Abstract:
:Poly(vinyl alcohol) was crosslinked with ethylene glycol diglycidyl ether to obtain hydrogel-forming polymers. The polymers were also substituted with oleoyl chloride, providing hydrogels with weak solubility. These new polymeric materials were evaluated for the formulation of sustained drug delivery systems. Vancomycin hydrochloride was used as a peptidic model drug whose sustained release should minimize its inactivation in the upper part of the gastrointestinal tract. Spray-dried mixtures of the drug and the polymer [at 1:4 and 1:8 (w:w) ratios] were prepared and the release of the drugs from the mixtures was evaluated in vitro at pH 2.0, 5.5, 7.4, and 8.0. The results indicated that the crosslinked polymers slowed down the release of the drugs with respect to the pure drug at each pH. The degree of crosslinking of ethylene glycol diglycidyl ether and the extent of substitution with oleoyl chloride were found to influence drug release.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Orienti I,Treré R,Luppi B,Bigucci F,Cerchiara T,Zuccari G,Zecchi Vdoi
10.1002/1521-4184(200203)335:2/3<89::AID-ARDP89>3.keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
89-93issue
2-3eissn
0365-6233issn
1521-4184journal_volume
335pub_type
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journal_title:Archiv der Pharmazie
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