Abstract:
:New condensed derivatives of anpirtoline, in which the pyridine ring is replaced with quinoline, quinazoline, 7-chloroquinoline, and 7-chloroquinazoline nuclei, have been synthesized. Their receptor binding profiles (5-HT1A, 5-HT1B) and analgesic activity (hot plate, acetic acid induced writhing) have been studied. The analgesic activity of compounds 4e-4g, and 4l are at least comparable to that of clinically used drugs flupirtine and tramadol under the same conditions.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Rádl S,Hezky P,Proska J,Krejcí Idoi
10.1002/1521-4184(200011)333:11<381::aid-ardp381>3keywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
381-6issue
11eissn
0365-6233issn
1521-4184pii
10.1002/1521-4184(200011)333:11<381::AID-ARDP381>3journal_volume
333pub_type
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