Abstract:
:A novel dimer of 2-(4-pyridylmethyl)-1-indanone (2) was obtained while carrying out aldol condensation of 1-indanone with pyridine-4-carboxaldehyde in potassium hydroxide. The structure of dimer 3 has been established using various spectral techniques and was screened for its ability to inhibit the cytochrome P(450) enzyme aromatase. The dimer showed strong inhibition of human placental aromatase and was found 3 times more potent (RP = 3, IC(50) = 10.2 microM) as compared to aminoglutethimide (RP = 1, IC(50) = 18.5 microM.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Gupta R,Jindal DP,Jit B,Narang G,Palusczak A,Hartmann RWdoi
10.1002/ardp.200400853keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
398-401issue
7eissn
0365-6233issn
1521-4184journal_volume
337pub_type
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