Abstract:
:The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was observed. Combinations with established cytostatic agents like platinum complexes or other antitumor compounds also yielded partly additive effects. In experiments performed with asparaginase L-aspartic acid-beta-hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Laske R,Schönenberger H,Holler Edoi
10.1002/ardp.19913240305subject
Has Abstractpub_date
1991-03-01 00:00:00pages
153-60issue
3eissn
0365-6233issn
1521-4184journal_volume
324pub_type
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