Abstract:
:Marine organisms play an important role in natural product-based drug research due to accumulation of structurally unique and bioactive metabolites. The exploration of marine-derived compounds may significantly extend the scientific knowledge of potential scaffolds for antibiotic drug discovery. Development of novel antitubercular agents is especially significant as the emergence of drug-resistant Mycobacterium tuberculosis strains remains threateningly high. Marine invertebrates (i.e., sponges, corals, gorgonians) as a source of new chemical entities are the center of research for several scientific groups, and the wide spectrum of biological activities of marine-derived compounds encourages scientists to carry out investigations in the field of antibiotic research, including tuberculosis treatment. The present review covers published data on antitubercular natural products from marine invertebrates grouped according to their biogenetic origin. Studies on the structure-activity relationships of these important leads are highlighted as well.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Daletos G,Ancheeva E,Chaidir C,Kalscheuer R,Proksch Pdoi
10.1002/ardp.201600128subject
Has Abstractpub_date
2016-10-01 00:00:00pages
763-773issue
10eissn
0365-6233issn
1521-4184journal_volume
349pub_type
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