The natural history of congenital hypothyroidism with delayed TSH elevation in neonatal intensive care newborns.

abstract：OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

journal_title：Clinical endocrinology

authors： Chubb SA,Davis WA,Inman Z,Davis TM

更新日期：2005-04-01 00:00:00

abstract：CONTEXT:Vitamin D-dependent rickets type 1A (VDDR-IA, OMIM 264700) is a rare autosomal recessive disorder and is caused by mutations in the CYP27B1 gene. OBJECTIVES:We aim to investigate CYP27B1 mutation in seven patients from four separate families and characterize the genotype-phenotype correlation. METHODS:The ent...

journal_title：Clinical endocrinology

authors： Durmaz E,Zou M,Al-Rijjal RA,Bircan I,Akçurin S,Meyer B,Shi Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in patients with 21-hydroxylase deficiency (21OHD). OBJECTIVE:Patients, methods and design From a cross-sectional population-based study of 101 adult Norwegian patients with 21OHD, sixty-two participated i...

journal_title：Clinical endocrinology

authors： Nermoen I,Rørvik J,Holmedal SH,Hykkerud DL,Fougner KJ,Svartberg J,Husebye ES,Løvås K

更新日期：2011-12-01 00:00:00

abstract：:The opiate control of the pituitary-adrenal axis has been investigated in normal subjects. The infusion of 1 mg of the met-enkephalin analogue, DAMME, led to a fall in circulating cortisol in spite of a fall in blood pressure. Conversley, 16 mg of the opiate antagonist, naloxone led to brisk and pronounced elevations ...

journal_title：Clinical endocrinology

authors： Grossman A,Gaillard RC,McCartney P,Rees LH,Besser GM

更新日期：1982-09-01 00:00:00

abstract：INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and s...

journal_title：Clinical endocrinology

authors： Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

journal_title：Clinical endocrinology

authors： Laursen T,Jørgensen JO,Christiansen JS

更新日期：1994-09-01 00:00:00

abstract：:A convenient, sensitive radioimmunoassay of free thyroxine in serum dialysates is described. The method utilizes a solid phase separation system (pre-formed double antibody) and a relatively short incubation period (220 min) with a staggered addition of tracer. Blanks were low and consistent. The normal range for non-...

journal_title：Clinical endocrinology

authors： Giles AF

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To explore vitamin D status in relation to diabetes, based on data from a national health examination survey in Thailand. DESIGN AND METHODS:A total of 2641 adults, aged 15-98 years, were randomly selected according to geographical region from the Thai 4th National Health Examination Survey sample. Logistic ...

journal_title：Clinical endocrinology

authors： Chailurkit LO,Aekplakorn W,Ongphiphadhanakul B

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:To assess the capacity of thyroid follicular cells to function as antigen presenting cells, we have examined their ability to stimulate allogeneic T cells. DESIGN:Thyroid follicular cells were pretreated with interferon-gamma or phorbol myristate acetate, washed thoroughly, and their capacity to induce allog...

journal_title：Clinical endocrinology

authors： Tandon N,Weetman AP

更新日期：1992-09-01 00:00:00

abstract：:Eleven women with secondary amenorrhoea and hyperprolactinaemia were treated with lisuride, a new semisynthetic ergot derivative. Acute administration of lisuride (100 microgram orally) significantly suppressed serum prolactin (PRL) levels in nine out of eleven subjects. In these nine patients, prolonged treatment wit...

journal_title：Clinical endocrinology

authors： De Cecco L,Foglia G,Ragni N,Rossato P,Venturini PL

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

journal_title：Clinical endocrinology

authors： Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：:Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanis...

journal_title：Clinical endocrinology

authors： Monticone S,Losano I,Tetti M,Buffolo F,Veglio F,Mulatero P

更新日期：2018-10-01 00:00:00

abstract：:We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

journal_title：Clinical endocrinology

authors： Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

更新日期：1983-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a highly basic 28 amino-acid peptide which was first isolated from porcine small intestine (Said & Mutt, 1970). It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences si...

journal_title：Clinical endocrinology

authors： Prysor-Jones RA,Jenkins JS

更新日期：1988-12-01 00:00:00

abstract：OBJECTIVE:Ghrelin has been implicated in energy homeostasis, body weight regulation and glucose metabolism. Level of unacylated ghrelin (UAG), but not acylated ghrelin (AG), has been suggested to increase during long-term exercise. However, the association of the level of UAG with exercise-induced changes of insulin se...

journal_title：Clinical endocrinology

authors： Cederberg H,Koivisto VM,Jokelainen J,Surcel HM,Keinänen-Kiukaanniemi S,Rajala U

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

journal_title：Clinical endocrinology

authors： Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：:There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

journal_title：Clinical endocrinology

authors： Ginsberg J,Rafter DJ,von Westarp C,Murray PG

更新日期：1987-04-01 00:00:00

abstract：:The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has...

journal_title：Clinical endocrinology

authors： Cesareo R,Palermo A,Pasqualini V,Cianni R,Gaspa G,Manfrini S,Pacella CM

更新日期：2017-12-01 00:00:00

abstract：:Fasting plasma proinsulin, insulin and glucose concentrations were measured in ten women with mild gestational diabetes and ten controls matched for race, age (32 +/- 6 vs 31 +/- 6 years), body mass index (28 +/- 8 vs 27 +/- 6) and gestational week (24 +/- 4 vs 25 +/- 4 weeks). There was no significant difference in f...

journal_title：Clinical endocrinology

authors： Dornhorst A,Davies M,Anyaoku V,Hampton SM,Elkeles RS,Beard RW,Johnston DG

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

journal_title：Clinical endocrinology

authors： Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

更新日期：2009-07-01 00:00:00

abstract：:We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid s...

journal_title：Clinical endocrinology

authors： Nicholls MG,Julius S,Zweifler AJ

更新日期：1981-09-01 00:00:00

abstract：:The ratios of reverse triiodothyronine (rT3) to triiodothyronine (T3) concentrations were similar (0.89 +/- 0.09) in twenty-three autonomous thyroid nodules (fourteen decompensated, nine compensated) and paranodular tissues (0.82 +/- 0.08), whereas the serum ratio was significantly lower (0.098 +/- 0.014). This is com...

journal_title：Clinical endocrinology

authors： Reinwein D,Durrer H,Emrich D,Meinhold H,Wenzel KW

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

journal_title：Clinical endocrinology

authors： Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN:The MEDLINE/PubMed and EMBASE database, from the earliest available date of i...

journal_title：Clinical endocrinology

authors： Kim BH,Kim SJ,Kim M,Lee SW,Jeong SY,Pak K,Kim K,Kim IJ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (...

journal_title：Clinical endocrinology

authors： Qasim AN,Budharaju V,Mehta NN,St Clair C,Farouk S,Braunstein S,Schutta M,Iqbal N,Rader DJ,Reilly MP

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Little is known of the hormone environment of the developing early human embryo. We have therefore measured selected steroids in the intrauterine fluids of early pregnancy. DESIGN:Measurement of progesterone, 17 alpha-hydroxyprogesterone, oestradiol-17 beta, testosterone, androstenedione, cortisol and dehydr...

journal_title：Clinical endocrinology

authors： Atkinson G,Campbell DJ,Cawood ML,Oakey RE

更新日期：1996-04-01 00:00:00

abstract：:Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for...

journal_title：Clinical endocrinology

authors： Okosieme OE,Khan I,Taylor PN

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To study the mechanism through which mifepristone interrupts folliculogenesis. DESIGN:Normally ovulating women undergoing donor intrauterine insemination (IUI) treatment were investigated during two menstrual cycles treated with gonadotrophins. In the first cycle (FSH cycle), the women were given 150 IU reco...

journal_title：Clinical endocrinology

authors： Messinis IE,Krishnan M,Kazem R,Khadilkar S,Templeton AA

更新日期：1997-03-01 00:00:00