The natural history of congenital hypothyroidism with delayed TSH elevation in neonatal intensive care newborns.

abstract：OBJECTIVE:Antithyroidal drugs (ATD) are used in the management of Graves' disease either as primary therapy for several months while awaiting remission of the disease or as pretreatment for several weeks prior to definitive radioactive iodine therapy (RAI). We have reported previously that pretreatment with propylthiou...

journal_title：Clinical endocrinology

authors： Hancock LD,Tuttle RM,LeMar H,Bauman J,Patience T

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:IGF-1 stimulates growth, development and function of lymphocytes. The aim of this study was to examine whether functional variants of the IGF-1 gene are associated with absolute lymphocyte subset counts in neonates. STUDY DESIGN AND MEASUREMENTS:This study was embedded in the Generation R Study, a prospectiv...

journal_title：Clinical endocrinology

authors： Duijts L,Bakker-Jonges LE,Mook-Kanamori DO,Labout JA,Hofman A,van Duijn CM,van Dongen JJ,Hooijkaas H,Moll HA,Jaddoe VW

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To compare biochemical variables, renal function and calcium and vitamin D intakes in euparathyroid and hyperparathyroid patients with primary osteoporosis and osteopenia and describe the measures necessary to normalize serum PTH in the patients with secondary hyperparathyroidism. DESIGN AND PATIENTS:We revi...

journal_title：Clinical endocrinology

authors： Yendt ER,Kovacs KA,Jones G

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults. METHODS:This study was based on cros...

journal_title：Clinical endocrinology

authors： Tang L,Zhang F,Tong N

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

journal_title：Clinical endocrinology

authors： Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

journal_title：Clinical endocrinology

authors： Hammami MM,Haq A,AlSedairy S

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is a rare hereditary disorder. We present four patients from a single family with FIHP, and genetic analysis of their parathyroid adenomas and parathyroid carcinoma. DESIGN:DNA was extracted from tumours resected at surgery. Tumours were examined for loss ...

journal_title：Clinical endocrinology

authors： Yoshimoto K,Endo H,Tsuyuguchi M,Tanaka C,Kimura T,Iwahana H,Kato G,Sano T,Itakura M

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that patients with hyperprolactinaemia due to biologically inactive macroprolactin will not show the characteristically increased dopaminergic inhibition of TSH release seen in patients with microprolactinomas secreting biologically active monomeric PRL. DESIGN:Comparison of the TSH an...

journal_title：Clinical endocrinology

authors： Pinto LP,Hanna FW,Evans LM,Davies JS,John R,Scanlon MF

更新日期：2003-11-01 00:00:00

abstract：:The urine clearance of TRH after intravenous injection in man has been measured by radioimmunoassay. Between 4.4 percent and 10.7 percent of the dose was excreted within 90 min, the majority within 30 min. The TRH excreted was immunochemically and chromatographically indistinguishable from synthetic TRH and was inacti...

journal_title：Clinical endocrinology

authors： Jeffcoate SL,White N

更新日期：1975-07-01 00:00:00

abstract：OBJECTIVE:Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in ...

journal_title：Clinical endocrinology

authors： Zhao T,Zhao J

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:Cabergoline therapy normalizes prolactin levels and reduces the size of macroprolactinomas. However there are no data indicating whether cabergoline can normalize growth hormone secretion in patients who were growth hormone deficient at the time of diagnosis of a macroprolactinoma. SUBJECTS AND METHODS:We st...

journal_title：Clinical endocrinology

authors： George LD,Nicolau N,Scanlon MF,Davies JS

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：:A single fasting level of serum prolactin was measured in each of sixty control subjects and eighty-three psychiatric patients of both sexes who had been on neuroleptic therapy for 2-4 weeks (acute treatment) or at least 5 years (chronic treatment) and who were aged either 17-45 or 48-85 years. All groups of patients ...

journal_title：Clinical endocrinology

authors： Rivera JL,Lal S,Ettigi P,Hontela S,Muller HF,Friesen HG

更新日期：1976-05-01 00:00:00

abstract：CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoi...

journal_title：Clinical endocrinology

authors： Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Urine calcium after an overnight fast is higher in osteoporotic than in normal post-menopausal women. The question is whether this is the cause or effect of the bone-losing state. OBJECTIVE:To establish whether the elevated obligatory calcium loss in osteoporotic women is due to a raised filtered load of ca...

journal_title：Clinical endocrinology

authors： Nordin BE,Horowitz M,Need A,Morris HA

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

journal_title：Clinical endocrinology

authors： Moreira AC,Castro M,Machado HR

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Provocative stimulation tests for GH assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to evaluate the capability of pegvisomant, as an enhancer of GH secretion, in unmasking false-positive results in short children undergoing GH test...

journal_title：Clinical endocrinology

authors： Radetti G,Wu Z,Elsedfy HH,El Kholy M,Bozzola M,Strasburger CJ

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:There is evidence showing that GH and IGF-I have specific receptors in the heart and that these hormones are able to promote cardiac remodelling and inotropism. It has been reported that patients with dilated cardiomyopathy (DCM) benefit from treatment with rhGH showing a striking increase in cardiac contract...

journal_title：Clinical endocrinology

authors： Broglio F,Fubini A,Morello M,Arvat E,Aimaretti G,Gianotti L,Boghen MF,Deghenghi R,Mangiardi L,Ghigo E

更新日期：1999-04-01 00:00:00

abstract：:Acid glycosaminoglycans were measured in the tissues of a virtually untreated 83-year-old woman with myxoedema. Intercellular oedema was demonstrated histologically in the tongue, myocardium, striated muscles, and in the skin. Tissue oedema was absent in two female control patients. All tissues from the patient with m...

journal_title：Clinical endocrinology

authors： Parving HH,Helin G,Garbarsch C,Johansen AA,Jensen BA,Helin P,Lund P,Lyngsøe J

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVE:To investigate two patients with the hyperparathyroidism-jaw tumour (HPT-JT) syndrome and three patients with familial isolated hyperparathyroidism (FIHP), together with 31 parathyroid tumours (2 HPT-JT, 2 FIHP and 27 sporadic) for HRPT2 mutations. The HPT-JT syndrome and FIHP are autosomal dominant disorders...

journal_title：Clinical endocrinology

authors： Bradley KJ,Cavaco BM,Bowl MR,Harding B,Cranston T,Fratter C,Besser GM,Conceição Pereira M,Davie MW,Dudley N,Leite V,Sadler GP,Seller A,Thakker RV

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction and obesity during pregnancy have been associated with negative neonatal and obstetric outcomes. Thyroid hormone reference ranges have not been established for the pregnant Hispanic population. This study defines thyroid hormone reference ranges during early pregnancy in Chilean women and ...

journal_title：Clinical endocrinology

authors： Mosso L,Martínez A,Rojas MP,Latorre G,Margozzini P,Lyng T,Carvajal J,Campusano C,Arteaga E,Boucai L

更新日期：2016-12-01 00:00:00

abstract：:To quantify the role of endogenous oestrogen activity in osteoporosis we measured relative metacarpal cortical area (RCA), body mass, serum oestrone, oestradiol, androstenedione, and sex hormone binding globulin (SHBG) in 746 postmenopausal women aged 53 to 76 years, sampled from the general population. The occurrence...

journal_title：Clinical endocrinology

authors： van Hemert AM,Birkenhäger JC,De Jong FH,Vandenbroucke JP,Valkenburg HA

更新日期：1989-10-01 00:00:00

abstract：:The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h period has shown the existence of a circadian rhythm in normal males which is absent in patients with primary hyperparathyroidism. The physiological significance of this observation is reflected in the presence of parallel changes in nephroge...

journal_title：Clinical endocrinology

authors： Logue FC,Fraser WD,Gallacher SJ,Cameron DA,O'Reilly DS,Beastall GH,Patel U,Boyle IT

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:We assessed the relative risk of both serum TSH and antithyroid antibody concentrations with regard to progression of thyroid failure and studied the lipid profiles of individuals with elevated TSH levels. DESIGN, PATIENTS AND MEASUREMENTS:In a randomly selected group of 427 women aged 40-60 (mean 55) years ...

journal_title：Clinical endocrinology

authors： Geul KW,van Sluisveld IL,Grobbee DE,Docter R,de Bruyn AM,Hooykaas H,van der Merwe JP,van Hemert AM,Krenning EP,Hennemann G

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVES:We wished to determine whether women with multinodular goitre and spontaneous subclinical hyperthyroidism have decreased bone density. DESIGN AND SUBJECTS:Bone density was measured at the distal and proximal forearm. Data were expressed as Z-scores relative to the mean values out of 125 control subjects mat...

journal_title：Clinical endocrinology

authors： Mudde AH,Reijnders FJ,Kruseman AC

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. PATIENTS:One hundred and two boys, 13.6-15.5 years of age, who were referred because of short stature and delayed puberty. METHODS:The boys were randomly allocated to one of the following treatmen...

journal_title：Clinical endocrinology

authors： Zadik Z,Sinai T,Zung A,Reifen R

更新日期：2004-06-01 00:00:00

abstract：:A 30 year old woman presenting with infertility was found to have elevated serum immunoreactive prolactin, TSH and total T3. These findings were eventually attributed to assay artifact when she was shown to have anti-rabbit antibodies in her serum. The possibility of laboratory artifact should be considered in clinica...

journal_title：Clinical endocrinology

authors： Jeffcoate WJ,Selby C,Powell RJ

更新日期：1988-01-01 00:00:00

abstract：:A controlled therapeutic trial on seventy-four 70-year-old women was carried out with the purpose of finding the optimal treatment for post menopausal osteoporosis. The bone mineral content (BMC) was measured by I-photonabsorptiometry at two sites in the distal part of the forearms, where the trabecular/cortical ratio...

journal_title：Clinical endocrinology

authors： Jensen GF,Christiansen C,Transbøl I

更新日期：1982-05-01 00:00:00

abstract：:In order to investigate the mechanism of GIP secretion and the role of endogenous GIP in the enteroinsular axis in duodenal ulcer patients, we have compared plasma GIP, insulin, and blood glucose responses to oral glucose ingestion in 10 duodenal ulcer patients, 5 patients with total gastrectomy, and 20 normal subject...

journal_title：Clinical endocrinology

authors： Takemura J,Seino Y,Yamamura T,Yoshiya K,Ishikawa Y,Itoh N,Imura H

更新日期：1983-09-01 00:00:00

abstract：OBJECTIVE:There are advantages and disadvantages with all of the presently available types of testosterone replacement for hypogonadal men. We performed this investigation to establish detailed data about the pharmacokinetics, pharmacodynamics, feasibility and side-effects of subcutaneously implanted testosterone (T) p...

journal_title：Clinical endocrinology

authors： Jockenhövel F,Vogel E,Kreutzer M,Reinhardt W,Lederbogen S,Reinwein D

更新日期：1996-07-01 00:00:00