Abstract:
:A series of oximes deriving from 5-arylidene-pyrrolidine-2,3,4-triones and pyridine-2,3,4-triones has been prepared. The presence of the tautomeric nitrosoenol was proven in solutions of alpha-ketooxime 7a. The binding affinity of the new oximes toward the N-methyl-D-aspartate (glycine site) receptor has been measured as a basis for more detailed structure-activity relationship studies. Oxime 13b showed the highest binding potency acting as glycine antagonist in nanomolar concentration.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Poschenrieder H,Höfner G,Stachel HDdoi
10.1002/(sici)1521-4184(19999)332:9<309::aid-ardp3keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
309-16issue
9eissn
0365-6233issn
1521-4184pii
10.1002/(SICI)1521-4184(19999)332:9<309::AID-ARDP3journal_volume
332pub_type
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