The natural history of congenital hypothyroidism with delayed TSH elevation in neonatal intensive care newborns.


OBJECTIVE:To assess the clinical and neurological outcomes in newborns with primary congenital hypothyroidism presented with delayed TSH elevation (dTSH), and to define parameters that may predict the evolution of transient vs. permanent hypothyroidism in these newborns. DESIGN AND PATIENTS:An observational study was performed of a cohort of 113 children with a history of dTSH. MEASUREMENTS:Birth parameters, thyroid screening results, thyroid gland imaging, levothyroxine dose and neurological outcome were compared between newborns with spontaneous recovery and children with a final diagnosis of either transient or permanent hypothyroidism. RESULTS:Of the children with a history of dTSH, 93% demonstrated recovery, either spontaneously or following levothyroxine treatment (transient hypothyroidism). Newborns with spontaneous recovery demonstrated milder thyroid dysfunction at the newborn screening compared to those who started levothyroxine treatment. Levothyroxine dose was lower in children with transient vs. permanent hypothyroidism only during the first 6 months of life; otherwise, these groups were similar in birth parameters, thyroid screening results and gland images. Seventeen out of 61 children (28%) that underwent neurological assessment demonstrated a developmental delay. Duration of treatment was highly variable in children with transient hypothyroidism. CONCLUSIONS:Thyroid dysfunction is transient in most cases of dTSH. No reliable parameters can predict a priori transient vs. permanent hypothyroidism.


Clin Endocrinol (Oxf)


Clinical endocrinology


Zung A,Radi A,Almashanu S




Has Abstract


2020-05-01 00:00:00












  • Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the Fremantle Diabetes Study.

    abstract:OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chubb SA,Davis WA,Inman Z,Davis TM

    更新日期:2005-04-01 00:00:00

  • Clinical and genetic analysis of patients with vitamin D-dependent rickets type 1A.

    abstract:CONTEXT:Vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700) is a rare autosomal recessive disorder and is caused by mutations in the CYP27B1 gene. OBJECTIVES:We aim to investigate CYP27B1 mutation in seven patients from four separate families and characterize the genotype-phenotype correlation. METHODS:The ent...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Durmaz E,Zou M,Al-Rijjal RA,Bircan I,Akçurin S,Meyer B,Shi Y

    更新日期:2012-09-01 00:00:00

  • High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency.

    abstract:BACKGROUND:Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE:Patients, methods and design From a cross-sectional population-based study of 101 adult Norwegian patients with 21OHD, sixty-two participated i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nermoen I,Rørvik J,Holmedal SH,Hykkerud DL,Fougner KJ,Svartberg J,Husebye ES,Løvås K

    更新日期:2011-12-01 00:00:00

  • Opiate modulation of the pituitary-adrenal axis: effects of stress and circadian rhythm.

    abstract::The opiate control of the pituitary-adrenal axis has been investigated in normal subjects. The infusion of 1 mg of the met-enkephalin analogue, DAMME, led to a fall in circulating cortisol in spite of a fall in blood pressure. Conversley, 16 mg of the opiate antagonist, naloxone led to brisk and pronounced elevations ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Grossman A,Gaillard RC,McCartney P,Rees LH,Besser GM

    更新日期:1982-09-01 00:00:00

  • Relationship between insulin sensitivity and bone mineral density in primary hyperparathyroidism.

    abstract:INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

    更新日期:2014-09-01 00:00:00

  • Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.

    abstract:OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Laursen T,Jørgensen JO,Christiansen JS

    更新日期:1994-09-01 00:00:00

  • An improved method for the radioimmunoassay of free-thyroxine in serum dialysates.

    abstract::A convenient, sensitive radioimmunoassay of free thyroxine in serum dialysates is described. The method utilizes a solid phase separation system (pre-formed double antibody) and a relatively short incubation period (220 min) with a staggered addition of tracer. Blanks were low and consistent. The normal range for non-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Giles AF

    更新日期:1982-01-01 00:00:00

  • The association between vitamin D status and type 2 diabetes in a Thai population, a cross-sectional study.

    abstract:OBJECTIVE:To explore vitamin D status in relation to diabetes, based on data from a national health examination survey in Thailand. DESIGN AND METHODS:A total of 2641 adults, aged 15-98 years, were randomly selected according to geographical region from the Thai 4th National Health Examination Survey sample. Logistic ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chailurkit LO,Aekplakorn W,Ongphiphadhanakul B

    更新日期:2012-11-01 00:00:00

  • Thyroid cells in Graves' disease and Hashimoto's thyroiditis stimulate allogeneic T cells when pretreated with phorbol ester.

    abstract:OBJECTIVE:To assess the capacity of thyroid follicular cells to function as antigen presenting cells, we have examined their ability to stimulate allogeneic T cells. DESIGN:Thyroid follicular cells were pretreated with interferon-gamma or phorbol myristate acetate, washed thoroughly, and their capacity to induce allog...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tandon N,Weetman AP

    更新日期:1992-09-01 00:00:00

  • The effect of lisuride hydrogen maleate in the hyperprolactinaemia-amenorrhoea syndrome: clinical and hormonal responses.

    abstract::Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

    更新日期:1978-12-01 00:00:00

  • Serum free cortisol as an ancillary tool in the interpretation of the low-dose 1-μg ACTH test.

    abstract:OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

    更新日期:2011-09-01 00:00:00

  • Ontogeny of foetal exposure to maternal cortisol using midtrimester amniotic fluid as a biomarker.

    abstract:OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

    更新日期:2007-05-01 00:00:00

  • Diagnostic approach to low-renin hypertension.

    abstract::Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanis...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Monticone S,Losano I,Tetti M,Buffolo F,Veglio F,Mulatero P

    更新日期:2018-10-01 00:00:00

  • The effect of minor increments in plasma thyroxine on heart rate and urinary sodium excretion.

    abstract::We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

    更新日期:1983-05-01 00:00:00

  • Vasoactive intestinal peptide and anterior pituitary function.

    abstract::Vasoactive intestinal peptide (VIP) is a highly basic 28 amino-acid peptide which was first isolated from porcine small intestine (Said & Mutt, 1970). It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences si...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Prysor-Jones RA,Jenkins JS

    更新日期:1988-12-01 00:00:00

  • Unacylated ghrelin is associated with changes in insulin sensitivity and lipid profile during an exercise intervention.

    abstract:OBJECTIVE:Ghrelin has been implicated in energy homeostasis, body weight regulation and glucose metabolism. Level of unacylated ghrelin (UAG), but not acylated ghrelin (AG), has been suggested to increase during long-term exercise. However, the association of the level of UAG with exercise-induced changes of insulin se...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cederberg H,Koivisto VM,Jokelainen J,Surcel HM,Keinänen-Kiukaanniemi S,Rajala U

    更新日期:2012-01-01 00:00:00

  • Predictive factors related to the recurrence at US-guided fine needle aspiration in postoperative patients with differentiated thyroid cancer.

    abstract:OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

    更新日期:2011-02-01 00:00:00

  • Increased incidence of neoplasia in patients with pituitary adenomas. The Pituitary Study Group.

    abstract:OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

    更新日期:1998-10-01 00:00:00

  • The effects of dithiothreitol on thyroid stimulation in vitro.

    abstract::There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ginsberg J,Rafter DJ,von Westarp C,Murray PG

    更新日期:1987-04-01 00:00:00

  • Radiofrequency ablation for the management of thyroid nodules: A critical appraisal of the literature.

    abstract::The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Cesareo R,Palermo A,Pasqualini V,Cianni R,Gaspa G,Manfrini S,Pacella CM

    更新日期:2017-12-01 00:00:00

  • Abnormalities in fasting circulating proinsulin concentration in mild gestational diabetes.

    abstract::Fasting plasma proinsulin, insulin and glucose concentrations were measured in ten women with mild gestational diabetes and ten controls matched for race, age (32 +/- 6 vs 31 +/- 6 years), body mass index (28 +/- 8 vs 27 +/- 6) and gestational week (24 +/- 4 vs 25 +/- 4 weeks). There was no significant difference in f...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Dornhorst A,Davies M,Anyaoku V,Hampton SM,Elkeles RS,Beard RW,Johnston DG

    更新日期:1991-03-01 00:00:00

  • Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.

    abstract:OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

    更新日期:2009-07-01 00:00:00

  • Withdrawal of endogenous sympathetic drive lowers blood pressure in primary aldosteronism.

    abstract::We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nicholls MG,Julius S,Zweifler AJ

    更新日期:1981-09-01 00:00:00

  • The thyroidal production of reverse triiodothyronine in autonomous adenoma.

    abstract::The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is com...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reinwein D,Durrer H,Emrich D,Meinhold H,Wenzel KW

    更新日期:1977-08-01 00:00:00

  • GH replacement reduces increased lipid peroxidation in GH-deficient adults.

    abstract:BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

    更新日期:2008-06-01 00:00:00

  • Diagnostic performance of HMGA2 gene expression for differentiation of malignant thyroid nodules: A systematic review and meta-analysis.

    abstract:OBJECTIVE:The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN:The MEDLINE/PubMed and EMBASE database, from the earliest available date of i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析


    authors: Kim BH,Kim SJ,Kim M,Lee SW,Jeong SY,Pak K,Kim K,Kim IJ

    更新日期:2018-12-01 00:00:00

  • Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes.

    abstract:OBJECTIVES:Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Qasim AN,Budharaju V,Mehta NN,St Clair C,Farouk S,Braunstein S,Schutta M,Iqbal N,Rader DJ,Reilly MP

    更新日期:2011-01-01 00:00:00

  • Steroids in human intrauterine fluids of early pregnancy.

    abstract:OBJECTIVE:Little is known of the hormone environment of the developing early human embryo. We have therefore measured selected steroids in the intrauterine fluids of early pregnancy. DESIGN:Measurement of progesterone, 17 alpha-hydroxyprogesterone, oestradiol-17 beta, testosterone, androstenedione, cortisol and dehydr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Atkinson G,Campbell DJ,Cawood ML,Oakey RE

    更新日期:1996-04-01 00:00:00

  • Preconception management of thyroid dysfunction.

    abstract::Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Okosieme OE,Khan I,Taylor PN

    更新日期:2018-09-01 00:00:00

  • Effect of mifepristone on folliculogenesis in women treated with recombinant FSH.

    abstract:OBJECTIVE:To study the mechanism through which mifepristone interrupts folliculogenesis. DESIGN:Normally ovulating women undergoing donor intrauterine insemination (IUI) treatment were investigated during two menstrual cycles treated with gonadotrophins. In the first cycle (FSH cycle), the women were given 150 IU reco...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Messinis IE,Krishnan M,Kazem R,Khadilkar S,Templeton AA

    更新日期:1997-03-01 00:00:00