Abstract:
:In continuation of our effort aimed towards the development of novel aldose reductase inhibitors, several phenylacetic acids bearing an alkoxy substituent in position 3 or 4, respectively, were prepared and screened. The latter represent formal ring opening products of the cyclohexylmethyloxyphenylacetic acids IIa and IIb, recently elaborated in our group. Out of these series, compounds 4aa and 4ba characterized by an n-heptyloxy subunit turned out to be the most potent inhibitors. Based on these unexpected results, we suggest that such an alkyl side chain acts as a useful surrogate for the 4-bromo-2-fluorobenzyl residue often found in potent aldose reductase inhibitors.
journal_name
Arch Pharm (Weinheim)journal_title
Archiv der Pharmazieauthors
Rakowitz D,Gmeiner A,Matuszczak Bdoi
10.1002/ardp.200600054subject
Has Abstractpub_date
2006-10-01 00:00:00pages
559-63issue
10eissn
0365-6233issn
1521-4184journal_volume
339pub_type
杂志文章abstract::To identify new agents for the treatment of American cutaneous leishmaniasis, a series of eight 1,4-bis(substituted benzalhydrazino)phthalazines was evaluated against Leishmania braziliensis and Leishmania mexicana parasites. These compounds represent a disubstituted version of the 1-chloro-4-(monoaryl/heteroarylhydra...
journal_title:Archiv der Pharmazie
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abstract::Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Som...
journal_title:Archiv der Pharmazie
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doi:10.1002/ardp.19953280304
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pub_type: 杂志文章
doi:10.1002/ardp.200900119
更新日期:2009-11-01 00:00:00
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journal_title:Archiv der Pharmazie
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doi:10.1002/ardp.200800005
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journal_title:Archiv der Pharmazie
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doi:10.1002/(sici)1521-4184(19999)332:9<309::aid-ardp3
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
doi:10.1002/ardp.19923250103
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
doi:10.1002/ardp.200700007
更新日期:2007-07-01 00:00:00
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journal_title:Archiv der Pharmazie
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更新日期:2001-06-01 00:00:00
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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journal_title:Archiv der Pharmazie
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