Abstract:
:New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, isoquinoline, quinazoline, and phthalazine nuclei, have been synthesized. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 7d, 8b, 8c, and 8e are at least comparable to that of the clinically used drugs flupirtine and tramadol under the same conditions.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Rádl S,Kovárová L,Hezky P,Vosátka V,Königová O,Proska J,Krejcí Idoi
10.1002/(sici)1521-4184(19996)332:6<208::aid-ardp2keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
208-12issue
6eissn
0365-6233issn
1521-4184pii
10.1002/(SICI)1521-4184(19996)332:6<208::AID-ARDP2journal_volume
332pub_type
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