Abstract:
:Syntheses of a new series of biologically potent α-aminophosphonates were accomplished by one-pot Kabachnik-Fields reaction using TiO2-SiO2 as solid supported catalyst under microwave irradiation conditions. The chemical structures of all the newly synthesized compounds were confirmed by analytical and spectral (IR, 1H, 13C, 31P NMR, and mass) data. Their anticancer nature was evaluated by screening the in vitro activity on two human cancer cell lines, HeLa and SK-BR-3. Compounds 4i and 4o showed the best activity on these cancer cells even though the majority of the compounds, and particularly 4l and 4p, have good cytotoxic activity against them.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Chinthaparthi RR,Bhatnagar I,Gangireddy CS,Syama SC,Cirandur SRdoi
10.1002/ardp.201300214subject
Has Abstractpub_date
2013-09-01 00:00:00pages
667-76issue
9eissn
0365-6233issn
1521-4184journal_volume
346pub_type
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