Abstract:
:The design, synthesis, and investigation of antitumor and anti-lipase activities of some coumarin-triazole hybrid molecules are reported. The synthesis of these hybrid molecules was performed under microwave irradiation and conventional heating procedures. The newly synthesized hybrid molecules were investigated as inhibitors against four tumor cell lines (BT20 human breast carcinoma, SK-Mel 128 melanoma, DU-145 prostate carcinoma, and A549 lung carcinoma) and porcine pancreatic lipase (PPL). Most of these compounds showed notable antitumor activities against the tested tumor cell lines, and compounds 8i and 8l showed the best anti-lipase activity of 99.30 ± 0.56% and 99.85 ± 1.21%, respectively, at a concentration of 10 μM.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Kahveci B,Yılmaz F,Menteşe E,Ülker Sdoi
10.1002/ardp.201600369subject
Has Abstractpub_date
2017-08-01 00:00:00issue
8eissn
0365-6233issn
1521-4184journal_volume
350pub_type
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