Sex hormone binding globulin in postmenopausal women: a predictor of osteoporosis superior to endogenous oestrogens.


:To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence of fractures and the rate of loss of RCA (delta-RCA) were determined over the previous 9 years. Both RCA and delta-RCA were significantly related to body mass, serum oestrone, oestradiol, and SHBG. The influence of the first three variables appeared to be bone preserving, whereas the latter appeared to be bone wasting. Serum oestradiol, SHBG and body mass proved to have an independent relationship with RCA in multivariate regression analysis. The relationship to delta-RCA was statistically independent for serum SHBG only. Serum androstenedione was unrelated to either RCA or delta-RCA. In the total study population, body mass, serum oestrone, oestradiol and SHBG were not related to the occurrence of fractures over the previous 9 years. In the subgroup of 249 elderly women, aged 65-76 years, SHBG levels were significantly higher for women with type I osteoporotic fractures (vertebral and forearm fractures) as compared to controls. The results suggest a bone wasting influence of SHBG in postmenopausal women, possibly resulting in an increased risk of type I osteoporotic fractures in elderly women.


Clin Endocrinol (Oxf)


Clinical endocrinology


van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA




Has Abstract


1989-10-01 00:00:00












  • Inhibition of 3-beta-hydroxy steroid dehydrogenase activity in first trimester human pregnancy with trilostane and WIN 32729.

    abstract::The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

    更新日期:1983-10-01 00:00:00

  • Prolactin secretion and biological activity in females with galactorrhoea and normal circulating prolactin concentrations at rest.

    abstract::Prolactin secretion and biological activity have been investigated in 20 females with persistent idiopathic galactorrhoea who had normal resting serum prolactin levels at presentation. Results were compared with those in 34 normal controls. Hyperprolactinaemia, which was persistent in one and intermittent in the other...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Johnston DG,Haigh J,Prescott RW,Heaton A,Kendall-Taylor P,Baylis P,Alberti KG,Rowe R,Friesen H,Cook D

    更新日期:1985-05-01 00:00:00

  • Impact of age, phenotype and cardio-renal function on plasma C-type and B-type natriuretic peptide forms in an adult population.

    abstract:CONTEXT:In contrast to the cardiac hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), variations in plasma concentrations of C-type natriuretic peptide (CNP) in healthy adults are ill-defined, limiting their clinical application. OBJECTIVE:Our objective was to define the effect of age, ph...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Prickett TC,Olney RC,Cameron VA,Ellis MJ,Richards AM,Espiner EA

    更新日期:2013-05-01 00:00:00

  • Nephrogenous cyclic AMP in primary hepatocellular carcinoma patients with or without hypercalcaemia.

    abstract:OBJECTIVE:To study the relationship between the excretion of nephrogenous cyclic AMP (NcAMP) and other blood and urine parameters as an index of PTH-like activity in patients with primary hepatocellular carcinoma. DESIGN:After overnight fast, a double voided urine and a blood sample were collected from each subject fo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

    更新日期:1991-12-01 00:00:00

  • The secretion of thyrotrophin with impaired biological activity in patients with hypothalamic-pituitary disease.

    abstract::We describe here two patients with hypothyroidism due to pituitary-hypothalamic disease in whom basal thyrotrophin (TSH) levels measured by radioimmunoassay (RIA) were elevated yet when measured by a cytochemical bioassay (CBA) were found to be normal. This finding and the absence of the normal rise of thyroid hormone...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Petersen VB,McGregor AM,Belchetz PE,Elkeles RS,Hall R

    更新日期:1978-05-01 00:00:00

  • Direct inhibition of ovarian steroidogenesis by cortisol and the modulatory role of 11 beta-hydroxysteroid dehydrogenase.

    abstract:OBJECTIVE:The association of adrenal hyperactivity with ovarian dysfunction may involve direct inhibition of ovarian steroidogenesis by glucocorticoids. Therefore, the objectives of this study were to investigate the direct effects of cortisol on luteinizing hormone (LH) action in human granulosa-lutein cells and the m...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Michael AE,Pester LA,Curtis P,Shaw RW,Edwards CR,Cooke BA

    更新日期:1993-06-01 00:00:00

  • Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism.

    abstract:RATIONALE:Low serum testosterone is commonly observed in men with type 2 diabetes (T2DM), but the neuroendocrine pathophysiology remains to be elucidated. OBJECTIVES:The hypothalamic neuropeptide kisspeptin integrates metabolic signals with the reproductive axis in animal models. We hypothesized that administration of...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: George JT,Veldhuis JD,Tena-Sempere M,Millar RP,Anderson RA

    更新日期:2013-07-01 00:00:00

  • The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain.

    abstract:OBJECTIVE:Given the important role of the beta2-adrenoceptor (beta2-AR) in lipid mobilization and the lack of studies in Southern European countries, the aim of this study was to investigate the role of the glutamine 27 glutamic acid (Gln27Glu) beta2-AR polymorphism in the susceptibility to obesity and its metabolic co...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: González Sánchez JL,Proenza AM,Martínez Larrad MT,Ramis JM,Fernández Pérez C,Palou A,Serrano Ríos M

    更新日期:2003-10-01 00:00:00

  • Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

    abstract:RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Coussa A,Hasan HA,Barber TM

    更新日期:2020-12-01 00:00:00

  • The effects of arginine, insulin and metoclopramide on growth hormone, prolactin and cortisol release in children.

    abstract::The growth hormone (GH) and prolactin (PRL) responses to metoclopramide (MCP) were compared to those with arginine and insulin-induced hypoglycaemia in eight children. While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ijaiya K,Roth B,Schwenk A

    更新日期:1980-06-01 00:00:00

  • Voice characteristics in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in lack of cortisol and often aldosterone and overproduction of androgens. Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice. D...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nygren U,Södersten M,Falhammar H,Thorén M,Hagenfeldt K,Nordenskjöld A

    更新日期:2009-01-01 00:00:00

  • The effects of oestrogen exposure on bone mass in male to female transsexuals.

    abstract:OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

    更新日期:1998-12-01 00:00:00

  • Clinical significance of elevated level of serum antithyroglobulin antibody in patients with differentiated thyroid cancer after thyroid ablation.

    abstract:OBJECTIVE:This study was designed to investigate whether an elevated serum antithyroglobulin antibody (TgAb) reflects cancer recurrence in thyroglobulin (Tg)-undetectable patients with differentiated thyroid carcinoma (DTC) after thyroid ablation. DESIGN:We measured serum TgAb level and evaluated the disease status in...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chung JK,Park YJ,Kim TY,So Y,Kim SK,Park DJ,Lee DS,Lee MC,Cho BY

    更新日期:2002-08-01 00:00:00

  • Binding of immunoglobulin-G from patients with thyroid autoimmune disease to normal T lymphocytes.

    abstract::Sera from patients with Graves' disease and Hashimoto's thyroiditis were reacted with normal T lymphocyte preparations in an attempt to detect binding of immunoglobulin G (IgG) to T cells. Sera from normal subjects and patients with toxic adenomas served as controls. Each serum was reacted with at least three differen...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pacini F,Sridama V,Pressendo J,DeGroot LJ,Medof ME

    更新日期:1983-07-01 00:00:00

  • Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF-I and endogenous IGFBP-3.

    abstract::Seckel syndrome is an autosomal-recessive disorder with a frequency of less than 1/10 000 births in which there are multiple malformations including severe short stature. We report on a patient with Seckel syndrome with a current body height of -7.5 SDS. Laboratory investigations at the age of 19 months revealed high ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schmidt A,Chakravarty A,Brommer E,Fenne BD,Siebler T,De Meyts P,Kiess W

    更新日期:2002-08-01 00:00:00

  • The effects of acute hyponatraemia on bone turnover in patients with subarachnoid haemorrhage: A preliminary report.

    abstract:CONTEXT:Animal data and cross-sectional human studies have established that chronic hyponatraemia predisposes to osteoporosis; the effects of acute hyponatraemia on bone turnover have not been determined. Our objective was to test the hypothesis that acute hyponatraemia leads to dynamic effects on bone turnover. DESIG...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Garrahy A,Galloway I,Hannon AM,Dineen R,Javadpour M,Tormey WP,Gan KJ,Twomey PJ,Mc Kenna MJ,Kilbane M,Crowley RK,Sherlock M,Thompson CJ

    更新日期:2020-11-11 00:00:00

  • Bone remodelling markers and serum cytokines in patients with hyperthyroidism.

    abstract:OBJECTIVE:This study was designed in order to evaluate bone turnover with bone formation and resorption markers in hyperthyroidism and its possible relationship with serum cytokines interleukin 6 (IL-6) and tumour necrosis-alpha (TNF-alpha), levels of thyroid hormones and thyroid autoantibodies. DESIGN AND PATIENTS:Tw...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Akalin A,Colak O,Alatas O,Efe B

    更新日期:2002-07-01 00:00:00

  • Determinants of sex hormone-binding globulin in normal postmenopausal women.

    abstract:OBJECTIVE:To examine the factors influencing the levels of sex hormone-binding globulin (SHBG) in normal postmenopausal women by assessing the relationship between SHBG and measured anthropometric, metabolic and hormonal variables. DESIGN:Cross-sectional, observational study. SUBJECTS AND METHODS:Seventy normal postm...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wu F,Ames R,Evans MC,France JT,Reid IR

    更新日期:2001-01-01 00:00:00

  • GH replacement reduces increased lipid peroxidation in GH-deficient adults.

    abstract:BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

    更新日期:2008-06-01 00:00:00

  • Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.

    abstract:OBJECTIVE:Primary glucocorticoid resistance is characterized by decreased sensitivity to cortisol signalling. We have performed genetic analysis of the glucocorticoid receptor (GR) gene in 12 unrelated patients with primary cortisol resistance as defined by a pathological dexamethasone suppression test. METHODS:Exon s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ruiz M,Lind U,Gåfvels M,Eggertsen G,Carlstedt-Duke J,Nilsson L,Holtmann M,Stierna P,Wikström AC,Werner S

    更新日期:2001-09-01 00:00:00

  • Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients.

    abstract:OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Picolos MK,Lavis VR,Orlander PR

    更新日期:2005-11-01 00:00:00

  • The thyroidal production of reverse triiodothyronine in autonomous adenoma.

    abstract::The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is com...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reinwein D,Durrer H,Emrich D,Meinhold H,Wenzel KW

    更新日期:1977-08-01 00:00:00

  • Plasma androgenic activity in women with acne vulgaris and in healthy girls before, during and after puberty.

    abstract::The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increase during p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Odlind V,Carlström K,Michaëlsson G,Vahlqvist A,Victor A,Mellbin T

    更新日期:1982-03-01 00:00:00

  • Effect of oral frusemide on diagnostic indices of thyroid function.

    abstract::We studied the acute effect of standard therapeutic doses of oral frusemide on indices of thyroid function in 34 hospital in-patients with congestive cardiac failure. A transient decrease in total T4, elevation in the T3 resin uptake and consequent increase in the free T4 index (FT4I) were seen 2-5 h after ingestion o...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Newnham HH,Hamblin PS,Long F,Lim CF,Topliss DJ,Stockigt JR

    更新日期:1987-04-01 00:00:00

  • Effect of an OT antagonist on the control of the midcycle LH surge in women.

    abstract:OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vanakara P,Dafopoulos K,Papastergiopoulou L,Kallitsaris A,Papageorgiou I,Messinis IE

    更新日期:2009-07-01 00:00:00

  • Testosterone administration increases adrenal response to adrenocorticotrophin.

    abstract:OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Polderman KH,Gooren LJ,van der Veen EA

    更新日期:1994-05-01 00:00:00

  • Thyroid scintigraphy in the era of fine-needle aspiration cytology.

    abstract:PURPOSE:To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA). METHODS:We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test ad...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pirola I,Di Lodovico E,Casella C,Pezzaioli L,Facondo P,Ferlin A,Lombardi D,Cappelli C

    更新日期:2020-12-17 00:00:00

  • Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women.

    abstract:CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

    更新日期:2009-11-01 00:00:00

  • Leucine metabolism in patients with Cushing's syndrome before and after successful treatment.

    abstract:OBJECTIVE:Results from studies on the effect of glucocorticosteroids on protein turnover in both rat and man have been conflicting. The aim of this study was to investigate the primary cause of muscle wasting in patients with Cushing's syndrome. DESIGN:Studies of whole body 1(-14)C-leucine turnover in patients with Cu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bowes SB,Benn JJ,Scobie IN,Umpleby AM,Lowy C,Sönksen PH

    更新日期:1993-11-01 00:00:00

  • What is the optimal bone-preserving strategy for patients with Addison's disease?

    abstract::Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multifactorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances and, in some patients, supraphysiologic glucocorticoid replacement...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lee P,Greenfield JR

    更新日期:2015-08-01 00:00:00