Abstract:
:The biotransformation of the positively inotropically active compound N-methyl-N-(2-hydroxy-3-phenoxy-propyl)-11-(2-aminoethyl)-6,11- dihydrodibenz[b,e]-oxepine, neutral fumarate, (Doxaminol, racemic mixture of diastereomeres) in dogs is examined. The metabolits M1-M7 were isolated and their chemical structures identified by 1H-NMR, 13C-NMR and mass spectroscopic methods. 2-Hydroxy-3-phenoxypropionic acid, phenoxyacetic acid, 3-(4'-hydroxy)-phenoxy-1,2-propandiol and phenylacetic acid were formed by side chain oxidation of the parent molecule. Furthermore, the following conjugates were characterized: Doxaminol-O-glucuronide, 4'-hydroxydoxaminol-O-glucuronide, and 1-hydroxy-3-phenoxy-2-propyl sulfate.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Neidlein R,Volland C,Kramer Wdoi
10.1002/ardp.19903230503subject
Has Abstractpub_date
1990-05-01 00:00:00pages
259-65issue
5eissn
0365-6233issn
1521-4184journal_volume
323pub_type
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