Abstract:
:3'-Azidonucleosides 4 have been synthesized by condensation of silylated (Z)-5-ethylidenehydantoin and (Z)-5-benzylidenehydantoin with methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-D-erythro-pento furanoside (3). The nucleosides 4 were deblocked on treatment with tetrabutylammonium fluoride. The ethylidene group isomerized from Z to E configuration during the nucleoside synthesis. The new nucleosides did not show any appreciable activities against HIV-1 or HSV-1.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
el-Barbary AA,Khodair AI,Pedersen EBdoi
10.1002/ardp.19943271010subject
Has Abstractpub_date
1994-10-01 00:00:00pages
653-5issue
10eissn
0365-6233issn
1521-4184journal_volume
327pub_type
杂志文章abstract::The plant pentacyclic alkaloid camptothecin and its structural analogs were extensively studied. These compounds are interesting due to the antitumor activity associated with their ability to inhibit topoisomerase I in tumor cells. During the last decades of the 20th century, a large number of the silicon-containing c...
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journal_title:Archiv der Pharmazie
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