Abstract:
:Synthesis of a new series of 1beta-methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on the oxadiazole ring investigated. In particular, compounds 13a and 13c with ester and carbamoyl substituted oxadiazole moieties showed the most potent antibacterial activity.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Oh CH,Dong HG,Lee JS,Lee SC,Hong JH,Cho JHdoi
10.1002/ardp.200300768keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
567-72issue
12eissn
0365-6233issn
1521-4184journal_volume
336pub_type
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