Abstract:
:Several chloro- and iodo-lignanolides have been obtained by direct halogenation of aromatic rings from yatein and 4'-O-demethylyatein. They were assayed as antineoplastics, in order to check the influence in the activity of substitution in both aromatic rings. Although these compounds show a modest antineoplastic activity, it is far from that displayed by yatein and podophyllotoxin. These results confirm that demethylation and the introduction of halo substituents diminish the activity of lignans of the dibenzylbutyrolactone type.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Medarde M,Peláez-Lamamié de Clairac R,López JL,Grávalos DG,San Feliciano Sdoi
10.1002/ardp.19953280903subject
Has Abstractpub_date
1995-09-01 00:00:00pages
640-4issue
9eissn
0365-6233issn
1521-4184journal_volume
328pub_type
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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