The natural history of congenital hypothyroidism with delayed TSH elevation in neonatal intensive care newborns.

Abstract:

OBJECTIVE:To assess the clinical and neurological outcomes in newborns with primary congenital hypothyroidism presented with delayed TSH elevation (dTSH), and to define parameters that may predict the evolution of transient vs. permanent hypothyroidism in these newborns. DESIGN AND PATIENTS:An observational study was performed of a cohort of 113 children with a history of dTSH. MEASUREMENTS:Birth parameters, thyroid screening results, thyroid gland imaging, levothyroxine dose and neurological outcome were compared between newborns with spontaneous recovery and children with a final diagnosis of either transient or permanent hypothyroidism. RESULTS:Of the children with a history of dTSH, 93% demonstrated recovery, either spontaneously or following levothyroxine treatment (transient hypothyroidism). Newborns with spontaneous recovery demonstrated milder thyroid dysfunction at the newborn screening compared to those who started levothyroxine treatment. Levothyroxine dose was lower in children with transient vs. permanent hypothyroidism only during the first 6 months of life; otherwise, these groups were similar in birth parameters, thyroid screening results and gland images. Seventeen out of 61 children (28%) that underwent neurological assessment demonstrated a developmental delay. Duration of treatment was highly variable in children with transient hypothyroidism. CONCLUSIONS:Thyroid dysfunction is transient in most cases of dTSH. No reliable parameters can predict a priori transient vs. permanent hypothyroidism.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Zung A,Radi A,Almashanu S

doi

10.1111/cen.14173

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

443-449

issue

5

eissn

0300-0664

issn

1365-2265

journal_volume

92

pub_type

杂志文章
  • Factors affecting inadequate sampling of ultrasound-guided fine-needle aspiration biopsy of thyroid nodules.

    abstract:PURPOSE:The aim of this study was to evaluate the overall ultrasonographic features and clinical factors that contribute to inadequate sampling in ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules. MATERIALS AND METHODS:From April 2008 to December 2008, 4077 US-FNABs in 3767 consecutive pati...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2011.04011.x

    authors: Choi SH,Han KH,Yoon JH,Moon HJ,Son EJ,Youk JH,Kim EK,Kwak JY

    更新日期:2011-06-01 00:00:00

  • Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques.

    abstract:BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02448.x

    authors: Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

    更新日期:2006-02-01 00:00:00

  • Growth hormone (GH) replacement in hypopituitary adults with GH deficiency evaluated by a utility-weighted quality of life index: a precursor to cost-utility analysis.

    abstract:OBJECTIVES:To examine quality of life (QoL) measured by a utility-weighted index in GH-deficient adults on GH replacement and analyse the impact of demographic and clinical characteristics on changes in utilities during treatment. DESIGN:Utilities for items in the QoL-Assessment of Growth Hormone Deficiency in Adults ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.03010.x

    authors: Kołtowska-Häggström M,Kind P,Monson JP,Jonsson B

    更新日期:2008-01-01 00:00:00

  • Thyrotoxic hypokalaemic periodic paralysis in a Turkish population: three new case reports and analysis of the case series.

    abstract:OBJECTIVE:Thyrotoxic hypokalaemic periodic paralysis (THPP) is an uncommon condition with intermittent episodes of muscle weakness and occasionally severe paralysis. THPP is a common complication of hyperthyroidism in Asian populations, and has also been reported in other ethnic groups including Caucasians. This study ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.03014.x

    authors: Cesur M,Bayram F,Temel MA,Ozkaya M,Kocer A,Ertorer ME,Koc F,Kaya A,Gullu S

    更新日期:2008-01-01 00:00:00

  • Normal long-term health-related quality of life can be achieved in patients with functional pituitary adenomas having surgery as primary treatment.

    abstract:BACKGROUND:Previous studies report impaired health-related quality of life (HRQoL) in patients with functional pituitary adenomas (FPA). We assessed HRQoL in FPA patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12550

    authors: Ritvonen E,Karppinen A,Sintonen H,Vehkavaara S,Kivipelto L,Roine RP,Niemelä M,Schalin-Jäntti C

    更新日期:2015-03-01 00:00:00

  • Case of hyperthyroidism due to a chromophobe adenoma.

    abstract::A A 23-year-old man with secondary hypogonadism was also found to be thyrotoxic. Results of thyroid function tests were in the hyperthyroid range but the serum TSH was inappropriately high. A pituitary tumour was demonstrated and following hypophysectomy he became biochemically hypothyroid. Evidence is presented and d...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1976.tb02825.x

    authors: Baylis PH

    更新日期:1976-03-01 00:00:00

  • T-cell sensitization to autologous thyroid cells and normal non-specific suppressor T-cell function in Graves' disease.

    abstract::We have employed a syngeneic system utilizing thyroid cell monolayers initiated following thyroid surgery co-cultured with autologous T cells to demonstrate T cell autosensitization in patients with Graves' disease. Antigen-induced blastogenesis was monitored using 24 h [3H]thymidine uptake. Control experiments with 5...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb01077.x

    authors: Davies TF,Bermas B,Platzer M,Roman SH

    更新日期:1985-02-01 00:00:00

  • Age as a determinant of the impact of growth hormone therapy on predicted adult height.

    abstract:OBJECTIVE:Final adult height is determined by both childhood and pubertal growth. The later is a function of growth velocity and bone maturation, and both are regulated by growth hormone. In a study of the safety and efficacy of GH therapy, we analysed the impact of age on bone maturation and predicted adult height. P...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1994.tb02553.x

    authors: Hochberg Z,Leiberman E,Landau H,Koren R,Zadik Z

    更新日期:1994-09-01 00:00:00

  • Hyperthyroidism associated with metastatic thyroid carcinoma.

    abstract::We report a patient with unilateral thyroid carcinoma, who developed hyperfunction of the thyroid gland during the metastatic progression of the thyroid carcinoma. Concurrently with this event, TSI increased and it is suggested that the differentiated aggressive metastatic thyroid neoplasm had initiated the autoimmune...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1994.tb01837.x

    authors: Steffensen FH,Aunsholt NA

    更新日期:1994-11-01 00:00:00

  • The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain.

    abstract:BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2008.03170.x

    authors: Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

    更新日期:2008-08-01 00:00:00

  • Endemic infantile hypothyroidism in a severe endemic goitre area of central Africa.

    abstract::Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1984.tb00089.x

    authors: Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

    更新日期:1984-03-01 00:00:00

  • Is postablation whole-body 131 I scintigraphy still necessary in intermediate-risk papillary thyroid cancer patients with pre-ablation stimulated thyroglobulin

    abstract:OBJECTIVE:Postablation whole-body scintigraphy, which is performed 5-7 days after administration of ablation activity of radioactive iodine-131 (131 I) in patients with thyroid cancer, is considered a routine procedure for remnant ablation and a useful tool for disease staging. However, the relationship of pre-ablation...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13158

    authors: Liu B,Chen Y,Jiang L,He Y,Huang R,Kuang A

    更新日期:2017-01-01 00:00:00

  • The assay for thyroid stimulating immunoglobulins using cultured human thyroid cells.

    abstract::Recent reports have shown that thyroid-stimulating immunoglobulins (TSI) may be detected by measuring cyclic AMP increases in cultures of isolated thyroid cells in response to added patient immunoglobulins (Ig). We have compared the frequency that TSI may be detected in the Ig fraction of 114 sera from 112 patients wi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb01088.x

    authors: Grant SJ,Luttrell BM,Hales IB

    更新日期:1985-10-01 00:00:00

  • Adrenal vein sampling: External validation of multinomial regression modelling and left adrenal vein-to-peripheral vein ratio to predict lateralization index without right adrenal vein sampling.

    abstract:BACKGROUND:Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein-to-peripheral vein ratio (LAV/PV) were proposed to predict the lateralization index without the right AVS. OBJECTIVE:To assess external validity of MRM and LAV...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.14295

    authors: Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

    更新日期:2020-12-01 00:00:00

  • Increased mortality and morbidity in patients with chronic hypoparathyroidism: A population-based study.

    abstract:OBJECTIVES:A population-based study was undertaken to determine the mortality and morbidity for people with hypoparathyroidism compared to the general population. METHODS:In this study, patients identified with chronic hypoparathyroidism using data linkage from regional datasets were compared with five age- and gender...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13895

    authors: Vadiveloo T,Donnan PT,Leese CJ,Abraham KJ,Leese GP

    更新日期:2019-02-01 00:00:00

  • Nontruncated amino-terminal parathyroid hormone overproduction in two patients with parathyroid carcinoma: a possible link to HRPT2 gene inactivation.

    abstract:OBJECTIVE:Some patients with parathyroid carcinoma present with an over-production of nontruncated amino-terminal (NT-N) parathyroid hormone (PTH), a post-transcriptionally modified form of PTH(1-84). This is usually picked up on an elevated whole (W) PTH (third-generation)/total (T) (second-generation) PTH assay ratio...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2011.04021.x

    authors: Caron P,Simonds WF,Maiza JC,Rubin M,Cantor T,Rousseau L,Bilezikian JP,Souberbielle JC,D'Amour P

    更新日期:2011-06-01 00:00:00

  • High incidence of positive autoantibodies against thyroid peroxidase and thyroglobulin in patients with sarcoidosis.

    abstract:OBJECTIVE:Although abnormalities of the humoral immune system, such as increased immunoglobulin production, are known in sarcoidosis, the relationship between sarcoidosis and autoimmune disorders in uncertain. We studied the incidence of thyroid autoantibodies and the prevalence of Hashimoto's thyroiditis in patients w...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1997.1630976.x

    authors: Nakamura H,Genma R,Mikami T,Kitahara A,Natsume H,Andoh S,Nagasawa S,Nishiyama K,Chida K,Sato A,Yoshimi T

    更新日期:1997-04-01 00:00:00

  • Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabolic disorders.

    abstract:CONTEXT:Subjects with nonalcoholic fatty liver disease (NAFLD) have a high risk of developing type 2 diabetes and cardiovascular diseases. Low serum potassium concentration or low dietary potassium intake can result in metabolic disorders. OBJECTIVE:Our objective was to evaluate the association between low serum potas...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12168

    authors: Sun K,Lu J,Jiang Y,Xu M,Xu Y,Zhang J,Xu B,Sun J,Sun W,Ren C,Liu J,Wang W,Bi Y,Ning G

    更新日期:2014-03-01 00:00:00

  • Evidence for a hypothalamic alteration of catecholamine metabolism in polycystic ovary syndrome.

    abstract::The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1988.tb01230.x

    authors: Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

    更新日期:1988-09-01 00:00:00

  • Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes.

    abstract:OBJECTIVE:The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. However, there have been no previous reports on the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02344.x

    authors: Liang H,Murase Y,Katuta Y,Asano A,Kobayashi J,Mabuchi H

    更新日期:2005-09-01 00:00:00

  • Comparison of the diagnostic accuracy of combined elastosonography and BRAF analysis vs cytology and ultrasonography for thyroid nodule suspected of malignancy.

    abstract:OBJECTIVE:Diagnosing thyroid nodules preoperatively using traditional diagnostic tools - ultrasonography (US) and cytology - still carries a considerable degree of uncertainty, and surgery is recommended for a far from negligible number of patients simply for diagnostic purposes. Thyroid elastosonography (USE) and BRAF...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2012.04427.x

    authors: Nacamulli D,Nico L,Barollo S,Zambonin L,Pennelli G,Girelli ME,Casal Ide E,Pelizzo MR,Vianello F,Negro I,Watutantrige-Fernando S,Mantero F,Rugge M,Mian C

    更新日期:2012-10-01 00:00:00

  • Serum prolactin concentration in patients taking neuroleptic drugs.

    abstract:OBJECTIVE:Non-tumour causes of hyperprolactinaemia, including prolactin-elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000 mU/I, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrat...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1998.00569.x

    authors: Pollock A,McLaren EH

    更新日期:1998-10-01 00:00:00

  • Interest of Chromogranin A for diagnosis and follow-up of endocrine tumours.

    abstract:OBJECTIVE:To determine the interest of Chromogranin A (CgA) determination for diagnosis and follow-up in patients with gastroenteropancreatic endocrine tumours (GEP-ET) and multiple endocrine neoplasia type 1 (MEN-1). PATIENTS AND METHODS:CgA levels were measured with an immunoradiometric assay in 124 sporadic GEP-ET,...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2004.02030.x

    authors: Nehar D,Lombard-Bohas C,Olivieri S,Claustrat B,Chayvialle JA,Penes MC,Sassolas G,Borson-Chazot F

    更新日期:2004-05-01 00:00:00

  • Treatment of post-menopausal osteoporosis with a combination of growth hormone and pamidronate: a placebo controlled trial.

    abstract:OBJECTIVE:It is known that growth hormone can induce accelerated bone turnover in GH deficient people as well as healthy elderly people. In this study we examined the effect of recombinant human GH (rhGH) on bone mineral mass and bone turnover in the presence of the bone resorption inhibiting agent, pamidronate. Effect...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1995.tb02920.x

    authors: Erdtsieck RJ,Pols HA,Valk NK,van Ouwerkerk BM,Lamberts SW,Mulder P,Birkenhäger JC

    更新日期:1995-11-01 00:00:00

  • Risk for severe hypoglycaemia with unawareness in GH-deficient patients during the insulin tolerance test.

    abstract:OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02436.x

    authors: Holmer H,Link K,Erfurth EM

    更新日期:2006-02-01 00:00:00

  • Gonadal-pituitary hormone levels in gynaecomastia.

    abstract::Plasma levels of LH, FSH, oestradiol 17 beta and testosterone were measured in twenty-two men with gynaecomastia. The group was divided by age into those under and those over 50-years-old and the mean hormone levels of the two groups were compared with two groups of age-matched normal men. In the young men with gynaec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1980.tb01025.x

    authors: McFadyen IJ,Bolton AE,Cameron EH,Hunter WM,Raab G,Forrest AP

    更新日期:1980-07-01 00:00:00

  • Differences in testosterone metabolism by beard and scalp hair follicle dermal papilla cells.

    abstract:OBJECTIVE:Androgens have paradoxically different effects on hair follicles depending on body site, stimulating beard growth while inducing regression in some areas of the scalp. The mesenchyme derived dermal papilla at the base of the hair follicle regulates many aspects of the growth of follicular epithelium, and is p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1993.tb02420.x

    authors: Thornton MJ,Laing I,Hamada K,Messenger AG,Randall VA

    更新日期:1993-12-01 00:00:00

  • Milk-alkali syndrome is a major cause of hypercalcaemia among non-end-stage renal disease (non-ESRD) inpatients.

    abstract:OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02383.x

    authors: Picolos MK,Lavis VR,Orlander PR

    更新日期:2005-11-01 00:00:00

  • Determinants of plasma PTH and their implication for defining a reference interval.

    abstract:BACKGROUND:To improve the diagnostic sensitivity of PTH measurements, more data on the upper limit of the reference interval for PTH levels were requested at a recent international consensus conference. As PTH levels vary inversely with plasma 25-hydroxyvitamin D (25OHD) levels and as vitamin D insufficiency is widespr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2010.03894.x

    authors: Rejnmark L,Vestergaard P,Heickendorff L,Mosekilde L

    更新日期:2011-01-01 00:00:00

  • A new germline VHL gene mutation in three patients with apparently sporadic pheochromocytoma.

    abstract:CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12032

    authors: D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

    更新日期:2013-03-01 00:00:00