors： Thuesen L,Christensen SE,Weeke J,Orskov H,Henningsen P

更新日期：1989-06-01 00:00:00

abstract：:It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

journal_title：Clinical endocrinology

authors： Thompson CJ,White MC,Baylis PH

更新日期：1989-05-01 00:00:00

abstract：:Thyroid function, the clinical occurrence of goitre and ultrasonically determined thyroid gland volume were investigated in 23 patients with phenytoin- and 28 patients with carbamazepine-treated convulsive disorders and compared with matched healthy controls. In the phenytoin treated group median thyroid volume was 26...

journal_title：Clinical endocrinology

authors： Hegedüs L,Hansen JM,Lühdorf K,Perrild H,Feldt-Rasmussen U,Kampmann JP

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVE:A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and auto...

journal_title：Clinical endocrinology

authors： Jennings CE,Owen CJ,Wilson V,Pearce SH

更新日期：2005-03-01 00:00:00

abstract：:Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanis...

journal_title：Clinical endocrinology

authors： Monticone S,Losano I,Tetti M,Buffolo F,Veglio F,Mulatero P

更新日期：2018-10-01 00:00:00

abstract：:The effect of clomiphene citrate on the occurrence and timing of the endogenous LH surge in superovulated cycles is unclear. To study further this event, five normally ovulating women were treated with clomiphene citrate 100 mg per day in two different cycles, that is, for 5 days in one cycle (days 2 to 6, CC-5) and f...

journal_title：Clinical endocrinology

authors： Messinis IE,Templeton A

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

journal_title：Clinical endocrinology

authors： Fuller PJ,Alexiadis M,Jobling T,McNeilage J

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

journal_title：Clinical endocrinology

authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:The diagnosis of the nonclassical form of 21-hydroxylase (NC-21OH) deficiency, established before molecular studies, is based on basal 17OH-progesterone (17OH-P) values > 15 nmol/l or ACTH-stimulated 17OH-P values > 30 nmol/l. This disease is caused by mutations in the structural gene that can be grouped into...

journal_title：Clinical endocrinology

authors： Bachega TA,Billerbeck AE,Marcondes JA,Madureira G,Arnhold IJ,Mendonca BB

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

journal_title：Clinical endocrinology

authors： Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

更新日期：1992-12-01 00:00:00

abstract：:Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evid...

journal_title：Clinical endocrinology

authors： Livingstone C,Borai A

更新日期：2014-06-01 00:00:00

abstract：:OBJECTIVE The aim of the study was to investigate whether pyridostigmine, a cholinesterase inhibitor which is thought to act at the hypothalamus to inhibit somatostatin secretion, would augment spontaneous or GHRH-stimulated serum GH levels in patients with GH-insufficiency. DESIGN Oral pyridostigmine 60 mg or placebo...

journal_title：Clinical endocrinology

authors： Kirk JM,Ross RJ,Trainer PJ,Froud AL,Davies SC,Savage MO,Besser GM

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

journal_title：Clinical endocrinology

authors： Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

更新日期：2011-02-01 00:00:00

abstract：:The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of st...

journal_title：Clinical endocrinology

authors： Ellemann K,Thorsteinsson B,Fugleberg S,Feldt-Rasmussen B,Andersen OO,Grønbaek P,Binder C

更新日期：1987-05-01 00:00:00

abstract：:Oestrogens are known to enhance both basal and stimulated GH secretion. To examine whether this effect is mediated through the hypothalamus or the pituitary we performed insulin tolerance and GH-releasing hormone (GHRH) tests with and without oestrogen priming in a group of 14 short children. Pretreatment with stilboe...

journal_title：Clinical endocrinology

authors： Ross RJ,Grossman A,Davies PS,Savage MO,Besser GM

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Depot somatostatin analogues are well accepted as either adjuvant or primary therapy for acromegaly, and their long dosage intervals facilitate adherence to treatment. Our objective was to evaluate whether lanreotide Autogel 120 mg, every 4-8 weeks, was as effective in controlling acromegaly as lan...

journal_title：Clinical endocrinology

authors： Lucas T,Astorga R,Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly.

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), ther...

journal_title：Clinical endocrinology

authors： Churchill SJ,Wang ET,Bhasin G,Alexander C,Bresee C,Pall M,Azziz R,Mathur R,Pisarska MD

更新日期：2015-09-01 00:00:00

abstract：CONTEXT:Unlike pituitary macroadenomas, microadenomas (micros) are not commonly associated with hypopituitarism. In clinical practice, we have observed that patients with ACTH-secreting micros have a higher than expected prevalence of central hypothyroidism (HT), and we speculated that this effect might be because of g...

journal_title：Clinical endocrinology

authors： Mathioudakis N,Thapa S,Wand GS,Salvatori R

更新日期：2012-12-01 00:00:00

abstract：:The response of serum calcium, PTH, CT and gastrin to an infusion of secretin (3 CU/kg/h) over a period of 90 min was studied in ten healthy males and two female patients with hypoparathyroidism. In the healthy males serum calcium, after a transient fall, significantly increased at 45 min after the onset of the infusi...

journal_title：Clinical endocrinology

authors： Lo Cascio V,Piubello W,Cominacini L,Vantini I,Galvanini G,Ederle A,Cavallini G,Scuro LA

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE:To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian). DESIGN AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Madeira JL,Nishi MY,Nakaguma M,Benedetti AF,Biscotto IP,Fernandes T,Pequeno T,Figueiredo T,Franca MM,Correa FA,Otto AP,Abrão M,Miras MB,Santos S,Jorge AA,Costalonga EF,Mendonca BB,Arnhold IJ,Carvalho LR

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine (1) the diurnal variation in SHBG and (2) the inter-relationships of insulin, IGF-I, SHBG and IGFBP-1 over 24 hours in 10 women with anovulatory PCOS and compare them with weight-matched ovulatory controls. PATIENTS AND METHODS:The two groups comprised 10 anovulatory wom...

journal_title：Clinical endocrinology

authors： Hamilton-Fairley D,White D,Griffiths M,Anyaoku V,Koistinen R,Seppälä M,Franks S

更新日期：1995-08-01 00:00:00

abstract：:To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence...

journal_title：Clinical endocrinology

authors： van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA

更新日期：1989-10-01 00:00:00