Abstract:
OBJECTIVE:To assess the clinical and neurological outcomes in newborns with primary congenital hypothyroidism presented with delayed TSH elevation (dTSH), and to define parameters that may predict the evolution of transient vs. permanent hypothyroidism in these newborns. DESIGN AND PATIENTS:An observational study was performed of a cohort of 113 children with a history of dTSH. MEASUREMENTS:Birth parameters, thyroid screening results, thyroid gland imaging, levothyroxine dose and neurological outcome were compared between newborns with spontaneous recovery and children with a final diagnosis of either transient or permanent hypothyroidism. RESULTS:Of the children with a history of dTSH, 93% demonstrated recovery, either spontaneously or following levothyroxine treatment (transient hypothyroidism). Newborns with spontaneous recovery demonstrated milder thyroid dysfunction at the newborn screening compared to those who started levothyroxine treatment. Levothyroxine dose was lower in children with transient vs. permanent hypothyroidism only during the first 6 months of life; otherwise, these groups were similar in birth parameters, thyroid screening results and gland images. Seventeen out of 61 children (28%) that underwent neurological assessment demonstrated a developmental delay. Duration of treatment was highly variable in children with transient hypothyroidism. CONCLUSIONS:Thyroid dysfunction is transient in most cases of dTSH. No reliable parameters can predict a priori transient vs. permanent hypothyroidism.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Zung A,Radi A,Almashanu Sdoi
10.1111/cen.14173subject
Has Abstractpub_date
2020-05-01 00:00:00pages
443-449issue
5eissn
0300-0664issn
1365-2265journal_volume
92pub_type
杂志文章abstract:OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...
journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.2005.02246.x
更新日期:2005-04-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.2012.04394.x
更新日期:2012-09-01 00:00:00
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更新日期:2011-12-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2265.1982.tb01590.x
更新日期:1982-09-01 00:00:00
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doi:10.1111/cen.12472
更新日期:2014-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1982.tb03153.x
更新日期:1982-01-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1978.tb01506.x
更新日期:1978-12-01 00:00:00
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doi:10.1111/j.1365-2265.2007.02785.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1983.tb02881.x
更新日期:1983-05-01 00:00:00
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doi:10.1111/j.1365-2265.1988.tb03716.x
更新日期:1988-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2011.04135.x
更新日期:2012-01-01 00:00:00
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更新日期:2011-02-01 00:00:00
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doi:10.1111/j.1365-2265.1987.tb00798.x
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更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2008.03437.x
更新日期:2009-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.1981.tb00663.x
更新日期:1981-09-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1977.tb01310.x
更新日期:1977-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-06-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.2010.03879.x
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1365-2265.1996.710532.x
更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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doi:10.1046/j.1365-2265.1997.1290951.x
更新日期:1997-03-01 00:00:00