Abstract:
:Gypsogenin (1) was obtained by acidic hydrolysis from its saponin. While the parent compound 1 acted as a selective inhibitor for butyrylcholinesterase (from equus) possessing a moderate mixed-type inhibition of the enzyme, Ki values as low as 2.67 ± 0.59 μM were determined for (3β,4α) 3-O-acetyl-olean-12-ene-23,28-dinitrile (11) and acetylcholinesterase (AChE, from electric eel). Thus, 11 possesses one-fifth of the inhibitory activity of the "gold standard" galantamine hydrobromide; this compound is one of the first pentacyclic triterpenoids described as a potent AChE-selective inhibitor.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Heller L,Schwarz S,Weber BA,Csuk Rdoi
10.1002/ardp.201400103subject
Has Abstractpub_date
2014-10-01 00:00:00pages
707-16issue
10eissn
0365-6233issn
1521-4184journal_volume
347pub_type
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